Background
Methods
Study population and design
Study 1: Evaluation of IDCR changes with volume in hospitalized hemodialysis patients
Study 2: Evaluation of IDCR as a marker of volume overload in maintenance hemodialysis outpatients
Study 3: Evaluation of IDCR as a predictor of mortality
Statistical analyses
Results
Study 1: Evaluation of IDCR changes with volume in hospitalized hemodialysis patients
Number of patients, n | 35b |
---|---|
Age, mean ± SD, years | 55 ± 14 |
Women, n (%) | 16 (45) |
Race, n (%) | |
White | 24 (68) |
Black | 6 (17) |
Hispanic | 4 (12) |
Asian | 1 (3) |
Time on hemodialysis, mean ± SD, years | 4.5 ± 1.9 |
Mean IDCR ± SD, mg/dL/h | |
Hospital day 1 (35 obs) | 0.093 ± 0.033 |
Hospital day 2 (35 obs) | 0.078 ± 0.028 |
Hospital day 3 (10 obs) | 0.075 ± 0.026 |
Hospital day 4 (3 obs) | 0.074 ± 0.016 |
Hospital day 5 (1 obs) | 0.061 ±a |
Number of patients, n | 33b |
---|---|
Age, mean ± SD, years | 58 ± 15 |
Women, n (%) | 14 (41) |
Race, n (%) | |
White | 21 (64) |
Black | 8 (24) |
Hispanic | 3 (9) |
Asian | 1 (3) |
Time on hemodialysis, mean ± SD, years | 4.2 ± 2.1 |
Mean IDCR ± SD, mg/dL/h | |
Baseline (33 obs)a | 0.059 ± 0.020 |
One HD session (33 obs) | 0.074 ± 0.023 |
Two HD sessions (11 obs) | 0.082 ± 0.027 |
Three HD sessions (2 obs) | 0.105 ± 0.005 |
Study 2: Evaluation of IDCR as a marker of volume overload in maintenance hemodialysis outpatients
Number of patients, n | 25 |
---|---|
Age, mean ± SD, years | 52 ± 18 |
Women, n (%) | 12 (48) |
Race, n (%) | |
White | 11 (44) |
Black | 7 (28) |
Hispanic | 5 (20) |
Asian | 2 (8) |
Time on hemodialysis, mean ± SD, years | 3.8 ± 2.4 |
Number with volume overload by nephrologist’s assessment (%) | 11 (44) |
Study 3: Evaluation of IDCR as a predictor of mortality
Total | IDCR < 0.05 | IDCR > 0.05 | |
---|---|---|---|
Number of patients, n | 39 | 23 | 16 |
Age, mean ± SD, years | 66 ± 14 | 68 ± 13 | 64 ± 16 |
Women, n (%) | 22 (56) | 12 (52) | 10 (62) |
Race, n (%) | |||
White | 21 (54) | 13 (57) | 8 (50) |
Black | 9 (23) | 6 (26) | 3 (19) |
Hispanic | 6 (15) | 3 (13) | 3 (19) |
Asian | 3 (8) | 1 (4) | 2 (12) |
Years on hemodialysis at start of follow-up, mean ± SD | 1.8 ± 0.5 | 1.9 ± 0.6 | 1.6 ± 0.5 |
Presence of CAD or PADc, n (%) | 20 (51) | 9 (39) | 11 (69) |
LVEFc < 40%, n (%) | 6 (15) | 2 (9) | 4 (25) |
Number of deaths during follow-up, n (%) | 21 (54) | 18 (78) | 3 (19) |
Median survival, days | 1126 | 32b | Not calculateda |