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01.12.2012 | Research | Ausgabe 1/2012 Open Access

World Journal of Surgical Oncology 1/2012

The prognostic factors of resected non-small cell lung cancer with chest wall invasion

Zeitschrift:
World Journal of Surgical Oncology > Ausgabe 1/2012
Autoren:
Chang Young Lee, Chun Sung Byun, Jin Gu Lee, Dae Joon Kim, Byoung Chul Cho, Kyung Young Chung, In Kyu Park
Wichtige Hinweise

Electronic supplementary material

The online version of this article (doi:10.​1186/​1477-7819-10-9) contains supplementary material, which is available to authorized users.

Competing interests

Drs. Lee CY, Byun CS, Lee JG, Kim DJ, Cho BC, Chung KY and Park IK have no conflicts of interest or financial ties to disclose.

Authors' contributions

CYL: Conception and design, drafting the article, final revision, CSB: Acquisition of data, interpretation of data, JGL: Revision for important content, DJK: Interpretation of data, revision for important content, BCC: Interpretation of data, revision for important content, KYC: Acquisition of data, interpretation of data, revision, IKP: Conception and design, revision, final approval. All authors read and approved the final manuscript.

Abstract

Background

We retrospectively reviewed the clinical features and surgical outcomes of patients with a surgically resected NSCLC invading chest wall in order to identify prognostic factors that impact long term survival.

Methods

Between January 1990 and December 2009, 107 patients who underwent surgical resection for chest wall invading NSCLC were reviewed. Tumors invading only the parietal pleura were defined as superficial invasions, and those involving the soft tissue or ribs were defined as deep invasions.

Results

There were 91 men and 16 women; median age was 64 years (range 30 to 80 years). Overall 5 year survival rate was 26.3%. The univariate prognostic factors for survival included gender, extent of resection (pneumonectomy vs lobectomy), tumor size(> 5 cm vs ≤ 5 cm), nodal status (N0 or N1 vs N2), completeness of resection (complete vs incomplete) and completeness of adjuvant chemotherapy. At multivariate analysis, five independent prognostic factors were shown; depth of invasion (superficial vs deep), tumor size, nodal status, completeness of resection, and completeness of adjuvant chemotherapy. In patients with completely resected T3N0 NSCLC, completion of chemotherapy is the only prognostic factor for long term survival.

Conclusions

Completeness of resection, nodal status, depth of invasion, tumor size, and adjuvant chemotherapy were prognostic factors for long-term survival in NSCLC patients with chest wall invasion. Because of poor prognosis in cases with chest wall invasion that have N2 positive LN, that is difficult to achieve complete resection and that need pneumonectomy, definite chemoradiotherapy or neoadjuvant chemoradiotherapy should be considered first in these cases.
Zusatzmaterial
Authors’ original file for figure 1
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Authors’ original file for figure 2
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Authors’ original file for figure 3
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Literatur
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