Background
Results
Lead | Age (days) | P (s) | PR (s) | QRS (s) | QTc (s) | T (s) |
---|---|---|---|---|---|---|
I | Birth | 0.043 ± 0.008 | 0.075 ± 0.015 | 0.036 ± 0.007a*
| 0.233 ± 0.023a
| 0.068 ± 0.014 |
7 | 0.039 ± 0.008 | 0.070 ± 0.017 | 0.036 ± 0.007a
| 0.226 ± 0.033a
| 0.068 ± 0.019 | |
14 | 0.037 ± 0.007 | 0.067 ± 0.012 | 0.035 ± 0.009a
| 0.236 ± 0.020ab
| 0.060 ± 0.014 | |
21 | 0.037 ± 0.006 | 0.070 ± 0.0086 | 0.040 ± 0.008a
| 0.249 ± 0.020bc
| 0.066 ± 0.011 | |
28 | 0.039 ± 0.006 | 0.072 ± 0.014 | 0.035 ± 0.006a
| 0.249 ± 0.019c
| 0.068 ± 0.007 | |
35 | 0.039 ± 0.007 | 0.077 ± 0.017 | 0.042 ± 0.009b
| 0.255 ± 0.027d
| 0.069 ± 0.014 | |
II | Birth | 0.040 ± 0.008 | 0.070 ± 0.016 | 0.039 ± 0.006 | 0.234 ± 0.022ab
| 0.076 ± 0.012 |
7 | 0.039 ± 0.007 | 0.074 ± 0.022 | 0.040 ± 0.011 | 0.226 ± 0.020 b
| 0.068 ± 0.015 | |
14 | 0.039 ± 0.008 | 0.066 ± 0.008 | 0.039 ± 0.009 | 0.230 ± 0.022b
| 0.060 ± 0.015 | |
21 | 0.040 ± 0.007 | 0.073 ± 0.009 | 0.052 ± 0.049 | 0.248 ± 0.017ac
| 0 066 ± 0.010 | |
28 | 0.041 ± 0.006 | 0.074 ± 0.009 | 0.042 ± 0.008 | 0.255 ± 0.019c
| 0.070 ± 0.010 | |
35 | 0.040 ± 0.005 | 0.075 ± 0.011 | 0.042 ± 0.008 | 0.263 ± 0.027c
| 0.067 ± 0.011 | |
III | Birth | 0.040 ± 0.006 | 0.069 ± 0.014a
| 0.036 ± 0.008 | 0.231 ± 0.022ab
| 0.068 ± 0.014ac
|
7 | 0.037 ± 0.008 | 0.067 ± 0.015a
| 0.038 ± 0.007 | 0.217 ± 0.025b
| 0.059 ± 0.014b
| |
14 | 0.038 ± 0.008 | 0.066 ± 0.011a
| 0.037 ± 0.009 | 0.233 ± 0.017bc
| 0.060 ± 0.011bc
| |
21 | 0.041 ± 0.007 | 0.073 ± 0.010ab
| 0.037 ± 0.012 | 0.246 ± 0.01bd
| 0.061 ± 0.011bc
| |
28 | 0.040 ± 0.006 | 0.070 ± 0.010a
| 0.042 ± 0.013 | 0.252 ± 0.015d
| 0.066 ± 0.012abc
| |
35 | 0.042 ± 0.006 | 0.079 ± 0.014b
| 0.041 ± 0.008 | 0.260 ± 0.030d
| 0.067 ± 0.012c
| |
aVR | Birth | 0.039 ± 0.007 | 0.066 ± 0.012a
| 0.035 ± 0.007 | 0.236 ± 0.023ab
| 0.074 ± 0.011a
|
7 | 0.035 ± 0.005 | 0.067 ± 0.010a
| 0.035 ± 0.008 | 0.222 ± 0.026b
| 0.065 ± 0.017b
| |
14 | 0.037 ± 0.009 | 0.066 ± 0.009a
| 0.035 ± 0.007 | 0.230 ± 0.023ab
| 0.058 ± 0.012c
| |
21 | 0.035 ± 0.005 | 0.070 ± 0.007ab
| 0.037 ± 0.007 | 0.245 ± 0.020ac
| 0.067 ± 0.013b
| |
28 | 0.040 ± 0.005 | 0.075 ± 0.015b
| 0.035 ± 0.010 | 0.252 ± 0.017c
| 0.069 ± 0.008b
| |
35 | 0.037 ± 0.005 | 0.075 ± 0.011b
| 0.035 ± 0.007 | 0.261 ± 0.023c
| 0.072 ± 0.010b
| |
aVL | Birth | 0.040 ± 0.009ac
| 0.069 ± 0.017ab
| 0.047 ± 0.063 | 0.234 ± 0.027ab
| 0.059 ± 0.010ab
|
7 | 0.035 ± 0.007b
| 0.067 ± 0.013a
| 0.039 ± 0.009 | 0.219 ± 0.017b
| 0.060 ± 0.011abc
| |
14 | 0.035 ± 0.007bc
| 0.065 ± 0.0085a
| 0.038 ± 0.006 | 0.235 ± 0.022bc
| 0.056 ± 0.012a
| |
21 | 0.039 ± 0.007c
| 0.077 ± 0.017bc
| 0.040 ± 0.01 | 0.243 ± 0.015ac
| 0.065 ± 0.013b
| |
28 | 0.040 ± 0.008cd
| 0.075 ± 0.013bc
| 0.037 ± 0.007 | 0.251 ± 0.018cd
| 0.062 ± 0.011abc
| |
35 | 0.041 ± 0.009d
| 0.080 ± 0.016c
| 0.041 ± 0.009 | 0.261 ± 0.025d
| 0.067 ± 0.011c
| |
aVF | Birth | 0.041 ± 0.005ac
| 0.070 ± 0.016abcd
| 0.039 ± 0.007a
| 0.235 ± 0.023ab
| 0.072 ± 0.012ac
|
7 | 0.037 ± 0.006b
| 0.068 ± 0.015abc
| 0.036 ± 0.006a
| 0.219 ± 0.019b
| 0.062 ± 0.016bc
| |
14 | 0.037 ± 0.006b
| 0.066 ± 0.008b
| 0.040 ± 0.010ab
| 0.234 ± 0.020ab
| 0.060 ± 0.013b
| |
21 | 0.042 ± 0.005c
| 0.074 ± 0.010cd
| 0.040 ± 0.008ab
| 0.245 ± 0.018ac
| 0.065 ± 0.007bc
| |
28 | 0.043 ± 0.005ac
| 0.075 ± 0.007d
| 0.044 ± 0.008b
| 0.251 ± 0.018 ad
| 0.063 ± 0.010bc
| |
35 | 0.042 ± 0.006ac
| 0.075 ± 0.013d
| 0.040 ± 0.008ab
| 0.266 ± 0.027 d
| 0.068 ± 0.011c
| |
BA | Birth | 0.055 ± 0.033 | 0.075 ± 0.011 | 0.042 ± 0.006 | 0.233 ± 0.021ab
| 0.175 ± 0.0267ab
|
7 | 0.045 ± 0.009 | 0.078 ± 0.010 | 0.042 ± 0.007 | 0.222 ± 0.021a
| 0.162 ± 0.0259ab
| |
14 | 0.047 ± 0.008 | 0.075 ± 0.009 | 0.042 ± 0.009 | 0.225 ± 0.016a
| 0.167 ± 0.0189a
| |
21 | 0.046 ± 0.007 | 0.080 ± 0.008 | 0.042 ± 0.007 | 0.239 ± 0.015ac
| 0.184 ± 0.0204bc
| |
28 | 0.046 ± 0.008 | 0.082 ± 0.012 | 0.043 ± 0.005 | 0.247 ± 0.017cd
| 0.194 ± 0.0194c
| |
35 | 0.046 ± 0.005 | 0.082 ± 0.011 | 0.042 ± 0.006 | 0.258 ± 0.028d
| 0.210 ± 0.0343d
|
Lead | Age (days) | P (mV) | R (mV) | S (mV) | T (mV) |
---|---|---|---|---|---|
I | Birth | 0.097 ± 0.036 | 0.140 ± 0.168 | 0.085 ± 0.102 | 0.246 ± 0.159a*
|
7 | 0.105 ± 0.038 | 0.123 ± 0.120 | 0.115 ± 0.164 | −0.046 ± 0.213b
| |
14 | 0.103 ± 0.023 | 0.081 ± 0.099 | 0.114 ± 0.104 | 0.024 ± 0.128c
| |
21 | 0.104 ± 0.027 | 0.105 ± 0.087 | 0.085 ± 0.127 | 0.057 ± 0.140c
| |
28 | 0.111 ± 0.035 | 0.103 ± 0.110 | 0.113 ± 0.108 | 0.178 ± 0.115d
| |
35 | 0.109 ± 0.028 | 0.076 ± 0.091 | 0.147 ± 0.134 | 0.166 ± 0.124d
| |
II | Birth | 0.133 ± 0.054 | 0.225 ± 0.159a
| 0.073 ± 0.097 | 0.462 ± 0.160a
|
7 | 0.137 ± 0.044 | 0.128 ± 0.120b
| 0.107 ± 0.109 | 0.221 ± 0.119b
| |
14 | 0.130 ± 0.035 | 0.138 ± 0.105b
| 0.091 ± 0.103 | 0.159 ± 0.086bc
| |
21 | 0.132 ± 0.033 | 0.114 ± 0.096b
| 0.093 ± 0.109 | 0.152 ± 0.138c
| |
28 | 0.113 ± 0.034 | 0.135 ± 0.098b
| 0.100 ± 0.125 | 0.256 ± 0.152d
| |
35 | 0.125 ± 0.030 | 0.115 ± 0.094b
| 0.121 ± 0.148 | 0.295 ± 0.144d
| |
III | Birth | 0.109 ± 0.036a
| 0.175 ± 0.119 | 0.066 ± 0.100 | 0.244 ± 0.168a
|
7 | 0.107 ± 0.030a
| 0.179 ± 0.121 | 0.078 ± 0.113 | −0.020 ± 0.175b
| |
14 | 0.106 ± 0.020a
| 0.166 ± 0.107 | 0.056 ± 0.095 | 0.046 ± 0.175bd
| |
21 | 0.093 ± 0.017a
| 0.149 ± 0.113 | 0.075 ± 0.120 | 0.136 ± 0.126ce
| |
28 | 0.078 ± 0.053b
| 0.145 ± 0.112 | 0.070 ± 0.097 | 0.116 ± 0.139de
| |
35 | 0.096 ± 0.024a
| 0.140 ± 0.131 | 0.100 ± 0.159 | 0.159 ± 0.139e
| |
aVR | Birth | −0.122 ± 0.054 | 0.110 ± 0.0798 | 0.135 ± 0.175a
| −0.311 ± 0.205a
|
7 | −0.101 ± 0.056 | 0.133 ± 0.120 | 0.068 ± 0.105b
| 0.054 ± 0.211b
| |
14 | −0.115 ± 0.032 | 0.120 ± 0.0839 | 0.040 ± 0.080b
| 0.015 ± 0.154bc
| |
21 | −0.109 ± 0.028 | 0.0995 ± 0.103 | 0.067 ± 0.078b
| −0.069 ± 0.152c
| |
28 | −0.111 ± 0.030 | 0.120 ± 0.113 | 0.074 ± 0.109b
| −0.203 ± 0.157d
| |
35 | −0.114 ± 0.026 | 0.141 ± 0.109 | 0.040 ± 0.066b
| −0.183 ± 0.170d
| |
aVL | Birth | −0.047 ± 0.067a
| 0.110 ± 0.120 | 0.102 ± 0.115 | 0.057 ± 0.146 |
7 | −0.025 ± 0.088b
| 0.109 ± 0.096 | 0.114 ± 0.151 | −0.013 ± 0.147 | |
14 | −0.016 ± 0.085b
| 0.058 ± 0.091 | 0.126 ± 0.101 | 0.010 ± 0.127 | |
21 | −0.070 ± 0.054c
| 0.080 ± 0.099 | 0.092 ± 0.122 | 0.028 ± 0.148 | |
28 | −0.089 ± 0.019c
| 0.074 ± 0.106 | 0.102 ± 0.108 | 0.071 ± 0.097 | |
35 | −0.076 ± 0.048c
| 0.068 ± 0.105 | 0.135 ± 0.121 | 0.072 ± 0.150 | |
aVF | Birth | 0.118 ± 0.037 | 0.189 ± 0.118a
| 0.063 ± 0.105 | 0.315 ± 0.200a
|
7 | 0.112 ± 0.029 | 0.149 ± 0.092b
| 0.069 ± 0.094 | −0.042 ± 0.224b
| |
14 | 0.109 ± 0.023 | 0.125 ± 0.093b
| 0.069 ± 0.085 | 0.048 ± 0.153c
| |
21 | 0.106 ± 0.024 | 0.128 ± 0.098b
| 0.072 ± 0.108 | 0.153 ± 0.102d
| |
28 | 0.099 ± 0.025 | 0.132 ± 0.107b
| 0.073 ± 0.101 | 0.182 ± 0.143d
| |
35 | 0.105 ± 0.0215 | 0.112 ± 0.106b
| 0.094 ± 0.139 | 0.187 ± 0.132d
| |
BA | Birth | 0.232 ± 0.066a
| 0.034 ± 0.046 | 0.586 ± 0.229 | 0.452 ± 0.292a
|
7 | 0.217 ± 0.055a
| 0.036 ± 0.047 | 0.443 ± 0.156 | 0.284 ± 0.146b
| |
14 | 0.223 ± 0.045ab
| 0.014 ± 0.033 | 0.462 ± 0.140 | 0.267 ± 0.131b
| |
21 | 0.200 ± 0.043bc
| 0.024 ± 0.056 | 0.405 ± 0.092 | 0.315 ± 0.157a
| |
28 | 0.179 ± 0.030c
| 0.029 ± 0.044 | 0.401 ± 0.131 | 0.328 ± 0.160a
| |
35 | 0.175 ± 0.038c
| 0.025 ± 0.050 | 0.448 ± 0.173 | 0.332 ± 0.152a
|
Age (days) | Body weight (Kg) | BSA (m2) | Heart rate (bpm) | RR interval (ms) | Axis |
---|---|---|---|---|---|
Birth | 3.88 ± 0.88a
| 0.0025 ± 0.00037a
| 191.95 ± 42.17a*
| 334.86 ± 69.15a
| 29.63 ± 108.50° |
(2.40–5.60) | (0.0018–0.0032) | (193–160) | (490–230) | ||
7 | 5.30 ± 1.31b
| 0.0030 ± 0.00050b
| 214.95 ± 54.58b
| 297.04 ± 69.12a
| 5.31 ± 110.39° |
(3.00–7.60) | (0.0021–0.0039) | (305–122) | (413–197) | ||
14 | 6.84 ± 1.78c
| 0.0036 ± 0.00062c
| 195.50 ± 37.74ab
| 305.90 ± 57.22a
| −18.86 ± 115.31° |
(3.40–10.00) | (0.0022–0.0047) | (260–108) | (480–223) | ||
21 | 8.17 ± 2.05d
| 0.0041 ± 0.00067d
| 173.04 ± 30.72c
| 361.18 ± 56.17d
| −8.45 ± 113.61° |
(4.60–12.00) | (0.0028–0.0053) | (250–110) | (467–270) | ||
28 | 9.50 ± 2.45e
| 0.0045 ± 0.00077e
| 158.81 ± 22.14cd
| 379.81 ± 44.88b
| −37.77 ± 113.36° |
(5.55 ± 13.20) | (0.0031–0.0056) | (211–116) | (467–320) | ||
35 | 10.78 ± 2.91f
| 0.0049 ± 0.00088f
| 145.63 ± 37.80d
| 441.63 ± 115.28c
| −29.63 ± 117.39° |
(5.50 ± 15.10) | (0.0031–0.0062) | (260–92) | (230–423) |
Parameters | BSA | Body weight | ||||
---|---|---|---|---|---|---|
R | 95 % CI |
P
| R | 95 % CI |
P
| |
Heart rate | −0.2139 | −0.3713, −0.04466 | 0.0138 | −0.2170 | −0.3741, −0.04787 | 0.0124 |
P (ms) | 0.03876 | −0.1380, 0.2132 | 0.6590 | 0.03876 | −0.1380, 0.2132 | 0.6590 |
P (mV) | 0.05074 | −0.1262, 0.2246 | 0.5634 | 0.05074 | −0.1262, 0.2246 | 0.5634 |
PR (ms) | −0.03408 | −0.2087, 0.1426 | 0.6981 | −0.03408 | −0.2087, 0.1426 | 0.6981 |
QRS (ms) | −0.02338 | −0.1984, 0.1531 | 0.7902 | −0.02338 | −0.1984, 0.1531 | 0.7902 |
R (mV) | −0.3565 | −0.5009, −0.1927 | <0.0001 | −0.3637 | −0.5033, −0.2055 | <0.0001 |
QTc (mV) | 0.2523 | 0.08507, 0.4057 | 0.0035 | 0.2512 | 0.08394, 0.4048 | 0.0037 |
T (ms) | −0.09783 | −0.2691, 0.07940 | 0.2644 | −0.09783 | −0.2691, 0.07940 | 0.2644 |
T (mV) | 0.1863 | 0.01079, 0.3507 | 0.0324 | 0.1863 | 0.01079, 0.3507 | 0.0324 |
Axis (°) | −0.09967 | −0.2708, 0.07755 | 0.2555 | −0.09967 | −0.2708, 0.07755 | 0.2555 |
Lead | Types of waves | Number of animals (%) |
---|---|---|
I | Positive (+) Negative (−) Biphase (− +) | 96 (72,72 %) 31 (23,48 %) 5 (3,78 %) |
II | Positive (+) Negative (−) Biphase (− +) | 108 (81,81 %) 21 (15,90 %) 3 (2,27 %) |
III | Positive (+) Negative (−) Biphase (− +) | 98 (74,24 %) 30 (22,72 %) 4 (3,03 %) |
aVR | Positive (+) Negative (−) Biphase (− +) | 35 (26,51 %) 94 (71,21 %) 3 (2,27 %) |
aVL | Positive (+) Negative (−) Biphase (− +) | 86 (65,15 %) 45 (34,09 %) 1 (0,75 %) |
aVF | Positive (+) Negative (−) Biphase (− +) | 105 (79,54 %) 24 (18,18 %) 3 (2,27 %) |
BA | Positive (+) Negative (−) Biphase (− +) | 132 (100 %) 0 (0 %) 0 (0 %) |
Birth | 7 days | 14 days | 21 days | 28 days | 35 days | P value | |
---|---|---|---|---|---|---|---|
P min | 0.030 ± 0.00 | 0.027 ± 0.004 | 0.025 ± 0.005 | 0.028 ± 0.003 | 0.030 ± 0.0 | 0.031 ± 0.003 | 0.0796 |
P max | 0.075 ± 0.055 | 0.051 ± 0.006 | 0.055 ± 0.007 | 0.055 ± 0.005 | 0.052 ± 0.004 | 0.054 ± 0.007 | 0.3487 |
PWD | 0.045 ± 0.055 | 0.024 ± 0.005 | 0.030 ± 0.008 | 0.027 ± 0.004 | 0.022 ± 0.004 | 0.022 ± 0.007 | 0.4119 |
QTc min | 0.188 ± 0.009ab
| 0.179 ± 0.020a
| 0.187 ± 0.010ab
| 0.207 ± 0.009bc
| 0.211 ± 0.010c
| 0.195 ± 0.00abc
| 0.0004 |
QTc max | 0.274 ± 0.007ab
| 0.279 ± 0.022ab
| 0.274 ± 0.007ab
| 0.274 ± 0.007ab
| 0.283 ± 0.010ab
| 0.308 ± 0.007c
| <0.0001 |
QTcID | 0.086 ± 0.014ab
| 0.099 ± 0.029ac
| 0.086 ± 0.011ab
| 0.066 ± 0.006b
| 0.072 ± 0.010b
| 0.112 ± 0.004c
| <0.0001 |