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Erschienen in:

07.02.2019 | Original Article

The overall survival of breast cancer patients without adjuvant therapy

verfasst von: Sakura Onishi, Masataka Sawaki, Junko Ishiguro, Ayumi Kataoka, Madoka Iwase, Kayoko Sugino, Yayoi Adachi, Naomi Gondo, Haruru Kotani, Akiyo Yoshimura, Masaya Hattori, Keitaro Matsuo, Yasushi Yatabe, Hiroji Iwata

Erschienen in: Surgery Today | Ausgabe 7/2019

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Abstract

Purpose

There are little data regarding the overall survival (OS) of patients without adjuvant systemic therapy, because most patients have been subject to standardized systemic therapies. We evaluated the baseline risk to facilitate making decisions about adjuvant therapy.

Patients and methods

A total of 1835 breast cancer patients who did not receive adjuvant systemic therapy between 1964 and 1992 were retrospectively evaluated. We investigated the 10-year disease-free survival (DFS) and OS according to the number of metastatic lymph nodes, pathological T classification, stage, and estrogen receptor (ER) status.

Results

Survival curves showed that as the number of metastatic lymph nodes, pathological T classification, and staging increased, the 10-year OS and DFS decreased. In univariate and multivariable analyses, the number of metastatic lymph nodes was significantly associated with the DFS and OS, while in a univariate analysis, the pathological T classification and stage were significantly associated with the DFS and OS. ER positivity was a good prognostic factor for the 5-year DFS. However, between 6 and 7 years after surgery, ER negativity was a better prognostic factor than ER positivity.

Conclusion

We showed survival rates of patients without adjuvant therapy according to TNM classification and ER status. This information can aid in treatment selection for doctors and patients through a shared decision-making approach.
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Metadaten
Titel
The overall survival of breast cancer patients without adjuvant therapy
verfasst von
Sakura Onishi
Masataka Sawaki
Junko Ishiguro
Ayumi Kataoka
Madoka Iwase
Kayoko Sugino
Yayoi Adachi
Naomi Gondo
Haruru Kotani
Akiyo Yoshimura
Masaya Hattori
Keitaro Matsuo
Yasushi Yatabe
Hiroji Iwata
Publikationsdatum
07.02.2019
Verlag
Springer Singapore
Erschienen in
Surgery Today / Ausgabe 7/2019
Print ISSN: 0941-1291
Elektronische ISSN: 1436-2813
DOI
https://doi.org/10.1007/s00595-019-01775-z

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