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NeuroMolecular Medicine

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03.09.2019 | Original Paper

The Putative Association of TOB1-AS1 Long Non-coding RNA with Immune Tolerance: A Study on Multiple Sclerosis Patients

verfasst von: Reyhaneh Dehghanzad, Majid Pahlevan Kakhki, Asieh Alikhah, Mohammad Ali Sahraian, Mehrdad Behmanesh

Erschienen in: NeuroMolecular Medicine | Ausgabe 1/2020

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Abstract

The hallmark of multiple sclerosis (MS) pathogenesis is the breakdown of peripheral tolerance in the immune system. However, its molecular mechanism is not completely understood. Since long non-coding RNAs (lncRNAs) has played important roles in regulation of immunological pathways, here, we evaluated the expression of a novel lncRNA, TOB1-AS1, and its putative associated coding genes in the mechanism of maintaining immune tolerance in peripheral blood of MS patients to assess their possible roles in MS pathogenesis. In this study, 39 MS patients and 32 healthy matched controls were recruited. Real-time PCR standard curve method was used to quantify transcript levels of TOB1-AS1, TOB1, SKP2, and TSG. In addition, the potential sex hormone receptor binding sites on target genes promoter were analyzed using JASPR software. This work demonstrates a negative correlation between TOB1-AS1 expression and EDSS of patients. Also, a robust dysregulation of co-expression of TOB1-AS1 lncRNA and the coding genes in MS patients compared to controls was observed. Such dysregulation in this pathway may be related to MS pathogenesis and response to interferon treatment.

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Titel: The Putative Association of TOB1-AS1 Long Non-coding RNA with Immune Tolerance: A Study on Multiple Sclerosis Patients
verfasst von: Reyhaneh Dehghanzad
Majid Pahlevan Kakhki
Asieh Alikhah
Mohammad Ali Sahraian
Mehrdad Behmanesh
Publikationsdatum: 03.09.2019
Verlag: Springer US
Erschienen in: NeuroMolecular Medicine / Ausgabe 1/2020
Print ISSN: 1535-1084
Elektronische ISSN: 1559-1174
DOI: https://doi.org/10.1007/s12017-019-08567-1

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The Putative Association of TOB1-AS1 Long Non-coding RNA with Immune Tolerance: A Study on Multiple Sclerosis Patients

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