The online version of this article (doi:10.1186/1477-7819-10-9) contains supplementary material, which is available to authorized users.
Drs. Lee CY, Byun CS, Lee JG, Kim DJ, Cho BC, Chung KY and Park IK have no conflicts of interest or financial ties to disclose.
CYL: Conception and design, drafting the article, final revision, CSB: Acquisition of data, interpretation of data, JGL: Revision for important content, DJK: Interpretation of data, revision for important content, BCC: Interpretation of data, revision for important content, KYC: Acquisition of data, interpretation of data, revision, IKP: Conception and design, revision, final approval. All authors read and approved the final manuscript.
We retrospectively reviewed the clinical features and surgical outcomes of patients with a surgically resected NSCLC invading chest wall in order to identify prognostic factors that impact long term survival.
Between January 1990 and December 2009, 107 patients who underwent surgical resection for chest wall invading NSCLC were reviewed. Tumors invading only the parietal pleura were defined as superficial invasions, and those involving the soft tissue or ribs were defined as deep invasions.
There were 91 men and 16 women; median age was 64 years (range 30 to 80 years). Overall 5 year survival rate was 26.3%. The univariate prognostic factors for survival included gender, extent of resection (pneumonectomy vs lobectomy), tumor size(> 5 cm vs ≤ 5 cm), nodal status (N0 or N1 vs N2), completeness of resection (complete vs incomplete) and completeness of adjuvant chemotherapy. At multivariate analysis, five independent prognostic factors were shown; depth of invasion (superficial vs deep), tumor size, nodal status, completeness of resection, and completeness of adjuvant chemotherapy. In patients with completely resected T3N0 NSCLC, completion of chemotherapy is the only prognostic factor for long term survival.
Completeness of resection, nodal status, depth of invasion, tumor size, and adjuvant chemotherapy were prognostic factors for long-term survival in NSCLC patients with chest wall invasion. Because of poor prognosis in cases with chest wall invasion that have N2 positive LN, that is difficult to achieve complete resection and that need pneumonectomy, definite chemoradiotherapy or neoadjuvant chemoradiotherapy should be considered first in these cases.
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- The prognostic factors of resected non-small cell lung cancer with chest wall invasion
Chang Young Lee
Chun Sung Byun
Jin Gu Lee
Dae Joon Kim
Byoung Chul Cho
Kyung Young Chung
In Kyu Park
- BioMed Central
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