nach oben

International Urogynecology Journal

Erschienen in:

21.06.2019 | Review Article

The negative effect of urologic chronic pelvic pain syndrome on female sexual function: a systematic review and meta-analysis

verfasst von: Yupeng Guan, Gang Yu, Guoren Wang, Zhiming Bai

Erschienen in: International Urogynecology Journal | Ausgabe 11/2019

Einloggen, um Zugang zu erhalten

Abstract

Introduction and hypothesis

To explore the effect of urologic chronic pelvic pain syndrome (UCPPS) on female sexual function.

Methods

Database searches were conducted in PubMed, EMBASE, the Cochrane Library, and Google Scholar for published literature using the Female Sexual Function Index (FSFI) or reporting the prevalence of dyspareunia. Data extraction and quality evaluation were performed on the literature that met the inclusion criteria, and a meta-analysis was performed using STATA 12.0 and RevMan5.3 software to calculate the mean differences (MD) and odds ratios (OR) and their 95% confidence intervals (CI).

Results

A total of nine case-control studies enrolling 4965 subjects were investigated. The present meta-analysis results demonstrated a strong correlation between UCPPS and dyspareunia (OR = 11.27, 95% CI: 5.15–24.67, P < 0.00001). The UCPPS group had significantly lower scores in each domain of the FSFI compared with the healthy control group: total score (MD = −11.35, 95% CI: −14.54– − 8.16, P < 0.00001); desire (MD = −1.04, 95% CI: −1.20– − 0.88, P < 0.00001); arousal (MD = −1.78, 95% CI: −2.36– − 1.20, P < 0.00001); lubrication (MD = −2.11, 95% CI: −2.49– − 1.73, P < 0.00001); orgasm (MD = −1.50, 95% CI: −1.72– − 1.28, P < 0.00001); satisfaction (MD = −1.54, 95% CI: −1.97– − 1.12, P < 0.00001); pain (MD = −2.89, 95% CI: −3.63– − 2.14, P < 0.00001).

Conclusions

UCPPS had a significantly negative effect on female sexual function, particularly in the lubrication, pain, and total score domains. In addition, UCPPS patients had a significantly higher risk of dyspareunia. Psychosocial variables may be a potential pathogenesis of female sexual dysfunction (FSD). Future well-designed research is called for to develop a comprehensive estimate of the association between UCPPS and FSD.

Landis JR, Williams DA, Lucia MS, Clauw DJ, Naliboff BD, Robinson NA, et al. The MAPP research network: design, patient characterization and operations. BMC Urol. 2014;14:58. https://doi.org/10.1186/1471-2490-14-58.CrossRefPubMedPubMedCentral

Rosen R, Brown C, Heiman J, Leiblum S, Meston C, Shabsigh R, et al. The female sexual function index (FSFI): a multidimensional self-report instrument for the assessment of female sexual function. J Sex Marital Ther. 2000;26(2):191–208. https://doi.org/10.1080/009262300278597.CrossRefPubMed

Wiegel M, Meston C, Rosen R. The female sexual function index (FSFI): cross-validation and development of clinical cutoff scores. J Sex Marital Ther. 2005;31(1):1–20. https://doi.org/10.1080/00926230590475206.CrossRefPubMed

Stroup DF, Berlin JA, Morton SC, Olkin I, Williamson GD, Rennie D, et al. Meta-analysis of observational studies in epidemiology: a proposal for reporting. Meta-analysis of observational studies in epidemiology (MOOSE) group. JAMA. 2000;283(15):2008–12.CrossRefPubMed

Wells G, Shea B, O’Connell D, Peterson J, Welch V, Losos M, et al. The Newcastle-Ottawa scale (NOS) for assessing the quality of nonrandomised studies in meta-analyses. 2017. http://www.ohrica/programs/clinical_epidemiology/oxford.asp.

Gardella B, Porru D, Nappi RE, Dacco MD, Chiesa A, Spinillo A. Interstitial cystitis is associated with vulvodynia and sexual dysfunction—a case-control study. J Sex Med. 2011;8(6):1726–34. https://doi.org/10.1111/j.1743-6109.2011.02251.x.CrossRefPubMed

Gardella B, Porru D, Ferdeghini F, Martinotti Gabellotti E, Nappi RE, Rovereto B, et al. Insight into urogynecologic features of women with interstitial cystitis/painful bladder syndrome. Eur Urol. 2008;54(5):1145–53. https://doi.org/10.1016/j.eururo.2008.01.079.CrossRefPubMed

Nickel JC, Tripp DA, Pontari M, Moldwin R, Mayer R, Carr LK, et al. Psychosocial phenotyping in women with interstitial cystitis/painful bladder syndrome: a case control study. J Urol. 2010;183(1):167–72. https://doi.org/10.1016/j.juro.2009.08.133.CrossRefPubMed

Warren JW, Clauw DJ, Wesselmann U, Langenberg PW, Howard FM, Morozov V. Sexuality and reproductive risk factors for interstitial cystitis/painful bladder syndrome in women. Urology. 2011;77(3):570–5. https://doi.org/10.1016/j.urology.2010.10.018.CrossRefPubMed

10.

Zaslau S, Riggs DR, Perlmutter AE, Jackson BJ, Osborne J, Kandzari SJ. Sexual dysfunction in patients with painful bladder syndrome is age related and progressive. Can J Urol. 2008;15(4):4158–62.PubMed

11.

Zondervan KT, Yudkin PL, Vessey MP, Jenkinson CP, Dawes MG, Barlow DH, et al. Chronic pelvic pain in the community—symptoms, investigations, and diagnoses. Am J Obstet Gynecol. 2001;184(6):1149–55. https://doi.org/10.1067/mob.2001.112904.CrossRefPubMed

12.

Ottem DP, Carr LK, Perks AE, Lee P, Teichman JM. Interstitial cystitis and female sexual dysfunction. Urology. 2007;69(4):608–10. https://doi.org/10.1016/j.urology.2006.12.024.CrossRefPubMed

13.

Peters KM, Killinger KA, Carrico DJ, Ibrahim IA, Diokno AC, Graziottin A. Sexual function and sexual distress in women with interstitial cystitis: a case-control study. Urology. 2007;70(3):543–7. https://doi.org/10.1016/j.urology.2007.04.037.CrossRefPubMed

14.

Schrepf A, O'Donnell M, Luo Y, Bradley CS, Kreder K, Lutgendorf S. Inflammation and inflammatory control in interstitial cystitis/bladder pain syndrome: associations with painful symptoms. Pain. 2014;155(9):1755–61. https://doi.org/10.1016/j.pain.2014.05.029.CrossRefPubMedPubMedCentral

15.

Yoon HS, Yoon H. Correlations of interstitial cystitis/painful bladder syndrome with female sexual activity. Korean J Urol. 2010;51(1):45–9. https://doi.org/10.4111/kju.2010.51.1.45.CrossRefPubMedPubMedCentral

16.

Lee M-H, Chen W-C, Chiu C-D, Wu H-C. Dyspareunia and chronic pelvic pain in patients with interstitial cystitis/bladder pain syndrome. Urol Sci. 2015;26(3):206–9. https://doi.org/10.1016/j.urols.2015.07.004.CrossRef

17.

Nickel JC, Parsons CL, Forrest J, Kaufman D, Evans R, Chen A, et al. Improvement in sexual functioning in patients with interstitial cystitis/painful bladder syndrome. J Sex Med. 2008;5(2):394–9. https://doi.org/10.1111/j.1743-6109.2007.00686.x.CrossRefPubMed

18.

Aaron LA, Herrell R, Ashton S, Belcourt M, Schmaling K, Goldberg J, et al. Comorbid clinical conditions in chronic fatigue: a co-twin control study. J Gen Intern Med. 2001;16(1):24–31.PubMedPubMedCentral

19.

Heitkemper M, Jarrett M. Overlapping conditions in women with irritable bowel syndrome. Urol Nurs. 2005;25(1):25–30 quiz 31.PubMed

20.

Kaya S, Hermans L, Willems T, Roussel N, Meeus M. Central sensitization in urogynecological chronic pelvic pain: a systematic literature review. Pain Physician. 2013;16(4):291–308.PubMed

21.

Lai HH, Gardner V, Ness TJ, RWt G. Segmental hyperalgesia to mechanical stimulus in interstitial cystitis/bladder pain syndrome: evidence of central sensitization. J Urol. 2014;191(5):1294–9. https://doi.org/10.1016/j.juro.2013.11.099.CrossRefPubMed

22.

Woolf CJ. Central sensitization: implications for the diagnosis and treatment of pain. Pain. 2011;152(3 Suppl):S2–15. https://doi.org/10.1016/j.pain.2010.09.030.CrossRefPubMed

23.

Fall M, Baranowski AP, Elneil S, Engeler D, Hughes J, Messelink EJ, et al. EAU guidelines on chronic pelvic pain. Eur Urol. 2010;57(1):35–48. https://doi.org/10.1016/j.eururo.2009.08.020.CrossRefPubMed

24.

Rodriguez MA, Afari N, Buchwald DS. Evidence for overlap between urological and nonurological unexplained clinical conditions. J Urol. 2009;182(5):2123–31. https://doi.org/10.1016/j.juro.2009.07.036.CrossRefPubMedPubMedCentral

25.

Nickel JC, Shoskes D, Irvine-Bird K. Clinical phenotyping of women with interstitial cystitis/painful bladder syndrome: a key to classification and potentially improved management. J Urol. 2009;182(1):155–60. https://doi.org/10.1016/j.juro.2009.02.122.CrossRefPubMed

26.

Tonyali S, Yilmaz M. Sexual dysfunction in interstitial cystitis. Curr Urol. 2017;11(1):1–3. https://doi.org/10.1159/000447186.CrossRefPubMedPubMedCentral

27.

Clemens JQ, Mullins C, Kusek JW, Kirkali Z, Mayer EA, Rodriguez LV, et al. The MAPP research network: a novel study of urologic chronic pelvic pain syndromes. BMC Urol. 2014;14:57. https://doi.org/10.1186/1471-2490-14-57.CrossRefPubMedPubMedCentral

28.

Engeler DS, Baranowski AP, Dinis-Oliveira P, Elneil S, Hughes J, Messelink EJ, et al. The 2013 EAU guidelines on chronic pelvic pain: is management of chronic pelvic pain a habit, a philosophy, or a science? 10 years of development. Eur Urol. 2013;64(3):431–9. https://doi.org/10.1016/j.eururo.2013.04.035.CrossRefPubMed

29.

van de Merwe JP, Nordling J, Bouchelouche P, Bouchelouche K, Cervigni M, Daha LK, et al. Diagnostic criteria, classification, and nomenclature for painful bladder syndrome/interstitial cystitis: an ESSIC proposal. Eur Urol. 2008;53(1):60–7. https://doi.org/10.1016/j.eururo.2007.09.019.CrossRefPubMed

30.

Lo CK, Mertz D, Loeb M. Newcastle-Ottawa scale: comparing reviewers’ to authors’ assessments. BMC Med Res Methodol. 2014;14:45. https://doi.org/10.1186/1471-2288-14-45.CrossRefPubMedPubMedCentral

Titel: The negative effect of urologic chronic pelvic pain syndrome on female sexual function: a systematic review and meta-analysis
verfasst von: Yupeng Guan
Gang Yu
Guoren Wang
Zhiming Bai
Publikationsdatum: 21.06.2019
Verlag: Springer International Publishing
Erschienen in: International Urogynecology Journal / Ausgabe 11/2019
Print ISSN: 0937-3462
Elektronische ISSN: 1433-3023
DOI: https://doi.org/10.1007/s00192-019-03984-z

Neu im Fachgebiet Gynäkologie und Geburtshilfe

17.04.2024 | Postoperative nausea and vomiting | Nachrichten

Update Gynäkologie

Bestellen Sie unseren Fach-Newsletter und bleiben Sie gut informiert – ganz bequem per eMail.

Newsletter bestellen

Live-Webinar: Aktuelle Leitlinien bei Herz-Kreislauf-Erkrankungen

Springer Medizin

The negative effect of urologic chronic pelvic pain syndrome on female sexual function: a systematic review and meta-analysis

Abstract

Introduction and hypothesis

Methods

Results

Conclusions

Neu im Fachgebiet Gynäkologie und Geburtshilfe

Hochrisiko-Eingriffe für postoperative Übelkeit

Adjuvante Brustkrebstherapie: Doppelt hält besser

Manche Gestagene können das Risiko für Meningeome erhöhen

Stillende Frauen haben geringeres kardiovaskuläres Risiko

Update Gynäkologie

Live-Webinar: Aktuelle Leitlinien bei Herz-Kreislauf-Erkrankungen

Springer Medizin

Abstract

Introduction and hypothesis

Methods

Results

Conclusions

Bitte loggen Sie sich ein, um Zugang zu diesem Inhalt zu erhalten

Weitere Artikel der Ausgabe 11/2019

Surgical treatment of primary uterine prolapse: a comparison of vaginal native tissue surgical techniques

Variation in bony landmarks and predictors of success with sacral neuromodulation

Laser treatment for the management of genitourinary syndrome of menopause after breast cancer. Hope or hype?

Robotic sacrocolpopexy: adverse events reported to the FDA over the last decade

Pelvic floor muscle knowledge and relationship with muscle strength in Brazilian women: a cross-sectional study

Prevalence of metabolic syndrome and its components in women with and without pelvic organ prolapse and its association with prolapse severity according to the Pelvic Organ Prolapse Quantification system

Neu im Fachgebiet Gynäkologie und Geburtshilfe

Hochrisiko-Eingriffe für postoperative Übelkeit

Adjuvante Brustkrebstherapie: Doppelt hält besser

Manche Gestagene können das Risiko für Meningeome erhöhen

Stillende Frauen haben geringeres kardiovaskuläres Risiko

Update Gynäkologie