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Erschienen in: Medical Molecular Morphology 1/2016

01.03.2016 | Case Report

The reduced expression of proximal tubular transporters in acquired Fanconi syndrome with κ light chain deposition

verfasst von: Akihiro Tojo, Kensuke Asaba, Satoshi Kinugasa, Yoichiro Ikeda, Yukako Shintani, Masashi Fukayama, Masaomi Nangaku

Erschienen in: Medical Molecular Morphology | Ausgabe 1/2016

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Abstract

In a case of acquired Fanconi syndrome associated with smoldering myeloma, we confirmed the deposition of protease-resistant κ light chain proteins in a proximal tubular injury and found the decreased expression of apical tubular transporters including sodium glucose co-transporter, sodium phosphate co-transporter, uric acid transporter 1, and a decrease of Na+/K+-ATPase in the basolateral membrane. The protease-resistant kappa light chain has a pathological role in the expression of tubular transporters in the proximal tubule and causes Fanconi syndrome associated with smoldering myeloma.
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Metadaten
Titel
The reduced expression of proximal tubular transporters in acquired Fanconi syndrome with κ light chain deposition
verfasst von
Akihiro Tojo
Kensuke Asaba
Satoshi Kinugasa
Yoichiro Ikeda
Yukako Shintani
Masashi Fukayama
Masaomi Nangaku
Publikationsdatum
01.03.2016
Verlag
Springer Japan
Erschienen in
Medical Molecular Morphology / Ausgabe 1/2016
Print ISSN: 1860-1480
Elektronische ISSN: 1860-1499
DOI
https://doi.org/10.1007/s00795-015-0114-3