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28.11.2016 | 2016 SSAT Quick Shot Presentation | Ausgabe 2/2017

Journal of Gastrointestinal Surgery 2/2017

The Long-Term Efficacy and Safety of Pyloroplasty Combined with Gastric Electrical Stimulation Therapy in Gastroparesis

Zeitschrift:
Journal of Gastrointestinal Surgery > Ausgabe 2/2017
Autoren:
Brian R. Davis, Irene Sarosiek, Mohammad Bashashati, Ben Alvarado, Richard W. McCallum

Abstract

Introduction

Gastroparesis is delayed gastric emptying without mechanical obstruction. Symptomatic improvement can be 50–60% with gastric electrical stimulation. To address delayed gastric emptying, pyloroplasty was added. This study examines the long-term efficacy and safety of simultaneous gastric electrical stimulator implantation and pyloroplasty.

Methods

In this prospective single-arm trial conducted from 2012 to 2015, 27 [23 females; mean age 43 (22–63)] gastroparesis patients who underwent simultaneous gastric electrical stimulator implantation with Heineke-Mikulicz pyloroplasty were studied. Six (25%) underwent simultaneous robot-assisted pyloroplasty and gastric electrical stimulator implantation. Diagnosis of gastroparesis was based on the 4-h gastric emptying test defined as >60% retention of isotope at 2 h and >10% at 4 h. Total symptom scores assessing severity of nausea, early satiety, bloating, vomiting, post-prandial fullness, and epigastric pain were obtained at baseline and at follow-up visits, ranging from 3 to 38 months (mean: 17).

Results

Follow-up data from 24 patients were available for analysis. There was 71% improvement in total symptom score on follow-up. Mean retention decreased by 29.6 and 48.7% at 2 and 4 h and gastric emptying was normalized in 60%. There were no post-surgical complications.

Conclusions

Combination of gastric electrical stimulator and pyloroplasty significantly accelerated gastric emptying and improved gastroparesis symptoms. Combining these two surgical therapies improves both subjective and objective endpoints in drug refractory gastroparesis.

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