Background
Methods
Subjects
Clinical and biochemical measurements
Measurement of plasma ANGPTL8
ApoB-depleted plasma preparation
Cholesterol efflux capacity measurement
Statistical analysis
Results
Characteristics of subjects
Variables | CAD (n = 120) | nonCAD (n = 90) | P | DM(n = 37) | nonDM (n = 173) | P |
---|---|---|---|---|---|---|
Male (%) | 63.6 | 57.3 | NS | 59.8 | 61.3 | NS |
Age (years) | 63.96 ± 7.85 | 63.09 ± 8.25 | NS | 64.32 ± 7.36 | 63.41 ± 8.18 | NS |
BMI (kg/m2) | 24.17 ± 3.92 | 24.42 ± 3.02 | NS | 25.47 ± 3.40 | 24.00 ± 3.54 | 0.024 |
TG (mg/dl) | 128.43 ± 71.74 | 129.32 ± 79.72 | NS | 147.92 ± 91.23 | 124.00 ± 69.97 | NS |
TC (mg/dl) | 145.40 ± 35.96 | 158.16 ± 39.83 | 0.005 | 146.95 ± 40.22 | 151.97 ± 37.51 | NS |
HDL-C (mg/dl) | 40.60 ± 10.05 | 44.08 ± 11.21 | 0.028 | 39.06 ± 9.28 | 42.92 ± 10.83 | NS |
LDL-C (mg/dl) | 88.16 ± 30.16 | 97.06 ± 31.32 | 0.021 | 88.17 ± 31.32 | 92.81 ± 30.94 | NS |
apoAI (g/L) | 1.08 ± 0.20 | 1.17 ± 0.25 | 0.008 | 1.08 ± 0.20 | 1.12 ± 0.23 | NS |
apoB (g/L) | 0.85 ± 0.25 | 0.89 ± 0.26 | NS | 0.89 ± 0.28 | 0.86 ± 0.25 | NS |
hsCRP (mg/L) | 4.93 (1.26–13.44) | 2.36 (1.17–7.00) | NS | 5.12 (1.62–8.28) | 3.23 (1.18–11.51) | NS |
FFA (mmol/L) | 0.52 ± 0.29 | 0.44 ± 0.27 | 0.047 | 0.57 ± 0.29 | 0.46 ± 0.28 | 0.045 |
Statin (%) | 55.5 | 3.8 | < 0.0001 | 35.1 | 32.9 | NS |
Smoking (%) | 46.4 | 30.5 | 0.036 | 37.8 | 40.0 | NS |
HF (%) | 72.7 | 42.7 | < 0.0001 | 72.9 | 57.2 | NS |
ANGPTL8 concentration in subjects
Cholesterol efflux capacity in subjects
Correlation analysis of clinical variables in subjects
ANGPTL8 (log-transformed) | Cholesterol efflux capacity | |||
---|---|---|---|---|
r | P | r | P | |
Age | 0.250 | < 0.001 | − 0.021 | NS |
HDL-C | − 0.075 | NS | 0.402 | < 0.0001 |
LDL-C | − 0.154 | 0.034 | 0.216 | < 0.01 |
TC | − 0.184 | 0.011 | 0.266 | < 0.0001 |
TG | − 0.099 | NS | 0.130 | NS |
ApoAI | − 0.124 | NS | 0.527 | < 0.0001 |
BUN | 0.347 | <0.0001 | − 0.125 | NS |
UA | 0.374 | < 0.0001 | − 0.251 | < 0.001 |
CR | 0.412 | < 0.0001 | − 0.126 | NS |
hsCRP (Log-transformed) | 0.098 | NS | − 0.244 | < 0.001 |
Multivariate analysis for the associations of clinical variables to cholesterol efflux capacity
Factors | β | Standardized β | P |
---|---|---|---|
apoAI | 0.057 | 0.481 | < 0.001 |
ANGPTL8 (log-transformed) | − 0.014 | − 0.143 | 0.023 |
hsCRP (log-transformed) | − 0.002 | − 0.048 | 0.482 |
LDL-C | 0.001 | 0.028 | 0.675 |
Statin use | − 0.008 | − 0.140 | 0.027 |