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18.11.2019 | Review

The NLRP3 Inflammasome and Its Role in Sepsis Development

verfasst von: Lucinéia Gainski Danielski, Amanda Della Giustina, Sandra Bonfante, Tatiana Barichello, Fabricia Petronilho

Erschienen in: Inflammation | Ausgabe 1/2020

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Abstract

The pathophysiology of sepsis is extremely complex. During this disease, the exacerbation of the inflammatory response causes oxidative stress, alterations in mitochondrial energy dynamics, and multiple organ failure. Some studies have highlighted the important role of the NLRP3 inflammasome in sepsis. This inflammasome is a macromolecular protein complex that finely regulates the activation of caspase-1 and the production and secretion of potent pro-inflammatory cytokines such as IL-1β and IL-18. In this review, we elucidate evidences to understand the connection between sepsis development and the NLRP3 inflammasome, the most widely investigated member of this class of receptor.

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Titel: The NLRP3 Inflammasome and Its Role in Sepsis Development
verfasst von: Lucinéia Gainski Danielski
Amanda Della Giustina
Sandra Bonfante
Tatiana Barichello
Fabricia Petronilho
Publikationsdatum: 18.11.2019
Verlag: Springer US
Erschienen in: Inflammation / Ausgabe 1/2020
Print ISSN: 0360-3997
Elektronische ISSN: 1573-2576
DOI: https://doi.org/10.1007/s10753-019-01124-9

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