Skeletal muscle adenosine triphosphate (ATP) levels are severely depleted during and following prolonged high intensity exercise. Recovery from these lower ATP levels can take days, which can affect performance on subsequent days of exercise. Untrained individuals often suffer the stress and consequences of acute, repeated bouts of exercise by not having the ability to perform or recovery sufficiently to exercise on subsequent days. Conversely, trained individuals may be able to recover more quickly due to their enhanced metabolic systems. D-Ribose (DR) has been shown to enhance the recovery in ATP; however, it is not known if recovery and performance can be benefitted with DR ingestion. Therefore, this study was designed to determine what influence DR might have on muscular performance, recovery, and metabolism during and following a multi-day exercise regimen.
The study was a double blind, crossover study in 26 healthy subjects compared 10 g/day of DR to 10 g/day of dextrose (DEX, control). All subjects completed 2 days of loading with either DR or DEX, followed by 3 additional days of supplementation and during these 3 days of supplementation, each subject underwent 60 min of high intensity interval exercise in separate daily sessions, which involved cycling (8 min of exercise at 60% and 2 min at 80% VO2max), followed by a 2 min power output (PO) test. Subjects were divided into two groups based on peak VO2 results, lower VO2 (LVO2) and higher peak VO2 (HVO2).
Mean and peak PO increased significantly from day 1 to day 3 for the DR trial compared to DEX in the LVO2 group. Rate of perceived exertion (RPE) and creatine kinase (CK) were significantly lower for DR than DEX in the LVO2 group. No differences in PO, RPE, heart rate, CK, blood urea nitrogen, or glucose were found between either supplement for the HVO2 group.
DR supplementation in the lower VO2 max group resulted in maintenance in exercise performance, as well as lower levels of RPE and CK. Unlike no observed benefits with DEX supplementation.
Roedde S, MacDougall JD, Sutton JR, Green HJ. Supercompensation of muscle glycogen in trained and untrained subjects. Can J Appl Sport Sci. 1986;11(1):42–6. PubMed
Dela F, Mikines KJ, von Linstow M, Secher NH, Galbo H. Effect of training on insulin-mediated glucose uptake in human muscle. Am J Phys. 2006;263(6 Pt 1):E1134–43.
Sidossis LS, Wolfe RR, Coggan AR. Regulation of fatty acid oxidation in untrained vs. trained men during exercise. Am J Phys. 1998;274(3 Pt 1):E510–5.
Darr KC, Bassett DR, Morgan BJ, Thomas DP. Effects of age and training status on heart rate recovery after peak exercise. Am J Physiol Heart Circ Physiol. 1988;254(2):H340–3.
Hellsten-Westing Y, Norman B, Balsom PD, Sjodin B. Decreased resting levels of adenine nucleotides in human skeletal muscle after high-intensity training. J Appl Physiol. 1993;74(5):2523–8. PubMed
Stathis CG, Febbraio MA, Carey MF, Snow RJ. Influence of sprint training on human skeletal muscle purine nucleotide metabolism. J Appl Physiol. 1994;76(4):1802–9. PubMed
Hargreaves M, McKenna MJ, Jenkins DG, Warmington SA, Li JL, Snow RL, Febbraio MA. Muscle metabolites and performance during high-intensity, intermittent exercise. J Appl Physiol. 1998;84(5):1687–91. PubMed
Tullson PC, Bangsbo J, Hellsten Y, Richter EA. IMP metabolism in human skeletal muscle after exhaustive exercise. J Appl Physiol. 1995;78(1):146–52. PubMed
Eijnde BO, Van Leemputte M, Brouns F, Van Der Vuss GJ, Labarque V, Ramaekers M, Schuylenberg R, Verbessem P, Wijnen LT, Hespel P. No effects of oral ribose supplementation on repeated maximal exercise and de novo ATP resynthesis. J Appl Physiol. 2001;91:2275–81. PubMed
Van Gammeren D, Falk D, Antonio J. The effects of four weeks of ribose supplementation on body composition and exercise performance in healthy, young, male recreational bodybuilders: a double blind, placebo controlled trial. Curr Ther Res. 2002;63(8):486–95. CrossRef
Raue U, Gallagher PM, Williamson DL, Trappe SW. Effects of ribose supplementation on performance during repeated high-intensity cycle sprints. Med Sci Sport Exerc. 2001;33(5):S44. CrossRef
Sjordin B, Hellsten-Westing Y, Apple FS. Biochemical mechanisms for oxygen free radical formation during exercise. Sports Med. 1990;10(4):236–54. CrossRef
Shecterle LM, St. Cyr JA. Myocardial ischemia: alterations in myocardial cellular energy and diastolic function, a potential role for D-ribose. In: Lakshmanadoss U, editor. Novel strategies in ischemic heart disease. Croatia: In Tech; 2012. p. 219–28.
Brault JJ, Terjung RL. Purine salvage to adenine nucleotides in different skeletal muscle fiber types. J Appl Physiol. 2001;91(1):231–8. PubMed
Berardi J, Ziegenfuss T, Hall B. Effect of ribose supplementation on sprint performance: a pilot study. Med Sci Sports Exerc. 2000;32(5):S260.
Saltin B, Rowell LB. Functional adaptations to physical activity and inactivity. Fed Proc. 1980;39(5):1506–13. PubMed
- The influence of D-ribose ingestion and fitness level on performance and recovery
John G. Seifert
John A. St Cyr
- BioMed Central
Journal of the International Society of Sports Nutrition
Elektronische ISSN: 1550-2783
Neu im Fachgebiet Orthopädie und Unfallchirurgie
Mail Icon II