Introduction
Materials and methods
99mTc-MDP imaging
223Ra imaging
223Ra image analysis & dosimetry
18F-fluoride imaging
18F-fluoride image analysis
18F-fluoride and 223Ra comparison
Uncertainty analysis
Statistical analysis
Results
223Ra image analysis & dosimetry
Patient number | Lesion site | Vol [ml] | Therapy | Absorbed dose [Gy] (223Ra and daughter isotopes) | Effective half-life [hrs] |
---|---|---|---|---|---|
1 |
T5 vertebra
|
5.9
| 1 |
10.2 ± 1.5
|
273.6 ± 0.0*
|
2 |
11.3 ± 2.3
|
237.5 ± 180.9
| |||
Left femoral head
|
29.1
| 1 |
3.6 ± 0.7
|
273.6 ± 0.0*
| |
2 |
4.7 ± 0.2
|
273.6 ± 0.0*
| |||
C4 vertebra
|
8.5
| 1 |
10.9 ± 1.6
|
273.6 ± 0.0*
| |
2 |
11.2 ± 1.2
|
273.6 ± 0.0*
| |||
Right SI joint
|
6.6
| 1 |
6.2 ± 1.1
|
273.6 ± 0.0*
| |
2 |
8.5 ± 0.4
|
181.7 ± 23.8
| |||
S1 vertebra
|
7.7
| 1 |
3.8 ± 0.6
|
273.6 ± 0.0*
| |
2 |
4.3 ± 0.9
|
273.6 ± 0.0*
| |||
L3 vertebral process
|
3.7
| 1 |
7.3 ± 3.3
|
157.0 ± 141.0
| |
2 |
10.0 ± 1.7
|
273.6 ± 0.0*
| |||
Left pelvis (ischeum)
|
5.5
| 1 |
3.4 ± 1.0
|
273.6 ± 0.0*
| |
2 |
4.4 ± 1.4
|
273.6 ± 0.0*
| |||
2 |
L5 vertebra
|
41.2
| 1 |
6.2 ± 0.3
|
159.9 ± 23.7
|
2 |
4.2 ± 0.7
|
127.4 ± 47.3
| |||
T12 vertebra
|
1.2
| 1 |
43.8 ± 11.2
|
143.0 ± 100.1
| |
2 |
44.1 ± 16.4
|
66.6 ± 50.6
| |||
R pelvis
|
7.1
| 1 |
4.9 ± 0.8
|
83.8 ± 24.9
| |
2 |
17.5 ± 2.9
|
218.9 ± 198.1
| |||
L3 vertebra
|
5.6
| 1 |
10.4 ± 0.9
|
108.5 ± 22.1
| |
2 |
5.5 ± 0.5
|
102.6 ± 19.2
| |||
R rib 9
|
2.8
| 1 |
6.4 ± 1.2
|
92.7 ± 36.7
| |
2 |
4.0 ± 0.9
|
59.5 ± 24.5
| |||
Sternum
|
18.7
| 1 |
6.0 ± 0.4
|
91.0 ± 12.2
| |
2 |
5.2 ± 0.2
|
91.4 ± 7.7
| |||
3 |
Right skull
|
39.9
| 1 |
1.6 ± 0.3
|
135.7 ± 90.1
|
2 |
1.1 ± 0.2
|
94.6 ± 30.6
| |||
Left skull
|
1.9
| 1 |
1.5 ± 1.0
|
84.4 ± 153.3
| |
2 |
1.5 ± 0.7
|
136.9 ± 162.4
| |||
T11 vertebra
|
9.2
| 1 |
4.9 ± 0.6
|
76.3 ± 23.2
| |
2 |
5.8 ± 1.2
|
83.8 ± 35.0
| |||
L3 vertebra
|
10.8
| 1 |
1.5 ± 0.7
|
141.2 ± 282.8
| |
2 |
5.3 ± 1.8
|
76.5 ± 47.8
| |||
L4 vertebra
|
22.9
| 1 |
1.7 ± 0.8
|
61.1 ± 69.7
| |
2 |
2.6 ± 0.3
|
71.7 ± 17.1
| |||
Right rib 7
|
13.9
| 1 |
4.0 ± 1.3
|
92.0 ± 41.0
| |
2 |
2.7 ± 0.5
|
61.0 ± 20.2
| |||
4 |
L2 vertebra
|
39.4
| 1 |
0.6 ± 0.3
|
70.9 ± 51.7
|
2 |
1.0 ± 0.2
|
44.4 ± 20.3
| |||
L3 vertebra
|
56.4
| 1 |
1.0 ± 0.4
|
66.8 ± 37.8
| |
2 |
1.0 ± 0.2
|
45.0 ± 17.1
| |||
T12 vertebra
|
32.0
| 1 |
1.5 ± 0.1
|
178.3 ± 27.7
| |
2 |
1.2 ± 0.2
|
94.1 ± 7.7
| |||
L femoral head
|
68.9
| 1 |
1.4 ± 0.1
|
114.4 ± 25.6
| |
2 |
1.1 ± 0.1
|
78.3 ± 12.0
| |||
R femoral head
|
67.5
| 1 |
1.1 ± 0.2
|
94.0 ± 31.9
| |
2 |
1.0 ± 0.2
|
98.3 ± 34.9
| |||
5 |
L1 vertebra
|
45.5
| 1 |
1.8 ± 0.3
|
112.0 ± 43.6
|
2 |
2.5 ± 0.2
|
240.7 ± 81.9
| |||
T11 vertebra
|
42.3
| 1 |
2.2 ± 0.3
|
145.5 ± 53.2
| |
2 |
3.0 ± 0.0
|
232.0 ± 8.8
| |||
Right femoral head
|
59.0
| 1 |
8.1 ± 0.5
|
273.6 ± 0.0*
| |
2 |
7.0 ± 0.5
|
273.6 ± 0.0*
| |||
Left femoral head
|
105.0
| 1 |
3.6 ± 0.3
|
261.5 ± 87.3
| |
2 |
3.4 ± 0.0
|
257.2 ± 11.8
| |||
Right tibia
|
66.8
| 1 2 |
5.7 ± 0.9
|
168.2 ± 86.7
| |
8.3 ± 1.3
|
273.6 ± 0.0*
|
Isotope | Contribution to total lesion dose [%] |
---|---|
Ra-223
|
21.3
|
Rn-219
|
24.6
|
Ra-215
|
26.9
|
Pb-211
|
1.6
|
Bi-211
|
23.9
|
Po-211
|
0.1
|
Tl-207
|
1.7
|