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Erschienen in: Virchows Archiv 6/2018

05.02.2018 | Review and Perspectives

The pattern is the issue: recent advances in adenocarcinoma of the uterine cervix

verfasst von: Andres A. Roma, Oluwole Fadare

Erschienen in: Virchows Archiv | Ausgabe 6/2018

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Abstract

In this article, we review a novel risk stratification system for endocervical adenocarcinoma, developed by an international consortium of pathologists after reviewing over 350 such tumors. Their analysis culminated in a three-tiered histopathologic system based on morphologic examination of the tumor, independent of clinical features and stage (depth of invasion). It resulted in better determination of patients’ tumors and likelihood of lymph node metastasis as well as aggressive behavior. A non-destructive pattern (that in some cases was in the histologic differential diagnosis with adenocarcinoma in situ) had an indolent behavior and was labeled pattern A. The other two patterns had destructive invasion, one only focally (pattern B) while pattern C showed diffuse destructive invasion. This system can help select appropriate treatment modalities avoiding unnecessary complications. We comment on specifics of this system as well as issues in differentiation of the tumor patterns, its clinical utility and recent advances in the molecular arena.
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Metadaten
Titel
The pattern is the issue: recent advances in adenocarcinoma of the uterine cervix
verfasst von
Andres A. Roma
Oluwole Fadare
Publikationsdatum
05.02.2018
Verlag
Springer Berlin Heidelberg
Erschienen in
Virchows Archiv / Ausgabe 6/2018
Print ISSN: 0945-6317
Elektronische ISSN: 1432-2307
DOI
https://doi.org/10.1007/s00428-018-2312-6

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