01.12.2015 | Original Article
The improvement of metabolic control after using metformin in patients with type 1 diabetes mellitus and excessive visceral fat tissue treated with intensive insulin therapy—pilot study
Erschienen in: International Journal of Diabetes in Developing Countries | Ausgabe 4/2015
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The use of exogenous insulin and incorrect nutritional habits are conducive to obesity and excess weight. This leads to the development of insulin resistance, even in patients with type 1 diabetes mellitus. The aim of this study was to assess the effects of metformin as adjunctive therapy on anthropometric parameters and metabolic control in patients with type 1 diabetes mellitus. The study included a group 45 patients with elevated adipose tissue content as measured by electrical bioimpedance. Thirty-nine patients (11 males and 28 females) of the group fulfill the study protocol. The mean age was 33.5 ± 11.9 years and duration of diabetes 12.6 ± 7.4 years. Metformin was administered for at least 6 months at a mean dose of 1032 ± 718 mg/day. Application of metformin resulted in a statistically significant reduction in total adipose tissue (4.8 ± 4.0 vs. 2.9 ± 4.4 kg, p = 0.03), waist circumference (96.4 ± 9.5 vs. 89.1 ± 11.1 cm, p = 0.003), and VAI (4.1 ± 2.4 vs. 2.5 ± 1.8, p = 0.006). Reduction in insulin requirement (0.7 ± 0.1 vs. 0.6 ± 0.2 units/kg/day, p = 0.02), fasting glycemia (166.5 ± 52.5 vs. 135.7 ± 48 mg/dl, p = 0.01), and postprandial glycemia (196.9 ± 74.3 vs. 137.1 ± 37.5 mg/dl, p = 0.00002) was also observed. In addition, decrease in triglyceride serum concentration (128.2 ± 52.9 vs. 94.0 ± 32.1 mg/dl, p = 0.002) and non-HDL cholesterol (154.5 ± 41.3 vs. 130.0 ± 39.7 mg/dl, p = 0.01) was achieved. Addition of metformin to insulin therapy of patients with type 1 diabetes mellitus and elevated adipose tissue content is safe and may lead to measurable clinical benefits.
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