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Osteoporosis International

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24.06.2020 | Original Article

The micro-structural analysis of lumbar vertebrae in alcoholic liver cirrhosis

verfasst von: J. Jadzic, D. Cvetkovic, P. Milovanovic, N. Tomanovic, V. Zivkovic, S. Nikolic, M. Djuric, D. Djonic

Erschienen in: Osteoporosis International | Ausgabe 11/2020

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Abstract

Summary

Although vertebral fracture is more common among alcoholic liver cirrhosis patients when compared to general population, current data on three-dimensional micro-architecture are scarce. Our study showed significant trabecular deterioration in lumbar vertebrae obtained from alcoholic liver cirrhosis donors, suggesting that they should be advised to undergo early-stage screening for osteoporosis.

Purpose

Recent studies showed an increased incidence of vertebral fractures in alcoholic liver cirrhosis (ALC) patients, while data about vertebral micro-structure are still limited. The aim of this study was to compare trabecular and cortical micro-architecture of lumbar vertebrae between ALC patients and healthy age- and sex-matched controls.

Methods

Our study included lumbar vertebral samples of male cadaveric donors, divided into ALC (n = 20, age: 59 ± 6 years) and control group (n = 20, age: 59 ± 8 years). Following pathohistological verification of liver cirrhosis, trabecular and cortical bone micro-architecture was analyzed by micro-computed tomography (micro-CT).

Results

Micro-CT evaluation of the trabecular bone in lumbar vertebrae showed a significant decrease in bone volume fraction, trabecular thickness, trabecular number, and connectivity (p < 0.01). In contrast to trabecular deterioration, prominent alteration in cortical parameters was not observed in lumbar vertebrae of ALC patients (p > 0.05).

Conclusions

Our data indicate that susceptibility to non-traumatic fractures in ALC patients could be explained by alterations in trabecular bone micro-architecture. Thus, we genuinely recommend osteological screening of the lumbar spine for all ALC patients in order to evaluate individual fracture risk.

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Titel: The micro-structural analysis of lumbar vertebrae in alcoholic liver cirrhosis
verfasst von: J. Jadzic
D. Cvetkovic
P. Milovanovic
N. Tomanovic
V. Zivkovic
S. Nikolic
M. Djuric
D. Djonic
Publikationsdatum: 24.06.2020
Verlag: Springer London
Erschienen in: Osteoporosis International / Ausgabe 11/2020
Print ISSN: 0937-941X
Elektronische ISSN: 1433-2965
DOI: https://doi.org/10.1007/s00198-020-05509-7

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The micro-structural analysis of lumbar vertebrae in alcoholic liver cirrhosis

Abstract

Summary

Purpose

Methods

Results

Conclusions

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