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23.10.2019 | Nephrology - Review

The prevalence of frailty in patients on hemodialysis: a systematic review and meta-analysis

verfasst von: Yaxi Zhao, Qinyu Liu, Jie Ji

Erschienen in: International Urology and Nephrology | Ausgabe 1/2020

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Abstract

Purpose

Coexistence of frailty and hemodialysis is related to higher risk of hospitalization, falls and mortality. Given the potential reversibility of frailty, reaching the epidemiology of frailty in hemodialysis is of great importance. However, estimates of the prevalence of frailty in patients on hemodialysis vary widely. We tried to synthesize the existing body of literature on the prevalence of frailty in patients on hemodialysis.

Methods

We searched Pubmed, Embase, Web of Science and Cochrane for studies of the prevalence in patients on hemodialysis. The prevalence of frailty was synthesized across eligible studies using a random-effects model. We explored potential origin of heterogeneity in the estimates by meta-regression analysis.

Results

Prevalence range from 6.0 to 82.0% and the pooled prevalence of frailty in patients on dialysis was 34.3% (95% confidence interval (CI) 24.5–44.1%; z = 6.87; p = 0.00). The pooled estimates of prevalence for patients aged < 55, 55–65, and ≥ 65 were 56.0% (95% CI 28.9–83.2%; z = 4.04; p = 0.00), 32.3% (95% CI 22.9–41.7%; z = 6.74; p = 0.00), and 20.3% (95% CI 7.9–32.8%; z = 3.2; p = 0.00), respectively. There were no significant relationships between frailty in hemodialysis and factors such as years of publication, sample size (continuous), sample size(> 500 vs ≤ 500), diagnostic method (the Fried Frailty vs other), country (Europe & USA vs Asia) and duration of hemodialysis.

Conclusions

Frailty influences almost three in ten patients on hemodialysis. Understanding the underlying pathophysiology mechanisms and weakening the impacts of frailty in patients on hemodialysis are called on to action in the future work.
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Metadaten
Titel
The prevalence of frailty in patients on hemodialysis: a systematic review and meta-analysis
verfasst von
Yaxi Zhao
Qinyu Liu
Jie Ji
Publikationsdatum
23.10.2019
Verlag
Springer Netherlands
Erschienen in
International Urology and Nephrology / Ausgabe 1/2020
Print ISSN: 0301-1623
Elektronische ISSN: 1573-2584
DOI
https://doi.org/10.1007/s11255-019-02310-2

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