Background
Methods
Subjects
Blood sampling
Statistical analysis
Results
Comparison of RDW and PDW values between patients with GC and healthy controls
ROC curves analysis results
Relationships between RDW, PDW and clinicopathological characteristics
Characteristics | Cases (n) | RDW < 13 n(%) | RDW ≥ 13 n(%) |
P valuea
| PDW < 11.5 n(%) | PDW ≥ 11.5 n(%) |
P Valuea
|
---|---|---|---|---|---|---|---|
Gender | 0.467 | 0.039 | |||||
Male | 176 | 83(75.5) | 93(79.5) | 91(83.5) | 85(72.0) | ||
Female | 51 | 27(24.5) | 24(20.5) | 18(16.5) | 33(28.0) | ||
Age(years) | < 0.001 | 0.007 | |||||
< 60 | 119 | 76(69.1) | 43(36.8) | 47(43.1) | 72(61.0) | ||
≥ 60 | 108 | 34(30.9) | 74(63.2) | 62(56.9) | 46(39.0) | ||
Tumor diameter (cm) | 0.001 | 0.005 | |||||
≤ 4 | 101 | 61(55.5) | 40(34.2) | 38(34.9) | 63(53.4) | ||
> 4 | 116 | 49(44.5) | 77(65.8) | 71(65.1) | 55(46.6) | ||
Differentiation | 0.569 | 0.785 | |||||
Well | 7 | 3(2.7) | 4(3.4) | 3(2.8) | 4(3.4) | ||
Moderate | 71 | 31(28.2) | 40(34.2) | 32(29.4) | 39(33.1) | ||
Poor | 149 | 76(69.1) | 73(62.4) | 74(67.9) | 75(63.6) | ||
Depth of tumor | 0.008 | 0.047 | |||||
T1 + T2 | 64 | 40(36.4) | 24(20.5) | 24(22.0) | 40(33.9) | ||
T3 + T4 | 163 | 70(63.6) | 93(79.5) | 85(78.0) | 78(66.1) | ||
Lymph node metastasis | 0.014 | 0.085 | |||||
N0 | 73 | 44(40.0) | 29(24.8) | 29(26.6) | 44(37.3) | ||
N1 + N2 + N3 | 154 | 66(60.0) | 88(75.2) | 80(73.4) | 74(62.7) | ||
Distance metastasis | 0.257 | 0.417 | |||||
M0 | 194 | 91(82.7) | 103(88.0) | 91(83.5) | 103(87.3) | ||
M1 | 33 | 19(17.3) | 14(12.0) | 18(16.5) | 15(12.7) | ||
pStage | 0.111 | 0.131 | |||||
I + II | 83 | 46(41.8) | 37(31.6) | 36(33.1) | 47(39.8) | ||
III + IV | 144 | 64(58.2) | 80(68.4) | 73(66.9) | 71(60.2) | ||
CEA(ng/ml) | 0.250 | 0.004 | |||||
≤ 5 | 188 | 92(87.6) | 96(82.1) | 83(78.3) | 105(92.1) | ||
> 5 | 34 | 13(12.4) | 21(17.9) | 23(21.7) | 9(7.9) | ||
CA125(U/ml) | 0.553 | 0.041 | |||||
≤ 35 | 181 | 85(94.4) | 96(92.3) | 86(89.6) | 95(96.9) | ||
> 35 | 13 | 5(5.6) | 8(7.7) | 10(10.4) | 3(3.1) | ||
CA199(U/ml) | 0.563 | 0.637 | |||||
≤ 39 | 183 | 84(85.7) | 99(88.4) | 86(86.0) | 97(88.2) | ||
> 39 | 27 | 14(14.3) | 13(11.6) | 14(14.0) | 13(11.8) |
Characteristics | Cases (N) | RDW < 12.85 n(%) | RDW ≥ 12.85 n(%) |
P valuea
| PDW < 11.95 n(%) | PDW ≥ 11.95 n(%) |
P Valuea
|
---|---|---|---|---|---|---|---|
Gender | 1.000 | 0.711 | |||||
Male | 126 | 63(76.8) | 63(76.8) | 64(78.0) | 62(75.6) | ||
Female | 38 | 19(23.2) | 19(23.2) | 18(22.0) | 20(24.4) | ||
Age(years) | 0.008 | 0.271 | |||||
< 60 | 73 | 45(54.9) | 28(34.1) | 33(40.2) | 40(48.8) | ||
≥ 60 | 91 | 37(45.1) | 54(65.9) | 49(59.8) | 42(51.2) | ||
Tumor diameter (cm) | 0.732 | 0.732 | |||||
≤ 4 | 155 | 77(93.9) | 78(95.1) | 77(93.9) | 78(95.1) | ||
> 4 | 9 | 5(6.1) | 4(4.9) | 5(6.1) | 4(4.9) | ||
Differentiation | 0.437 | 0.537 | |||||
Well | 21 | 12(14.6) | 9(11.0) | 11(13.4) | 10(12.2) | ||
Moderate | 74 | 33(40.2) | 41(50.0) | 40(48.8) | 34(41.5) | ||
Poor | 69 | 37(45.1) | 32(39.0) | 31(37.8) | 38(46.3) | ||
Lymph node metastasis | 0.392 | 0.200 | |||||
N0 | 138 | 67(81.7) | 71(86.6) | 72(87.8) | 66(80.5) | ||
N1 + N2 + N3 | 26 | 15(18.3) | 11(13.4) | 10(12.2) | 16(19.5) | ||
Distance metastasis | 0.053 | 0.246 | |||||
M0 | 157 | 76(92.7) | 81(98.8) | 80(97.6) | 77(93.9) | ||
M1 | 7 | 6(7.3) | 1(1.2) | 2(2.4) | 5(6.1) | ||
pStage | 0.053 | 0.246 | |||||
I + II | 157 | 76(92.7) | 81(98.8) | 76(92.7) | 70(85.4) | ||
III + IV | 7 | 6 (7.3) | 1(1.2) | 6(7.3) | 12(14.6) | ||
CEA(ng/ml) | 0.110 | 0.384 | |||||
≤ 5 | 134 | 67(93.1) | 67(98.5) | 65(94.2) | 69(97.2) | ||
> 5 | 6 | 5(6.9) | 1(1.5) | 4(5.8) | 2(2.8) | ||
CA125(U/ml) | 0.955 | 0.504 | |||||
≤ 35 | 75 | 36(97.3) | 39(97.5) | 33(100.0) | 42(95.5) | ||
> 35 | 2 | 1(2.7) | 1(2.5) | 0 (0.0) | 2(4.5) | ||
CA199(U/ml) | 0.563 | 0.117 | |||||
≤ 39 | 183 | 84(85.7) | 99(88.4) | 64(95.5) | 69(100.0) | ||
> 39 | 27 | 14(14.3) | 13(11.6) | 3(4.5) | 0(0.0) |
Associations of RDW and PDW with survival of GC
Associations of RDW and PDW with prognosis of GC
Clinicopathological feature | Univariatea(OS) | Multivariateb(OS) | Univariatea(DFS) | Multivariateb(DFS) | ||||
---|---|---|---|---|---|---|---|---|
HR (95% CI) |
P value | HR(95% CI) |
P value | HR (95% CI) |
P value | HR(95% CI) |
P value | |
RDW(<13/≥13) | 1.801 (0.985–3.291) | 0.056 | 1.807 (1.015–3.217) | 0.044 | ||||
PDW(<11.5/≥11.5) | 0.701 (0.385–1.275) | 0.244 | 0.754 (0.425–1.337) | 0.333 | ||||
Gender(Male/Female) | 0.764 (0.355–1.648) | 0.493 | 0.908 (0.452–1.827) | 0.787 | ||||
Age(<60/≥60) | 1.541 (0.844–2.814) | 0.160 | 1.535 (0.863–2.730) | 0.044 | ||||
Tumor diameter(≤4/>4) | 2.890 (1.553–5.375) | 0.001 | 2.633 (1.465–4.731) | 0.001 | ||||
Differentiation (Well/Moderate/ Poor) | 1.968 (1.027–3.772) | 0.041 | 1.650 (0.926–2.941) | 0.089 | ||||
Depth of tumor (T1 + T2/T3 + T4) | 2.169 (1.613–2.916) | < 0.001 | 1.722(1.170–2.535) | 0.006 | 2.097 (1.569–2.802) | < 0.001 | 1.655(1.130–2.422) | 0.010 |
Lymph node metastasis (N0/N1 + N2 + N3) | 5.548 (2.335–13.181) | < 0.001 | 4.548 (2.118–9.763) | < 0.001 | ||||
Distance metastasis (M0/M1) | 2.403 (1.112–5.193) | 0.026 | 2.137 (0.996–4.584) | 0.051 | ||||
pStage(I + II/III + IV) | 7.841 (3.075–19.994) | < 0.001 | 4.311(1.591–11.682) | 0.004 | 6.179 (2.755–13.858) | < 0.001 | 3.517(1.470–8.413) | 0.005 |
CEA(≤5/>5) | 1.240 (0.552–2.788) | 0.602 | 1.116 (0.500–2.492) | 0.789 | ||||
CA125(≤35/>35) | 2.606 (0.353–19.240) | 0.348 | 2.606 (0.353–19.240) | 0.348 | ||||
CA199(≤39/>39) | 2.405 (1.173–4.930) | 0.017 | 2.478 (1.249–4.917) | 0.009 |
Variables | Univariatea (OS) | Univariatea (DFS) | Multivariateb(DFS) | |||
---|---|---|---|---|---|---|
HR(95% CI) |
P value | HR(95% CI) |
P value | HR(95% CI) |
P value | |
RDW(<12.85/≥12.85) | 57.198(0.042–7.805E4) | 0.272 | 5.776(1.292–25.821) | 0.022 | 5.346(1.195–23.917) | 0.028 |
PDW(<11.95/≥11.95) | 0.265 (0.029–2.387) | 0.236 | 0.158(0.035–0.707) | 0.016 | 0.170(0.038–0.761) | 0.020 |
Gender(Male/Female) | 1.526 (0.158–14.733) | 0.715 | 2.983(0.973–9.150) | 0.056 | ||
Age(<60/≥60) | 2.264 (0.242–21.168) | 0.474 | 1.145(0.378–3.470) | 0.811 | ||
Tumor diameter(≤4/>4) | 0.046 (0.000–1.144E7) | 0.754 | 2.507(0.318–19.758) | 0.383 | ||
Differentiation (Well/Moderate/ Poor) | 2.384 (0.487–11.664) | 0.284 | 0.717(0.334–1.540) | 0.394 | ||
Lymph node metastasis (N0/N1 + N2 + N3) | 1.460 (0.201–10.620) | 0.708 | 1.706(0.513–5.671) | 0.383 | ||
Distance metastasis (M0/M1) | 0.047(0.000–1.212E9) | 0.803 | 0.047(0.000–1.401E4) | 0.634 | ||
pStage(I + II/III + IV) | 2.243 (0.250–20.161) | 0.471 | 1.478(0.330–6.615) | 0.609 | ||
CEA(≤5/>5) | 0.045 (0.000–2.044E14) | 0.602 | 0.046(0.000–3.688E4) | 0.657 | ||
CA125(≤35/>35) | 1.000(0.000–2584.626) | 1.000 | 0.046(0.000–4.070E7) | 0.770 | ||
CA199(≤39/>39) | 0.039 (0.000–5.365E7) | 0.762 | 0.042(0.000–1.509E4) | 0.627 |