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17.09.2016 | Original Article – Cancer Research | Ausgabe 2/2017

Journal of Cancer Research and Clinical Oncology 2/2017

The ratio of cancer cells to stroma after induction therapy in the treatment of non-small cell lung cancer

Zeitschrift:
Journal of Cancer Research and Clinical Oncology > Ausgabe 2/2017
Autoren:
Masaki Goto, Masahito Naito, Koichi Saruwatari, Kakeru Hisakane, Motohiro Kojima, Satoshi Fujii, Takeshi Kuwata, Atsushi Ochiai, Shogo Nomura, Keiju Aokage, Tomoyuki Hishida, Junji Yoshida, Kohei Yokoi, Masahiro Tsuboi, Genichiro Ishii
Wichtige Hinweise

Electronic supplementary material

The online version of this article (doi:10.​1007/​s00432-016-2271-8) contains supplementary material, which is available to authorized users.

Abstract

Purpose

Induction therapy induces degenerative changes of various degrees in both cancerous and non-cancerous cells of non-small cell lung cancer (NSCLC). The effect of induction therapy on histological characteristics, in particular the ratio of residual cancer cells to non-cancerous components, is unknown.

Methods

Seventy-four NSCLC patients treated with induction therapy followed by surgery were enrolled. Residual cancer cells were identified using anti-pan-cytokeratin antibody (AE1/AE3). We analyzed and quantified the following three factors via digital image analysis; (1) the tumor area containing cancer cells and non-cancerous components (TA), (2) the total area of AE1/AE3 positive cancer cells (TACC), (3) the percentage of TACC to TA (%TACC). These factors were also analyzed in a matched control group (surgery alone, n = 80).

Results

The median TACC of the induction therapy group was significantly lower than that of the control group (p < 0.01). In addition, the median %TACC of the induction therapy group (5.9 %) was significantly lower than that of the control group (58.6 %) (p < 0.01). TACC had a strong positive correlation with TA in the control group (r = 0.93), but not in the induction therapy group. Conversely, TACC had a strong positive correlation with %TACC in the induction therapy group (r = 0.95), but not in the control group.

Conclusion

Unlike the control group, the smaller the total area of residual cancer cells, the higher residual tumor contained non-cancerous components in the induction group, which may be the characteristic histological feature of NSCLC after induction therapy.

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Zusatzmaterial
Supplementary material 1 (DOCX 16 kb)
432_2016_2271_MOESM1_ESM.docx
Supplementary material 2 (PPTX 90 kb)
432_2016_2271_MOESM2_ESM.pptx
Literatur
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