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01.12.2012 | Original investigation | Ausgabe 1/2012 Open Access

Cardiovascular Diabetology 1/2012

The prognostic value of different glucose abnormalities in patients with acute myocardial infarction treated invasively

Cardiovascular Diabetology > Ausgabe 1/2012
Michal Mazurek, Jacek Kowalczyk, Radoslaw Lenarczyk, Teresa Zielinska, Agnieszka Sedkowska, Patrycja Pruszkowska-Skrzep, Andrzej Swiatkowski, Beata Sredniawa, Oskar Kowalski, Lech Polonski, Krzysztof Strojek, Zbigniew Kalarus
Wichtige Hinweise

Electronic supplementary material

The online version of this article (doi:10.​1186/​1475-2840-11-78) contains supplementary material, which is available to authorized users.

Competing interests

The authors state, that they have read and approved the manuscript, the paper is original, has not been published and is not under simultaneous consideration for publication elsewhere, and none of the authors has any competing interest to disclose.

Authors’ contributions

The corresponding author MM collection of data, and JK conception and design, analysis and interpretation of data, drafting of the manuscript, final approval of the manuscript submitted. RL, LP, KS, and ZK interpretation of data, revising manuscript critically for important intellectual content, final approval of the manuscript submitted. TZ, AS, PSP, SA, BS, OK collection of data, analysis and interpretation of data, final approval of the manuscript submitted. All authors read and approved the final manuscript.



Diabetes (DM) deteriorates the prognosis in patients with coronary heart disease. However, the prognostic value of different glucose abnormalities (GA) other than DM in subjects with acute myocardial infarction (AMI) treated invasively remains unclear.


To assess the incidence and impact of GA on clinical outcomes in AMI patients treated with percutaneous coronary intervention (PCI).


A single-center, prospective registry encompassed 2733 consecutive AMI subjects treated with PCI. In all in-hospital survivors (n = 2527, 92.5%) without the history of DM diagnosed before or during index hospitalization standard oral glucose tolerance test (OGTT) was performed during stable condition before hospital discharge and interpreted according to WHO criteria. The mean follow-up period was 37.5 months.


The incidence of GA was as follows: impaired fasting glycaemia - IFG (n = 376, 15%); impaired glucose tolerance - IGT (n = 560, 22%); DM (n = 425, 17%); new onset DM (n = 384, 15%); and normal glucose tolerance – NGT (n = 782, 31%). During the long-term follow-up, death rate events for previously known DM, new onset DM and IGT were significantly more frequent than those for IFG and NGT (12.3; 9.6 and 9.4 vs. 5.6 and 6.4%, respectively, P < 0.05). The strongest and common independent predictors of death in GA patients were glomerular filtration rate < 60 ml/min/1,73 m^2 (HR 2.0 and 2.8) and left ventricle ejection fraction < 35% (HR 2.5 and 1.8, all P < 0.05) respectively.


Glucose abnormalities are very common in AMI patients. DM, new onset DM and IGT increase remote mortality. Impaired glucose tolerance bears similar long-term prognosis as diabetes.
Authors’ original file for figure 1
Authors’ original file for figure 2
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