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30.04.2020

The mediator role of unmet needs on quality of life in myeloma patients

verfasst von: M. G. Pereira, M. Vilaça, M. Pereira, G. Ferreira, S. Monteiro, H. Coelho, C. Geraldes, C. Gonçalves, F. Leal da Costa, H. Marques, R. Bacalhau

Erschienen in: Quality of Life Research | Ausgabe 10/2020

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Abstract

Purpose

The diagnosis of multiple myeloma (MM) has a significant impact on patients. This study analyzed the mediating role of patients’ unmet needs in the relationship between psychological morbidity/social support and quality of life (QoL).

Methods

This study included 213 patients with MM recruited from the outpatient medical oncology and clinical hematology services from five hospitals. Patients who meet the study criteria were referred by physicians and invited to participate in the study by the researcher. All participants answered the following questionnaires: Hospital Anxiety and Depression Scale, Satisfaction with Social Support Scale, Short-Form Survivor Unmet Needs Survey, and The European Organization for Research and Treatment of Cancer’s Multiple Myeloma Module. Descriptive statistics, bivariate correlations, and structural equation modeling were performed to analyze the data.

Results

The indirect effect of psychological morbidity on patients’ future perspectives (MYFP) was partially mediated by information unmet needs (INF), while the indirect effect of psychological morbidity on treatment side effects (MYSE) was partially mediated by relationship and emotional unmet needs (REH). In turn, the indirect effect of psychological morbidity on disease symptoms (MYDS) was fully mediated by REH. Social support had an indirect effect on MYDS and MYSE fully mediated by REH.

Conclusion

Intervention programs tailored to promote MM patients’ QoL should specifically address information and emotional needs, raising awareness and training health professionals, caregivers, and family members to attend MM patients’ unmet needs.

Kazandjian, D. (2016). Multiple myeloma epidemiology and survival: A unique malignancy. Seminars in Oncology, 43, 676–681. https://doi.org/10.1053/j.seminoncol.2016.11.004.CrossRefPubMedPubMedCentral

Gozzetti, A., Candi, V., Papini, G., & Bocchia, M. (2014). Therapeutic advancements in multiple myeloma. Front Oncol, 4, 1–5. https://doi.org/10.3389/fonc.2014.00241.CrossRef

Alexander, D. D., Mink, P. J., Adami, H. O., Cole, P., Mandel, J. S., Oken, M. M., et al. (2007). Multiple myeloma: A review of the epidemiologic literature. Inter J Cancer, 120, 40–61. https://doi.org/10.1002/ijc.22718.CrossRef

Molassiotis, A., Wilson, B., Blair, S., Howe, T., & Cavet, J. (2011). Unmet supportive care needs, psychological well-being and quality of life in patients living with multiple myeloma and their partners. Psychooncology, 20(1), 88–97. https://doi.org/10.1002/pon.1710.CrossRefPubMed

Turesson, I., Bjorkholm, M., Blimark, C. H., Kristinsson, S., Velez, R., & Landgren, O. (2018). Rapidly changing myeloma epidemiology in the general population: Increased incidence, older patients, and longer survival. European Journal of Haematology, 101, 237–244. https://doi.org/10.1111/ejh.13083.CrossRef

Molassiotis, A., Wilson, B., Blair, S., Howe, T., & Cavet, J. (2011). Living with multiple myeloma: Experiences of patients and their informal caregivers. Supportive Care in Cancer, 19, 101–111. https://doi.org/10.1007/s00520-009-0793-1.CrossRefPubMed

Snowden, J. A., Ahmedzai, S. H., Ashcroft, J., et al. (2011). Guidelines for supportive care in multiple myeloma 2011. British Journal of Haematology, 154, 76–103. https://doi.org/10.1111/j.1365-2141.2011.08574.x.CrossRefPubMed

Sanson-Fisher, R., Girgis, A., Boyes, A., Bonevski, B., Burton, L., & Cook, P. (2000). The unmet supportive care needs of patients with cancer. Cancer, 88, 226–237. https://doi.org/10.1002/(sici)1097-0142(20000101)88:1%3c226:aid-cncr30%3e3.3.co;2-g.CrossRefPubMed

Lamers, J., Hartmann, M., Goldschmidt, H., Brechtel, A., Hillengass, J., & Herzog, W. (2013). Psychosocial support in patients with multiple myeloma at time of diagnosis: Who wants what? Psychooncology, 22, 2313–2320. https://doi.org/10.1002/pon.3284.CrossRefPubMed

10.

Bevans, M., Wehrlen, L., Prachenko, O., Soeken, K., Zabora, J., & Wallen, G. R. (2011). Distress screening in allogeneic hematopoietic stem cell (HSCT) caregivers and patients. Psychooncology, 20, 615–622. https://doi.org/10.1002/pon.1906.CrossRefPubMedPubMedCentral

11.

Broers, S., Kaptein, A. A., Le Cessie, S., Fibbe, W., & Hengeveld, M. W. (2000). Psychological functioning and quality of life following bone marrow transplantation. Journal of Psychosomatic Research, 48, 11–21. https://doi.org/10.1016/S0022-3999(99)00059-8.CrossRefPubMed

12.

Mosher, C. E., Redd, W. H., Rini, C. M., Burkhalter, J. E., & DuHamel, K. N. (2009). Physical, psychological, and social sequelae following hematopoietic stem cell transplantation: A review of the literature. Psychooncology, 18, 113–127. https://doi.org/10.1002/pon.1399.CrossRefPubMedPubMedCentral

13.

Lee, S. J., Loberiza, F. R., Antin, J. H., et al. (2005). Routine screening for psychosocial distress following hematopoietic stem cell transplantation. Bone Marrow Transplantation, 35, 77–83. https://doi.org/10.1038/sj.bmt.1704709.CrossRefPubMed

14.

Stark, D., Kiely, M., Smith, A., Velikova, G., House, A., & Selby, P. (2002). Anxiety disorders in Cancer patients: Their nature, associations, and relation to quality of life. Journal of Clinical Oncology, 20, 3137–3148. https://doi.org/10.1200/JCO.2002.08.549.CrossRefPubMed

15.

Ramsenthaler, C., Gao, W., Siegert, R. J., Edmonds, P. M., Schey, S. A., & Higginson, I. J. (2019). Symptoms and anxiety predict declining health-related quality of life in multiple myeloma: A prospective, multi-centre longitudinal study. Palliative Medicine, 33, 541–551. https://doi.org/10.1177/0269216319833588.CrossRefPubMed

16.

Oberoi, D. V., White, V. M., Seymour, J. F., et al. (2017). Distress and unmet needs during treatment and quality of life in early cancer survivorship: A longitudinal study of haematological cancer patients. European Journal of Haematology, 99, 423–430. https://doi.org/10.1111/ejh.12941.CrossRefPubMed

17.

Allart, P., Soubeyran, P., & Cousson-Gélie, F. (2013). Are psychosocial factors associated with quality of life in patients with haematological cancer? A critical review of the literature. Psychooncology, 22, 241–249. https://doi.org/10.1002/pon.3026.CrossRefPubMed

18.

Usta, Y. Y. (2012). Importance of social support in cancer patients. Asian Pacific Journal of Cancer Prevention, 13, 3569–3572. https://doi.org/10.7314/apjcp.2012.13.8.3569.CrossRefPubMed

19.

Sharpe, L., Butow, P., Smith, C., McConnell, D., & Clarke, S. (2005). The relationship between available support, unmet needs and caregiver burden in patients with advanced cancer and their careers. Psychooncology, 14, 102–114. https://doi.org/10.1002/pon.825.CrossRefPubMed

20.

Wilson, I. B., & Cleary, P. D. (1995). Linking clinical variables with health-related quality of life. JAMA, 273, 59–65.CrossRef

21.

Osborne, T. R., Ramsenthaler, C., de Wolf-Linder, S., Schey, S. A., Siegert, R. J., Edmonds, P. M., et al. (2014). Understanding what matters most to people with multiple myeloma: A qualitative study of views on quality of life. BMC Cancer, 14, 1–12. https://doi.org/10.1186/1471-2407-14-496.CrossRef

22.

Okediji, P. T., Salako, O., & Fatiregun, O. O. (2017). Pattern and predictors of unmet supportive care needs in cancer Patients. Cureus, 9, e1234. https://doi.org/10.7759/cureus.1234.CrossRefPubMedPubMedCentral

23.

Parker, P. A., Baile, W. F., de Moor, C., & Cohen, L. (2003). Psychosocial and demographic predictors of quality of life in a large sample of cancer patients. Psychooncology, 12, 183–193. https://doi.org/10.1002/pon.635.CrossRefPubMed

24.

Cheng, K. K. F., Wong, W. H., & Koh, C. (2015). Unmet needs mediate the relationship between symptoms and quality of life in breast cancer survivors. Supportive Care in Cancer, 24, 2025–2033. https://doi.org/10.1007/s00520-015-2994-0.CrossRefPubMed

25.

So, W. K., Choi, K. C., Chen, J. M., et al. (2014). Quality of life in head and neck cancer survivors at 1 year after treatment: The mediating role of unmet supportive care needs. Supportive Care in Cancer, 22, 2917–2926. https://doi.org/10.1007/s00520-014-2278-0.CrossRefPubMed

26.

Dürner, J., Reinecker, H., & Csef, H. (2013). Individual quality of life in patients with multiple myeloma. Springerplus, 2, 397. https://doi.org/10.1186/2193-1801-2-397.CrossRefPubMedPubMedCentral

27.

Nielsen, L. K., Jarden, M., Andersen, C. L., Frederiksen, H., & Abildgaard, N. (2017). A systematic review of health-related quality of life in longitudinal studies of myeloma patients. European Journal of Haematology, 99, 3–17. https://doi.org/10.1111/ejh.12882.CrossRefPubMed

28.

Rajkumar, S. V., Dimopoulos, M. A., Palumbo, A., et al. (2014). International Myeloma Working Group updated criteria for the diagnosis of multiple myeloma. The lancet Oncology, 15, e538–e548. https://doi.org/10.1016/S1470-2045(14)70442-5.CrossRefPubMed

29.

Zigmond, A. S., & Snaith, R. P. (1983). The hospital anxiety and depression scale. Acta Psychiatrica Scand., 67, 361–370. https://doi.org/10.1111/j.1600-0447.1983.tb09716.x.CrossRef

30.

Pais-Ribeiro, J. L., Silva, I., Ferreira, T., Martins, A., Meneses, R., & Baltar, M. (2007). Validation study of a Portuguese version of the Hospital Anxiety and Depression Scale. Psychol Health Med, 12, 225–237. https://doi.org/10.1080/13548500500524088.CrossRefPubMed

31.

Pais-Ribeiro, J. L. (1999). Escala de Satisfação com o Suporte Social (ESSS) [Satisfaction with Social Support Scale]. Análise Psicológica 17:547–558. https://www.scielo.mec.pt/scielo.php?script=sci_arttext&pid=S0870-82311999000300010&lng=pt&tlng=pt.

32.

Campbell, H. S., Hall, A. E., Sanson-Fisher, R. W., Barker, D., Turner, D., & Taylor-Brown, J. (2014). Development and validation of the Short-Form Survivor Unmet Needs Survey (SF-SUNS). Supportive Care in Cancer, 22, 1071–1079. https://doi.org/10.1007/s00520-013-2061-7.CrossRefPubMed

33.

Pereira, M.G., Pereira, M., Vilaça, M., Ferreira, G., Faria, S., Monteiro, S., Bacalhau, R. (2019). Validation of the Short-Form Survivor Unmet Needs Survey in Portuguese Myeloma Patients and their Caregivers. Manuscript submitted for publication.

34.

Cocks, K., Cohen, D., Wisløff, F., et al. (2007). An international field study of the reliability and validity of a disease specific questionnaire module (the QLQ-MY20) in assessing the quality of life of patients with multiple myeloma. European Journal of Cancer, 43, 1670–1678. https://doi.org/10.1016/j.ejca.2007.04.022.CrossRefPubMed

35.

Pereira, M. G., Ferreira, G., Pereira, M., et al. (2019). Validation of the Quality of Life Multiple Myeloma Module Questionnaire (QLQ-MY20) in Portuguese myeloma patients. Eur J Cancer Care. https://doi.org/10.1111/ecc.13128.CrossRef

36.

Hair, J. F., Black, W., Babin, B., & Anderson, R. (2010). Multivariate Data Analysis: A Global Perspective. New Jersey: Pearson Education.

37.

Kline, R. B. (2015). Principles and Practice of Structural Equation Modeling (4th ed.). New York: The Guilford Press.

38.

Preacher, K.J., Coffman, D.L. (2006) Computing power and minimum sample size for RMSEA [Computer software]. Retrived from https://quantpsy.org/.

39.

Preacher, K. J., Cai, L., & MacCallum, R. C. (2007). Alternatives to traditional model comparison strategies for covariance structure models. In T. D. Little, J. A. Bovaird, & N. A. Card (Eds.), Modeling Contextual Effects in Longitudinal Studies (pp. 33–62). New Jersey: Lawrence Erlbaum Associates.

40.

Palumbo, A., Avet-Loiseau, H., Oliva, S., et al. (2015). Revised international staging system for multiple myeloma: A report from international myeloma working group. Journal of Clinical Oncology, 33, 2863–2869. https://doi.org/10.1200/JCO.2015.61.2267.CrossRefPubMedPubMedCentral

41.

Faller, H., Koch, U., Brähler, E., et al. (2015). Satisfaction with information and unmet information needs in men and women with cancer. Journal of Cancer Survivorship, 10, 62–70. https://doi.org/10.1007/s11764-015-0451-1.CrossRefPubMed

42.

Harrison, J. D., Young, J. M., Price, M. A., Butow, P. N., & Solomon, M. J. (2009). What are the unmet supportive care needs of people with cancer? A systematic review. Supportive Care in Cancer, 17, 1117–1128. https://doi.org/10.1007/s00520-009-0615-5.CrossRefPubMed

43.

Mortensen, G. L., & Salomo, M. (2016). Quality of life in patients with multiple myeloma: A qualitative study. J Cancer Sci Ther, 8, 289–293. https://doi.org/10.4172/1948-5956.1000430.CrossRef

44.

Amir, Z., Wilson, K., Hennings, J., & Young, A. (2012). The meaning of cancer: implications for family finances and consequent impact on lifestyle, activities, roles and relationships. Psychooncology, 21, 1167–1174. https://doi.org/10.1002/pon.2021.CrossRefPubMed

45.

Jenkins, V., Fallowfield, L., & Saul, J. (2001). Information needs of patients with cancer: Results from a large study in UK cancer centres. British Journal of Cancer, 84, 48–51. https://doi.org/10.1054/bjoc.2000.1573.CrossRefPubMedPubMedCentral

46.

Snyder, C. F., Dy, S. M., Hendricks, D. E., Brahmer, J. R., Carducci, M. A., Wolff, A. C., et al. (2007). Asking the right questions: Investigating needs assessments and health-related quality-of-life questionnaires for use in oncology clinical practice. Supportive Care in Cancer, 15, 1075–1085. https://doi.org/10.1007/s00520-007-0223-1.CrossRefPubMed

47.

Monterosso, L., Taylor, K., Platt, V., et al. (2018). Living with multiple myeloma: A focus group study of unmet needs and preferences for survivorship care. J Patient Exp, 5, 6–15. https://doi.org/10.1177/2374373517715011.CrossRefPubMed

48.

Jordan, K., Proskorovsky, I., Lewis, P., et al. (2014). Effect of general symptom level, specific adverse events, treatment patterns, and patient characteristics on health-related quality of life in patients with multiple myeloma: Results of a European, multicentre cohort study. Supportive Care in Cancer, 22, 417–426. https://doi.org/10.1007/s00520-013-1991-4.CrossRefPubMed

Titel: The mediator role of unmet needs on quality of life in myeloma patients
verfasst von: M. G. Pereira
M. Vilaça
M. Pereira
G. Ferreira
S. Monteiro
H. Coelho
C. Geraldes
C. Gonçalves
F. Leal da Costa
H. Marques
R. Bacalhau
Publikationsdatum: 30.04.2020
Verlag: Springer International Publishing
Erschienen in: Quality of Life Research / Ausgabe 10/2020
Print ISSN: 0962-9343
Elektronische ISSN: 1573-2649
DOI: https://doi.org/10.1007/s11136-020-02511-8

Springer Medizin

Abstract

Purpose

Methods

Results

Conclusion

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