Skip to main content

18.01.2024 | Research

The influence of the angiotensin-converting enzyme gene polymorphism and physical activity level on blood pressure and heart rate variability behavior

verfasst von: Victor Gonçalves Corrêa Neto, Estêvão Rios Monteiro, Diego V. Gomes, Paula Guedes Cocate, Geraldo de A. Maranhão Neto, Humberto Miranda, Francine de Oliveira, Lia Carolina M. da Silva, Dayse Aparecida da Silva, Alexandre Palma

Erschienen in: Sport Sciences for Health

Einloggen, um Zugang zu erhalten

Abstract

This study compared blood pressure (BP) and heart rate variability (HRV) values considering the angiotensin-converting enzyme (ACE) polymorphisms and physical activity (PA) level. Participants were stratified according to their ACE polymorphism and PA level. Polymerase chain reaction (PCR) was used to detect polymorphisms and PA level was assessed by questionnaire. Participants had their BP measured by an oscillometer and the HRV rerded using a heart monitor. Participants grouped by polymorphism II showed higher values of root mean square successive difference when compared to individuals with DD polymorphism. “Highly active”, compared to “active”, individuals exhibited a lower diastolic BP. There was no statistically significant difference in the behavior of the dependent variables between the different PA levels within each polymorphism. Polymorphism II attenuated parasympathetic activity in cardiac autonomic modulation and the “highly active” group displayed lower values of diastolic BP. PA level did not affect any variable when polymorphisms were considered.
Literatur
1.
Zurück zum Zitat Bolin LP, Saul AD, Bethune Scroggs LL, Horne C (2022) A pilot study investigating the relationship between heart rate variability and blood pressure in young adults at risk for cardiovascular disease. Clin Hypertens 28(1):2CrossRefPubMedPubMedCentral Bolin LP, Saul AD, Bethune Scroggs LL, Horne C (2022) A pilot study investigating the relationship between heart rate variability and blood pressure in young adults at risk for cardiovascular disease. Clin Hypertens 28(1):2CrossRefPubMedPubMedCentral
2.
Zurück zum Zitat Flynn JT, Kaelber DC, Baker-Smith CM, Blowey D, Carroll AE, Daniels SR, Subcommittee on screening and management of high blood pressure in children et al (2017) Clinical practice guideline for screening and management of high blood pressure in children and adolescents. Pediatrics 140:e20171904CrossRefPubMed Flynn JT, Kaelber DC, Baker-Smith CM, Blowey D, Carroll AE, Daniels SR, Subcommittee on screening and management of high blood pressure in children et al (2017) Clinical practice guideline for screening and management of high blood pressure in children and adolescents. Pediatrics 140:e20171904CrossRefPubMed
3.
Zurück zum Zitat Williams B, Mancia G, Spiering W, Agabiti Rosei E, Azizi M, Burnier M et al (2018) ESC/ESH guidelines for the management of arterial hypertension: the task force for the management of arterial hypertension of the European society of cardiology and the European society of hypertension: the task force for the management of arterial hypertension of the European society of cardiology and the European society of hypertension. J Hypertens 36(10):1953–2041. https://doi.org/10.1097/HJH.0000000000001940. (Published correction appears in J Hypertens. 2019 Jan; 37(1):226)CrossRefPubMed Williams B, Mancia G, Spiering W, Agabiti Rosei E, Azizi M, Burnier M et al (2018) ESC/ESH guidelines for the management of arterial hypertension: the task force for the management of arterial hypertension of the European society of cardiology and the European society of hypertension: the task force for the management of arterial hypertension of the European society of cardiology and the European society of hypertension. J Hypertens 36(10):1953–2041. https://​doi.​org/​10.​1097/​HJH.​0000000000001940​. (Published correction appears in J Hypertens. 2019 Jan; 37(1):226)CrossRefPubMed
4.
Zurück zum Zitat Grässler B, Thielmann B, Böckelmann I, Hökelmann A (2021) Effects of different exercise interventions on heart rate variability and cardiovascular health factors in older adults: a systematic review. Eur Rev Aging Phys Act 18(1):24CrossRefPubMedPubMedCentral Grässler B, Thielmann B, Böckelmann I, Hökelmann A (2021) Effects of different exercise interventions on heart rate variability and cardiovascular health factors in older adults: a systematic review. Eur Rev Aging Phys Act 18(1):24CrossRefPubMedPubMedCentral
5.
Zurück zum Zitat Joyce D, Barrett M (2019) State of the science: heart rate variability in health and disease. BMJ Support Palliat Care 9:274–276CrossRefPubMed Joyce D, Barrett M (2019) State of the science: heart rate variability in health and disease. BMJ Support Palliat Care 9:274–276CrossRefPubMed
6.
Zurück zum Zitat Fisch GS (2017) Whither the genotype-phenotype relationship? An historical and methodological appraisal. Am J Med Genet C Semin Med Genet 175:343–353CrossRefPubMed Fisch GS (2017) Whither the genotype-phenotype relationship? An historical and methodological appraisal. Am J Med Genet C Semin Med Genet 175:343–353CrossRefPubMed
7.
Zurück zum Zitat Pescatello L, Macdonald HV, Lamberti L, Johnson BT (2015) Exercise for hypertension: a prescription update integrating existing recommendations with emerging research. Curr Hyperten Rep 17:87CrossRef Pescatello L, Macdonald HV, Lamberti L, Johnson BT (2015) Exercise for hypertension: a prescription update integrating existing recommendations with emerging research. Curr Hyperten Rep 17:87CrossRef
8.
Zurück zum Zitat Figueiredo T, Rhea MR, Peterson M, Miranda H, Bentes CM, Dos Reis VM et al (2015) Influence of number of sets on blood pressure and heart rate variability after a strength training session. J Strength Cond Res 29:1556–1563CrossRefPubMed Figueiredo T, Rhea MR, Peterson M, Miranda H, Bentes CM, Dos Reis VM et al (2015) Influence of number of sets on blood pressure and heart rate variability after a strength training session. J Strength Cond Res 29:1556–1563CrossRefPubMed
10.
Zurück zum Zitat Figueiredo T, De Salles BF, Dias I, Reis VM, Fleck SJ et al (2014) Acute hypotensive effects after a strength training session: a review. Int SportMed J 15:308–329 Figueiredo T, De Salles BF, Dias I, Reis VM, Fleck SJ et al (2014) Acute hypotensive effects after a strength training session: a review. Int SportMed J 15:308–329
11.
Zurück zum Zitat Lee DY, Rhee E, Cho JH, Kwon H, Park SEE, Kim YH et al (2018) Appropriate amount of regular exercise is associated with a reduced mortality risk. Med Sci Sports Exerc 50:2451–2458CrossRefPubMed Lee DY, Rhee E, Cho JH, Kwon H, Park SEE, Kim YH et al (2018) Appropriate amount of regular exercise is associated with a reduced mortality risk. Med Sci Sports Exerc 50:2451–2458CrossRefPubMed
12.
Zurück zum Zitat Martinez-Gomez D, Esteban-Cornejo I, Lopez-Garcia E, Garcia-Esquinas E, Sadarangani KP, Veiga OL et al (2018) Physical activity less than the recommended amount may prevent the onset of major biological risk factors for cardiovascular disease: a cohort study of 198.919 adults. Br J Sports Med 54:238–244CrossRefPubMed Martinez-Gomez D, Esteban-Cornejo I, Lopez-Garcia E, Garcia-Esquinas E, Sadarangani KP, Veiga OL et al (2018) Physical activity less than the recommended amount may prevent the onset of major biological risk factors for cardiovascular disease: a cohort study of 198.919 adults. Br J Sports Med 54:238–244CrossRefPubMed
13.
Zurück zum Zitat American College of Sports Medicine & American Heart Association (2007) Physical activity and public health: updated recommendation for adults from the American college of sports medicine and the American heart association. Med Sci Sports Exerc 39:1423–1434CrossRef American College of Sports Medicine & American Heart Association (2007) Physical activity and public health: updated recommendation for adults from the American college of sports medicine and the American heart association. Med Sci Sports Exerc 39:1423–1434CrossRef
14.
Zurück zum Zitat Yoshinaga M, Hatake S, Tachikawa T, Shinomiya M, Miyazak A, Takahashy H (2011) Impact of lifestyles of adolescents and their parents on cardiovascular risk factors in adolescents. J Atheros Thromb 18:981–990CrossRef Yoshinaga M, Hatake S, Tachikawa T, Shinomiya M, Miyazak A, Takahashy H (2011) Impact of lifestyles of adolescents and their parents on cardiovascular risk factors in adolescents. J Atheros Thromb 18:981–990CrossRef
15.
Zurück zum Zitat Mueck-Weymann M, Janshoff G, Mueck H (2004) Stretching increases heart rate variability in healthy athletes complaining about limited muscular flexibility. Clin Auton Res, Oxford 14(1):15–18CrossRef Mueck-Weymann M, Janshoff G, Mueck H (2004) Stretching increases heart rate variability in healthy athletes complaining about limited muscular flexibility. Clin Auton Res, Oxford 14(1):15–18CrossRef
16.
Zurück zum Zitat Figueiredo T, Menezes P, Kattenbraker MS, Polito MD, Reis VM, Simão R (2013) Influence of exercise order on blood pressure and heart rate variability after a strength training session. J Sports Med Phys Fitness 53:12–17 Figueiredo T, Menezes P, Kattenbraker MS, Polito MD, Reis VM, Simão R (2013) Influence of exercise order on blood pressure and heart rate variability after a strength training session. J Sports Med Phys Fitness 53:12–17
17.
Zurück zum Zitat Bernstein KE, Ong FS, Lamar BW, Blackwell WLB, Shah KW, Giani JF et al (2013) A modern understanding of the traditional and nontraditional biological functions of angiotensin-converting enzyme. Pharmacol Revs 65:1–46CrossRef Bernstein KE, Ong FS, Lamar BW, Blackwell WLB, Shah KW, Giani JF et al (2013) A modern understanding of the traditional and nontraditional biological functions of angiotensin-converting enzyme. Pharmacol Revs 65:1–46CrossRef
18.
Zurück zum Zitat Gard PR (2010) Implications of the angiotensin converting enzyme gene insertion/deletion polymorphism in health and disease: a snapshot review. Int J Mol Epidemiol Genet 1:145–157PubMedPubMedCentral Gard PR (2010) Implications of the angiotensin converting enzyme gene insertion/deletion polymorphism in health and disease: a snapshot review. Int J Mol Epidemiol Genet 1:145–157PubMedPubMedCentral
19.
Zurück zum Zitat Cosenso-Martin LM, Vaz-de-Melo RO, Pereira LR, Cesarino CC, Yugar-Toledo C, Cipullo JP et al (2015) Angiotensin-converting enzyme insertion/deletion polymorphism, 24-h blood pressure profile and left ventricular hypertrophy in hypertensive individuals: a cross-sectional study. Eur J Med Res 20:74CrossRefPubMedPubMedCentral Cosenso-Martin LM, Vaz-de-Melo RO, Pereira LR, Cesarino CC, Yugar-Toledo C, Cipullo JP et al (2015) Angiotensin-converting enzyme insertion/deletion polymorphism, 24-h blood pressure profile and left ventricular hypertrophy in hypertensive individuals: a cross-sectional study. Eur J Med Res 20:74CrossRefPubMedPubMedCentral
20.
Zurück zum Zitat Kolomeichuk SN, Alekseev RV, Putilov AA, Meigal AYU (2017) Association of polymorphic variants of ace and BDKRB2 with heart rate variability in athletes of the republic of Karelia. Bull Russ State Med Uni 4:45–52CrossRef Kolomeichuk SN, Alekseev RV, Putilov AA, Meigal AYU (2017) Association of polymorphic variants of ace and BDKRB2 with heart rate variability in athletes of the republic of Karelia. Bull Russ State Med Uni 4:45–52CrossRef
21.
Zurück zum Zitat Matsudo S, Araújo T, Matsudo V, Andrade D, Andrade E, Oliveira LC et al (2001) Questionário Internacional de Atividade Física (IPAQ): estudo de validade e reprodutibilidade no Brasil. Rev Bras Ativ Fis Saúde 6:5–18 Matsudo S, Araújo T, Matsudo V, Andrade D, Andrade E, Oliveira LC et al (2001) Questionário Internacional de Atividade Física (IPAQ): estudo de validade e reprodutibilidade no Brasil. Rev Bras Ativ Fis Saúde 6:5–18
22.
Zurück zum Zitat Whelton PK, Carey RM, Aronow WS et al (2018) 2017 ACC/AHA/AAPA/ABC/ACPM/AGS/APhA/ASH/ASPC/NMA/PCNA guideline for the prevention, detection, evaluation, and management of high blood pressure in adults: executive summary: a report of the American college of cardiology/American heart association task force on clinical practice guidelines. Circulation 138(17):e426–e483. https://doi.org/10.1161/CIR.0000000000000597CrossRefPubMed Whelton PK, Carey RM, Aronow WS et al (2018) 2017 ACC/AHA/AAPA/ABC/ACPM/AGS/APhA/ASH/ASPC/NMA/PCNA guideline for the prevention, detection, evaluation, and management of high blood pressure in adults: executive summary: a report of the American college of cardiology/American heart association task force on clinical practice guidelines. Circulation 138(17):e426–e483. https://​doi.​org/​10.​1161/​CIR.​0000000000000597​CrossRefPubMed
24.
Zurück zum Zitat Task Force of the European Society of Cardiology and the North American Society of Pacing and Electrophysiology (1996) Heart rate variability standards of measurement, physiological interpretation, and clinical use. Eur Heart J, Lond 17(3):354–381CrossRef Task Force of the European Society of Cardiology and the North American Society of Pacing and Electrophysiology (1996) Heart rate variability standards of measurement, physiological interpretation, and clinical use. Eur Heart J, Lond 17(3):354–381CrossRef
25.
Zurück zum Zitat Lindpaintner K, Pfeffer MA, Kreutz R, Stampfer MJ, Grodstein F, LaMotte F et al (1995) A prospective evaluation of an angiotensin converting enzyme gene polymorphism and the risk of ischemic heart disease. N Engl J Med 332:706–711CrossRefPubMed Lindpaintner K, Pfeffer MA, Kreutz R, Stampfer MJ, Grodstein F, LaMotte F et al (1995) A prospective evaluation of an angiotensin converting enzyme gene polymorphism and the risk of ischemic heart disease. N Engl J Med 332:706–711CrossRefPubMed
26.
Zurück zum Zitat Lin MH, Tseng CH, Tseng CC, Huang CH, Chong CK, Tseng CP (2001) Real-time PCR for rapid genotyping of angiotensin-converting enzyme insertion/deletion polymorphism. Clin Biochem 34:661–666CrossRefPubMed Lin MH, Tseng CH, Tseng CC, Huang CH, Chong CK, Tseng CP (2001) Real-time PCR for rapid genotyping of angiotensin-converting enzyme insertion/deletion polymorphism. Clin Biochem 34:661–666CrossRefPubMed
28.
Zurück zum Zitat Chan YH (2003) Biostatistics 101: data presentation. Singap Med J 44(6):280–285 Chan YH (2003) Biostatistics 101: data presentation. Singap Med J 44(6):280–285
29.
Zurück zum Zitat Zain M, Awan FR (2014) Renin angiotensin aldosterone system (RAAS): its biology and drug targets for treating diabetic nephropathy. Pak J Pharm Sci 27(5):1379–1391PubMed Zain M, Awan FR (2014) Renin angiotensin aldosterone system (RAAS): its biology and drug targets for treating diabetic nephropathy. Pak J Pharm Sci 27(5):1379–1391PubMed
30.
Zurück zum Zitat Silva RFD, Lacchini R, Pinheiro LC, Dionísio TJ, Jacomini A, Tanus-Santos JE et al (2018) Preliminary study about the relationship between estimated training status and RAS polymorphisms on blood pressure and ACE activity in the elderly. J Renin Angiotensin Aldosterone Syst 19(2):1470320318782622CrossRefPubMedPubMedCentral Silva RFD, Lacchini R, Pinheiro LC, Dionísio TJ, Jacomini A, Tanus-Santos JE et al (2018) Preliminary study about the relationship between estimated training status and RAS polymorphisms on blood pressure and ACE activity in the elderly. J Renin Angiotensin Aldosterone Syst 19(2):1470320318782622CrossRefPubMedPubMedCentral
32.
Zurück zum Zitat Kors JA, Swenne CA, Greiser KH (2007) Cardiovascular diseases, risk factors, and heart rate variability in the general population. J Electrocardiol 40:s19–s21CrossRef Kors JA, Swenne CA, Greiser KH (2007) Cardiovascular diseases, risk factors, and heart rate variability in the general population. J Electrocardiol 40:s19–s21CrossRef
34.
Zurück zum Zitat Nishikino M, Matsunaga T, Yasuda K, Adachi T, Moritani T, Tsujimoto T et al (2006) Genetic variation in the rennin – angiotensin system and autonomic nervous system function in young health Japanese subjects. J Clin Endocrinol Metab 91:4674–4681CrossRef Nishikino M, Matsunaga T, Yasuda K, Adachi T, Moritani T, Tsujimoto T et al (2006) Genetic variation in the rennin – angiotensin system and autonomic nervous system function in young health Japanese subjects. J Clin Endocrinol Metab 91:4674–4681CrossRef
40.
Zurück zum Zitat Suliga E, Ciesla E, Rebak D, Koziel D, Gluszek S (2018) Relationship between sitting time, physical activity, and metabolic syndrome among adults depending on body mass index. Med Sci Monit 24:7633–7645CrossRefPubMedPubMedCentral Suliga E, Ciesla E, Rebak D, Koziel D, Gluszek S (2018) Relationship between sitting time, physical activity, and metabolic syndrome among adults depending on body mass index. Med Sci Monit 24:7633–7645CrossRefPubMedPubMedCentral
41.
Zurück zum Zitat Goessler KF, Cornelisen VA, Oliveira EM, Mota GF, Polito MD (2015) ACE polymorphisms and the acute response of blood pressure to a walk in medicated hypertensive patients. J Rennin Angiotensin Aldosterone Syst 16:720–729CrossRef Goessler KF, Cornelisen VA, Oliveira EM, Mota GF, Polito MD (2015) ACE polymorphisms and the acute response of blood pressure to a walk in medicated hypertensive patients. J Rennin Angiotensin Aldosterone Syst 16:720–729CrossRef
43.
Zurück zum Zitat Medronho RM, Bloch KV, Luiz RR, Werneck GL (2009) Epidemiologia. Atheneu, Rio de Janeiro, pp 284–285 Medronho RM, Bloch KV, Luiz RR, Werneck GL (2009) Epidemiologia. Atheneu, Rio de Janeiro, pp 284–285
Metadaten
Titel
The influence of the angiotensin-converting enzyme gene polymorphism and physical activity level on blood pressure and heart rate variability behavior
verfasst von
Victor Gonçalves Corrêa Neto
Estêvão Rios Monteiro
Diego V. Gomes
Paula Guedes Cocate
Geraldo de A. Maranhão Neto
Humberto Miranda
Francine de Oliveira
Lia Carolina M. da Silva
Dayse Aparecida da Silva
Alexandre Palma
Publikationsdatum
18.01.2024
Verlag
Springer Milan
Erschienen in
Sport Sciences for Health
Print ISSN: 1824-7490
Elektronische ISSN: 1825-1234
DOI
https://doi.org/10.1007/s11332-023-01160-x

Arthropedia

Grundlagenwissen der Arthroskopie und Gelenkchirurgie. Erweitert durch Fallbeispiele, Videos und Abbildungen. 
» Jetzt entdecken

Update Orthopädie und Unfallchirurgie

Bestellen Sie unseren Fach-Newsletter und bleiben Sie gut informiert.