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Supportive Care in Cancer

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05.01.2022 | Original Article

The preventive effects of perioperative oral care on surgical site infections after pancreatic cancer surgery: a retrospective study

verfasst von: Hiroshi Nobuhara, Yasuhiro Matsugu, Junko Tanaka, Tomoyuki Akita, Keiko Ito

Erschienen in: Supportive Care in Cancer | Ausgabe 4/2022

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Abstract

Purpose

Pancreatic ductal adenocarcinoma (PDAC) is the most malignant cancer of the gastrointestinal system, and is associated with high rates of postoperative complications, including surgical site infections (SSIs). Perioperative oral care is an effective measure for preventing postoperative pneumonia. However, the preventive effects of perioperative oral care on SSIs have not been reported. We investigated the preventive effects of perioperative oral care on SSIs after pancreatic cancer surgery.

Methods

A total of 103 patients with PDAC who underwent radical resection at Hiroshima Prefectural Hospital (2011–2018) were enrolled in this retrospective study. Of the 103 patients, 75 received perioperative oral care by dentists and dental hygienists (oral care group), whereas 28 did not (control group). Univariate and multivariate analyses with propensity score as a covariate were used to investigate the incidence and risk factors of SSIs in the oral care and control groups.

Results

The incidence of SSIs was significantly lower in the oral care group than in the control group (12.0% vs. 39.3%, P = 0.004). Logistic regression analysis revealed that a soft pancreas, the surgical procedure (pancreaticoduodenectomy), blood transfusion, diabetes mellitus, and the absence of oral care intervention were risk factors for SSIs. The odds ratio for the absence of oral care intervention was 6.090 (95% confidence interval: 1.750–21.200, P = 0.004).

Conclusion

Our results suggest that perioperative oral care may reduce the risk of developing SSIs after pancreatic cancer surgery. These findings need to be evaluated in future prospective studies.

Trial registration

UMIN registration number: UMIN000042082; October 15, 2020, retrospectively registered.

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Titel: The preventive effects of perioperative oral care on surgical site infections after pancreatic cancer surgery: a retrospective study
verfasst von: Hiroshi Nobuhara
Yasuhiro Matsugu
Junko Tanaka
Tomoyuki Akita
Keiko Ito
Publikationsdatum: 05.01.2022
Verlag: Springer Berlin Heidelberg
Erschienen in: Supportive Care in Cancer / Ausgabe 4/2022
Print ISSN: 0941-4355
Elektronische ISSN: 1433-7339
DOI: https://doi.org/10.1007/s00520-021-06791-9

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The preventive effects of perioperative oral care on surgical site infections after pancreatic cancer surgery: a retrospective study