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Erschienen in: Endocrine 3/2016

22.03.2016 | Original Article

The prevalence and predictive value of the SLC30A8 R325W polymorphism and zinc transporter 8 autoantibodies in the development of GDM and postpartum type 1 diabetes

verfasst von: Jonatan Dereke, Sanna Palmqvist, Charlotta Nilsson, Mona Landin–Olsson, Magnus Hillman

Erschienen in: Endocrine | Ausgabe 3/2016

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Abstract

The objectives were to evaluate possible associations between the SLC30A8 R325W polymorphism and gestational diabetes mellitus (GDM) as well as postpartum development of type 2 diabetes. Furthermore, we wanted to confirm the prevalence of zinc transporter 8 autoantibodies (ZnT8A), as previously reported, in a larger population and study its predictive value in relation to other β cell specific autoantibodies in postpartum development of type 1 diabetes. Women diagnosed with GDM (n = 776) and women without diabetes (n = 511) were included in the study. Autoantibodies were analyzed in all women using enzyme-linked immunosorbent assay. DNA was extracted when possible from women with GDM (n = 536) and all of the controls. R325W was detected through polymerase chain reaction and specific restriction digestion. The R325W C-allele were more frequent in women with GDM compared to in controls (OR 1.47, 95 % CI 1.16–1.88, p = 0.0018) but not significantly increased in women with GDM and postpartum development of type 2 diabetes. Autoantibodies were found in 6.8 % (53/776) of the women with GDM and approximately 3.2 % (25/776) were ZnT8A positive. Approximately 19 % (10/53) of the autoantibody positive women with GDM developed postpartum type 1 diabetes. In conclusion, this is the first study to report a significant association between the R325W C-allele and increased risk of developing GDM. All of the autoantibody positive women with GDM who developed postpartum type 1 diabetes were positive for autoantibodies against glutamic acid decarboxylase (GADA). Thus ZnT8A did not have any additional predictive value in postpartum development of type 1 diabetes.
Literatur
1.
Zurück zum Zitat S.O. Emdin, G.G. Dodson, J.M. Cutfield, S.M. Cutfield, Role of zinc in insulin biosynthesis. Some possible zinc-insulin interactions in the pancreatic B-cell. Diabetologia. 19, 174–182 (1980)CrossRefPubMed S.O. Emdin, G.G. Dodson, J.M. Cutfield, S.M. Cutfield, Role of zinc in insulin biosynthesis. Some possible zinc-insulin interactions in the pancreatic B-cell. Diabetologia. 19, 174–182 (1980)CrossRefPubMed
2.
Zurück zum Zitat F. Chimienti, S. Devergnas, A. Favier, M. Seve, Identification and cloning of a β-cell-specific zinc transporter, ZnT-8, localized into insulin secretory granules. Diabetes. 53, 2330–2337 (2004)CrossRefPubMed F. Chimienti, S. Devergnas, A. Favier, M. Seve, Identification and cloning of a β-cell-specific zinc transporter, ZnT-8, localized into insulin secretory granules. Diabetes. 53, 2330–2337 (2004)CrossRefPubMed
3.
Zurück zum Zitat H. Schneider, J. Downey, A. Smith, B.H. Zinselmeyer, C. Rush, J.M. Brewer, B. Wei, N. Hogg, P. Garside, C.E. Rudd, Reversal of the TCR stop signal by CTLA-4. Science. 313, 1972–1975 (2006)CrossRefPubMed H. Schneider, J. Downey, A. Smith, B.H. Zinselmeyer, C. Rush, J.M. Brewer, B. Wei, N. Hogg, P. Garside, C.E. Rudd, Reversal of the TCR stop signal by CTLA-4. Science. 313, 1972–1975 (2006)CrossRefPubMed
4.
Zurück zum Zitat R. Sladek, G. Rocheleau, J. Rung, C. Dina, L. Shen, D. Serre, P. Boutin, D. Vincent, A. Belisle, S. Hadjadj, B. Balkau, B. Heude, G. Charpentier, T.J. Hudson, A. Montpetit, A.V. Pshezhetsky, M. Prentki, B.I. Posner, D.J. Balding, D. Meyre, C. Polychronakos, P. Froguel, A genome-wide association study identifies novel risk loci for type 2 diabetes. Nature. 445, 881–885 (2007)CrossRefPubMed R. Sladek, G. Rocheleau, J. Rung, C. Dina, L. Shen, D. Serre, P. Boutin, D. Vincent, A. Belisle, S. Hadjadj, B. Balkau, B. Heude, G. Charpentier, T.J. Hudson, A. Montpetit, A.V. Pshezhetsky, M. Prentki, B.I. Posner, D.J. Balding, D. Meyre, C. Polychronakos, P. Froguel, A genome-wide association study identifies novel risk loci for type 2 diabetes. Nature. 445, 881–885 (2007)CrossRefPubMed
5.
Zurück zum Zitat T.W. Boesgaard, J. Zilinskaite, M. Vanttinen, M. Laakso, P.A. Jansson, A. Hammarstedt, U. Smith, N. Stefan, A. Fritsche, H. Haring, M. Hribal, G. Sesti, D.P. Zobel, O. Pedersen, T. Hansen, Consortium E2008The common SLC30A8 Arg325Trp variant is associated with reduced first-phase insulin release in 846 non-diabetic offspring of type 2 diabetes patients–the EUGENE2 study. Diabetologia. 51, 816–820 (2008)CrossRefPubMed T.W. Boesgaard, J. Zilinskaite, M. Vanttinen, M. Laakso, P.A. Jansson, A. Hammarstedt, U. Smith, N. Stefan, A. Fritsche, H. Haring, M. Hribal, G. Sesti, D.P. Zobel, O. Pedersen, T. Hansen, Consortium E2008The common SLC30A8 Arg325Trp variant is associated with reduced first-phase insulin release in 846 non-diabetic offspring of type 2 diabetes patients–the EUGENE2 study. Diabetologia. 51, 816–820 (2008)CrossRefPubMed
6.
Zurück zum Zitat S. Cauchi, C. Proenca, H. Choquet, S. Gaget, Graeve F. De, M. Marre, B. Balkau, J. Tichet, D. Meyre, M. Vaxillaire, P. Froguel, Group DESIRS. Analysis of novel risk loci for type 2 diabetes in a general French population: the D.E.S.I.R. study. J. Mol. Med. 86, 341–348 (2008)CrossRefPubMed S. Cauchi, C. Proenca, H. Choquet, S. Gaget, Graeve F. De, M. Marre, B. Balkau, J. Tichet, D. Meyre, M. Vaxillaire, P. Froguel, Group DESIRS. Analysis of novel risk loci for type 2 diabetes in a general French population: the D.E.S.I.R. study. J. Mol. Med. 86, 341–348 (2008)CrossRefPubMed
7.
Zurück zum Zitat K. Kirchhoff, F. Machicao, A. Haupt, S.A. Schafer, O. Tschritter, H. Staiger, N. Stefan, H.U. Haring, A. Fritsche, Polymorphisms in the TCF7L2, CDKAL1 and SLC30A8 genes are associated with impaired proinsulin conversion. Diabetologia. 51, 597–601 (2008)CrossRefPubMed K. Kirchhoff, F. Machicao, A. Haupt, S.A. Schafer, O. Tschritter, H. Staiger, N. Stefan, H.U. Haring, A. Fritsche, Polymorphisms in the TCF7L2, CDKAL1 and SLC30A8 genes are associated with impaired proinsulin conversion. Diabetologia. 51, 597–601 (2008)CrossRefPubMed
8.
Zurück zum Zitat G. Chauhan, C.J. Spurgeon, R. Tabassum, S. Bhaskar, S.R. Kulkarni, A. Mahajan, S. Chavali, M.V.K. Kumar, S. Prakash, O.P. Dwivedi, S. Ghosh, C.S. Yajnik, N. Tandon, D. Bharadwaj, G.R. Chandak, Impact of common variants of PPARG, KCNJ11, TCF7L2, SLC30A8, HHEX, CDKN2A, IGF2BP2, and CDKAL1 on the risk of type 2 diabetes in 5,164 Indians. Diabetes. 59, 2068–2074 (2010)CrossRefPubMedPubMedCentral G. Chauhan, C.J. Spurgeon, R. Tabassum, S. Bhaskar, S.R. Kulkarni, A. Mahajan, S. Chavali, M.V.K. Kumar, S. Prakash, O.P. Dwivedi, S. Ghosh, C.S. Yajnik, N. Tandon, D. Bharadwaj, G.R. Chandak, Impact of common variants of PPARG, KCNJ11, TCF7L2, SLC30A8, HHEX, CDKN2A, IGF2BP2, and CDKAL1 on the risk of type 2 diabetes in 5,164 Indians. Diabetes. 59, 2068–2074 (2010)CrossRefPubMedPubMedCentral
9.
Zurück zum Zitat M.A. Gamboa-Meléndez, A. Huerta-Chagoya, H. Moreno-Macías, P. Vázquez-Cárdenas, M.L. Ordóñez-Sánchez, R. Rodríguez-Guillén, L. Riba, M. Rodríguez-Torres, M.T. Guerra-García, L.E. Guillén-Pineda, S. Choudhry, L. Del Bosque-Plata, S. Canizales-Quinteros, G. Pérez-Ortiz, F. Escobedo-Aguirre, A. Parra, I. Lerman-Garber, C.A. Aguilar-Salinas, M.T. Tusié-Luna, Contribution of common genetic variation to the risk of type 2 diabetes in the Mexican Mestizo population. Diabetes. 61, 3314–3321 (2012)CrossRefPubMedPubMedCentral M.A. Gamboa-Meléndez, A. Huerta-Chagoya, H. Moreno-Macías, P. Vázquez-Cárdenas, M.L. Ordóñez-Sánchez, R. Rodríguez-Guillén, L. Riba, M. Rodríguez-Torres, M.T. Guerra-García, L.E. Guillén-Pineda, S. Choudhry, L. Del Bosque-Plata, S. Canizales-Quinteros, G. Pérez-Ortiz, F. Escobedo-Aguirre, A. Parra, I. Lerman-Garber, C.A. Aguilar-Salinas, M.T. Tusié-Luna, Contribution of common genetic variation to the risk of type 2 diabetes in the Mexican Mestizo population. Diabetes. 61, 3314–3321 (2012)CrossRefPubMedPubMedCentral
10.
Zurück zum Zitat Y.-H. Lee, E.S. Kang, S.H. Kim, S.J. Han, C.H. Kim, H.J. Kim, C.W. Ahn, B.S. Cha, M. Nam, C.M. Nam, H.C. Lee, Association between polymorphisms in SLC30A8, HHEX, CDKN2A/B, IGF2BP2, FTO, WFS1, CDKAL1, KCNQ1 and type 2 diabetes in the Korean population. J. Hum. Genet. 53, 991–998 (2008)CrossRefPubMed Y.-H. Lee, E.S. Kang, S.H. Kim, S.J. Han, C.H. Kim, H.J. Kim, C.W. Ahn, B.S. Cha, M. Nam, C.M. Nam, H.C. Lee, Association between polymorphisms in SLC30A8, HHEX, CDKN2A/B, IGF2BP2, FTO, WFS1, CDKAL1, KCNQ1 and type 2 diabetes in the Korean population. J. Hum. Genet. 53, 991–998 (2008)CrossRefPubMed
11.
Zurück zum Zitat L.J. Scott, K.L. Mohlke, L.L. Bonnycastle, C.J. Willer, Y. Li, W.L. Duren, M.R. Erdos, H.M. Stringham, P.S. Chines, A.U. Jackson, L. Prokunina-Olsson, C.-J. Ding, A.J. Swift, N. Narisu, T. Hu, R. Pruim, R. Xiao, X.-Y. Li, K.N. Conneely, N.L. Riebow, A.G. Sprau, M. Tong, P.P. White, K.N. Hetrick, M.W. Barnhart, C.W. Bark, J.L. Goldstein, L. Watkins, F. Xiang, J. Saramies, T.A. Buchanan, R.M. Watanabe, T.T. Valle, L. Kinnunen, G.R. Abecasis, E.W. Pugh, K.F. Doheny, R.N. Bergman, J. Tuomilehto, F.S. Collins, M. Boehnke, A genome-wide association study of type 2 diabetes in Finns detects multiple susceptibility variants. Science. 316, 1341–1345 (2007)CrossRefPubMedPubMedCentral L.J. Scott, K.L. Mohlke, L.L. Bonnycastle, C.J. Willer, Y. Li, W.L. Duren, M.R. Erdos, H.M. Stringham, P.S. Chines, A.U. Jackson, L. Prokunina-Olsson, C.-J. Ding, A.J. Swift, N. Narisu, T. Hu, R. Pruim, R. Xiao, X.-Y. Li, K.N. Conneely, N.L. Riebow, A.G. Sprau, M. Tong, P.P. White, K.N. Hetrick, M.W. Barnhart, C.W. Bark, J.L. Goldstein, L. Watkins, F. Xiang, J. Saramies, T.A. Buchanan, R.M. Watanabe, T.T. Valle, L. Kinnunen, G.R. Abecasis, E.W. Pugh, K.F. Doheny, R.N. Bergman, J. Tuomilehto, F.S. Collins, M. Boehnke, A genome-wide association study of type 2 diabetes in Finns detects multiple susceptibility variants. Science. 316, 1341–1345 (2007)CrossRefPubMedPubMedCentral
12.
Zurück zum Zitat Y. Tabara, H. Osawa, R. Kawamoto, H. Onuma, I. Shimizu, T. Miki, K. Kohara, H. Makino, Replication study of candidate genes associated with type 2 diabetes based on genome-wide screening. Diabetes. 58, 493–498 (2009)CrossRefPubMedPubMedCentral Y. Tabara, H. Osawa, R. Kawamoto, H. Onuma, I. Shimizu, T. Miki, K. Kohara, H. Makino, Replication study of candidate genes associated with type 2 diabetes based on genome-wide screening. Diabetes. 58, 493–498 (2009)CrossRefPubMedPubMedCentral
13.
Zurück zum Zitat C. Brorsson, R. Bergholdt, M. Sjögren, S. Eising, K.M. Sørensen, D.M. Hougaard, M. Orho-Melander, L. Groop, F. Pociot, A non-synonymous variant in SLC30A8 is not associated with type 1 diabetes in the Danish population. Mol. Genet. Metab. 94, 386–388 (2008)CrossRefPubMed C. Brorsson, R. Bergholdt, M. Sjögren, S. Eising, K.M. Sørensen, D.M. Hougaard, M. Orho-Melander, L. Groop, F. Pociot, A non-synonymous variant in SLC30A8 is not associated with type 1 diabetes in the Danish population. Mol. Genet. Metab. 94, 386–388 (2008)CrossRefPubMed
14.
Zurück zum Zitat S.M. Raj, J.M.M. Howson, N.M. Walker, J.D. Cooper, D.J. Smyth, S.F. Field, H.E. Stevens, J.A. Todd, No association of multiple type 2 diabetes loci with type 1 diabetes. Diabetologia. 52, 2109–2116 (2009)CrossRefPubMedPubMedCentral S.M. Raj, J.M.M. Howson, N.M. Walker, J.D. Cooper, D.J. Smyth, S.F. Field, H.E. Stevens, J.A. Todd, No association of multiple type 2 diabetes loci with type 1 diabetes. Diabetologia. 52, 2109–2116 (2009)CrossRefPubMedPubMedCentral
15.
Zurück zum Zitat M. Ekelund, N. Shaat, P. Almgren, E. Anderberg, M. Landin-Olsson, V. Lyssenko, L. Groop, K. Berntorp, Genetic prediction of postpartum diabetes in women with gestational diabetes mellitus. Diabetes. Res. Clin. Pract. 97, 394–398 (2012)CrossRefPubMed M. Ekelund, N. Shaat, P. Almgren, E. Anderberg, M. Landin-Olsson, V. Lyssenko, L. Groop, K. Berntorp, Genetic prediction of postpartum diabetes in women with gestational diabetes mellitus. Diabetes. Res. Clin. Pract. 97, 394–398 (2012)CrossRefPubMed
16.
Zurück zum Zitat J.M. Wenzlau, K. Juhl, L. Yu, O. Moua, S.A. Sarkar, P. Gottlieb, M. Rewers, G.S. Eisenbarth, J. Jensen, H.W. Davidson, J.C. Hutton, The cation efflux transporter ZnT8 (Slc30A8) is a major autoantigen in human type 1 diabetes. Proc. Natl. Acad. Sci. 104, 17040–17045 (2007)CrossRefPubMedPubMedCentral J.M. Wenzlau, K. Juhl, L. Yu, O. Moua, S.A. Sarkar, P. Gottlieb, M. Rewers, G.S. Eisenbarth, J. Jensen, H.W. Davidson, J.C. Hutton, The cation efflux transporter ZnT8 (Slc30A8) is a major autoantigen in human type 1 diabetes. Proc. Natl. Acad. Sci. 104, 17040–17045 (2007)CrossRefPubMedPubMedCentral
17.
Zurück zum Zitat S. Li, H. Li, B. Chen, D. Lu, W. Deng, Y. Jiang, Z. Zhou, Z. Yang, Identification of novel HLA-A*0201-restricted cytotoxic T lymphocyte epitopes from zinc transporter 8. Vaccine. 31, 1610–1615 (2013)CrossRefPubMed S. Li, H. Li, B. Chen, D. Lu, W. Deng, Y. Jiang, Z. Zhou, Z. Yang, Identification of novel HLA-A*0201-restricted cytotoxic T lymphocyte epitopes from zinc transporter 8. Vaccine. 31, 1610–1615 (2013)CrossRefPubMed
18.
Zurück zum Zitat M. Scotto, G. Afonso, E. Larger, C. Raverdy, F.A. Lemonnier, J.C. Carel, D. Dubois-Laforgue, B. Baz, D. Levy, J.F. Gautier, O. Launay, G. Bruno, C. Boitard, L.A. Sechi, J.C. Hutton, H.W. Davidson, R. Mallone, Zinc transporter (ZnT)8 (186–194) is an immunodominant CD8 + T cell epitope in HLA-A2 + type 1 diabetic patients. Diabetologia. 55, 2026–2031 (2012)CrossRefPubMedPubMedCentral M. Scotto, G. Afonso, E. Larger, C. Raverdy, F.A. Lemonnier, J.C. Carel, D. Dubois-Laforgue, B. Baz, D. Levy, J.F. Gautier, O. Launay, G. Bruno, C. Boitard, L.A. Sechi, J.C. Hutton, H.W. Davidson, R. Mallone, Zinc transporter (ZnT)8 (186–194) is an immunodominant CD8 + T cell epitope in HLA-A2 + type 1 diabetic patients. Diabetologia. 55, 2026–2031 (2012)CrossRefPubMedPubMedCentral
19.
Zurück zum Zitat P. Achenbach, V. Lampasona, U. Landherr, K. Koczwara, S. Krause, H. Grallert, C. Winkler, M. Pflüger, T. Illig, E. Bonifacio, A.G. Ziegler, Autoantibodies to zinc transporter 8 and SLC30A8 genotype stratify type 1 diabetes risk. Diabetologia. 52, 1881–1888 (2009)CrossRefPubMed P. Achenbach, V. Lampasona, U. Landherr, K. Koczwara, S. Krause, H. Grallert, C. Winkler, M. Pflüger, T. Illig, E. Bonifacio, A.G. Ziegler, Autoantibodies to zinc transporter 8 and SLC30A8 genotype stratify type 1 diabetes risk. Diabetologia. 52, 1881–1888 (2009)CrossRefPubMed
20.
Zurück zum Zitat C. Andersson, F. Vaziri-Sani, A. Delli, B. Lindblad, A. Carlsson, G. Forsander, J. Ludvigsson, C. Marcus, U. Samuelsson, S. Ivarsson, A. Lernmark, H.E. Larsson, Triple specificity of ZnT8 autoantibodies in relation to HLA and other islet autoantibodies in childhood and adolescent type 1 diabetes. Pediatric. Diabetes. 14, 97–105 (2013)CrossRefPubMed C. Andersson, F. Vaziri-Sani, A. Delli, B. Lindblad, A. Carlsson, G. Forsander, J. Ludvigsson, C. Marcus, U. Samuelsson, S. Ivarsson, A. Lernmark, H.E. Larsson, Triple specificity of ZnT8 autoantibodies in relation to HLA and other islet autoantibodies in childhood and adolescent type 1 diabetes. Pediatric. Diabetes. 14, 97–105 (2013)CrossRefPubMed
21.
Zurück zum Zitat G. Huang, Y. Xiang, L. Pan, X. Li, S. Luo, Z. Zhou, Zinc transporter 8 autoantibody (ZnT8A) could help differentiate latent autoimmune diabetes in adults (LADA) from phenotypic type 2 diabetes mellitus. Diabetes. Metab. Res. Rev. 29(5), 363–368 (2013)CrossRefPubMed G. Huang, Y. Xiang, L. Pan, X. Li, S. Luo, Z. Zhou, Zinc transporter 8 autoantibody (ZnT8A) could help differentiate latent autoimmune diabetes in adults (LADA) from phenotypic type 2 diabetes mellitus. Diabetes. Metab. Res. Rev. 29(5), 363–368 (2013)CrossRefPubMed
22.
Zurück zum Zitat V. Lampasona, A. Petrone, C. Tiberti, M. Capizzi, M. Spoletini, S. di Pietro, M. Songini, S. Bonicchio, F. Giorgino, E. Bonifacio, E. Bosi, R. Buzzetti, D. NIRA, Zinc transporter 8 antibodies complement GAD and IA-2 antibodies in the identification and characterization of adult-onset autoimmune diabetes non insulin requiring autoimmune diabetes (NIRAD) 4. Diabetes. Care. 33, 104–108 (2010)CrossRefPubMed V. Lampasona, A. Petrone, C. Tiberti, M. Capizzi, M. Spoletini, S. di Pietro, M. Songini, S. Bonicchio, F. Giorgino, E. Bonifacio, E. Bosi, R. Buzzetti, D. NIRA, Zinc transporter 8 antibodies complement GAD and IA-2 antibodies in the identification and characterization of adult-onset autoimmune diabetes non insulin requiring autoimmune diabetes (NIRAD) 4. Diabetes. Care. 33, 104–108 (2010)CrossRefPubMed
23.
Zurück zum Zitat F.K. Gorus, E.V. Balti, I. Vermeulen, S. Demeester, Dalem A. Van, O. Costa, H. Dorchy, S. Tenoutasse, T. Mouraux, Block C. De, P. Gillard, K. Decochez, J.M. Wenzlau, J.C. Hutton, D.G. Pipeleers, I. Weets, Belgian Diabetes R., Screening for insulinoma antigen 2 and zinc transporter 8 autoantibodies: a cost-effective and age-independent strategy to identify rapid progressors to clinical onset among relatives of type 1 diabetic patients. Clin. Exp. Immunol. 171, 82–90 (2012)CrossRefPubMedCentral F.K. Gorus, E.V. Balti, I. Vermeulen, S. Demeester, Dalem A. Van, O. Costa, H. Dorchy, S. Tenoutasse, T. Mouraux, Block C. De, P. Gillard, K. Decochez, J.M. Wenzlau, J.C. Hutton, D.G. Pipeleers, I. Weets, Belgian Diabetes R., Screening for insulinoma antigen 2 and zinc transporter 8 autoantibodies: a cost-effective and age-independent strategy to identify rapid progressors to clinical onset among relatives of type 1 diabetic patients. Clin. Exp. Immunol. 171, 82–90 (2012)CrossRefPubMedCentral
24.
Zurück zum Zitat C. Ignell, R. Claesson, E. Anderberg, K. Berntorp, Trends in the prevalence of gestational diabetes mellitus in southern Sweden, 2003–2012. Acta. Obstet. Gynecol. Scand. 93, 420–424 (2014)CrossRefPubMed C. Ignell, R. Claesson, E. Anderberg, K. Berntorp, Trends in the prevalence of gestational diabetes mellitus in southern Sweden, 2003–2012. Acta. Obstet. Gynecol. Scand. 93, 420–424 (2014)CrossRefPubMed
25.
Zurück zum Zitat C. Nilsson, D. Ursing, C. Törn, A. Åberg, M. Landin-Olsson, Presence of GAD antibodies during gestational diabetes mellitus predicts type 1 diabetes. Diabetes. Care. 30, 1968–1971 (2007)CrossRefPubMed C. Nilsson, D. Ursing, C. Törn, A. Åberg, M. Landin-Olsson, Presence of GAD antibodies during gestational diabetes mellitus predicts type 1 diabetes. Diabetes. Care. 30, 1968–1971 (2007)CrossRefPubMed
26.
Zurück zum Zitat J. Dereke, C. Nilsson, M. Landin-Olsson, M. Hillman, Prevalence of zinc transporter 8 antibodies in gestational diabetes mellitus. Diabet. Med. 29, e436–e439 (2012)CrossRefPubMed J. Dereke, C. Nilsson, M. Landin-Olsson, M. Hillman, Prevalence of zinc transporter 8 antibodies in gestational diabetes mellitus. Diabet. Med. 29, e436–e439 (2012)CrossRefPubMed
27.
Zurück zum Zitat T. Lind, P.R. Phillips, Influence of pregnancy on the 75-g OGTT. A prospective multicenter study. The diabetic pregnancy study group of the European Association for the Study of Diabetes. Diabetes. 40(Suppl 2), 8–13 (1991)CrossRefPubMed T. Lind, P.R. Phillips, Influence of pregnancy on the 75-g OGTT. A prospective multicenter study. The diabetic pregnancy study group of the European Association for the Study of Diabetes. Diabetes. 40(Suppl 2), 8–13 (1991)CrossRefPubMed
28.
Zurück zum Zitat C. Nilsson, C. Andersson, D. Ursing, H. Strevens, M. Landin-Olsson, Outcomes of women with gestational diabetes mellitus in Sweden. Eur. J. Obstet. Gynecol. Reprod. Biol. 193, 132–135 (2015)CrossRefPubMed C. Nilsson, C. Andersson, D. Ursing, H. Strevens, M. Landin-Olsson, Outcomes of women with gestational diabetes mellitus in Sweden. Eur. J. Obstet. Gynecol. Reprod. Biol. 193, 132–135 (2015)CrossRefPubMed
29.
Zurück zum Zitat S.A. Miller, D.D. Dykes, H.F. Polesky, A simple salting out procedure for extracting DNA from human nucleated cells. Nucleic. Acids. Res. 16, 1215 (1988)CrossRefPubMedPubMedCentral S.A. Miller, D.D. Dykes, H.F. Polesky, A simple salting out procedure for extracting DNA from human nucleated cells. Nucleic. Acids. Res. 16, 1215 (1988)CrossRefPubMedPubMedCentral
30.
Zurück zum Zitat Q. Huang, J.Y. Yin, X.P. Dai, J. Wu, X. Chen, C.S. Deng, M. Yu, Z.C. Gong, H.H. Zhou, Z.Q. Liu, Association analysis of SLC30A8 rs13266634 and rs16889462 polymorphisms with type 2 diabetes mellitus and repaglinide response in Chinese patients. Eur. J. Clin. Pharmacol. 66, 1207–1215 (2010)CrossRefPubMed Q. Huang, J.Y. Yin, X.P. Dai, J. Wu, X. Chen, C.S. Deng, M. Yu, Z.C. Gong, H.H. Zhou, Z.Q. Liu, Association analysis of SLC30A8 rs13266634 and rs16889462 polymorphisms with type 2 diabetes mellitus and repaglinide response in Chinese patients. Eur. J. Clin. Pharmacol. 66, 1207–1215 (2010)CrossRefPubMed
31.
Zurück zum Zitat J. Lauenborg, N. Grarup, P. Damm, K. Borch-Johnsen, T. Jorgensen, O. Pedersen, T. Hansen, Common type 2 diabetes risk gene variants associate with gestational diabetes. J. Clin. Endocrinol. Metab. 94, 145–150 (2009)CrossRefPubMed J. Lauenborg, N. Grarup, P. Damm, K. Borch-Johnsen, T. Jorgensen, O. Pedersen, T. Hansen, Common type 2 diabetes risk gene variants associate with gestational diabetes. J. Clin. Endocrinol. Metab. 94, 145–150 (2009)CrossRefPubMed
Metadaten
Titel
The prevalence and predictive value of the SLC30A8 R325W polymorphism and zinc transporter 8 autoantibodies in the development of GDM and postpartum type 1 diabetes
verfasst von
Jonatan Dereke
Sanna Palmqvist
Charlotta Nilsson
Mona Landin–Olsson
Magnus Hillman
Publikationsdatum
22.03.2016
Verlag
Springer US
Erschienen in
Endocrine / Ausgabe 3/2016
Print ISSN: 1355-008X
Elektronische ISSN: 1559-0100
DOI
https://doi.org/10.1007/s12020-016-0932-7

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