nach oben

Pediatric Nephrology

Erschienen in:

01.08.2012 | Review

The influence of gender and sexual hormones on incidence and outcome of chronic kidney disease

verfasst von: Sebastian Kummer, Gero von Gersdorff, Markus J. Kemper, Jun Oh

Erschienen in: Pediatric Nephrology | Ausgabe 8/2012

Einloggen, um Zugang zu erhalten

Abstract

It has long been known that the female sex is associated with a better clinical outcome in chronic renal diseases. Although many experimental, clinical, and epidemiological studies in adults have attempted to explain the difference in disease progression between females and males, a definitive understanding of the underlying mechanisms is still lacking. Hormone-modulating therapies are being increasingly used for various indications (such as post-menopausal hormone replacement, estrogen- or androgen-receptor antagonists for cancer therapy). Therefore, a deeper knowledge of the interaction between sexual hormones and progression of kidney disease is important, as hormone-modulating therapy for non-renal indication may influence both kidney structure and function. In addition, specific modulation of the sexual hormone system, such as the use of selective estrogen receptor modulators, may represent a therapeutic option for patients with renal diseases. Although conclusive data on this topic in the pediatric population are still lacking, the aim of this review is to familiarize pediatric nephrologists with gender-specific differences in renal physiology, pathophysiology, and the progression of kidney diseases. Experimental models that analyze the effects of sexual hormones on renal structure and function are discussed. It is hoped that this review will stimulate researchers to focus on pediatric studies that will provide a deeper insight into the interaction of gender hormones and the kidney both before and during puberty.

Berg UB (2006) Differences in decline in GFR with age between males and females. Reference data on clearances of inulin and PAH in potential kidney donors. Nephrol Dial Transplant 21:2577–2582PubMedCrossRef

Neugarten J, Acharya A, Silbiger SR (2000) Effect of gender on the progression of nondiabetic renal disease: a meta-analysis. J Am Soc Nephrol 11:319–329PubMed

Cattran DC, Reich HN, Beanlands HJ, Miller JA, Scholey JW, Troyanov S (2008) The impact of sex in primary glomerulonephritis. Nephrol Dial Transplant 23:2247–2253PubMedCrossRef

Molina JF, Drenkard C, Molina J, Cardiel MH, Uribe O, Anaya JM, Gomez LJ, Felipe O, Ramirez LA, Alarcon-Segovia D (1996) Systemic lupus erythematosus in males. A study of 107 Latin American patients. Medicine 75:124–130PubMedCrossRef

Raile K, Galler A, Hofer S, Herbst A, Dunstheimer D, Busch P, Holl RW (2007) Diabetic nephropathy in 27,805 children, adolescents, and adults with type 1 diabetes: effect of diabetes duration, A1C, hypertension, dyslipidemia, diabetes onset, and sex. Diabetes Care 30:2523–2528PubMedCrossRef

Svensson M, Nystrom L, Schon S, Dahlquist G (2006) Age at onset of childhood-onset type 1 diabetes and the development of end-stage renal disease: a nationwide population-based study. Diabetes Care 29:538–542PubMedCrossRef

Norris KC, Agodoa LY (2005) Unraveling the racial disparities associated with kidney disease. Kidney Int 68:914–924PubMedCrossRef

Carrero JJ (2010) Gender differences in chronic kidney disease: underpinnings and therapeutic implications. Kidney Blood Press Res 33:383–392PubMedCrossRef

Reed E, Cohen DJ, Barr ML, Ho E, Reemtsma K, Rose EA, Hardy M, Suciu-Foca N (1992) Effect of recipient gender and race on heart and kidney allograft survival. Transplant Proc 24:2670–2671PubMed

10.

Zeier M, Dohler B, Opelz G, Ritz E (2002) The effect of donor gender on graft survival. J Am Soc Nephrol 13:2570–2576PubMedCrossRef

11.

Kasiske BL, Umen AJ (1986) The influence of age, sex, race, and body habitus on kidney weight in humans. Arch Pathol Lab Med 110:55–60PubMed

12.

Nyengaard JR, Bendtsen TF (1992) Glomerular number and size in relation to age, kidney weight, and body surface in normal man. Anat Rec 232:194–201PubMedCrossRef

13.

Vereerstraeten P, Wissing M, De Pauw L, Abramowicz D, Kinnaert P (1999) Male recipients of kidneys from female donors are at increased risk of graft loss from both rejection and technical failure. Clin Transplant 13:181–186PubMedCrossRef

14.

Panajotopoulos N, Ianhez LE, Neumann J, Sabbaga E, Kalil J (1990) Immunological tolerance in human transplantation. The possible existence of a maternal effect. Transplantation 50:443–445PubMedCrossRef

15.

Silbiger SR, Neugarten J (1995) The impact of gender on the progression of chronic renal disease. Am J Kidney Dis 25:515–533PubMedCrossRef

16.

Fakhouri F, Bocquet N, Taupin P, Presne C, Gagnadoux MF, Landais P, Lesavre P, Chauveau D, Knebelmann B, Broyer M, Grunfeld JP, Niaudet P (2003) Steroid-sensitive nephrotic syndrome: from childhood to adulthood. Am J Kidney Dis 41:550–557PubMedCrossRef

17.

Ruth EM, Kemper MJ, Leumann EP, Laube GF, Neuhaus TJ (2005) Children with steroid-sensitive nephrotic syndrome come of age: long-term outcome. J Pediatr 147:202–207PubMedCrossRef

18.

Kyrieleis HA, Levtchenko EN, Wetzels JF (2007) Long-term outcome after cyclophosphamide treatment in children with steroid-dependent and frequently relapsing minimal change nephrotic syndrome. Am J Kidney Dis 49:592–597PubMedCrossRef

19.

Kyrieleis HA, Lowik MM, Pronk I, Cruysberg HR, Kremer JA, Oyen WJ, van den Heuvel BL, Wetzels JF, Levtchenko EN (2009) Long-term outcome of biopsy-proven, frequently relapsing minimal-change nephrotic syndrome in children. Clin J Am Soc Nephrol 4:1593–1600PubMedCrossRef

20.

Staples AO, Greenbaum LA, Smith JM, Gipson DS, Filler G, Warady BA, Martz K, Wong CS (2010) Association between clinical risk factors and progression of chronic kidney disease in children. Clin J Am Soc Nephrol 5:2172–2179PubMedCrossRef

21.

Elema JD, Arends A (1975) Focal and segmental glomerular hyalinosis and sclerosis in the rat. Lab Invest 33:554–561PubMed

22.

Hajdu A, Rona G (1971) The protective effect of estrogens against spontaneous pancratic islet and renal changes in aging male rats. Experientia 27:956–957PubMedCrossRef

23.

Lemos CC, Mandarim-de-Lacerda CA, Dorigo D, Coimbra TM, Bregman R (2005) Chronic renal failure in male and female rats. J Nephrol 18:368–373PubMed

24.

Neugarten J (2002) Gender and the progression of renal disease. J Am Soc Nephrol 13:2807–2809PubMedCrossRef

25.

Tofovic SP, Dubey R, Salah EM, Jackson EK (2002) 2-Hydroxyestradiol attenuates renal disease in chronic puromycin aminonucleoside nephropathy. J Am Soc Nephrol 13:2737–2747PubMedCrossRef

26.

Gross ML, Adamczak M, Rabe T, Harbi NA, Krtil J, Koch A, Hamar P, Amann K, Ritz E (2004) Beneficial effects of estrogens on indices of renal damage in uninephrectomized SHRsp rats. J Am Soc Nephrol 15:348–358PubMedCrossRef

27.

Ritz E, Schwenger V (2005) Lifestyle modification and progressive renal failure. Nephrology 10:387–392PubMedCrossRef

28.

Tsimihodimos V, Dounousi E, Siamopoulos KC (2008) Dyslipidemia in chronic kidney disease: an approach to pathogenesis and treatment. Am J Nephrol 28:958–973PubMedCrossRef

29.

Nguyen S, Hsu CY (2007) Excess weight as a risk factor for kidney failure. Curr Opin Nephrol Hypertens 16:71–76PubMedCrossRef

30.

Westenhoefer J (2005) Age and gender dependent profile of food choice. Forum Nutr:44–51

31.

Graff-Iversen S, Thelle DS, Hammar N (2008) Serum lipids, blood pressure and body weight around the age of the menopause. Eur J Cardiovasc Prev Rehabil 15:83–88PubMedCrossRef

32.

Mudali S, Dobs AS, Ding J, Cauley JA, Szklo M, Golden SH (2005) Endogenous postmenopausal hormones and serum lipids: the atherosclerosis risk in communities study. J Clin Endocrinol Metab 90:1202–1209PubMedCrossRef

33.

Feig DI (2009) Uric acid: a novel mediator and marker of risk in chronic kidney disease? Curr Opin Nephrol Hypertens 18:526–530PubMedCrossRef

34.

Krishnan E, Pandya BJ, Chung L, Dabbous O (2011) Hyperuricemia and the risk for subclinical coronary atherosclerosis—data from a prospective observational cohort study. Arthritis Res Ther 13:R66PubMedCrossRef

35.

Martinez-Maldonado M (2001) Role of hypertension in the progression of chronic renal disease. Nephrol Dial Transplant 16[Suppl 1]:63–66PubMedCrossRef

36.

Khoury S, Yarows SA, O’Brien TK, Sowers JR (1992) Ambulatory blood pressure monitoring in a nonacademic setting. Effects of age and sex. Am J Hypertens 5:616–623PubMed

37.

McBride SM, Flynn FW, Ren J (2005) Cardiovascular alteration and treatment of hypertension: do men and women differ? Endocrine 28:199–207PubMedCrossRef

38.

Munger K, Baylis C (1988) Sex differences in renal hemodynamics in rats. Am J Physiol 254:F223–231PubMed

39.

Miller JA, Anacta LA, Cattran DC (1999) Impact of gender on the renal response to angiotensin II. Kidney Int 55:278–285PubMedCrossRef

40.

Reckelhoff JF, Zhang H, Srivastava K, Granger JP (1999) Gender differences in hypertension in spontaneously hypertensive rats: role of androgens and androgen receptor. Hypertension 34:920–923PubMedCrossRef

41.

Oelkers WK (1996) Effects of estrogens and progestogens on the renin-aldosterone system and blood pressure. Steroids 61:166–171PubMedCrossRef

42.

Chidambaram M, Duncan JA, Lai VS, Cattran DC, Floras JS, Scholey JW, Miller JA (2002) Variation in the renin angiotensin system throughout the normal menstrual cycle. J Am Soc Nephrol 13:446–452PubMed

43.

Ahmed SB, Hovind P, Parving HH, Rossing P, Price DA, Laffel LM, Lansang MC, Stevanovic R, Fisher ND, Hollenberg NK (2005) Oral contraceptives, angiotensin-dependent renal vasoconstriction, and risk of diabetic nephropathy. Diabetes Care 28:1988–1994PubMedCrossRef

44.

Chapman AB, Abraham WT, Zamudio S, Coffin C, Merouani A, Young D, Johnson A, Osorio F, Goldberg C, Moore LG, Dahms T, Schrier RW (1998) Temporal relationships between hormonal and hemodynamic changes in early human pregnancy. Kidney Int 54:2056–2063PubMedCrossRef

45.

Monster TB, Janssen WM, de Jong PE, de Jong-van den Berg LT (2001) Oral contraceptive use and hormone replacement therapy are associated with microalbuminuria. Arch Intern Med 161:2000–2005PubMedCrossRef

46.

Ahmed SB, Culleton BF, Tonelli M, Klarenbach SW, Macrae JM, Zhang J, Hemmelgarn BR (2008) Oral estrogen therapy in postmenopausal women is associated with loss of kidney function. Kidney Int 74:370–376PubMedCrossRef

47.

Schopick EL, Fisher ND, Lin J, Forman JP, Curhan GC (2009) Post-menopausal hormone use and albuminuria. Nephrol Dial Transplant 24:3739–3744PubMedCrossRef

48.

Manning PJ, Sutherland WH, Allum AR, de Jong SA, Jones SD (2003) HRT does not improve urinary albumin excretion in postmenopausal diabetic women. Diabetes Res Clin Pract 60:33–39PubMedCrossRef

49.

Karl M, Berho M, Pignac-Kobinger J, Striker GE, Elliot SJ (2006) Differential effects of continuous and intermittent 17beta-estradiol replacement and tamoxifen therapy on the prevention of glomerulosclerosis: modulation of the mesangial cell phenotype in vivo. Am J Pathol 169:351–361PubMedCrossRef

50.

Klinge CM (2008) Estrogenic control of mitochondrial function and biogenesis. J Cell Biochem 105:1342–1351PubMedCrossRef

51.

Mattingly KA, Ivanova MM, Riggs KA, Wickramasinghe NS, Barch MJ, Klinge CM (2008) Estradiol stimulates transcription of nuclear respiratory factor-1 and increases mitochondrial biogenesis. Mol Endocrinol 22:609–622PubMedCrossRef

52.

Persky AM, Green PS, Stubley L, Howell CO, Zaulyanov L, Brazeau GA, Simpkins JW (2000) Protective effect of estrogens against oxidative damage to heart and skeletal muscle in vivo and in vitro. Proc Soc Exp Biol Med 223:59–66PubMedCrossRef

53.

Dionne IJ, Kinaman KA, Poehlman ET (2000) Sarcopenia and muscle function during menopause and hormone-replacement therapy. J Nutr Health Aging 4:156–161PubMed

54.

Flynn JM, Lannigan DA, Clark DE, Garner MH, Cammarata PR (2008) RNA suppression of ERK2 leads to collapse of mitochondrial membrane potential with acute oxidative stress in human lens epithelial cells. Am J Physiol Endocrinol Metab 294:E589–E599PubMedCrossRef

55.

Bjornstrom L, Sjoberg M (2005) Mechanisms of estrogen receptor signaling: convergence of genomic and nongenomic actions on target genes. Mol Endocrinol 19:833–842PubMedCrossRef

56.

Koh PO (2007) Estradiol prevents the injury-induced decrease of 90 ribosomal S6 kinase (p90RSK) and Bad phosphorylation. Neurosci Lett 412:68–72PubMedCrossRef

57.

Catanuto P, Doublier S, Lupia E, Fornoni A, Berho M, Karl M, Striker GE, Xia X, Elliot S (2009) 17 beta-estradiol and tamoxifen upregulate estrogen receptor beta expression and control podocyte signaling pathways in a model of type 2 diabetes. Kidney Int 75:1194–1201PubMedCrossRef

58.

Doublier S, Lupia E, Catanuto P, Periera-Simon S, Xia X, Korach K, Berho M, Elliot SJ, Karl M (2011) Testosterone and 17beta-estradiol have opposite effects on podocyte apoptosis that precedes glomerulosclerosis in female estrogen receptor knockout mice. Kidney Int 79:404–413PubMedCrossRef

59.

Ma H, Togawa A, Soda K, Zhang J, Lee S, Ma M, Yu Z, Ardito T, Czyzyk J, Diggs L, Joly D, Hatakeyama S, Kawahara E, Holzman L, Guan JL, Ishibe S (2010) Inhibition of podocyte FAK protects against proteinuria and foot process effacement. J Am Soc Nephrol 21:1145–1156PubMedCrossRef

60.

Neugarten J, Acharya A, Lei J, Silbiger S (2000) Selective estrogen receptor modulators suppress mesangial cell collagen synthesis. Am J Physiol Renal Physiol 279:F309–318PubMed

61.

Guccione M, Silbiger S, Lei J, Neugarten J (2002) Estradiol upregulates mesangial cell MMP-2 activity via the transcription factor AP-2. Am J Physiol Renal Physiol 282:F164–169PubMed

62.

Blush J, Lei J, Ju W, Silbiger S, Pullman J, Neugarten J (2004) Estradiol reverses renal injury in Alb/TGF-beta1 transgenic mice. Kidney Int 66:2148–2154PubMedCrossRef

63.

Melamed ML, Blackwell T, Neugarten J, Arnsten JH, Ensrud KE, Ishani A, Cummings SR, Silbiger SR (2011) Raloxifene, a selective estrogen receptor modulator, is renoprotective: a post-hoc analysis. Kidney Int 79:241–249PubMedCrossRef

64.

Nitsch W, Thein K (1955) Therapy of the nephrotic syndrome with estradiol. Ther Ggw 94:364–366PubMed

Titel: The influence of gender and sexual hormones on incidence and outcome of chronic kidney disease
verfasst von: Sebastian Kummer
Gero von Gersdorff
Markus J. Kemper
Jun Oh
Publikationsdatum: 01.08.2012
Verlag: Springer-Verlag
Erschienen in: Pediatric Nephrology / Ausgabe 8/2012
Print ISSN: 0931-041X
Elektronische ISSN: 1432-198X
DOI: https://doi.org/10.1007/s00467-011-1963-1

Neu im Fachgebiet Pädiatrie

23.04.2024 | Typ-1-Diabetes | Nachrichten

Update Pädiatrie

Bestellen Sie unseren Fach-Newsletter und bleiben Sie gut informiert.

Newsletter bestellen

Springer Medizin

The influence of gender and sexual hormones on incidence and outcome of chronic kidney disease

Abstract

Neu im Fachgebiet Pädiatrie

Neuer Typ-1-Diabetes bei Kindern am Wochenende eher übersehen

Neue Studienergebnisse zur Myopiekontrolle mit Atropin

Spinale Muskelatrophie: Neugeborenen-Screening lohnt sich

Fünf Dinge, die im Kindernotfall besser zu unterlassen sind

Update Pädiatrie

Springer Medizin

Abstract

Bitte loggen Sie sich ein, um Zugang zu diesem Inhalt zu erhalten

Weitere Artikel der Ausgabe 8/2012

Investigating mechanisms of chronic kidney disease in mouse models

Dehydration at admission increased the need for dialysis in hemolytic uremic syndrome children

Vitamin D status in children with chronic kidney disease

Neonatal atypical hemolytic uremic syndrome due to methylmalonic aciduria and homocystinuria

Nephrotic syndrome presenting in a patient with primary Sjögren’s syndrome—answers

Migration background and patient satisfaction in a pediatric nephrology outpatient clinic

Neu im Fachgebiet Pädiatrie

Neuer Typ-1-Diabetes bei Kindern am Wochenende eher übersehen

Neue Studienergebnisse zur Myopiekontrolle mit Atropin

Spinale Muskelatrophie: Neugeborenen-Screening lohnt sich

Fünf Dinge, die im Kindernotfall besser zu unterlassen sind

Update Pädiatrie