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Journal of Assisted Reproduction and Genetics

Erschienen in:

30.04.2016 | Letter to Editor

The PlA2 variant of the platelet glycoprotein IIIa as a genetic risk factor for IVF implantation failure: accumulating evidence

verfasst von: Nikolaos Vlachadis, Nikolaos Vrachnis, Emmanuel Economou

Erschienen in: Journal of Assisted Reproduction and Genetics | Ausgabe 7/2016

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Excerpt

We read with great interest the recent article of Patounakis et al. [1] who examined the potential role of nine genetic thrombophilic factors in in vitro fertilization (IVF) outcome. Even though the authors came to the conclusion that the thrombophilic single nucleotide polymorphisms (SNPs) which were evaluated, individually or cumulatively, do not have any significant effect, an important clinical finding, the correlation of the genetic polymorphism PIA1/PIA2 (T1565C-Leu33Pro) (rs5918) of the platelet glycoprotein llla (Gpllla) gene with implantation failure after IVF embryo-transfer (IVF-ET failure), was overlooked. …

Patounakis G, Bergh E, Forman EJ, Tao X, Lonczak A, Franasiak JM, et al. Multiple thrombophilic single nucleotide polymorphisms lack a significant effect on outcomes in fresh IVF cycles: an analysis of 1717 patients. J Assist Reprod Genet. 2016;33:67–73.CrossRefPubMed

Di Nisio M, Rutjes AW, Ferrante N, Tiboni GM, Cuccurullo F, Porreca E. Thrombophilia and outcomes of assisted reproduction technologies: a systematic review and meta-analysis. Blood. 2011;118:2670–8.CrossRefPubMed

Grandone E, Colaizzo D, Lo Bue A, Checola MG, Cittadini E, Margaglione M. Inherited thrombophilia and in vitro fertilization implantation failure. Fertil Steril. 2001;76:201–2.CrossRefPubMed

Qublan HS, Eid SS, Ababneh HA, Amarin ZO, Smadi AZ, Al-Khafaji FF, et al. Acquired and inherited thrombophilia: implication in recurrent IVF and embryo transfer failure. Hum Reprod. 2006;21:2694–8.CrossRefPubMed

Safdarian L, Najmi Z, Aleyasin A, Aghahosseini M, Rashidi M, Asadollah S. Recurrent IVF failure and hereditary thrombophilia. Iran J Reprod Med. 2014;12:467–70.PubMedPubMedCentral

Haggarty P, McCallum H, McBain H, Andrews K, Duthie S, McNeill G, et al. Effect of B vitamins and genetics on success of in-vitro fertilisation: prospective cohort study. Lancet. 2006;367:1513–9.CrossRefPubMed

Floyd CN, Mustafa A, Ferro A. The PlA1/A2 polymorphism of glycoprotein IIIa as a risk factor for myocardial infarction: a meta-analysis. PLoS One. 2014;9, e101518.CrossRefPubMedPubMedCentral

Floyd CN, Ellis BH, Ferro A. The PlA1/A2 polymorphism of glycoprotein IIIa as a risk factor for stroke: a systematic review and meta-analysis. PLoS One. 2014;9, e100239.CrossRefPubMedPubMedCentral

Komsa-Penkova R, Golemanov G, Tsankov B, Ivanov P, Beshev L, Tonchev P. Rs5918ITGB3 polymorphism, smoking, and BMI as risk factors for early onset and recurrence of DVT in young women. Clin Appl Thromb Hemost. 2016. doi:10.1177/1076029615624778.

10.

Vlachadis N, Tsamadias V, Kouskouni E, Vitoratos N, Hatziveis K, Economou E. Genetic heterogeneity of platelet glycoproteins Ia and IIIa is associated with in vitro fertilisation implantation failure. J Obstet Gynaecol. 2015;35:733–6.CrossRefPubMed

11.

Ivanov P, Tsvyatkovska T, Konova E, Komsa-Penkova R. Inherited thrombophilia and IVF failure: the impact of coagulation disorders on implantation process. Am J Reprod Immunol. 2012;68:189–98.CrossRefPubMed

12.

Coulam CB, Jeyendran RS, Fishel LA, Roussev R. Multiple thrombophilic gene mutations are risk factors for implantation failure. Reprod Biomed Online. 2006;12:322–7.CrossRefPubMed

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Floyd CN, Ferro A. The PlA1/A2 polymorphism of glycoprotein IIIa in relation to efficacy of antiplatelet drugs: a systematic review and meta-analysis. Br J Clin Pharmacol. 2014;77:446–57.CrossRefPubMedPubMedCentral

14.

Vlachadis N, Tsamadias V, Economou E. Aspirin to improve IVF unexplained implantation rates: time for an individualized approach. Reprod Biomed Online. 2014;28:133.CrossRefPubMed

Titel: The PlA2 variant of the platelet glycoprotein IIIa as a genetic risk factor for IVF implantation failure: accumulating evidence
verfasst von: Nikolaos Vlachadis
Nikolaos Vrachnis
Emmanuel Economou
Publikationsdatum: 30.04.2016
Verlag: Springer US
Erschienen in: Journal of Assisted Reproduction and Genetics / Ausgabe 7/2016
Print ISSN: 1058-0468
Elektronische ISSN: 1573-7330
DOI: https://doi.org/10.1007/s10815-016-0722-4

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The PlA2 variant of the platelet glycoprotein IIIa as a genetic risk factor for IVF implantation failure: accumulating evidence

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