The online version of this article (doi:10.1186/1471-2261-14-130) contains supplementary material, which is available to authorized users.
The authors declare that they have no competing interests.
KD have made substantial contributions to conception and design, or acquisition of data, or analysis and interpretation of data. AA have made substantial contributions to conception and design, or acquisition of data, or analysis and interpretation of data. BBA have been involved in drafting the manuscript or revising it critically for important intellectual content. AY have been involved in drafting the manuscript or revising it critically for important intellectual content. FK have been involved in drafting the manuscript or revising it critically for important intellectual content AE have been involved in drafting the manuscript or revising it critically for important intellectual content. Each author should have participated sufficiently in the work to take public responsibility for appropriate portions of the content. All authors read and approved the final manuscript.
Neutrophil-to-lymphocyte ratio (NLR) is a marker of systemic inflammation that correlates with cardiac events. This study assessed the association between NLR and the presence of chronic coronary total occlusion (CTO).
The study population included 225 patients, a control group (n = 75), a coronary artery disease group (n = 75), and a CTO group (n = 75). NLR was compared in the three groups.
NLR levels were significantly higher in the CTO than in the other two groups (p < 0.001). Bivariate correlation analysis showed a positive correlation between NLR and SYNTAX Score, and multivariate logistic regression analysis found that NLR was an independent predictor of CTO. ROC analysis showed that an NLR cut-off of 2.09 could distinguish between patients with and without CTO (AUC = 0.74; 95% CI, 0.68–0.81), with a specificity of 69.3% and a sensitivity of 61%.
NLR may be useful as a marker of CTO.
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- The relation between neutrophil-to-lymphocyte ratio and coronary chronic total occlusions
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