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Erschienen in: Arthritis Research & Therapy 4/2011

01.12.2011 | Review

The lung as a possible target for the immune reaction in myositis

verfasst von: Sonye K Danoff, Livia Casciola-Rosen

Erschienen in: Arthritis Research & Therapy | Ausgabe 4/2011

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Abstract

Interstitial lung disease is a common manifestation of autoimmune myositis that confers significant morbidity and mortality. The vulnerability of the lung may offer insight into the etiology of this autoimmune disease. The frequency and patterns of lung injury vary based on the autoantibody. Antibodies against the aminoacyl-tRNA synthetases and melanoma differentiation-induced gene-5 are frequently associated with interstitial lung disease. Although the mechanisms underlying these associations have not been fully elucidated, emerging data highlight the importance of autoantigen expression and conformation in the target tissue (lung and muscle, in this case), as well as identifying relevant amplifying pathways (such as regeneration).
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Metadaten
Titel
The lung as a possible target for the immune reaction in myositis
verfasst von
Sonye K Danoff
Livia Casciola-Rosen
Publikationsdatum
01.12.2011
Verlag
BioMed Central
Erschienen in
Arthritis Research & Therapy / Ausgabe 4/2011
Elektronische ISSN: 1478-6362
DOI
https://doi.org/10.1186/ar3347

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