nach oben

Current Neurology and Neuroscience Reports

Erschienen in:

01.11.2010

The New Classification of Primary Progressive Aphasia into Semantic, Logopenic, or Nonfluent/Agrammatic Variants

verfasst von: Michael F. Bonner, Sharon Ash, Murray Grossman

Erschienen in: Current Neurology and Neuroscience Reports | Ausgabe 6/2010

Einloggen, um Zugang zu erhalten

Abstract

Primary progressive aphasia (PPA), typically resulting from a neurodegenerative disease such as frontotemporal lobar degeneration or Alzheimer’s disease, is characterized by a progressive loss of specific language functions with relative sparing of other cognitive domains. Three variants of PPA are now recognized: semantic variant, logopenic variant, and nonfluent/agrammatic variant. We discuss recent work characterizing the neurolinguistic, neuropsychological, imaging and pathologic profiles associated with these variants. Improved reliability of diagnoses will be increasingly important as trials for etiology-specific treatments become available. We also discuss the implications of these syndromes for theories of language function.

Mesulam MM: Primary progressive aphasia. Ann Neurol 2001, 49:425–432.CrossRefPubMed

Mesulam MM: Primary progressive aphasia--a language-based dementia. N Engl J Med 2003, 349:1535–1542.CrossRefPubMed

Gorno-Tempini ML, Dronkers NF, Rankin KP, et al.: Cognition and anatomy in three variants of primary progressive aphasia. Ann Neurol 2004, 55:335–346.CrossRefPubMed

• Grossman M: Primary progressive aphasia: clinicopathological correlations. Nat Rev Neurol 2010, 6:88–97. This paper summarizes the autopsy-confirmed pathology results from 145 PPA patients across seven institutions. The current findings for neuropsychological, neuroimaging, genetic, and cerebrospinal fluid biomarkers of the PPA variants are reviewed.CrossRefPubMed

Mesulam M, Wieneke C, Rogalski E, et al.: Quantitative template for subtyping primary progressive aphasia. Arch Neurol 2009, 66:1545–1551.CrossRefPubMed

Hu WT, McMillan C, Libon D, et al.: Multi-modal predictors for Alzheimer’s disease in non-fluent primary progressive aphasia. Neurology 2010, 75:595–602.CrossRefPubMed

• Hodges JR, Patterson K: Semantic dementia: a unique clinicopathological syndrome. Lancet Neurol 2007, 6:1004–1014. This paper provides an overview of SD. Clinical and pathologic features are summarized. The authors discuss neuropsychological findings and considerations in choosing testing methods for these patients.CrossRefPubMed

Meteyard L, Patterson K: The relation between content and structure in language production: an analysis of speech errors in semantic dementia. Brain Lang 2009, 110:121–134.CrossRefPubMed

Kertesz A, Jesso S, Harciarek M, et al.: What is semantic dementia?: a cohort study of diagnostic features and clinical boundaries. Arch Neurol 2010, 67:483–489.CrossRefPubMed

10.

Halpern C, Glosser G, Clark R, et al.: Dissociation of numbers and objects in corticobasal degeneration and semantic dementia. Neurology 2004, 62:1163–1169.PubMed

11.

Mesulam M, Rogalski E, Wieneke C, et al.: Neurology of anomia in the semantic variant of primary progressive aphasia. Brain 2009, 132(Pt 9):2553–2565.CrossRefPubMed

12.

Adlam AL, Patterson K, Rogers TT, et al.: Semantic dementia and fluent primary progressive aphasia: two sides of the same coin? Brain 2006, 129(Pt 11):3066–3080.CrossRefPubMed

13.

Knibb JA, Xuereb JH, Patterson K, et al.: Clinical and pathological characterization of progressive aphasia. Ann Neurol 2006, 59:156–165.CrossRefPubMed

14.

Patterson K, Nestor PJ, Rogers TT: Where do you know what you know? The representation of semantic knowledge in the human brain. Nat Rev Neurosci 2007, 8:976–987.CrossRefPubMed

15.

Weinstein J, Koenig P, Gunawardena D, et al.: Preserved musical semantic memory in semantic dementia. Arch Neurol 2010 (in press).

16.

Hailstone JC, Omar R, Warren JD: Relatively preserved knowledge of music in semantic dementia. J Neurol Neurosurg Psychiatry 2009, 80:808–809.CrossRefPubMed

17.

Yi HA, Moore P, Grossman M: Reversal of the concreteness effect for verbs in semantic dementia. Neuropsychology 2007, 21:9–19.CrossRefPubMed

18.

• Bonner MF, Vesely L, Price C, et al.: Reversal of the concreteness effect in semantic dementia. Cogn Neuropsychol 2009, 26:568–579. This paper examines the proposed deficit in visual semantic features in SD. The authors find that atrophy in ventral temporal cortex correlates with a deficit in concrete word knowledge.CrossRefPubMed

19.

Martin A: The representation of object concepts in the brain. Annu Rev Psychol 2007, 58:25–45.CrossRefPubMed

20.

Jefferies E, Patterson K, Jones RW, et al.: Comprehension of concrete and abstract words in semantic dementia. Neuropsychology 2009, 23:492–499.CrossRefPubMed

21.

Rohrer JD, Warren JD, Modat M, et al.: Patterns of cortical thinning in the language variants of frontotemporal lobar degeneration. Neurology 2009, 72:1562–1569.CrossRefPubMed

22.

Avants B, Anderson C, Grossman M, et al.: Spatiotemporal normalization for longitudinal analysis of gray matter atrophy in frontotemporal dementia. Med Image Comput Comput Assist Interv 2007, 10(Pt 2):303–310.PubMed

23.

Rohrer JD, McNaught E, Foster J, et al.: Tracking progression in frontotemporal lobar degeneration: serial MRI in semantic dementia. Neurology 2008, 71:1445–1451.CrossRefPubMed

24.

Duda JT, Avants BB, Asmuth JC, et al.: A fiber tractography based examination of neurodegeneration on language-network neuroanatomy. Med Image Comput Comput Assist Interv 2008, 12:191–198.

25.

Agosta F, Henry RG, Migliaccio R, et al.: Language networks in semantic dementia. Brain 2010, 133:286–299.CrossRefPubMed

26.

Josephs KA, Whitwell JL, Duffy JR, et al.: Progressive aphasia secondary to Alzheimer disease vs FTLD pathology. Neurology 2008, 70:25–34.CrossRefPubMed

27.

Grossman M, Libon DJ, Forman MS, et al.: Distinct antemortem profiles in patients with pathologically defined frontotemporal dementia. Arch Neurol 2007, 64:1601–1609.CrossRefPubMed

28.

•• Gorno-Tempini ML, Brambati SM, Ginex V, et al.: The logopenic/phonological variant of primary progressive aphasia. Neurology 2008, 71:1227–1234. This paper characterizes the language impairments and neuroimaging data in six lvPPA patients. This is one of only a handful of studies characterizing this patient group. The results are discussed in light of the proposed phonological-loop deficit for lvPPA.CrossRefPubMed

29.

Kertesz A, Davidson W, McCabe P: Primary progressive aphasia: diagnosis, varieties, evolution. J Int Neuropsychol Soc 2003, 9:710–719.CrossRefPubMed

30.

Sonty SP, Mesulam M, Thompson CK, et al.: Primary progressive aphasia: PPA and the language network. Ann Neurol 2003, 53:35–49.CrossRefPubMed

31.

Galton CJ, Patterson K, Xuereb JH, et al.: Atypical and typical presentations of Alzheimer’s disease: a clinical, neuropsychological, neuroimaging and pathological study of 13 cases. Brain 2000, 123:484–498.CrossRefPubMed

32.

Mendez MF, Clark DG, Shapira JS, et al.: Speech and language in progressive nonfluent aphasia compared with early Alzheimer’s disease. Neurology 2003, 61:1108–1113.PubMed

33.

Rohrer JD, Ridgway GR, Crutch SJ, et al.: Progressive logopenic/phonological aphasia: erosion of the language network. Neuroimage 2010, 49:984–993.CrossRefPubMed

34.

Baldo JV, Dronkers NF: The role of inferior parietal and inferior frontal cortex in working memory. Neuropsychology 2006, 20:529–538.CrossRefPubMed

35.

Grossman M, Mega M, Cummings J, et al.: The aphasias and related disturbances. In Clinical Neurology. Edited by Baker AB, Joynt RJ. Philadelphia: Lippincott Williams and Wilkins; 2004:1–83.

36.

Grossman M, Ash S: Primary progressive aphasia: a review. Neurocase 2004, 10:3–18.CrossRefPubMed

37.

Knibb JA, Woollams AM, Hodges JR, et al.: Making sense of progressive non-fluent aphasia: an analysis of conversational speech. Brain 2009, 132(Pt 10):2734–2746.CrossRefPubMed

38.

•• Ash S, McMillan C, Gunawardena D, et al.: Speech errors in progressive non-fluent aphasia. Brain Lang 2010, 113:13–20. This paper provides a detailed, quantitative study of speech sound errors in the connected speech of navPPA patients, with linguistic, neuropsychological, and neural correlates. It is argued that speech errors in navPPA mainly arise within the language system and are not caused by a motor impairment.CrossRefPubMed

39.

Ash S, Moore P, Vesely L, et al.: Non-fluent speech in frontotemporal lobar degeneration. J Neurolinguistics 2009, 22:370–383.CrossRef

40.

Josephs KA, Duffy JR, Strand EA, et al.: Clinicopathological and imaging correlates of progressive aphasia and apraxia of speech. Brain 2006, 129(Pt 6):1385–1398.CrossRefPubMed

41.

Ogar JM, Dronkers NF, Brambati SM, et al.: Progressive nonfluent aphasia and its characteristic motor speech deficits. Alzheimer Dis Assoc Disord 2007, 21:S23–S30.CrossRefPubMed

42.

Peelle JE, Troiani V, Gee J, et al.: Sentence comprehension and voxel-based morphometry in progressive nonfluent aphasia, semantic dementia, and nonaphasic frontotemporal dementia. J Neurolinguistics 2008, 21:418–432.CrossRefPubMed

43.

Peelle JE, Cooke A, Moore P, et al.: Syntactic and thematic components of sentence processing in progressive nonfluent aphasia and nonaphasic frontotemporal dementia. J Neurolinguistics 2007, 20:482–494.CrossRefPubMed

44.

Weintraub S, Rubin NP, Mesulam MM: Primary progressive aphasia: longitudinal course, neuropsychological profile, and language features. Arch Neurol 1990, 47:1329–1335.PubMed

45.

Libon DJ, Xie SX, Moore P, et al.: Patterns of neuropsychological impairment in frontotemporal dementia. Neurology 2007, 68:369–375.CrossRefPubMed

46.

Patterson K, Graham NL, Ralph MA, et al.: Progressive non-fluent aphasia is not a progressive form of non-fluent (post-stroke) aphasia. Aphasiology 2006, 20:1018–1034.CrossRef

47.

Gunawardena D, Ash S, McMillan CT, et al.: Why are progressive non-fluent aphasics non-fluent? Neurology 2010, 75:588–594.CrossRefPubMed

48.

Dronkers NF: A new brain region for coordinating speech articulation. Nature 1996, 384:159–161.CrossRefPubMed

49.

Hillis AE, Work M, Barker PB, et al.: Re-examining the brain regions crucial for orchestrating speech articulation. Brain 2004, 127(Pt 7):1479–1487.CrossRefPubMed

50.

Nestor PJ: Nuclear imaging can predict pathologic diagnosis in progressive nonfluent aphasia. Neurology 2007, 68:238–239.CrossRefPubMed

Titel: The New Classification of Primary Progressive Aphasia into Semantic, Logopenic, or Nonfluent/Agrammatic Variants
verfasst von: Michael F. Bonner
Sharon Ash
Murray Grossman
Publikationsdatum: 01.11.2010
Verlag: Current Science Inc.
Erschienen in: Current Neurology and Neuroscience Reports / Ausgabe 6/2010
Print ISSN: 1528-4042
Elektronische ISSN: 1534-6293
DOI: https://doi.org/10.1007/s11910-010-0140-4

Leitlinien kompakt für die Neurologie

Mit medbee Pocketcards sicher entscheiden.

^{Seit 2022 gehört die medbee GmbH zum Springer Medizin Verlag}

Kostenlos registrieren

Neu im Fachgebiet Neurologie

18.04.2024 | Arterielle Hypertonie | Nachrichten

Update Neurologie

Bestellen Sie unseren Fach-Newsletter und bleiben Sie gut informiert.

Newsletter bestellen

Live-Webinar: Aktuelle Leitlinien bei Herz-Kreislauf-Erkrankungen

Springer Medizin

The New Classification of Primary Progressive Aphasia into Semantic, Logopenic, or Nonfluent/Agrammatic Variants

Abstract

Leitlinien kompakt für die Neurologie

Neu im Fachgebiet Neurologie

Antihypertensiva schützen auch alte Menschen noch vor Demenz

Spinale Muskelatrophie: Neugeborenen-Screening lohnt sich

Manche Gestagene können das Risiko für Meningeome erhöhen

Parkinson: Größere Studie bestätigt Genauigkeit von Hauttest

Update Neurologie

Live-Webinar: Aktuelle Leitlinien bei Herz-Kreislauf-Erkrankungen

Springer Medizin

Abstract

Bitte loggen Sie sich ein, um Zugang zu diesem Inhalt zu erhalten

Weitere Artikel der Ausgabe 6/2010

A Review of Conduction Aphasia

Treatment Regimens for HIV Neurocognitive Dysfunctions in the Highly Active Antiretroviral Therapy (HAART) Era

Is the Magnesium Era for Aneurysmal Subarachnoid Hemorrhage Over?

Neuro-ophthalmologic Complications and Manifestations of Upper and Lower Motor Neuron Facial Paresis

Neurogenic Stuttering: Its Reticular Modulation

Neurologic Consequences of the Immune Reconstitution Inflammatory Syndrome (IRIS)

Leitlinien kompakt für die Neurologie

Neu im Fachgebiet Neurologie

Antihypertensiva schützen auch alte Menschen noch vor Demenz

Spinale Muskelatrophie: Neugeborenen-Screening lohnt sich

Manche Gestagene können das Risiko für Meningeome erhöhen

Parkinson: Größere Studie bestätigt Genauigkeit von Hauttest

Update Neurologie