Background
Methods
Patients
Study preparations
Study design
Statistical analysis
Results
Patient demographics
No treatment | 0.033 mg/kg/day | 0.067 mg/kg/day | ||||
---|---|---|---|---|---|---|
n | n | n | ||||
Gender | 15 | 31 | 34 | |||
Male, % | 46.7 | 7 | 64.5 | 20 | 58.8 | 20 |
Female, % | 53.3 | 8 | 35.5 | 11 | 41.2 | 14 |
Chronological age, years | 5.32 ± 1.38 | 15 | 5.34 ± 1.46 | 31 | 5.27 ± 1.15 | 34 |
Height, cm | 94.6 ± 8.6 | 15 | 95.9 ± 8.4 | 31 | 94.9 ± 7.3 | 34 |
Height SDS | -2.92 ± 0.53 | 15 | -2.95 ± 0.64 | 31 | -2.90 ± 0.67 | 34 |
BMI | 14.07 ± 1.40 | 15 | 14.42 ± 1.26 | 31 | 14.16 ± 1.24 | 34 |
IGF-I, ng/mL | 115.39 ± 51.01 | 15 | 117.25 ± 49.13 | 31 | 118.20 ± 49.10 | 34 |
IGF-I SDS | -1.03 ± 1.50 | 15 | -0.75 ± 1.06 | 31 | -0.63 ± 1.21 | 34 |
Insulin, μU/mL | 2.6 ± 1.7 | 10 | 3.6 ± 2.1 | 26 | 3.2 ± 1.9 | 28 |
Glucose, mg/dL | 79.8 ± 6.3 | 15 | 82.4 ± 10.4 | 31 | 78.2 ± 11.5 | 34 |
HbA1c (NGSP), % | 5.08 ± 0.32 | 15 | 5.10 ± 0.29 | 31 | 5.00 ± 0.19 | 34 |
TC, mg/dL | 173.5 ± 24.2 | 15 | 166.9 ± 29.8 | 31 | 181.4 ± 24.2 | 34 |
LDL-C, mg/dL | 96.7 ± 18.9 | 15 | 94.8 ± 26.2 | 31 | 104.7 ± 25.0 | 34 |
HDL-C, mg/dL | 60.4 ± 15.9 | 15 | 56.9 ± 9.6 | 31 | 61.9 ± 12.0 | 34 |
0.033 mg/kg/day | 0.067 mg/kg/day | |||||||||
---|---|---|---|---|---|---|---|---|---|---|
Total | Glucose intolerant type | Time point evaluated as the glucose intolerant type | Total | Glucose intolerant type | Time point evaluated as the glucose intolerant type | |||||
Before | 60 mina
| 120 min | Before | 60 min* | 120 min | |||||
Baseline | 31 (100 %) | 3 (9.7 %) | 1 (3.2 %) | 0 (0.0 %) | 2 (6.5 %) | 34 (100 %) | 1 (2.9 %) | 0 (0.0 %) | 0 (0.0 %) | 1 (2.9 %) |
52 weeks | 29 (100 %) | 3 (10.3 %) | 0 (0.0 %) | 2 (6.9 %) | 1 (3.4 %) | 34 (100 %) | 3 (8.8 %) | 0 (0.0 %) | 3 (8.8 %) | 0 (0.0 %) |
104 weeks | 29 (100 %) | 2 (6.9 %) | 0 (0.0 %) | 0 (0.0 %) | 2 (6.9 %) | 32 (100 %) | 2 (6.3 %) | 0 (0.0 %) | 0 (0.0 %) | 2 (6.3 %) |
156 weeks | 25 (100 %) | 1 (4.0 %) | 0 (0.0 %) | 0 (0.0 %) | 1 (4.0 %) | 29 (100 %) | 2 (6.9 %) | 0 (0.0 %) | 0 (0.0 %) | 2 (6.9 %) |
208 weeks | 25 (100 %) | 0 (0.0 %) | 0 (0.0 %) | 0 (0.0 %) | 0 (0.0 %) | 28 (100 %) | 3 (10.7 %) | 0 (0.0 %) | 2 (7.1 %) | 1 (3.6 %) |
260 weeks | 23 (100 %) | 1 (4.3 %) | 1 (4.3 %) | 0 (0.0 %) | 0 (0.0 %) | 27 (100 %) | 4 (14.8 %) | 0 (0.0 %) | 1 (3.7 %) | 3 (11.1 %) |
Influence on lipid metabolism
Influence on glucose metabolism
0.033 mg/kg/day n = 20 | 0.067 mg/kg/day n = 16 | |
---|---|---|
Baseline | 0.720 ± 0.465 | 0.646 ± 0.498 |
260 weeks | 2.154 ± 1.682 | 1.895 ± 1.197 |