Skip to main content
Erschienen in: Current Oral Health Reports 1/2020

29.01.2020 | Host Parasite Interactions in Periodontal Disease (C Genco and D Kinane, Section Editors)

The Periodontal Microenvironment: a Potential Reservoir for Intestinal Pathobionts in Crohn’s Disease

verfasst von: Jiho Sohn, Yijun Sun, Robert J. Genco, Keith L. Kirkwood

Erschienen in: Current Oral Health Reports | Ausgabe 1/2020

Einloggen, um Zugang zu erhalten

Abstract

Purpose of Review

Periodontal disease is a common bacteria-initiated inflammatory disease generating alveolar bone destruction around the dentition. Chronic periodontitis leads to the formation of a nutrient-rich periodontal microenvironment where opportunistic pathogens can thrive and flourish. The dissemination of these microbes from the oral cavity to other body sites can initiate or exacerbate disease, especially in susceptible individuals. This brief review will highlight the oral-gut axis and common bacterial etiologies associated with periodontal disease and Crohn’s disease as well as providing a perspective for future studies in this active area of investigation.

Recent Findings

Recent studies have indicated that there is an extensive transmission of oral bacteria along the gastrointestinal tract, suggesting the role of oral microbiota in intestinal pathologies. The presence of oral bacteria in the intestine strongly correlates with the severity of Crohn’s disease, one of the major types of inflammatory bowel disease. Periodontal disease is highly prevalent in Crohn’s disease, and the oral-gut microbiota transmission may be the mechanistic factor linking the two diseases.

Summary

A better understanding of the relationship between periodontal disease and Crohn’s disease may help define new therapeutic targets for the management of Crohn’s disease.
Literatur
8.
Zurück zum Zitat Atarashi, K. et al. Ectopic colonization of oral bacteria in the intestine drives TH1 cell induction and inflammation. Science,(2017) 365(80-. ) 359–365 . This work demonstrated via gnotobiotic mice that Klebsiella of oral origin can colonize the gut and induce TH1 cell induction, DOI: https://doi.org/10.1126/science.aan4526. Atarashi, K. et al. Ectopic colonization of oral bacteria in the intestine drives TH1 cell induction and inflammation. Science,(2017) 365(80-. ) 359–365 . This work demonstrated via gnotobiotic mice that Klebsiella of oral origin can colonize the gut and induce TH1 cell induction, DOI: https://​doi.​org/​10.​1126/​science.​aan4526.
14.
Zurück zum Zitat Kinane DF, Stathopoulou PG, Papapanou PN. Periodontal diseases. Nat Rev Dis Prim. 2017;3:17038.CrossRefPubMed Kinane DF, Stathopoulou PG, Papapanou PN. Periodontal diseases. Nat Rev Dis Prim. 2017;3:17038.CrossRefPubMed
15.
Zurück zum Zitat Eke PI. Update on prevalence of periodontitis in adults in the United States: NHANES 2009-2012. J Peridontology. 2015;86:611–22.CrossRef Eke PI. Update on prevalence of periodontitis in adults in the United States: NHANES 2009-2012. J Peridontology. 2015;86:611–22.CrossRef
17.
Zurück zum Zitat Vieira Colombo AP, Magalhães CB, Hartenbach FARR, Martins do Souto R, Maciel da Silva-Boghossian C. Periodontal-disease-associated biofilm: a reservoir for pathogens of medical importance. Microb Pathog. 2015;94:27–34.CrossRefPubMed Vieira Colombo AP, Magalhães CB, Hartenbach FARR, Martins do Souto R, Maciel da Silva-Boghossian C. Periodontal-disease-associated biofilm: a reservoir for pathogens of medical importance. Microb Pathog. 2015;94:27–34.CrossRefPubMed
18.
Zurück zum Zitat Diaz PI, Hoare A, Hong B-Y. Subgingival microbiome shifts and community dynamics in periodontal diseases. J Calif Dent Assoc. 2016;44:421–35.PubMed Diaz PI, Hoare A, Hong B-Y. Subgingival microbiome shifts and community dynamics in periodontal diseases. J Calif Dent Assoc. 2016;44:421–35.PubMed
20.
Zurück zum Zitat Genco R, Offenbacher S, Beck J. Periodontal disease and cardiovascular disease: epidemiology and possible mechanisms. J Am Dent Assoc. 2002;133(Suppl):14S–22S.CrossRefPubMed Genco R, Offenbacher S, Beck J. Periodontal disease and cardiovascular disease: epidemiology and possible mechanisms. J Am Dent Assoc. 2002;133(Suppl):14S–22S.CrossRefPubMed
39.
Zurück zum Zitat Arimatsu K, et al. Oral pathobiont induces systemic inflammation and metabolic changes associated with alteration of gut microbiota. Sci Rep. 2014;4:1–9. Arimatsu K, et al. Oral pathobiont induces systemic inflammation and metabolic changes associated with alteration of gut microbiota. Sci Rep. 2014;4:1–9.
40.
Zurück zum Zitat Nakajima M, et al. Oral administration of P. gingivalis induces dysbiosis of gut microbiota and impaired barrier function leading to dissemination of enterobacteria to the liver. PLoS One. 2015;10:1–15. Nakajima M, et al. Oral administration of P. gingivalis induces dysbiosis of gut microbiota and impaired barrier function leading to dissemination of enterobacteria to the liver. PLoS One. 2015;10:1–15.
41.
Zurück zum Zitat Glick M. The oral-systemic health connection. A Guid to Patient Care. 2014. Glick M. The oral-systemic health connection. A Guid to Patient Care. 2014.
44.
Zurück zum Zitat Schmidt, T. S. B. et al. Extensive transmission of microbes along the gastrointestinal tract. (2019). This work used large DNA shotgut sequencing data from human saliva and stool samples and showed that there is extensive oral-gut microbiota transmission in healthy individuals, DOI: https://doi.org/10.1016/j.pedn.2020.01.002. Schmidt, T. S. B. et al. Extensive transmission of microbes along the gastrointestinal tract. (2019). This work used large DNA shotgut sequencing data from human saliva and stool samples and showed that there is extensive oral-gut microbiota transmission in healthy individuals, DOI: https://​doi.​org/​10.​1016/​j.​pedn.​2020.​01.​002.
48.
Zurück zum Zitat Staels B, Fonseca VA. Bile acids and metabolic regulation: mechanisms and clinical responses to bile acid sequestration. Diabetes Care. 2009;32(Suppl 2).CrossRefPubMedPubMedCentral Staels B, Fonseca VA. Bile acids and metabolic regulation: mechanisms and clinical responses to bile acid sequestration. Diabetes Care. 2009;32(Suppl 2).CrossRefPubMedPubMedCentral
56.
Zurück zum Zitat Podschun, R Ullmann, U. Klebsiella spp. as nosocomial pathogens: epidemiology, taxonomy, typing methods, and pathogenicity factors. 11, 589–603 (1998). Podschun, R Ullmann, U. Klebsiella spp. as nosocomial pathogens: epidemiology, taxonomy, typing methods, and pathogenicity factors. 11, 589–603 (1998).
59.
Zurück zum Zitat Signat BC, Pierre R, Poulet Danielle D. Role of Fusobacterium nucleatum in periodontal health and disease. Microb Ecol Health Dis. 1994;7:201–5. Signat BC, Pierre R, Poulet Danielle D. Role of Fusobacterium nucleatum in periodontal health and disease. Microb Ecol Health Dis. 1994;7:201–5.
64.
Zurück zum Zitat Kolenbrander, P. The genus Veillonella The Prokaryotes 87, 1022–1040 (2006). Kolenbrander, P. The genus Veillonella The Prokaryotes 87, 1022–1040 (2006).
68.
Zurück zum Zitat Luo H, Fan Q, Xiao S, Chen K. Changes in proton pump inhibitor prescribing trend over the past decade and pharmacists’ effect on prescribing practice at a tertiary hospital. BMC Health Serv Res. 2018;18:1–10. Luo H, Fan Q, Xiao S, Chen K. Changes in proton pump inhibitor prescribing trend over the past decade and pharmacists’ effect on prescribing practice at a tertiary hospital. BMC Health Serv Res. 2018;18:1–10.
75.
Zurück zum Zitat Brune F, Falk W, Fimmers R, S, Jepsen KJ. O042: Antibiotic resistance trends in human periodontitis microbiota (2008–2015). J Clin Periodontol. 2018;45:20. Brune F, Falk W, Fimmers R, S, Jepsen KJ. O042: Antibiotic resistance trends in human periodontitis microbiota (2008–2015). J Clin Periodontol. 2018;45:20.
77.
Zurück zum Zitat Xun Z, Zhang Q, Xu T, Chen N, Chen F. Dysbiosis and ecotypes of the salivary microbiome associated with inflammatory bowel diseases and the assistance in diagnosis of diseases using oral bacterial profiles. Front Microbiol. 2018;9:1–17.CrossRef Xun Z, Zhang Q, Xu T, Chen N, Chen F. Dysbiosis and ecotypes of the salivary microbiome associated with inflammatory bowel diseases and the assistance in diagnosis of diseases using oral bacterial profiles. Front Microbiol. 2018;9:1–17.CrossRef
Metadaten
Titel
The Periodontal Microenvironment: a Potential Reservoir for Intestinal Pathobionts in Crohn’s Disease
verfasst von
Jiho Sohn
Yijun Sun
Robert J. Genco
Keith L. Kirkwood
Publikationsdatum
29.01.2020
Verlag
Springer International Publishing
Erschienen in
Current Oral Health Reports / Ausgabe 1/2020
Elektronische ISSN: 2196-3002
DOI
https://doi.org/10.1007/s40496-020-00251-9

Weitere Artikel der Ausgabe 1/2020

Current Oral Health Reports 1/2020 Zur Ausgabe

Host Parasite Interactions in Periodontal Disease (C Genco and D Kinane, Section Editors)

Periodontal Disease and Systemic Interactions (Periodontal Medicine): Current Epidemiological Evidence

Host Parasite Interactions in Periodontal Disease (C Genco and D Kinane, Section Editors)

On the Role of Mentorship in Team Science

Host Parasite Interactions in Periodontal Disease (C Genco and D Kinane, Section Editors)

The Oral Microbiome and Lung Diseases

Host Parasite Interactions in Periodontal Disease (C Genco and D Kinane, Section Editors)

From Periodontitis to Periimplantitis—the Quest for the Missing Link

Host Parasite Interactions in Periodontal Disease (C Genco and D Kinane, Section Editors)

The Gastrointestinal Microbiome in Chronic Renal Diseases

Host Parasite Interactions in Periodontal Disease (C Genco and D Kinane, Section Editors)

Periodontitis: a Host-Mediated Disruption of Microbial Homeostasis

Newsletter

Bestellen Sie unseren kostenlosen Newsletter Update Zahnmedizin und bleiben Sie gut informiert – ganz bequem per eMail.