Introduction
Methods
Study design and setting
Admission selection
Data collection
Data analysis
Reliability study
Results
Respondent characteristics
Characteristic | LN | LS | HN | HS |
---|---|---|---|---|
Patients in each subgroup | 12 | 12 | 12 | 12 |
Gender: male | 6 | 6 | 6 | 6 |
Age group | ||||
• 1–28 days | 1 | 1 | 1 | 1 |
• 29–365 days | 4 | 4 | 4 | 4 |
• 1–4 years | 0 | 0 | 0 | 0 |
• 5–17 years | 7 | 7 | 7 | 7 |
Age: median [IQR] (years) | 9.5 [0–12.8] | 7.5 [0–13.0] | 5.0 [0–13.3] | 5.5 [0–11.3] |
Weight: median [IQR] (kg) | 32.5 [3.9–53.5] | 14.9 [3.1–44.8] | 20.0 [7.0–50.0] | 22.0 [5.5–37.0] |
Socio-economic status | ||||
• Low | 3 | 3 | 2 | 3 |
• Intermediate | 5 | 8 | 8 | 8 |
• High | 3 | 1 | 1 | 1 |
• Unknown | 1 | 0 | 1 | 0 |
Non-elective admission | 10 | 7d,f | 12 | 12 |
Medical admission | 12aa,c | 6 | 8 | 10 |
CPR or brain herniation as the cause for PICU admission | 0 | 0 | 9b | 3 |
Off-hours admission | 6 | 4 | 6 | 7 |
Chronic condition | ||||
• CCC | 9cc | 7 | 3b | 6 |
• NCCC | 2 | 1 | 0 | 3 |
• None | 1 | 4 | 9 | 3 |
Recalibrated PRISM mortality risk, median [IQR] (%) | 0.9 [0.7–1.4]a,ccc,eee | 0.6 [0.5–0.8]ddd,fff | 77.0 [21.4–87.4] | 43.6 [35.3–60.5] |
Recalibrated PIM2 mortality risk, median [IQR] (%) | 1.3 [0.8–6.1]ccc,e | 1.3 [1.0–2.2]d,fff | 56.1 [21.8–83.4]b | 14 [14–46] |
Mechanical ventilation | 11aa | 4dd,ff | 12 | 12 |
Ventilator days, median [IQR] | 6.5 [2.5–30.8]aaa | 0 [0–1.8]ddd,ff | 2.5 [1.0–9.3] | 6.5 [4.3–11.5] |
Central venous catheter | 10a | 5ff | 11 | 9 |
Central venous catheter days, median [IQR] | 4.5 [1.3–14.3]aa | 0 [0–2]dd,ff | 2.5 [1–17.5] | 6.5 [1–11.8] |
Extracorporal life support | 2* | 0 | 1 | 3 |
Length of stay, median [IQR] (days) | 16 [5.5–32.8]aa,c,e | 2 [2–2.8]dd | 2.5 [1–9.3]b | 11 [6.3–13] |
Mode of death (n = 24) | Not applicable | Not applicable | ||
- Brain death | 0c | 6 | ||
- Maximal treatment including CPR | 1 | 0 | ||
- Maximal treatment without CPR | 2 | 1 | ||
- Limiting or withdrawal of therapy | 9 | 5 |
Adverse events
Outcome measure | LN | LS | HN | HS |
---|---|---|---|---|
Patients with ≥ 1 AE(/n) | 10/12aaa,cc | 1/12dd | 2/12b | 7/12 |
AE PICU/PICU day, median [IQR] | 0.12 [0.07–0.29]aaa,cc | 0 [0–0]dd | 0 [0–0]b | 0.03 [0.0–0.17] |
Number of AEs, total | 25 | 2 | 8 | 10 |
Number of AEs/patient, median [IQR] | 2 [1–3.8] | 0 [0–0] | 0 [0–0] | 1 [0–1] |
Group | No AEs | Preventability | Severity | Classification |
---|---|---|---|---|
LN | 25 | 8 preventable AEs | I = 2 | Infection control = 1 |
Clinical monitoring = 1 | ||||
G–H = 3 | Drug or fluid related = 1 | |||
Diagnosis = 2 | ||||
E–F = 3 | Infection control = 2 | |||
Clinical monitoring = 1 | ||||
17 non-preventable AEs | I = 4 | Other = 3 | ||
Drug or fluid related = 1 | ||||
G–H = 5 | Other = 4 | |||
Drug or fluid related = 1 | ||||
E–F = 8 | Infection control = 4 | |||
Other = 3 | ||||
Technical = 1 | ||||
LS | 2 | 2 preventable AEs | H = 2 | Infection control = 1 |
Drug or fluid related = 1 | ||||
HN | 8 | 2 preventable AEs | G–H = 1 | Clinical monitoring = 1 |
E–F = 1 | Infection control = 1 | |||
6 non-preventable AEs | I = 1 | ECLS = 1 | ||
G–H = 1 | ECLS = 1 | |||
E–F = 4 | ECLS = 1 | |||
Other = 3 | ||||
HS | 10 | 3 preventable AEs | G–H = 1 | ECLS = 1 |
E–F = 2 | ECLS = 1 | |||
Clinical monitoring = 1 | ||||
7 non-preventable AEs | G–H = 5 | Clinical monitoring = 1 | ||
ECLS = 1 | ||||
Other = 3 | ||||
E–F = 2 | ECLS = 1 | |||
Technical = 1 | ||||
Total | 45 | 15 preventable | Clinical monitoring = 4 | |
30 unpreventable | Diagnosis = 2 | |||
Drug or fluid related = 2 | ||||
ECLS = 2 | ||||
Infection control = 5 | ||||
Clinical monitoring = 1 | ||||
Drug or fluid related = 2 | ||||
Technical = 2 | ||||
ECLS = 5 | ||||
Infection control = 4 | ||||
Other = 16 |