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01.12.2012 | Research | Ausgabe 1/2012 Open Access

Cardiovascular Ultrasound 1/2012

The pressure/volume relationship during dobutamine stress echocardiography in transplanted heart: comparison with quality of life and coronary anatomy

Cardiovascular Ultrasound > Ausgabe 1/2012
Giovanni Minardi, Giordano Zampi, Amedeo Pergolini, Giovanni Pulignano, Massimiliano Scappaticci, Francesca Moschella Orsini, Gaetano Pero, Paola Lilla Della Monica, Giovanni Cioffi, Francesco Musumeci
Wichtige Hinweise

Electronic supplementary material

The online version of this article (doi:10.​1186/​1476-7120-10-44) contains supplementary material, which is available to authorized users.

Competing interests

The authors declare that they have no competing interests.

Authors’ contributions

GM: concept and design, analysis and interpretetion, critical revisions and data collection; GZ: concept and design, analysis and interpretetion, drafting manuscript and data collection; AP: analysis and interpretetion and data collection; GP: concept and design, analysis and interpretetion and critical revisions; MS: literature search and data collection; FMO: literature search and data collection; GP: literature search and data collection PLDM: literature search and data collection. GC: analysis and interpretetion, drafting manuscript and data collection; FM: analysis and interpretation and critical revisions. All authors read and approved the final manuscript.



Cardiac allograft vasculopathy (CAV) is a major late complication in cardiac transplant recipients and has a relevant impact on outcome of these patients. Aims of this study: to compare, in cardiac transplant recipients patients, the diagnostic value of pressure/volume relationship (ESPVR) during dobutamine stress echocardiography (DSE) for coronary artery disease, assessed by Multislice Computed Tomography (MSCT), and by coronary angiography (CA). We also analyzed any possible relationship between ESPVR and the Health Related Quality of Life of the patients (HRQoL), evaluated by SF–36 questionnaire.


25 consecutive patients underwent DSE within 24 hours after MSCT coronary angiogram and then they underwent CA. The HRQoL questionnaire was administered to the patients in the settings of DSE. They were followed-up for 6 months.


DSE has a sensitivity in detecting CAV of 67%, specificity of 95%, positive predictive value of 67% and negative predictive value of 95%; DSE with ESPVR has a sensitivity of 100%, specificity of 95%, positive predictive value of 75%, negative predictive value of 100%; MSCT has a sensitivity of 100%; specificity of 82%; positive predictive value of 43%; negative predictive value of 100%. Htx recipients with a flat-biphasic ESPVR, although asymptomatic, perceived a worst HRQoL compared with the up-sloping ESPVR population, and this is statistically significant for the general health (p 0.0004), the vitality (p 0.0013) and the mental health (p 0.021) SF-36 subscale.


Evaluation with DSE and ESPVR is accurate in the clinical control of heart transplant recipients reserving invasive evaluation only for patients with abnormal contractility indexes.
Authors’ original file for figure 1
Authors’ original file for figure 2
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