nach oben

Tumor Biology

Erschienen in:

16.11.2015 | Original Article

The polymorphism in miR-25 attenuated the oncogenic function in gastric cancer

verfasst von: Jianping Zhou, Jiangang Zhou, Weimin Wang, Weiling Li, Lulu Wu, Gang Li, Jun Shi, Sujun Zhou

Erschienen in: Tumor Biology | Ausgabe 4/2016

Einloggen, um Zugang zu erhalten

Abstract

miR-25 was identified as an essential oncogene by promoting the growth and metastasis through TOB1 in gastric cancer (GC). The function of the single nucleotide polymorphism (SNP) located in the mature region of miR-25 (rs41274221) has not been investigated. In this study, we aimed to explore the involvement of rs41274221 in miR-25 in gastric cancer. We found that SNP rs41274221 in miR-25 was participated in the occurrence of GC by acting as a tumor protective factor associating with the tumor growth and metastasis. Besides, further investigation found that upregulation of miR-25 with AA genotype could attenuate the proliferation and invasion of tumor cells caused by wild-type miR-25. The dual-luciferase reporter assay also confirmed that miR-25 harbored the A allele which caused an incapacitation of binding at the TOB1. In conclusion, rs41274221 in miR-25 was a subgroup which may protect the patients from further growth and metastasis of gastric cancer and might serve as a novel biomarker for the disease.

Caldeira J, Figueiredo J, Bras-Pereira C, Carneiro P, Moreira AM, Pinto MT, et al. E-cadherin-defective gastric cancer cells depend on Laminin to survive and invade. Hum Mol Genet. 2015;24(20):5891–900.CrossRefPubMedPubMedCentral

Snyder EL, Watanabe H, Magendantz M, Hoersch S, Chen TA, Wang DG, et al. Nkx2-1 represses a latent gastric differentiation program in lung adenocarcinoma. Mol Cell. 2013;50:185–99.CrossRefPubMedPubMedCentral

Hartgrink HH, Jansen EP, van Grieken NC, van de Velde CJ. Gastric cancer. Lancet. 2009;374:477–90.CrossRefPubMedPubMedCentral

Elimova E, Ajani JA. Time-to-treatment failure as the primary end point of a first-line advanced gastric cancer randomized trial: how confused would you want us to be? J Clin Oncol. 2015;33:2410.CrossRefPubMed

Zhao CM, Hayakawa Y, Kodama Y, Muthupalani S, Westphalen CB, Andersen GT, et al.: Denervation suppresses gastric tumorigenesis. Sci Transl Med 2014;6:250ra115.

Graham DY. Helicobacter pylori update: gastric cancer, reliable therapy, and possible benefits. Gastroenterology. 2015;148:719–31. e713.CrossRefPubMedPubMedCentral

Sung H, Yang HH, Hu N, Su H, Taylor PR, Hyland PL: Functional annotation of high-quality SNP biomarkers of gastric cancer susceptibility: the Yin Yang of PSCA rs2294008. Gut 2015

Gibbings D, Mostowy S, Jay F, Schwab Y, Cossart P, Voinnet O. Corrigendum: selective autophagy degrades DICER and AGO2 and regulates miRNA activity. Nat Cell Biol. 2015;17:1088.CrossRefPubMed

Wu SL, Fu X, Huang J, Jia TT, Zong FY, Mu SR, et al.: Genome-wide analysis of YB-1-RNA interactions reveals a novel role of YB-1 in miRNA processing in glioblastoma multiforme. Nucleic Acids Res 2015.

10.

Tang W, Tang J, He J, Zhou Z, Qin Y, Qin J, et al. SLIT2/ROBO1-miR-218-1-RET/PLAG1: a new disease pathway involved in Hirschsprung’s disease. J Cell Mol Med. 2015;19:1197–207.CrossRefPubMedPubMedCentral

11.

Deng X, Zhao Y, Wang B. miR-519d-mediated downregulation of STAT3 suppresses breast cancer progression. Oncol Rep. 2015;34(4):2188–94.PubMed

12.

Imaoka H, Toiyama Y, Okigami M, Yasuda H, Saigusa S, Ohi M, et al.: Circulating microRNA-203 predicts metastases, early recurrence, and poor prognosis in human gastric cancer. Gastric Cancer 2015.

13.

Li W, Wang Y, Zhang Q, Tang L, Liu X, Dai Y, et al. MicroRNA-486 as a biomarker for early diagnosis and recurrence of non-small cell lung cancer. PLoS One. 2015;10:e0134220.CrossRefPubMedPubMedCentral

14.

Hou J, An X, Song Y, Gao T, Lei Y, Cao B. Two mutations in the caprine MTHFR 3′UTR regulated by microRNAs are associated with milk production traits. PLoS One. 2015;10:e0133015.CrossRefPubMedPubMedCentral

15.

Gao Y, Diao L, Li H, Guo Z. Single nucleotide polymorphisms of microRNA processing genes and outcome of non-Hodgkin’s lymphoma. Onco Targets Ther. 2015;8:1735–41.CrossRefPubMedPubMedCentral

16.

Li BS, Zuo QF, Zhao YL, Xiao B, Zhuang Y, Mao XH, et al. MicroRNA-25 promotes gastric cancer migration, invasion and proliferation by directly targeting transducer of ERBB2, 1 and correlates with poor survival. Oncogene. 2015;34:2556–65.CrossRefPubMed

17.

Komatsu S, Ichikawa D, Hirajima S, Kawaguchi T, Miyamae M, Okajima W, et al. Plasma microRNA profiles: identification of miR-25 as a novel diagnostic and monitoring biomarker in oesophageal squamous cell carcinoma. Br J Cancer. 2014;111:1614–24.CrossRefPubMedPubMedCentral

18.

Yu J, Liu P, Cui X, Sui Y, Ji G, Guan R, et al. Identification of novel subregions of LOH in gastric cancer and analysis of the HIC1 and TOB1 tumor suppressor genes in these subregions. Mol Cell. 2011;32:47–55.CrossRef

19.

Jiao Y, Sun KK, Zhao L, Xu JY, Wang LL, Fan SJ. Suppression of human lung cancer cell proliferation and metastasis in vitro by the transducer of ErbB-2.1 (TOB1). Acta Pharmacol Sin. 2012;33:250–60.CrossRefPubMed

20.

Matsuda S, Kawamura-Tsuzuku J, Ohsugi M, Yoshida M, Emi M, Nakamura Y, et al. Tob, a novel protein that interacts with p185erbB2, is associated with anti-proliferative activity. Oncogene. 1996;12:705–13.PubMed

21.

Sun Q, Gu H, Zeng Y, Xia Y, Wang Y, Jing Y, et al. Hsa-mir-27a genetic variant contributes to gastric cancer susceptibility through affecting miR-27a and target gene expression. Cancer Sci. 2010;101:2241–7.CrossRefPubMed

22.

Gonzalez-Giraldo Y, Camargo A, Lopez-Leon S, Adan A, Forero DA. A functional SNP in MIR124-1, a brain expressed miRNA gene, is associated with aggressiveness in a Colombian sample. Eur Psychiatry. 2015;30:499–503.CrossRefPubMed

Titel: The polymorphism in miR-25 attenuated the oncogenic function in gastric cancer
verfasst von: Jianping Zhou
Jiangang Zhou
Weimin Wang
Weiling Li
Lulu Wu
Gang Li
Jun Shi
Sujun Zhou
Publikationsdatum: 16.11.2015
Verlag: Springer Netherlands
Erschienen in: Tumor Biology / Ausgabe 4/2016
Print ISSN: 1010-4283
Elektronische ISSN: 1423-0380
DOI: https://doi.org/10.1007/s13277-015-4376-0

Neu im Fachgebiet Onkologie

23.04.2024 | Medikamente in Schwangerschaft und Stillzeit | Nachrichten

Live-Webinar: Aktuelle Leitlinien bei Herz-Kreislauf-Erkrankungen

Springer Medizin

The polymorphism in miR-25 attenuated the oncogenic function in gastric cancer

Abstract

Neu im Fachgebiet Onkologie

ICI-Therapie in der Schwangerschaft wird gut toleriert

Krebspatienten impfen: Was? Wen? Und wann nicht?

Müde im Alter? Auch an die Nebenniere denken

Stufenschema weist Prostatakarzinom zuverlässig nach

Update Onkologie

Live-Webinar: Aktuelle Leitlinien bei Herz-Kreislauf-Erkrankungen

Springer Medizin

Abstract

Bitte loggen Sie sich ein, um Zugang zu diesem Inhalt zu erhalten

Weitere Artikel der Ausgabe 4/2016

Hotspot TERT promoter mutations are rare events in testicular germ cell tumors

Mitotic arrest deficient-like 1 is correlated with poor prognosis in small-cell lung cancer after surgical resection

Increased expression of interleukin-8 is an independent indicator of poor prognosis in clear-cell renal cell carcinoma

miR-761 inhibits tumor progression by targeting MSI1 in ovarian carcinoma

Potential biomarker for checkpoint blockade immunotherapy and treatment strategy

Nuclear Gli1 expression is associated with pathological complete response and event-free survival in HER2-positive breast cancer treated with trastuzumab-based neoadjuvant therapy

Neu im Fachgebiet Onkologie

ICI-Therapie in der Schwangerschaft wird gut toleriert

Krebspatienten impfen: Was? Wen? Und wann nicht?

Müde im Alter? Auch an die Nebenniere denken

Stufenschema weist Prostatakarzinom zuverlässig nach

Update Onkologie