The influence of socio-economic status and multimorbidity patterns on healthcare costs: a six-year follow-up under a universal healthcare system

Multimorbidity has been defined two ways: the co-occurrence of two or more conditions in an individual within a specified period of time[1, 2]; and the coexistence of multiple illnesses of different types[3]. Previous studies have reported the prevalence of multimorbidity ranging from 55 to 98% among older populations and approximately 20–30% when a comprehensive range of ages was included[4]. Clinical guidelines tend to focus on single morbidities rather than the coexistence of multiple conditions and traditional payment structures generally favor services that target single diseases or conditions. As a result, healthcare systems can face considerable challenges in the treatment of patients with multimorbidity and this issue has been attracting considerable attention, particularly in countries with an aging population.

Multimorbidity has been linked to elevated healthcare utilization[4‐6]. New evidence suggests that increases in the use of resources cannot be attributed to an increase in chronic illness, but rather to the number of interventions required to deal with multiple health-related conditions[3, 7]. Previous studies have shown that patients of lower socioeconomic status tend to use more health care services, primarily due to a higher prevalence of multimorbidity[8]. In addition, socioeconomic status has been shown to be an important factor associated with multimorbidity[4, 9, 10]. In a study by Schäfer et. al., income was associated with the number of chronic conditions[11]. Agborsangaya et. al. reported that the prevalence of multimorbidity was lower among those reporting higher incomes[12]. Nonetheless, very few studies addressing the issues of multimorbidity and healthcare utilization have included occupation as a factors in the measurement of socioeconomic status[2]. This study sought to fill this gap.

Although the relationship between multimorbidity and healthcare utilization has previously been explored, little is known regarding the impact of multimorbidity on healthcare costs within a universal healthcare system, such as that found in Taiwan. Taiwan launched its National Health Insurance (NHI) program in 1995. More than 98% of the population is currently enrolled in the NHI program[13], and over 90% of all healthcare facilities are contracted by the Bureau of National Health Insurance (BNHI)[14]. The NHI program provides universal access to healthcare and comprehensive benefits, including inpatient and ambulatory care, dental services, prescribed medications, nursing care, traditional Chinese medicine therapy, and preventive services. Co-payment for health services is also waived for low income earners. This raises the question of whether inequities (referring to differences which are unnecessary and avoidable and, in addition, are also considered unfair and unjust[15]) in healthcare exist between socioeconomic classes under a universal healthcare system.

This longitudinal study employed the claims database of the National Health Insurance of Taiwan using a mixed linear modeling approach to explore the influence of socio-economic status, (as measured by occupation and income level) and multimorbidity patterns on healthcare costs.

A total of 959,990 NHI enrolees were followed from January 2005 to December 2010, resulting in 903,376 cases following exclusions due to death or withdrawal from the NHI program. Characteristics of the enrolees selected from the National Health Insurance Database are shown in Table 1. Enrolees exceeding 50 years of age accounted for more Rx-MG assignments (mean = 4.9) than younger people. Farmers and low income earners accounted for more Rx-MG assignments than those of other occupations (mean = 5.9 and 6.5, respectively). Physicians (and their relatives) accounted for fewer Rx-MG assignments; however, their annual total healthcare costs (RW: 1.03) and non-pharmaceutical costs (0.97) were higher than those of paramedical personnel (RW: 0.74 and 0.76), public servants (RW: 0.91 and 0.90), and other employees/self-employed (RW: 0.85 and 0.85). Low income earners had considerably higher costs than other enrolees, which may be attributed to the high prevalence of multimorbidity and the co-payment waiver. We also found that the distribution of Rx-MG counts and total costs presented statistically significant differences among gender, age groups, type of occupation, and income class (p < .001).

Table 2 illustrates the total annual costs according to occupation, income, and multimorbidity status (based on data from 2010). According to the medication received in 2010, 114 442 of the enrolees (12.7%) received no Rx-MG assignment, while the remainder received at least one. Nearly 80% of the enrolees included in this data presented multimorbidity (i.e. had two or more Rx-MG assignments). Physicians and their unemployed family members had the lowest prevalence of multimorbidity (66.2%) and the highest prevalence of no Rx-MG assignment (22.9%). Low income earners had the highest prevalence of multimorbidity (86.8%). Enrolees in the first rank of income had the lowest prevalence of multimorbidity. As shown in Table 2, individuals with more Rx-MG assignments were associated with higher total healthcare costs. Similar to the results in Table 1, low income earners were associated with the highest total costs across all levels of multimorbidity, followed by physicians and farmers. Fishermans had the lowest mean total cost across all level of multimorbidity. Low income earners and farmers had the highest proportion (21.9% and 18.3%, respectively) of severe multimorbidity (i.e. > = 9 Rx-MGs). Individuals in the lowest rank of income had the highest total costs across all levels of multimorbidity. Similar results were obtained for each year from 2005 to 2009 (data not shown in Table 2).

Table 3 presents the results of mixed linear modeling intended to reveal the effects of multimorbidity and socioeconomic characteristics on log-transformed total annual costs. Model 1 controlled for age and gender, the results of which indicated that occupation and income level were associated with total healthcare costs, such that individuals with higher income incurred higher medical costs than those with lower income levels. Model 2, which also included multimorbidity status, identified a significant relationship between multimorbidity and total medical costs, as evidenced by a relationship between increases in the number of Rx-MG assignments and higher total costs. Compared to employees/self-employed enrolees, physicians, paramedical personnel, and public servants accounted for higher total costs after controlling for the multimorbidity and demographic characteristics, while employers, fishermen, and low income earners accounted for lower total costs. Unemployed individuals also accounted for higher total costs than employers and employees/self-employed enrolees. Model 3, which included the interaction between occupation and multimorbidity, indicated a moderating effect between the two variables, in which the higher income group was significantly associated with higher total costs. When only the influence of occupation was considered in the model (i.e. cases without multimorbidity and no moderating effect between the two variables), physicians, paramedical personnel, and public servants accounted for the highest total costs (all p < .001). Low income earners still accounted for lower costs than employees/self-employed (p < .001). The magnitude of parameters estimated in Model 2 and Model 3 demonstrate that multimorbidity accounted for the majority of variations in total healthcare costs.

Table 3 outlines total annual costs and Table 4 summarizes the results of mixed linear modeling intended to reveal the effects of multimorbidity and socioeconomic characteristics on log-transformed non-pharmaceutical costs. After controlling for age and gender, Model 1 and Model 2 indicated that occupation, income level, and multimorbidity were all associated with non-pharmaceutical costs. Increases in the number of Rx-MG assignments and higher income were both associated with higher non-pharmaceutical costs. Similar to the results in Table 3, Model 3, which included the interaction between occupation and multimorbidity, indicated a moderating effect between the two variables. When only the influence of occupation was accounted for in the model, physicians, paramedical personnel, and public servants accounted for the highest total costs (all p < .001). Low income earners still accounted for lower costs than employees/self-employed (p < .001). Again, the magnitude of parameters estimated in Model 2 and Model 3 demonstrate that multimorbidity accounts for most of the variations in non-pharmaceutical costs.

This study explored the relationships among multimorbidity, socioeconomic status, and healthcare costs. The results of our mixed linear models with repeated measures clearly indicate that multimorbidity, occupation, and income were associated with variations in healthcare costs. A higher number of Rx-MG assignments was also associated with higher total costs. Occupation and income were associated with inequities in healthcare utilization.

Approximately 80% of the enrolees in this study had multimorbidity. The prevalence of multimorbidity in the literature varies widely between studies and much of this variance can be attributed to the method of data collection, operational definitions of multimorbidity, and the number of diseases/conditions selected[30‐32]. Our findings are similar to those of Fortin et al.[33], in which the diseases adopted for the estimation of multimorbidity led to considerable discrepancies in the prevalence of multimorbidity, particularly in younger age groups. They found that when multimorbidity was measured using an open list of chronic diseases, instead of seven selected chronic conditions, the estimated multimorbidity prevalence increased dramatically from 17.1% to 73.9% for the 25–45 year age group. The Johns Hopkins ACG/Rx-MG incorporates all medications for the measurement of morbidity; however, the drugs used to treat acute diseases or symptoms (e.g. acute allergy or infection) were excluded from this study. Therefore, it is not surprising that the prevalence of multimorbidity estimated in this study was higher than that of other studies, which used lists of selected chronic conditions only.

This study employed pharmacy claims to obtain RxMGs assignment from the ACG system. Despite the wide-spread application of diagnosis-based measures of multimorbidity[4, 34, 35], these tools often suffer with regard to accuracy and quality in diagnosis coding[24, 25, 36, 37]. Previous studies found that diagnoses identified using administrative data were highly specific but varied considerably in their sensitivity[37]. The ACG system also provides ADG assignments and has been used as a measure of multimorbidity[3, 34], however it assigns the same ADG groups for different diseases, which is contrary to the theoretical underpinnings of multimorbidity, making it less meaningful within a clinical context. For example, ‘adult-onset type 1 diabetes’ (ICD9:250.00) and ‘essential hypertension’ (ICD9:401.9) are both assigned to ‘ADG10’ (chronic medical: stable), despite the fact that patients with only adult-onset type 1 diabetes or patients with the same disease as well as essential hypertension cannot be considered the same in terms of multimorbidity.

Our results indicate that socioeconomic status is associated with multimorbidity and healthcare costs. Farmers, fishermen, and low income earners had the highest proportion of moderate (5–8 Rx-MGs) to severe multimorbidity (> = 9 Rx-MGs). This result is consistent with those of other studies. van den Akker et al. found that low socioeconomic status, as measured by educational level, type of health insurance (as a proxy of income) and occupational status, is strongly associated with both morbidity and multimorbidity[38]. This study did not include educational level; however, it can be assumed that individuals working as physicians, paramedical personnel, and public servants are likely to be highly educated[2]. People with better education tend to be better informed with regard to health-related issues, which directly influences their lifestyle choices as well as the socioeconomic status of their families[39]. Testing of the Polychoric Correlation revealed that the correlation between occupation and income level is relatively low (−0.077). Our results also showed that income and occupation both have an independent impact on multimorbidity. This corresponds with the results of previous studies in which income was reported to be independently associated with health status after controlling for other socio-economic factors[11, 40]. In this manner, multiple socioeconomic measures could be included simultaneously in multivariable models without (or with only marginal) problems of collinearity[40, 41].

Our results also indicate that enrolees recognized by the government as low income earners had a higher prevalence of multimorbidity and increased healthcare costs when the RxMGs count increased. This adds to the evidence that lower income is associated with a higher prevalence of multimorbidity[8, 11, 12, 31]. The greater utilization of healthcare among lower income groups may be due to the higher prevalence of multimorbidity.

This study also shows that after adjusting for age, gender, and multimorbidity, the interaction between occupation and multimorbidity revealed that low income earners had a positive moderating effect on the relationship between healthcare costs and increases in the count of RxMGs. We believe that this is because low income earners, who are eligible for a co-payment waiver, face a moral hazard with regard to the overuse of resources and tend to be isolated from the reality of increased healthcare costs. In this study, paramedical personnel, physicians and public servant accounted for higher medical costs. This study conducted sensitivity analysis to explore the odds of multimorbidity among the various occupations, stratified by calendar year. The results show that physicians and paramedical personnel faced lower odds of moderate and severe multimorbidity (> = 5 Rx-MGs). This may be explained by the fact that those with higher probability of higher education (e.g. public servant) or with more knowledge regarding the latest innovations in medicine (e.g. physicians and other medical professionals) are more likely to opt for more costly healthcare services and medications, such as brand-name drugs. Occupation, insurance status, and other individual-level socioeconomic characteristics are all closely linked to one’s access to, benefits from, and experiences with the health care system[42]. This study adds to a growing body of literature addressing inequities in the utilization of healthcare among patients from different socioeconomic backgrounds, regardless of their morbidity burden.

This study has several limitations. First, information related to the educational background of enrolees is unavailable in NHI claims data; therefore, the influence of this factor was not taken into account. Previous studies have indicated that educational differences can mitigate socioeconomic differences with regard to the utilization of healthcare. Although previous findings from studies on education and the prevalence of multimorbidity[2, 11, 12] have been inconsistent, future research on multimorbidity and socioeconomic status should nonetheless take this factor into account. Second, in this study, income was determined by monthly, salary-based figures. The Bureau of National Health Insurance has established a ceiling for the highest income group in the determination of premiums. As a result, the income values used to evaluate socioeconomic status may be biased, particularly for extremely high income earners and employees who receive bonuses as a major part of their income. Enrolees in different professions (e.g. blue-collar vs. white-collar) sharing the same employer will share the same code in the NHI data. This particular feature of the NHI claims database prohibited us from collapsing occupation categories into a more general form and may therefore limit the generalizability of the findings with regard to other countries. Finally, the high prevalence of multimorbidity found in this study may be due to the fact that the NHI pays for almost all prescription drugs and that the prescription data used in this study represents an aggregate from outpatient clinics, in-hospital pharmacies, and community pharmacies. The inclusion of such comprehensive data was intended to help capture all cases of acute and chronic morbidities. In addition, because medication costs represents a substantial portion (25%) of the total healthcare costs in Taiwan, the Rx-MGs assignments could effectively explain the variation in total healthcare costs. These unique features of Taiwanese NHI claims data might limit the generalizability of our findings.

This study determined that multimorbidity and socioeconomic status are significantly associated with healthcare costs. In addition, an increase in the instances of multimorbidity (as measured by Rx-MG assignment) is associated with higher total healthcare costs. Inequities in healthcare utilization were observed between different occupations. Physicians, paramedical personnel, and public servant were found to utilize healthcare services to a greater degree than other groups. Low income earners accounted for significantly lower healthcare costs. The interaction between occupation and multimorbidity was also observed. Overall, these results highlight the fact that socioeconomic status is strongly associated with inequities in healthcare and should be considered in any discussion on the utilization of healthcare by patients with multimorbidity.