nach oben

European Journal of Clinical Microbiology & Infectious Diseases

Erschienen in:

30.03.2022 | Review

The interplay between anticancer challenges and the microbial communities from the gut

verfasst von: Claire Amaris Hobson, Stéphane Bonacorsi, André Baruchel, Olivier Tenaillon, André Birgy

Erschienen in: European Journal of Clinical Microbiology & Infectious Diseases | Ausgabe 5/2022

Einloggen, um Zugang zu erhalten

Abstract

Cancer being an increasing burden on human health, the use of anticancer drugs has risen over the last decades. The physiological effects of these drugs are not only perceived by the host’s cells but also by the microbial cells it harbors as commensals, notably the gut microbiota. Since the early ‘50 s, the cytotoxicity of anticancer chemotherapy was evaluated on bacteria revealing some antimicrobial activities that result in an established perturbation of the gut microbiota. This perturbation can affect the host’s health through dysbiosis, which can lead to multiple complications, but has also been shown to have a direct effect on the treatment efficiency.

We, therefore, conducted a review of literature focusing on this triangular relationship involving the microbial communities from the gut, the host’s disease, and the anticancer treatment. We focused specifically on the antimicrobial effects of anticancer chemotherapy, their impact on mutagenesis in bacteria, and the perspectives of using bacteria-based tools to help in the diagnostic and treatment of cancer.

Sung H, Ferlay J, Siegel RL, Laversanne M, Soerjomataram I, Jemal A et al (2021) Global Cancer Statistics 2020: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries. CA Cancer J Clin 71:209–249. https://doi.org/10.3322/caac.21660CrossRefPubMed

Melichar B, Dvorák J, Hyspler R, Zadák Z (2005) Intestinal permeability in the assessment of intestinal toxicity of cytotoxic agents. Chemotherapy 51:336–338. https://doi.org/10.1159/000088957CrossRefPubMed

Pusztaszeri MP, Genta RM, Cryer BL (2007) Drug-induced injury in the gastrointestinal tract: clinical and pathologic considerations. Nat Clin Pract Gastroenterol Hepatol 4:442–453. https://doi.org/10.1038/ncpgasthep0896CrossRefPubMed

Montassier E, Al-Ghalith GA, Ward T, Corvec S, Gastinne T, Potel G et al (2016) Pretreatment gut microbiome predicts chemotherapy-related bloodstream infection. Genome Med 28(8):49. https://doi.org/10.1186/s13073-016-0301-4CrossRef

Samet A, Śledzińska A, Krawczyk B, Hellmann A, Nowicki S, Kur J et al (2013) Leukemia and risk of recurrent Escherichia coli bacteremia: genotyping implicates E. coli translocation from the colon to the bloodstream. Eur J Clin Microbiol Infect Dis 32:1393–400. https://doi.org/10.1007/s10096-013-1886-9CrossRefPubMedPubMedCentral

Mikulska M, Del Bono V, Bruzzi P, Raiola AM, Gualandi F, Van Lint MT et al (2012) Mortality after bloodstream infections in allogeneic haematopoietic stem cell transplant (HSCT) recipients. Infection 40:271–278. https://doi.org/10.1007/s15010-011-0229-yCrossRefPubMed

Hobson CA, Bonacorsi S, Fahd M, Baruchel A, Cointe A, Poey N et al (2019) Successful treatment of bacteremia due to NDM-1-producing Morganella morganii with aztreonam and ceftazidime-avibactam combination in a pediatric patient with hematologic malignancy. Antimicrob. Agents Chemother 63. https://doi.org/10.1128/AAC.02463-18

Hobson CA, Bonacorsi S, Hocquet D, Baruchel A, Fahd M, Storme T et al (2020) Impact of anticancer chemotherapy on the extension of beta-lactamase spectrum: an example with KPC-type carbapenemase activity towards ceftazidime-avibactam. Sci Rep 17(10):1–8. https://doi.org/10.1038/s41598-020-57505-wCrossRef

Hobson CA, Bonacorsi S, Jacquier H, Choudhury A, Magnan M, Cointe A et al (2020) KPC beta-lactamases are permissive to insertions and deletions conferring substrate spectrum modifications and resistance to ceftazidime-avibactam. Antimicrob. Agents Chemother [cited 2020 11];64. https://aac.asm.org/content/64/12/e01175-20. https://doi.org/10.1128/AAC.01175-20

10.

Taur Y, Xavier JB, Lipuma L, Ubeda C, Goldberg J, Gobourne A et al (2012) Intestinal domination and the risk of bacteremia in patients undergoing allogeneic hematopoietic stem cell transplantation. Clin Infect Dis 1(55):905–914. https://doi.org/10.1093/cid/cis580CrossRef

11.

Montassier E, Gastinne T, Vangay P, Al-Ghalith GA, Bruley des Varannes S, Massart S et al (2015) Chemotherapy-driven dysbiosis in the intestinal microbiome. Aliment Pharmacol Ther. 42:515–28. https://doi.org/10.1111/apt.13302CrossRefPubMed

12.

Hess AS, Kleinberg M, Sorkin JD, Netzer G, Johnson JK, Shardell M et al (2014) Prior colonization is associated with increased risk of antibiotic-resistant Gram-negative bacteremia in cancer patients. Diagn Microbiol Infect Dis 79:73–76. https://doi.org/10.1016/j.diagmicrobio.2014.01.022CrossRefPubMedPubMedCentral

13.

Haeusler GM, Mechinaud F, Daley AJ, Starr M, Shann F, Connell TG et al (2013) Antibiotic-resistant Gram-negative bacteremia in pediatric oncology patients–risk factors and outcomes. Pediatr Infect Dis J 32:723–726. https://doi.org/10.1097/INF.0b013e31828aebc8CrossRefPubMed

14.

Perez F, Adachi J, Bonomo RA (2014) Antibiotic-resistant Gram-negative bacterial infections in patients with cancer. Clin Infect Dis Off Publ Infect Dis Soc Am 15(59):S335–S339. https://doi.org/10.1093/cid/ciu612CrossRef

15.

Mikulska M, Viscoli C, Orasch C, Livermore DM, Averbuch D, Cordonnier C et al (2014) Aetiology and resistance in bacteraemias among adult and paediatric haematology and cancer patients. J Infect 68:321–331. https://doi.org/10.1016/j.jinf.2013.12.006CrossRefPubMed

16.

Chaput N, Lepage P, Coutzac C, Soularue E, Le Roux K, Monot C et al (2017) Baseline gut microbiota predicts clinical response and colitis in metastatic melanoma patients treated with ipilimumab. Ann Oncol Off J Eur Soc Med Oncol 1(28):1368–1379. https://doi.org/10.1093/annonc/mdx108CrossRef

17.

Dubin K, Callahan MK, Ren B, Khanin R, Viale A, Ling L et al (2016) Intestinal microbiome analyses identify melanoma patients at risk for checkpoint-blockade-induced colitis. Nat Commun 2:7. https://doi.org/10.1038/ncomms10391CrossRef

18.

Aarnoutse R, Ziemons J, Penders J, Rensen SS, de Vos-Geelen J, Smidt ML (2019 ) The clinical link between human intestinal microbiota and systemic cancer therapy. Int J Mol Sci [cited 2019 30];20. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6747354/. https://doi.org/10.3390/ijms20174145

19.

Schroeder BO, Bäckhed F (2016) Signals from the gut microbiota to distant organs in physiology and disease. Nat Med 6(22):1079–1089. https://doi.org/10.1038/nm.4185CrossRef

20.

Jia W, Li H, Zhao L, Nicholson JK (2008) Gut microbiota: a potential new territory for drug targeting. Nat Rev Drug Discov 7:123–129. https://doi.org/10.1038/nrd2505CrossRefPubMed

21.

Sivan A, Corrales L, Hubert N, Williams JB, Aquino-Michaels K, Earley ZM et al (2015) Commensal Bifidobacterium promotes antitumor immunity and facilitates anti-PD-L1 efficacy. Science 27(350):1084–1089. https://doi.org/10.1126/science.aac4255CrossRef

22.

Viaud S, Saccheri F, Mignot G, Yamazaki T, Daillère R, Hannani D et al (2013) The intestinal microbiota modulates the anticancer immune effects of cyclophosphamide. Science 22(342):971–976. https://doi.org/10.1126/science.1240537CrossRef

23.

van Vliet MJ, Tissing WJE, Dun CAJ, Meessen NEL, Kamps WA, de Bont ESJM et al (2009) Chemotherapy treatment in pediatric patients with acute myeloid leukemia receiving antimicrobial prophylaxis leads to a relative increase of colonization with potentially pathogenic bacteria in the gut. Clin Infect Dis Off Publ Infect Dis Soc Am 15(49):262–270. https://doi.org/10.1086/599346CrossRef

24.

Pope JL, Tomkovich S, Yang Y, Jobin C (2017) Microbiota as a mediator of cancer progression and therapy. Transl Res J Lab Clin Med 179:139–154. https://doi.org/10.1016/j.trsl.2016.07.021CrossRef

25.

Alexander JL, Wilson ID, Teare J, Marchesi JR, Nicholson JK, Kinross JM (2017) Gut microbiota modulation of chemotherapy efficacy and toxicity. Nat Rev Gastroenterol Hepatol 14:356–365. https://doi.org/10.1038/nrgastro.2017.20CrossRefPubMed

26.

Severyn CJ, Brewster R, Andermann TM (2019) Microbiota modification in hematology: still at the bench or ready for the bedside? Blood Adv 12(3):3461–3472. https://doi.org/10.1182/bloodadvances.2019000365CrossRef

27.

Ichim TE, Kesari S, Shafer K (2018) Protection from chemotherapy- and antibiotic-mediated dysbiosis of the gut microbiota by a probiotic with digestive enzymes supplement. Oncotarget 20(9):30919–30935. https://doi.org/10.18632/oncotarget.25778CrossRef

28.

Parkin DM (2006) The global health burden of infection-associated cancers in the year 2002. Int J Cancer 15(118):3030–3044. https://doi.org/10.1002/ijc.21731CrossRef

29.

Bossuet-Greif N, Vignard J, Taieb F, Mirey G, Dubois D, Petit C et al (2018) The colibactin genotoxin generates DNA interstrand cross-links in infected cells. mBio [cited 2021 6];9. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5874909/. https://doi.org/10.1128/mBio.02393-17

30.

Zou S, Fang L, Lee M-H (2018) Dysbiosis of gut microbiota in promoting the development of colorectal cancer. Gastroenterol Rep 6:1–12. https://doi.org/10.1093/gastro/gox031CrossRef

31.

Arthur JC, Perez-Chanona E, Mühlbauer M, Tomkovich S, Uronis JM, Fan T-J et al (2012) Intestinal inflammation targets cancer-inducing activity of the microbiota. Science 5(338):120–123. https://doi.org/10.1126/science.1224820CrossRef

32.

Dziubańska-Kusibab PJ, Berger H, Battistini F, Bouwman BAM, Iftekhar A, Katainen R et al (2020) Colibactin DNA-damage signature indicates mutational impact in colorectal cancer. Nat Med 26:1063–1069. https://doi.org/10.1038/s41591-020-0908-2CrossRefPubMed

33.

Pleguezuelos-Manzano C, Puschhof J, Rosendahl Huber A, van Hoeck A, Wood HM, Nomburg J et al (2020) Mutational signature in colorectal cancer caused by genotoxic pks + E. coli. Nature 580:269–73. https://doi.org/10.1038/s41586-020-2080-8CrossRefPubMedPubMedCentral

34.

Cougnoux A, Delmas J, Gibold L, Faïs T, Romagnoli C, Robin F et al (2016) Small-molecule inhibitors prevent the genotoxic and protumoural effects induced by colibactin-producing bacteria. Gut 1(65):278–285. https://doi.org/10.1136/gutjnl-2014-307241CrossRef

35.

Bruneau A, Baylatry M-T, Joly AC, Sokol H (2018) Gut microbiota: what impact on colorectal carcinogenesis and treatment? Bull Cancer (Paris) 105:70–80. https://doi.org/10.1016/j.bulcan.2017.10.025CrossRef

36.

Chang AH, Parsonnet J (2010) Role of bacteria in oncogenesis. Clin Microbiol Rev 23:837–857. https://doi.org/10.1128/CMR.00012-10CrossRefPubMedPubMedCentral

37.

Lamm DL (2000) Efficacy and safety of Bacille Calmette-Guérin immunotherapy in superficial bladder cancer. Clin Infect Dis 1(31):S86-90. https://doi.org/10.1086/314064CrossRef

38.

Redelman-Sidi G, Glickman MS, Bochner BH (2014) The mechanism of action of BCG therapy for bladder cancer—a current perspective. Nat Rev Urol 11:153–162. https://doi.org/10.1038/nrurol.2014.15CrossRefPubMed

39.

Chen J, Zhao K-N, Vitetta L (2019) Effects of intestinal microbial⁻elaborated butyrate on oncogenic signaling pathways. Nutrients 7:11. https://doi.org/10.3390/nu11051026CrossRef

40.

Basson A, Trotter A, Rodriguez-Palacios A, Cominelli F (2016) Mucosal interactions between genetics, diet, and microbiome in inflammatory bowel disease. Front Immunol [cited 2020 21];7. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4970383/. https://doi.org/10.3389/fimmu.2016.00290

41.

Sivaprakasam S, Prasad PD, Singh N (2016) Benefits of short-chain fatty acids and their receptors in inflammation and carcinogenesis. Pharmacol Ther 1(164):144–151. https://doi.org/10.1016/j.pharmthera.2016.04.007CrossRef

42.

Garrett WS (2015) Cancer and the microbiota. Science 3(348):80–86. https://doi.org/10.1126/science.aaa4972CrossRef

43.

Mager D (2006) Bacteria and cancer: cause, coincidence or cure? A review. J Transl Med 28(4):14. https://doi.org/10.1186/1479-5876-4-14CrossRef

44.

Lopez-Siles M, Duncan SH, Garcia-Gil LJ, Martinez-Medina M (2017) Faecalibacterium prausnitzii : from microbiology to diagnostics and prognostics. ISME J 11:841–852. https://doi.org/10.1038/ismej.2016.176CrossRefPubMedPubMedCentral

45.

Duncan SH, Louis P, Flint HJ (2004) Lactate-utilizing bacteria, isolated from human feces, that produce butyrate as a major fermentation product. Appl Environ Microbiol 70:5810–5817. https://doi.org/10.1128/AEM.70.10.5810-5817.2004CrossRefPubMedPubMedCentral

46.

Ye H, Adane B, Khan N, Alexeev E, Nusbacher N, Minhajuddin M et al (2018) Subversion of systemic glucose metabolism as a mechanism to support the growth of leukemia cells. Cancer Cell 8(34):659-673.e6. https://doi.org/10.1016/j.ccell.2018.08.016CrossRef

47.

Flores GE, Caporaso JG, Henley JB, Rideout JR, Domogala D, Chase J et al (2014) Temporal variability is a personalized feature of the human microbiome. Genome Biol [cited 2020 20];15. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4252997/.https://doi.org/10.1186/s13059-014-0531-y

48.

Nicholson JK, Holmes E, Kinross J, Burcelin R, Gibson G, Jia W et al (2012) Host-gut microbiota metabolic interactions. Science 8(336):1262–1267. https://doi.org/10.1126/science.1223813CrossRef

49.

Mandal RS, Saha S, Das S (2015) Metagenomic surveys of gut microbiota. Genomics Proteomics Bioinformatics 13:148–158. https://doi.org/10.1016/j.gpb.2015.02.005CrossRefPubMedPubMedCentral

50.

Rinninella E, Raoul P, Cintoni M, Franceschi F, Miggiano GAD, Gasbarrini A et al (2019) What is the healthy gut microbiota composition? A Changing ecosystem across age, environment, diet, and diseases. microorganisms [cited 2020 2];7. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6351938/. https://doi.org/10.3390/microorganisms7010014

51.

Turnbaugh PJ, Ley RE, Hamady M, Fraser-Liggett C, Knight R, Gordon JI (2007) The human microbiome project: exploring the microbial part of ourselves in a changing world. Nature 18(449):804–810. https://doi.org/10.1038/nature06244CrossRef

52.

Qin J, Li R, Raes J, Arumugam M, Burgdorf KS, Manichanh C et al (2010) A human gut microbial gene catalogue established by metagenomic sequencing. Nature 464:59–65. https://doi.org/10.1038/nature08821CrossRefPubMedPubMedCentral

53.

Kho ZY, Lal SK (2018) The human gut microbiome – a potential controller of wellness and disease. Front Microbiol [cited 2020 9];9. https://www.frontiersin.org/articles/10.3389/fmicb.2018.01835/. https://doi.org/10.3389/fmicb.2018.01835

54.

Ratajczak W, Rył A, Mizerski A, Walczakiewicz K, Sipak O, Laszczyńska M (2019) Immunomodulatory potential of gut microbiome-derived short-chain fatty acids (SCFAs). Acta Biochim Pol 4(66):1–12. https://doi.org/10.18388/abp.2018_2648CrossRef

55.

Rooks MG, Garrett WS (2016) Gut microbiota, metabolites and host immunity. Nat Rev Immunol 27(16):341–352. https://doi.org/10.1038/nri.2016.42CrossRef

56.

Bäckhed F, Ley RE, Sonnenburg JL, Peterson DA, Gordon JI (2005) Host-bacterial mutualism in the human intestine. Science 25(307):1915–1920. https://doi.org/10.1126/science.1104816CrossRef

57.

Bilotta AJ, Ma C, Yang W, Yu Y, Yu Y, Zhao X et al (2021) Propionate enhances cell speed and persistence to promote intestinal epithelial turnover and repair. Cell Mol Gastroenterol Hepatol 1(11):1023–1044. https://doi.org/10.1016/j.jcmgh.2020.11.011CrossRef

58.

Morrison DJ, Preston T (2016) Formation of short chain fatty acids by the gut microbiota and their impact on human metabolism. Gut Microbes 3(7):189–200. https://doi.org/10.1080/19490976.2015.1134082CrossRef

59.

Chattopadhyay I, Nandi D, Nag A (2020) The pint- sized powerhouse: illuminating the mighty role of the gut microbiome in improving the outcome of anti- cancer therapy. Semin. Cancer Biol [cited 2020 10];https://www.sciencedirect.com/science/article/pii/S1044579X20301693. https://doi.org/10.1016/j.semcancer.2020.07.012

60.

Goodman B, Gardner H (2018) The microbiome and cancer. J Pathol 244:667–676. https://doi.org/10.1002/path.5047CrossRefPubMed

61.

Lopetuso LR, Petito V, Graziani C, Schiavoni E, Sterbini FP, Poscia A et al (2018) Gut microbiota in health, diverticular disease, irritable bowel syndrome, and inflammatory bowel diseases: time for microbial marker of gastrointestinal disorders. Dig Dis 36:56–65. https://doi.org/10.1159/000477205CrossRefPubMed

62.

De Angelis M, Francavilla R, Piccolo M, De Giacomo A, Gobbetti M (2015) Autism spectrum disorders and intestinal microbiota. Gut Microbes 6:207–213. https://doi.org/10.1080/19490976.2015.1035855CrossRefPubMedPubMedCentral

63.

Cox AJ, West NP, Cripps AW (2015) Obesity, inflammation, and the gut microbiota. Lancet Diabetes Endocrinol 3:207–215. https://doi.org/10.1016/S2213-8587(14)70134-2CrossRefPubMed

64.

Rajagopala SV, Yooseph S, Harkins DM, Moncera KJ, Zabokrtsky KB, Torralba MG et al (2016) Gastrointestinal microbial populations can distinguish pediatric and adolescent acute lymphoblastic leukemia (ALL) at the time of disease diagnosis. BMC Genomics [cited 2021 1];17. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4986186/. https://doi.org/10.1186/s12864-016-2965-y

65.

Bai L, Zhou P, Li D, Ju X (2017) Changes in the gastrointestinal microbiota of children with acute lymphoblastic leukaemia and its association with antibiotics in the short term. J Med Microbiol 66:1297–1307. https://doi.org/10.1099/jmm.0.000568CrossRefPubMed

66.

Vicente-Dueñas C, Janssen S, Oldenburg M, Auer F, González-Herrero I, Casado-García A et al (2020) An intact gut microbiome protects genetically predisposed mice against leukemia. Blood 29(136):2003–2017. https://doi.org/10.1182/blood.2019004381CrossRef

67.

Burns MB, Lynch J, Starr TK, Knights D, Blekhman R (2015) Virulence genes are a signature of the microbiome in the colorectal tumor microenvironment. Genome Med 24(7):55. https://doi.org/10.1186/s13073-015-0177-8CrossRef

68.

Yu J, Feng Q, Wong SH, Zhang D, Liang Qy, Qin Y et al (2017) Metagenomic analysis of faecal microbiome as a tool towards targeted non-invasive biomarkers for colorectal cancer. Gut 66:70–8. https://doi.org/10.1136/gutjnl-2015-309800CrossRefPubMed

69.

Ren Z, Li A, Jiang J, Zhou L, Yu Z, Lu H et al (2019) Gut microbiome analysis as a tool towards targeted non-invasive biomarkers for early hepatocellular carcinoma. Gut 1(68):1014–1023. https://doi.org/10.1136/gutjnl-2017-315084CrossRef

70.

Ohigashi S, Sudo K, Kobayashi D, Takahashi O, Takahashi T, Asahara T et al (2013) Changes of the intestinal microbiota, short chain fatty acids, and fecal pH in patients with colorectal cancer. Dig Dis Sci 1(58):1717–1726. https://doi.org/10.1007/s10620-012-2526-4CrossRef

71.

Alhinai EA, Walton GE, Commane DM (2019) The role of the gut microbiota in colorectal cancer causation. Int J Mol Sci 24(20):5295. https://doi.org/10.3390/ijms20215295CrossRef

72.

Vivarelli S, Salemi R, Candido S, Falzone L, Santagati M, Stefani S et al (2019) Gut microbiota and cancer: from pathogenesis to therapy. Cancers 11:38. https://doi.org/10.3390/cancers11010038CrossRefPubMedCentral

73.

Cheng WY, Wu C-Y, Yu J (2020) The role of gut microbiota in cancer treatment: friend or foe? Gut 1(69):1867–1876. https://doi.org/10.1136/gutjnl-2020-321153CrossRef

74.

Arruebo M, Vilaboa N, Sáez-Gutierrez B, Lambea J, Tres A, Valladares M et al (2011) Assessment of the evolution of cancer treatment therapies. Cancers 3:3279–3330. https://doi.org/10.3390/cancers3033279CrossRefPubMedPubMedCentral

75.

Montassier E, Batard E, Massart S, Gastinne T, Carton T, Caillon J et al (2014) 16S rRNA gene pyrosequencing reveals shift in patient faecal microbiota during high-dose chemotherapy as conditioning regimen for bone marrow transplantation. Microb Ecol 67:690–699. https://doi.org/10.1007/s00248-013-0355-4CrossRefPubMed

76.

Iida N, Dzutsev A, Stewart CA, Smith L, Bouladoux N, Weingarten RA et al (2013) Commensal bacteria control cancer response to therapy by modulating the tumor microenvironment. Science 22(342):967–970. https://doi.org/10.1126/science.1240527CrossRef

77.

Guðmundsdóttir JS, Fredheim EGA, Koumans CIM, Hegstad J, Tang P-C, Andersson DI et al (2021) The chemotherapeutic drug methotrexate selects for antibiotic resistance. EBioMedicine [cited 2021 15];74. https://www.thelancet.com/journals/ebiom/article/PIIS2352-3964(21)00536-3/. https://doi.org/10.1016/j.ebiom.2021.103742

78.

Nakamura S, Oda Y, Shimada T, Oki I, Sugimoto K (1987) SOS-inducing activity of chemical carcinogens and mutagens in Salmonella typhimurium TA1535/pSK1002: examination with 151 chemicals. Mutat Res Lett 1(192):239–246. https://doi.org/10.1016/0165-7992(87)90063-7CrossRef

79.

Meunier A, Nerich V, Fagnoni-Legat C, Richard M, Mazel D, Adotevi O et al (2019) Enhanced emergence of antibiotic-resistant pathogenic bacteria after in vitro induction with cancer chemotherapy drugs. J Antimicrob Chemother 1(74):1572–1577. https://doi.org/10.1093/jac/dkz070CrossRef

80.

Foley GE, McCarthy RE, Binns VM, Snell EE, Guirard BM, Kidder GW et al (1958) A comparative study of the use of microorganisms in the screening of potential antitumor agents*. Ann N Y Acad Sci 76:413–441. https://doi.org/10.1111/j.1749-6632.1958.tb54862.xCrossRefPubMed

81.

Schabel FM, Pittillo RF (1961) Screening for and biological characterization of antitumor agents using microorganisms11the work reported here that was conducted in the authors’ laboratories was supported by Contract No. SA-43-ph-1809 with the Cancer Chemotherapy National Service Center, National Cancer Institute, National Institutes of Health. In: Umbreit WW, editor. Advances in Applied Microbiology. Academic Press; [cited 2022 7]. p. 223–56.https://www.sciencedirect.com/science/article/pii/S0065216408705112. https://doi.org/10.1016/S0065-2164(08)70511-2

82.

Falzone L, Salomone S, Libra M (2018) Evolution of cancer pharmacological treatments at the turn of the third millennium. Front Pharmacol [cited 2022 12];9. https://www.frontiersin.org/article/10.3389/fphar.2018.01300

83.

Hoff DDV, Slavik M, Muggia F(2020) 5-Azacytidine. Ann Intern Med [cited 2021 14]. https://www.acpjournals.org/doi/abs/10.7326/0003-4819-85-2-237

84.

Bischoff KB, Dedrick RL, Zaharko DS, Longstreth JA (1971) Methotrexate pharmacokinetics. J Pharm Sci 60:1128–1133. https://doi.org/10.1002/jps.2600600803CrossRefPubMed

85.

Teller MN (1961) Division of microbiology: antibiotics in experimental cancer chemotherapy*. Trans N Y Acad Sci 24:158–166. https://doi.org/10.1111/j.2164-0947.1961.tb00759.xCrossRefPubMed

86.

Paces V, Doskocil J, Sorm F (1968) The effect of 5-azacytidine on the synthesis of ribosomes in escherichia coli. FEBS Lett 1:55–58. https://doi.org/10.1016/0014-5793(68)80017-1CrossRefPubMed

87.

Bodet CA, Jorgensen JH, Drutz DJ (1985) Antibacterial activities of antineoplastic agents. Antimicrob Agents Chemother 28:437–439CrossRefPubMedPubMedCentral

88.

Michel J, Jacobs JY, Sacks T (1979) Bactericidal effect of combinations of antimicrobial drugs and antineoplastic antibiotics against gram-negative bacilli. Antimicrob Agents Chemother 16:761–766CrossRefPubMedPubMedCentral

89.

Levy HB (1963) Effect of actinomycin d on hela cell nuclear RNA metabolism. Proc Soc Exp Biol Med Soc Exp Biol Med N Y N 113:886–9. https://doi.org/10.3181/00379727-113-28521CrossRef

90.

Hamilton-Miller JM (1984) Antimicrobial activity of 21 anti-neoplastic agents. Br J Cancer 49:367–369CrossRefPubMedPubMedCentral

91.

Benedict WF, Baker MS, Haroun L, Choi E, Ames BN (1977) Mutagenicity of cancer chemotherapeutic agents in the Salmonella/microsome test. Cancer Res 37:2209–2213PubMed

92.

Beale G (1993) The discovery of mustard gas mutagenesis by Auerbach and Robson in 1941. Genetics 1(134):393–399CrossRef

93.

Iyer VN, Szybalski W (1958) Two simple methods for the detection of chemical mutagens. Appl Microbiol 6:23–29CrossRefPubMedPubMedCentral

94.

Scherr GH, Fishman M, Weaver RH (1954) The mutagenicity of some carcinogenic compounds for Escherichia Coli. Genetics 39:141–149CrossRefPubMedPubMedCentral

95.

Ames BN, Lee FD, Durston WE (1973) An improved bacterial test system for the detection and classification of mutagens and carcinogens. Proc Natl Acad Sci U S A 70:782–786CrossRefPubMedPubMedCentral

96.

Ames BN (1973) Carcinogens are mutagens: their detection and classification. Environ Health Perspect 6:115–118CrossRefPubMedPubMedCentral

97.

Mortelmans K, Zeiger E (2000) The Ames Salmonella/microsome mutagenicity assay. Mutat Res 20(455):29–60CrossRef

98.

Dunkel VC, Zeiger E, Brusick D, McCoy E, McGregor D, Mortelmans K et al (1984) Reproducibility of microbial mutagenicity assays: I. Tests with Salmonella typhimurium and Escherichia coli using a standardized protocol. Environ Mutagen 6(Suppl 2):1–251CrossRefPubMed

99.

Toolaram AP, Kümmerer K, Schneider M (2014) Environmental risk assessment of anti-cancer drugs and their transformation products: a focus on their genotoxicity characterization-state of knowledge and short comings. Mutat Res Rev Mutat Res. https://doi.org/10.1016/j.mrrev.2014.02.001

100.

Quillardet P, Huisman O, D’Ari R, Hofnung M (1982) SOS chromotest, a direct assay of induction of an SOS function in Escherichia coli K-12 to measure genotoxicity. Proc Natl Acad Sci U S A 79:5971–5975CrossRefPubMedPubMedCentral

101.

Radman M (1975) SOS repair hypothesis: phenomenology of an inducible DNA repair which is accompanied by mutagenesis. Basic Life Sci 5A:355–367. https://doi.org/10.1007/978-1-4684-2895-7_48CrossRefPubMed

102.

Michel B (2005) After 30 years of study, the bacterial SOS response still surprises us. PLoS Biol 3:e255. https://doi.org/10.1371/journal.pbio.0030255CrossRefPubMedPubMedCentral

103.

Matney TS, Nguyen TV, Connor TH, Theiss JC, Dana WJ (1985) Genotoxic classification of anticancer drugs. Teratog Carcinog Mutagen 1(5):319–328. https://doi.org/10.1002/tcm.1770050502CrossRef

104.

Hannan MA, al-Dakan AA, Hussain SS, Amer MH (1989) Mutagenicity of cisplatin and carboplatin used alone and in combination with four other anticancer drugs. Toxicology 55:183–91CrossRefPubMed

105.

Bouayadi K, Villani G, Salles B (1993) Resistance to cisplatin in an E. coli B/r NalR mutant. Mutat Res 1(294):77–87. https://doi.org/10.1016/0921-8777(93)90060-TCrossRef

106.

Keller KL, Overbeck-Carrick TL, Beck DJ (2001) Survival and induction of SOS in Escherichia coli treated with cisplatin, UV-irradiation, or mitomycin C are dependent on the function of the RecBC and RecFOR pathways of homologous recombination. Mutat Res 5(486):21–29CrossRef

107.

Szikriszt B, Póti Á, Pipek O, Krzystanek M, Kanu N, Molnár J et al (2016) A comprehensive survey of the mutagenic impact of common cancer cytotoxics. Genome Biol 17. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4862131. https://doi.org/10.1186/s13059-016-0963-7

108.

Parrella A, Lavorgna M, Criscuolo E, Russo C, Isidori M (2015) Eco-genotoxicity of six anticancer drugs using comet assay in daphnids. J Hazard Mater 9(286):573–580. https://doi.org/10.1016/j.jhazmat.2015.01.012CrossRef

109.

Papanicolas LE, Gordon DL, Wesselingh SL, Rogers GB (2018) Not just antibiotics: is cancer chemotherapy driving antimicrobial resistance? Trends Microbiol 26:393–400. https://doi.org/10.1016/j.tim.2017.10.009CrossRefPubMed

110.

Ames BN, Gurney EG, Miller JA, Bartsch H (1972) Carcinogens as frameshift mutagens: metabolites and derivatives of 2-acetylaminofluorene and other aromatic amine carcinogens. Proc Natl Acad Sci U S A 69:3128–3132CrossRefPubMedPubMedCentral

111.

Cohen SS, I J (1976) Synthesis and the lethality of bleomycin in bacteria. Cancer Res. 1(36):2768–74

112.

Dortet L, Nordmann P, Poirel L (2012) Association of the emerging carbapenemase NDM-1 with a bleomycin resistance protein in Enterobacteriaceae and Acinetobacter baumannii. Antimicrob Agents Chemother 56:1693–1697. https://doi.org/10.1128/AAC.05583-11CrossRefPubMedPubMedCentral

113.

Gieringer JH, Wenz AF, Just HM, Daschner FD (1986) Effect of 5-fluorouracil, mitoxantrone, methotrexate, and vincristine on the antibacterial activity of ceftriaxone, ceftazidime, cefotiam, piperacillin, and netilmicin. Chemotherapy 32:418–424CrossRefPubMed

114.

López-Jácome E, Franco-Cendejas R, Quezada H, Morales-Espinosa R, I I, González-Pedrajo B et al (2019) The race between drug introduction and appearance of microbial resistance. Current balance and alternative approaches. Curr Opin Pharmacol 48:48–56. https://doi.org/10.1016/j.coph.2019.04.016CrossRefPubMed

115.

Soo VWC, Kwan BW, Quezada H, Castillo-Juárez I, Pérez-Eretza B, García-Contreras SJ et al (2017) Repurposing of anticancer drugs for the treatment of bacterial infections. Curr Top Med Chem 17:1157–1176. https://doi.org/10.2174/1568026616666160930131737CrossRefPubMed

116.

Stringer AM, Gibson RJ, Bowen JM, Keefe DMK (2009) Chemotherapy-induced modifications to gastrointestinal microflora: evidence and implications of change. [cited 2020 9]. https://www.ingentaconnect.com/content/ben/cdm/2009/00000010/00000001/art00009. https://doi.org/10.2174/138920009787048419

117.

Pačes V, Doskočil J, Šorm F (1968) Incorporation of 5-azacytidine into nucleic acids of Escherichia coli. Biochim Biophys Acta BBA - Nucleic Acids Protein Synth. 161:352–60. https://doi.org/10.1016/0005-2787(68)90113-5CrossRef

118.

Friedman S, Cheong LC (1984) Effect of 5-azacytidine on deoxyribonucleic acid methylation in Escherichia coli K12. Biochem Pharmacol 15(33):2675–2679. https://doi.org/10.1016/0006-2952(84)90644-0CrossRef

119.

Peiris V, Oppenheim BA (1993) Antimicrobial activity of cytotoxic drugs may influence isolation of bacteria and fungi from blood cultures. J Clin Pathol 46:1124–1125CrossRefPubMedPubMedCentral

120.

Bjedov I, Tenaillon O, Gérard B, Souza V, Denamur E, Radman M et al (2003) Stress-induced mutagenesis in bacteria. Science 30(300):1404–1409. https://doi.org/10.1126/science.1082240CrossRef

121.

Beaber JW, Hochhut B, Waldor MK (2004) SOS response promotes horizontal dissemination of antibiotic resistance genes. Nature 1(427):72–74. https://doi.org/10.1038/nature02241CrossRef

122.

Moody MR, Morris MJ, Young VM, Moyé LA, Schimpff SC, Wiernik PH (1978) Effect of two cancer chemotherapeutic agents on the antibacterial activity of three antimicrobial agents. Antimicrob Agents Chemother 14:737–742CrossRefPubMedPubMedCentral

123.

Maier L, Pruteanu M, Kuhn M, Zeller G, Telzerow A, Anderson EE et al (2018) Extensive impact of non-antibiotic drugs on human gut bacteria. Nature 29(555):623–628. https://doi.org/10.1038/nature25979CrossRef

124.

Dortet L, Girlich D, Virlouvet A-L, Poirel L, Nordmann P, Iorga BI et al (2017) Characterization of BRPMBL, the bleomycin resistance protein associated with the carbapenemase NDM. Antimicrob Agents Chemother 61:e02413-e2416. https://doi.org/10.1128/AAC.02413-16CrossRefPubMedPubMedCentral

125.

Zwielehner J, Lassl C, Hippe B, Pointner A, Switzeny OJ, Remely M et al (2011) Changes in human fecal microbiota due to chemotherapy analyzed by TaqMan-PCR, 454 sequencing and PCR-DGGE fingerprinting. PLoS ONE 6:e28654. https://doi.org/10.1371/journal.pone.0028654CrossRefPubMedPubMedCentral

126.

Pietri SD, Ingham AC, Frandsen TL, Rathe M, Krych L, Castro-Mejía JL et al (2020) Gastrointestinal toxicity during induction treatment for childhood acute lymphoblastic leukemia: the impact of the gut microbiota. Int J Cancer 147:1953–1962. https://doi.org/10.1002/ijc.32942CrossRefPubMed

127.

Xu X, Zhang X (2015) Effects of cyclophosphamide on immune system and gut microbiota in mice. Microbiol Res 171:97–106. https://doi.org/10.1016/j.micres.2014.11.002CrossRefPubMed

128.

Rashid MU, Rosenborg S, Panagiotidis G, Löfdal KS, Weintraub A, Nord CE (2015) Ecological effect of ceftazidime/avibactam on the normal human intestinal microbiota. Int J Antimicrob Agents 46:60–65. https://doi.org/10.1016/j.ijantimicag.2015.02.027CrossRefPubMed

129.

Vétizou M, Pitt JM, Daillère R, Lepage P, Waldschmitt N, Flament C et al (2015) Anticancer immunotherapy by CTLA-4 blockade relies on the gut microbiota. Science 27(350):1079–1084. https://doi.org/10.1126/science.aad1329CrossRef

130.

Daillère R, Vétizou M, Waldschmitt N, Yamazaki T, Isnard C, Poirier-Colame V et al (2016) Enterococcus hirae and Barnesiella intestinihominis facilitate cyclophosphamide-induced therapeutic immunomodulatory effects. Immunity 18(45):931–943. https://doi.org/10.1016/j.immuni.2016.09.009CrossRef

131.

van Vliet MJ, Harmsen HJM, de Bont ESJM, Tissing WJE (2010) The role of intestinal microbiota in the development and severity of chemotherapy-induced mucositis. PLoS Pathog 27(6):e1000879. https://doi.org/10.1371/journal.ppat.1000879CrossRef

132.

Sonis ST (2004) The pathobiology of mucositis. Nat Rev Cancer 4:277–284. https://doi.org/10.1038/nrc1318CrossRefPubMed

133.

Yi M, Jiao D, Qin S, Chu Q, Li A, Wu K (2019) Manipulating gut microbiota composition to enhance the therapeutic effect of cancer immunotherapy. Integr Cancer Ther 1(18):1534735419876351. https://doi.org/10.1177/1534735419876351CrossRef

134.

Leite JB, Vilela EG, da Gama Torres HO, de Lourdes de Abreu Ferrari M, da Cunha AS (2014) Intestinal permeability in leukemic patients prior to chemotherapy. Rev Bras Hematol E Hemoter 36:409–13. https://doi.org/10.1016/j.bjhh.2014.07.007CrossRef

135.

De Pietri S, Frandsen TL, Christensen M, Grell K, Rathe M, Müller K (2021) Citrulline as a biomarker of bacteraemia during induction treatment for childhood acute lymphoblastic leukaemia. Pediatr Blood Cancer 68:e28793. https://doi.org/10.1002/pbc.28793CrossRefPubMed

136.

Bow EJ, Meddings JB (2006) Intestinal mucosal dysfunction and infection during remission-induction therapy for acute myeloid leukaemia. Leukemia 20:2087–2092. https://doi.org/10.1038/sj.leu.2404440CrossRefPubMed

137.

Blijlevens NMA, van Land B, Donnelly JP, M’Rabet L, de Pauw BE (2004) Measuring mucosal damage induced by cytotoxic therapy. Support Care Cancer Off J Multinatl Assoc Support Care Cancer 12:227–33. https://doi.org/10.1007/s00520-003-0572-3CrossRef

138.

Sundström GM, Wahlin A, Nordin-Andersson I, Suhr OB (1998) Intestinal permeability in patients with acute myeloid leukemia. Eur J Haematol 61:250–254CrossRefPubMed

139.

van Vliet MJ, Tissing WJE, Rings EHHM, Koetse HA, Stellaard F, Kamps WA et al (2009) Citrulline as a marker for chemotherapy induced mucosal barrier injury in pediatric patients. Pediatr Blood Cancer 15(53):1188–1194. https://doi.org/10.1002/pbc.22210CrossRef

140.

Krndija D, Marjou FE, Guirao B, Richon S, Leroy O, Bellaiche Y et al (2019) Active cell migration is critical for steady-state epithelial turnover in the gut. Science 16(365):705–710. https://doi.org/10.1126/science.aau3429CrossRef

141.

Roy S, Trinchieri G (2017) Microbiota: a key orchestrator of cancer therapy. Nat Rev Cancer 17:271–285. https://doi.org/10.1038/nrc.2017.13CrossRefPubMed

142.

Panebianco C, Andriulli A, Pazienza V (2018) Pharmacomicrobiomics: exploiting the drug-microbiota interactions in anticancer therapies. Microbiome [cited 2020 14];6. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5964925. https://doi.org/10.1186/s40168-018-0483-7

143.

Ghanem S, Kim CJ, Dutta D, Salifu M, Lim SH. Antimicrobial therapy during cancer treatment: beyond antibacterial effects. J Intern Med [cited 2021 29];n/a. https://onlinelibrary.wiley.com/doi/abs/10.1111/joim.13238. https://doi.org/10.1111/joim.13238

144.

Tlaskalová-Hogenová H, Štěpánková R, Kozáková H, Hudcovic T, Vannucci L, Tučková L et al (2011) The role of gut microbiota (commensal bacteria) and the mucosal barrier in the pathogenesis of inflammatory and autoimmune diseases and cancer: contribution of germ-free and gnotobiotic animal models of human diseases. Cell Mol Immunol 8:110. https://doi.org/10.1038/cmi.2010.67CrossRefPubMedPubMedCentral

145.

Ley RE, Turnbaugh PJ, Klein S, Gordon JI (2006) Microbial ecology: human gut microbes associated with obesity. Nature 21(444):1022–1023. https://doi.org/10.1038/4441022aCrossRef

146.

Mariat D, Firmesse O, Levenez F, Guimarăes V, Sokol H, Doré J et al (2009) The Firmicutes/Bacteroidetes ratio of the human microbiota changes with age. BMC Microbiol 9(9):123. https://doi.org/10.1186/1471-2180-9-123CrossRefPubMedPubMedCentral

147.

Ley RE, Bäckhed F, Turnbaugh P, Lozupone CA, Knight RD, Gordon JI (2005) Obesity alters gut microbial ecology. Proc Natl Acad Sci 2(102):11070–11075. https://doi.org/10.1073/pnas.0504978102CrossRef

148.

Ling Z, Liu X, Jia X, Cheng Y, Luo Y, Yuan L et al (2014) Impacts of infection with different toxigenic Clostridium difficile strains on faecal microbiota in children. Sci Rep 15(4):7485. https://doi.org/10.1038/srep07485CrossRef

149.

Peterson DA, Frank DN, Pace NR, Gordon JI (2008) Metagenomic approaches for defining the pathogenesis of inflammatory bowel diseases. Cell Host Microbe 12(3):417–427. https://doi.org/10.1016/j.chom.2008.05.001CrossRef

150.

Touchefeu Y, Montassier E, Nieman K, Gastinne T, Potel G, Bruley des Varannes S et al (2014) Systematic review: the role of the gut microbiota in chemotherapy- or radiation-induced gastrointestinal mucositis - current evidence and potential clinical applications. Aliment Pharmacol Ther 40:409–21. https://doi.org/10.1111/apt.12878CrossRefPubMed

151.

Galloway-Peña JR, Smith DP, Sahasrabhojane P, Ajami NJ, Wadsworth WD, Daver NG et al (2016) The role of the gastrointestinal microbiome in infectious complications during induction chemotherapy for acute myeloid leukemia. Cancer 15(122):2186–2196. https://doi.org/10.1002/cncr.30039CrossRef

152.

Viaud S, Daillère R, Yamazaki T, Lepage P, Boneca I, Goldszmid R et al (2014) Why should we need the gut microbiota to respond to cancer therapies? Oncoimmunology 1(3):e27574. https://doi.org/10.4161/onci.27574CrossRef

153.

Couzin-Frankel J (2013) Breakthrough of the year 2013. Cancer Immunother Sci 20(342):1432–1433. https://doi.org/10.1126/science.342.6165.1432CrossRef

154.

Gopalakrishnan V, Spencer CN, Nezi L, Reuben A, Andrews MC, Karpinets TV et al (2018) Gut microbiome modulates response to anti–PD-1 immunotherapy in melanoma patients. Science 5(359):97–103. https://doi.org/10.1126/science.aan4236CrossRef

155.

Lehouritis P, Cummins J, Stanton M, Murphy CT, McCarthy FO, Reid G et al (2015) Local bacteria affect the efficacy of chemotherapeutic drugs. Sci Rep 29(5):14554. https://doi.org/10.1038/srep14554CrossRef

156.

Vande Voorde J, Sabuncuoğlu S, Noppen S, Hofer A, Ranjbarian F, Fieuws S et al (2014) Nucleoside-catabolizing enzymes in mycoplasma-infected tumor cell cultures compromise the cytostatic activity of the anticancer drug gemcitabine. J Biol Chem 9(289):13054–13065. https://doi.org/10.1074/jbc.M114.558924CrossRef

157.

Gao Z, Guo B, Gao R, Zhu Q, Qin H (2015) Microbiota disbiosis is associated with colorectal cancer. Front Microbiol [cited 2020 2];6. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4313696. https://doi.org/10.3389/fmicb.2015.00020

158.

Galloway-Peña JR, Jenq RR, Shelburne SA (2017) Can consideration of the microbiome improve antimicrobial utilization and treatment outcomes in the oncology patient? Clin Cancer Res Off J Am Assoc Cancer Res. 23:3263–8. https://doi.org/10.1158/1078-0432.CCR-16-3173CrossRef

159.

Doré J, Multon M-C, Béhier J-M (2017) Participants of Giens XXXII, Round Table No. 2. The human gut microbiome as source of innovation for health: which physiological and therapeutic outcomes could we expect? Therapie 72:21–38. https://doi.org/10.1016/j.therap.2016.12.007CrossRefPubMed

160.

Mirnezami R, Nicholson J, Darzi A (2012) Preparing for precision medicine. N Engl J Med 9(366):489–491. https://doi.org/10.1056/NEJMp1114866CrossRef

161.

Morkūnas E, Skiecevičienė J, Kupčinskas J (2020) The impact of modulating the gastrointestinal microbiota in cancer patients. Best Pract Res Clin Gastroenterol 1(48–49):101700. https://doi.org/10.1016/j.bpg.2020.101700CrossRef

162.

Wallace BD, Wang H, Lane KT, Scott JE, Orans J, Koo JS et al (2010) Alleviating cancer drug toxicity by inhibiting a bacterial enzyme. Science 5(330):831–835. https://doi.org/10.1126/science.1191175CrossRef

163.

de Gunzburg J, Ghozlane A, Ducher A, Le Chatelier E, Duval X, Ruppé E et al (2018) Protection of the human gut microbiome from antibiotics. J Infect Dis 30(217):628–636. https://doi.org/10.1093/infdis/jix604CrossRef

164.

Baumgartner M, Pfrunder-Cardozo KR, Hall AR. Microbial community composition interacts with local abiotic conditions to drive colonization resistance in human gut microbiome samples. Proc R Soc B Biol Sci 288:20203106. https://doi.org/10.1098/rspb.2020.3106

165.

Zmora N, Zilberman-Schapira G, Suez J, Mor U, Dori-Bachash M, Bashiardes S et al (2018) Personalized gut mucosal colonization resistance to empiric probiotics is associated with unique host and microbiome features. Cell 174:1388-1405.e21. https://doi.org/10.1016/j.cell.2018.08.041CrossRefPubMed

166.

Gerbitz A, Schultz M, Wilke A, Linde H-J, Schölmerich J, Andreesen R et al (2004) Probiotic effects on experimental graft-versus-host disease: let them eat yogurt. Blood 1(103):4365–4367. https://doi.org/10.1182/blood-2003-11-3769CrossRef

167.

Wada M, Nagata S, Saito M, Shimizu T, Yamashiro Y, Matsuki T et al (2010) Effects of the enteral administration of Bifidobacterium breve on patients undergoing chemotherapy for pediatric malignancies. Support Care Cancer Off J Multinatl Assoc Support Care Cancer 18:751–9. https://doi.org/10.1007/s00520-009-0711-6CrossRef

168.

Van de Wiele T, Van den Abbeele P, Ossieur W, Possemiers S, Marzorati M (2015 ) The simulator of the human intestinal microbial ecosystem (SHIME®) [Internet]. In: Verhoeckx K, Cotter P, López-Expósito I, Kleiveland C, Lea T, Mackie A, et al., editors. The Impact of Food Bioactives on Health: in vitro and ex vivo models. Cham (CH): Springer; [cited 2018 17]. http://www.ncbi.nlm.nih.gov/books/NBK500150/

169.

Kumar R, Sood U, Gupta V, Singh M, Scaria J, Lal R (2020) Recent advancements in the development of modern probiotics for restoring human gut microbiome dysbiosis. Indian J Microbiol 1(60):12–25. https://doi.org/10.1007/s12088-019-00808-yCrossRef

170.

Chen D, Wu J, Jin D, Wang B, Cao H (2019) Fecal microbiota transplantation in cancer management: current status and perspectives. Int J Cancer 145:2021–2031. https://doi.org/10.1002/ijc.32003CrossRefPubMed

171.

Routy B, Chatelier EL, Derosa L, Duong CPM, Alou MT, Daillère R et al (2018) Gut microbiome influences efficacy of PD-1–based immunotherapy against epithelial tumors. Science 5(359):91–97. https://doi.org/10.1126/science.aan3706CrossRef

172.

Derrien M, Van Baarlen P, Hooiveld G, Norin E, Müller M, de Vos WM (2011) Modulation of mucosal immune response, tolerance, and proliferation in mice colonized by the mucin-degrader Akkermansia muciniphila. Front Microbiol 2:166. https://doi.org/10.3389/fmicb.2011.00166CrossRefPubMedPubMedCentral

173.

Cammarota G, Ianiro G, Tilg H, Rajilić-Stojanović M, Kump P, Satokari R et al (2017) European consensus conference on faecal microbiota transplantation in clinical practice. Gut 1(66):569–580. https://doi.org/10.1136/gutjnl-2016-313017CrossRef

174.

Zhang F, Luo W, Shi Y, Fan Z, Ji G (2012) Should we standardize the 1,700-year-old fecal microbiota transplantation? Am J Gastroenterol 107:1755; author reply p.1755–1756. https://doi.org/10.1038/ajg.2012.251

175.

Khoruts A, Sadowsky MJ (2016) Understanding the mechanisms of faecal microbiota transplantation. Nat Rev Gastroenterol Hepatol 13:508–516. https://doi.org/10.1038/nrgastro.2016.98CrossRefPubMedPubMedCentral

176.

Baruch EN, Youngster I, Ben-Betzalel G, Ortenberg R, Lahat A, Katz L et al (2021) Fecal microbiota transplant promotes response in immunotherapy-refractory melanoma patients. Science 5(371):602–609. https://doi.org/10.1126/science.abb5920CrossRef

177.

Olesen SW, Leier MM, Alm EJ, Kahn SA (2018) Searching for superstool: maximizing the therapeutic potential of FMT. Nat Rev Gastroenterol Hepatol 15:387–388. https://doi.org/10.1038/s41575-018-0019-4CrossRefPubMed

178.

Kellermayer R (2019) Fecal microbiota transplantation: great potential with many challenges. Transl Gastroenterol Hepatol [cited 2021 26];4. https://tgh.amegroups.com/article/view/5081. https://doi.org/10.21037/tgh.2019.05.10

179.

Malard F, Vekhoff A, Lapusan S, Isnard F, D’incan-Corda E, Rey J et al (2021) Gut microbiota diversity after autologous fecal microbiota transfer in acute myeloid leukemia patients. Nat Commun 12:3084. https://doi.org/10.1038/s41467-021-23376-6CrossRefPubMedPubMedCentral

180.

Torres-Fuentes C, Schellekens H, Dinan TG, Cryan JF (2017) The microbiota–gut–brain axis in obesity. Lancet Gastroenterol Hepatol 1(2):747–756. https://doi.org/10.1016/S2468-1253(17)30147-4CrossRef

181.

Cammarota G, Ianiro G, Kelly CR, Mullish BH, Allegretti JR, Kassam Z et al (2019) International consensus conference on stool banking for faecal microbiota transplantation in clinical practice. Gut 1(68):2111–2121. https://doi.org/10.1136/gutjnl-2019-319548CrossRef

182.

Payne AN, Zihler A, Chassard C, Lacroix C (2012) Advances and perspectives in in vitro human gut fermentation modeling. Trends Biotechnol 1(30):17–25. https://doi.org/10.1016/j.tibtech.2011.06.011CrossRef

183.

Williams Cf, Walton Ge, Jiang L, Plummer S, Garaiova I, Gibson Gr (2015) Comparative analysis of intestinal tract models. Annu Rev Food Sci Technol 6:329–50. https://doi.org/10.1146/annurev-food-022814-015429CrossRefPubMed

184.

Auchtung JM, Robinson CD, Britton RA (2015) Cultivation of stable, reproducible microbial communities from different fecal donors using minibioreactor arrays (MBRAs). Microbiome 30(3):42. https://doi.org/10.1186/s40168-015-0106-5CrossRef

185.

Chassaing B, Koren O, Goodrich JK, Poole AC, Srinivasan S, Ley RE et al (2015) Dietary emulsifiers impact the mouse gut microbiota promoting colitis and metabolic syndrome. Nature 519:92–96. https://doi.org/10.1038/nature14232CrossRefPubMedPubMedCentral

186.

Le Bastard Q, Ward T, Sidiropoulos D, Hillmann BM, Chun CL, Sadowsky MJ et al (2018) Fecal microbiota transplantation reverses antibiotic and chemotherapy-induced gut dysbiosis in mice. Sci Rep 18(8):6219. https://doi.org/10.1038/s41598-018-24342-xCrossRef

187.

Taur Y, Jenq RR, Perales M-A, Littmann ER, Morjaria S, Ling L et al (2014) The effects of intestinal tract bacterial diversity on mortality following allogeneic hematopoietic stem cell transplantation. Blood 14(124):1174–1182. https://doi.org/10.1182/blood-2014-02-554725CrossRef

188.

Taur Y, Coyte K, Schluter J, Robilotti E, Figueroa C, Gjonbalaj M et al (2018) Reconstitution of the gut microbiota of antibiotic-treated patients by autologous fecal microbiota transplant. Sci Transl Med 26:10. https://doi.org/10.1126/scitranslmed.aap9489CrossRef

Titel: The interplay between anticancer challenges and the microbial communities from the gut
verfasst von: Claire Amaris Hobson
Stéphane Bonacorsi
André Baruchel
Olivier Tenaillon
André Birgy
Publikationsdatum: 30.03.2022
Verlag: Springer Berlin Heidelberg
Erschienen in: European Journal of Clinical Microbiology & Infectious Diseases / Ausgabe 5/2022
Print ISSN: 0934-9723
Elektronische ISSN: 1435-4373
DOI: https://doi.org/10.1007/s10096-022-04435-2

Leitlinien kompakt für die Innere Medizin

Mit medbee Pocketcards sicher entscheiden.

^{Seit 2022 gehört die medbee GmbH zum Springer Medizin Verlag}

Kostenlos registrieren

Neu im Fachgebiet Innere Medizin

19.04.2024 | Vorhofflimmern | Nachrichten

Update Innere Medizin

Bestellen Sie unseren Fach-Newsletter und bleiben Sie gut informiert.

Newsletter bestellen

Live-Webinar: Aktuelle Leitlinien bei Herz-Kreislauf-Erkrankungen

Springer Medizin

The interplay between anticancer challenges and the microbial communities from the gut

Abstract

Leitlinien kompakt für die Innere Medizin

Neu im Fachgebiet Innere Medizin

Parodontalbehandlung verbessert Prognose bei Katheterablation

Antihypertensiva schützen auch alte Menschen noch vor Demenz

Stereotaktische Radiatio schlägt konventionelle Bestrahlung

Denken Sie bei starker Blutung auch an die Hemmkörper-Hämophilie

Update Innere Medizin

Live-Webinar: Aktuelle Leitlinien bei Herz-Kreislauf-Erkrankungen

Springer Medizin

Abstract

Bitte loggen Sie sich ein, um Zugang zu diesem Inhalt zu erhalten

Weitere Artikel der Ausgabe 5/2022

Evaluating outcomes associated with revised fluoroquinolone breakpoints for Enterobacterales urinary tract infections: A retrospective cohort study

Laboratory and clinical predictors of focal involvement and bacteremia in brucellosis

Risk factors for antibiotic resistance and mortality in patients with bloodstream infection of Escherichia coli

Characteristics and outcomes of carbapenemase harbouring carbapenem-resistant Klebsiella spp. bloodstream infections: a multicentre prospective cohort study in an OXA-48 endemic setting

Characterization of hypervirulent Klebsiella pneumoniae isolates in Belgium

Inoculum effect of Enterobacterales co-expressing OXA-48 and CTX-M on the susceptibility to ceftazidime/avibactam and meropenem

Leitlinien kompakt für die Innere Medizin

Neu im Fachgebiet Innere Medizin

Parodontalbehandlung verbessert Prognose bei Katheterablation

Antihypertensiva schützen auch alte Menschen noch vor Demenz

Stereotaktische Radiatio schlägt konventionelle Bestrahlung

Denken Sie bei starker Blutung auch an die Hemmkörper-Hämophilie

Update Innere Medizin