Porcine reproductive and respiratory syndrome virus (PRRSV) has been epidemic more than 30 years in America and 20 years in China. It is still one of the most important causative agents to the worldwide swine industry. Here, we systematically analyzed the prevalence status of PRRSV in China by a molecular epidemiological perspective. Now both PRRSV-1 and PRRSV-2 are circulating and approximately more than 80% of pig farms are seropositive for PRRSV. For PRRSV-2, there are four lineages (lineage 1, lineage 3, lineage 5, lineage 8) circulating in the fields. Lineage 8 (CH-1a-like) and lineage 5 (BJ-4-like) appeared almost at the same time during 1995-1996. Notably, BJ-4 shares 99.6% and 99.8% identity with VR2332 and RespPRRS MLV, respectively. It means that lineage 5 is likely to be imported from America. Now highly pathogenic PRRSV (HP-PRRSV) which was considered to be evolved from local diversity of lineage 8 strains is predominant with different variants. Lineage 3 appeared in 2010 which is mainly sporadic in south of China. Lineage 1, also known as NADC30-like strains in China, has been prevalent since 2013 and leads to PRRS pandemic again. For PRRSV-1, although sporadic at present, more than 9 provinces/regions have been reported. All the circulating strains belong to subtype I. It should be paid more attention since there are no vaccines available. Our analysis would help to deeply understand the prevalent status of PRRSV in China and provide useful information for prevention and control of porcine reproductive and respiratory syndrome (PRRS).
Holtkamp DJ, Kliebenstein JB, Neumann EJ, Zimmerman JJ, Rotto HF, Yoder TK, Wang C, Yeske PE, Mowrer CL, Haley CA. Assessment of the economic impact of porcine reproductive and respiratory syndrome virus on United States pork producers. J Swine Health Prod. 2013;21(2):72–84.
Keffaber KK. Reproductive failure of unknown etiology. Am. Assoc. swine Pract. Newsletter. 1989;1:1–9.
Chang CC, Chung WB, Lin MW, Weng CN, Yang PC, Chiu YT, Chu RM. Porcine reproductive and respiratory syndrome (PRRS) in Taiwan. I. Viral isolation. J Chin Soc Vet Sci. 1993;19(4):268–76.
Baron T, Albina E, Leforban Y, Madec F, Guilmoto H, Plana DJ, Vannier P. Report on the first outbreaks of the porcine reproductive and respiratory syndrome (PRRS) in France. Diagnosis and viral isolation. Ann Rech Vet. 1992;23:161–6. PubMed
Collins JE, Benfield DA, Christianson WT, Harris L, Hennings JC, Shaw DP, Goyal SM, McCullough S, Morrison RB, Joo HS, Et A. Isolation of swine infertility and respiratory syndrome virus (isolate ATCC VR-2332) in North America and experimental reproduction of the disease in gnotobiotic pigs. J Vet Diagn Investig. 1992;4:117–26. CrossRef
Wensvoort G, de Kluyver EP, Pol JM, Wagenaar F, Moormann RJ, Hulst MM, Bloemraad R, den Besten A, Zetstra T, Terpstra C. Lelystad virus, the cause of porcine epidemic abortion and respiratory syndrome: a review of mystery swine disease research at Lelystad. Vet Microbiol. 1992;33:185–93. CrossRefPubMed
Cavanagh D. Nidovirales: a new order comprising Coronaviridae and Arteriviridae. Arch Virol. 1997;142:629–33. PubMed
Kuhn JH, Lauck M, Bailey AL, Shchetinin AM, Vishnevskaya TV, Bào Y, Ng TFF, LeBreton M, Schneider BS, Gillis A, Tamoufe U, Diffo JLD, Takuo JM, Kondov NO, Coffey LL, Wolfe ND, Delwart E, Clawson AN, Postnikova E, Bollinger L, Lackemeyer MG, Radoshitzky SR, Palacios G, Wada J, Shevtsova ZV, Jahrling PB, Lapin BA, Deriabin PG, Dunowska M, Alkhovsky SV, Rogers J, Friedrich TC, O Connor DH, Goldberg TL. Reorganization and expansion of the nidoviral family Arteriviridae. Arch Virol. 2016;161:755–68. CrossRefPubMed
Shi M, Lam TTY, Hon CC, Murtaugh MP, Davies PR, Hui RKH, Li J, Wong LTW, Yip CW, Jiang JW, Leung FCC. Phylogeny-based evolutionary, demographical, and geographical dissection of north American type 2 porcine reproductive and respiratory syndrome viruses. J Virol. 2010;84:8700–11. CrossRefPubMedPubMedCentral
Mengeling WL, Lager KM, Vorwald AC. Clinical consequences of exposing pregnant gilts to strains of porcine reproductive and respiratory syndrome (PRRS) virus isolated from field cases of "atypical" PRRS. Am J Vet Res. 1998;59:1540–4. PubMed
Tian K, Yu X, Zhao T, Feng Y, Cao Z, Wang C, Hu Y, Chen X, Hu D, Tian X, Liu D, Zhang S, Deng X, Ding Y, Yang L, Zhang Y, Xiao H, Qiao M, Wang B, Hou L, Wang X, Yang X, Kang L, Sun M, Jin P, Wang S, Kitamura Y, Yan J, Gao GF. Emergence of fatal PRRSV variants: unparalleled outbreaks of atypical PRRS in China and molecular dissection of the unique hallmark. PLoS One. 2007;2:e526. CrossRefPubMedPubMedCentral
Martin DP, Murrell B, Golden M, Khoosal A, Muhire B. RDP4: detection and analysis of recombination patterns in virus genomes. Virus Evol. 2015;1:v3. CrossRef
Guo BQ, Chen ZS, Liu WX, Cui YZ. Isolation and identification of procine reproductive and respiratory syndrome virus from aborted fetues suspected of PRRS. Chin J Anim Poult Infect Dis. 1996;87(02):1–5. (in Chinese)
Yang HC, Guan SH, Yi XM, Gan MH. Isolation and identification of porcine reproductive and respiratory syndrome. Chin J Vet Med. 1997;10:9–10. (in Chinese)
Jian ZY, Ma ZY, Jiang P, Zhang ZX, Cai BX. Serological investigation of porcine reproductive and respiratoryu syndrome (PRRS): a preliminary report. Anim Husbandry Vet Med. 1996;6:11–2. (In Chinese)
Chen BW, Sun YJ, Luo CB, Sun YF, Pan FC, Lin ZX, Su YS, Li SG, Tong KZ. Isolation and identification of porcine reproductive and respiratory syndrome (PRRS) virus: a preliminary report. Chin J Vet Med. 1996;5:6–8. (In Chinese)
Zhao Y, Luo CB, Lin ZX, Chen R, Li SG, Chen BW, Liu SG. Expression of ORF5 gene of porcine reproductive and respiratory syndrome virus B13 strain in a baculovirus expression system. J AGR BIOT. 2000;3:211–5. (in Chinese)
Liu J, Zhou X, Zhai J, Li B, Wei C, Dai A, Yang X, Luo M. Genetic diversity and evolutionary characteristics of type 2 porcine reproductive and respiratory syndrome virus in southeastern China from 2009 to 2014. Arch Virol. 2017;
WH L, Tun HM, Sun BL, Mo J, Zhou QF, Deng YX, Xie QM, Bi YZ, Leung FC, Ma JY. Re-emerging of porcine respiratory and reproductive syndrome virus (lineage 3) and increased pathogenicity after genomic recombination with vaccine variant. Vet Microbiol. 2015;175:332–40. CrossRef
Zhou F, Chang HT, Zhao J, Chen L, Wang XW, Liu HY, Yao HX, Wang CQ, Wang X. Identification and molecular epidemiology of porcine reproductive and respiratory syndrome virus prevailing in Henan province from 2012 to 2013. Chin J Vet Sci. 2014;9:1398–404. (in Chinese)
Wang LJ, Guo Z, Qiao S, Chen XX, Zhang G. Complete genome sequence of a mosaic NADC30-like porcine reproductive and respiratory syndrome virus in China. Genome Announc. 2016;4
Li Y, Ji G, Wang J, Tan F, Zhuang J, Li X, Tian K. Complete genome sequence of an NADC30-like porcine reproductive and respiratory syndrome virus characterized by recombination with other strains. Genome Announc. 2016;4
Wenhui L, Zhongyan W, Guanqun Z, Zhili L, JingYun M, Qingmei X, Baoli S, Yingzuo B. Complete genome sequence of a novel variant porcine reproductive and respiratory syndrome virus (PRRSV) strain: evidence for recombination between vaccine and wild-type PRRSV strains. J Virol. 2012;86:9543. CrossRefPubMedPubMedCentral
Stadejek T, Oleksiewicz MB, Scherbakov AV, Timina AM, Krabbe JS, Chabros K, Potapchuk D. Definition of subtypes in the European genotype of porcine reproductive and respiratory syndrome virus: nucleocapsid characteristics and geographical distribution in Europe. Arch Virol. 2008;153:1479–88. CrossRefPubMed
Stadejek T, Stankevicius A, Storgaard T, Oleksiewicz MB, Belak S, Drew TW, Pejsak Z. Identification of radically different variants of porcine reproductive and respiratory syndrome virus in Eastern Europe: towards a common ancestor for European and American viruses. J Gen Virol. 2002;83:1861–73. CrossRefPubMed
Chen N, Liu Q, Qiao M, Deng X, Chen X, Sun M. Whole genome characterization of a novel porcine reproductive and respiratory syndrome virus 1 isolate: genetic evidence for recombination between Amervac vaccine and circulating strains in mainland China. Infect Genet Evol. 2017;54:308–13. CrossRefPubMed
Bonckaert C, van der Meulen K, Rodríguez-Ballarà I, Pedrazuela Sanz R, Martinez MF, Nauwynck HJ. Modified-live PRRSV subtype 1 vaccine UNISTRAIN® PRRS provides a partial clinical and virological protection upon challenge with east European subtype 3 PRRSV strain Lena. Porcine Health Manag. 2016;2
Mengeling WL, Vorwald AC, Lager KM, Clouser DF, Wesley RD. Identification and clinical assessment of suspected vaccine-related field strains of porcine reproductive and respiratory syndrome virus. Am J Vet Res. 1999;60:334–40. PubMed
Zhou L, Yang X, Tian Y, Yin S, Geng G, Ge X, Guo X, Yang H. Genetic diversity analysis of genotype 2 porcine reproductive and respiratory syndrome viruses emerging in recent years in China. Biomed Res Int. 2014;2014:1–13.
Zhao H, Han Q, Zhang L, Zhang Z, Wu Y, Shen H, Jiang P. Emergence of mosaic recombinant strains potentially associated with vaccine JXA1-R and predominant circulating strains of porcine reproductive and respiratory syndrome virus in different provinces of China. Virol J. 2017;14
Linhares DC, Johnson C, Morrison RB. Correction: economic analysis of vaccination strategies for PRRS control. PLoS One. 2016;11:e150444. CrossRef
Tian K. NADC30-Like Porcine Reproductive and Respiratory Syndrome in China. The Open Virology Journal. 2017;11:59–65.
- The prevalent status and genetic diversity of porcine reproductive and respiratory syndrome virus in China: a molecular epidemiological perspective
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