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01.12.2014 | Research article | Ausgabe 1/2014 Open Access

BMC Cardiovascular Disorders 1/2014

The relation between neutrophil-to-lymphocyte ratio and coronary chronic total occlusions

Zeitschrift:
BMC Cardiovascular Disorders > Ausgabe 1/2014
Autoren:
Kenan Demir, Ahmet Avci, Bulent Behlul Altunkeser, Ahmet Yilmaz, Fikret Keles, Ahmet Ersecgin
Wichtige Hinweise

Electronic supplementary material

The online version of this article (doi:10.​1186/​1471-2261-14-130) contains supplementary material, which is available to authorized users.

Competing interests

The authors declare that they have no competing interests.

Authors’ contributions

KD have made substantial contributions to conception and design, or acquisition of data, or analysis and interpretation of data. AA have made substantial contributions to conception and design, or acquisition of data, or analysis and interpretation of data. BBA have been involved in drafting the manuscript or revising it critically for important intellectual content. AY have been involved in drafting the manuscript or revising it critically for important intellectual content. FK have been involved in drafting the manuscript or revising it critically for important intellectual content AE have been involved in drafting the manuscript or revising it critically for important intellectual content. Each author should have participated sufficiently in the work to take public responsibility for appropriate portions of the content. All authors read and approved the final manuscript.

Abstract

Background

Neutrophil-to-lymphocyte ratio (NLR) is a marker of systemic inflammation that correlates with cardiac events. This study assessed the association between NLR and the presence of chronic coronary total occlusion (CTO).

Methods

The study population included 225 patients, a control group (n = 75), a coronary artery disease group (n = 75), and a CTO group (n = 75). NLR was compared in the three groups.

Results

NLR levels were significantly higher in the CTO than in the other two groups (p < 0.001). Bivariate correlation analysis showed a positive correlation between NLR and SYNTAX Score, and multivariate logistic regression analysis found that NLR was an independent predictor of CTO. ROC analysis showed that an NLR cut-off of 2.09 could distinguish between patients with and without CTO (AUC = 0.74; 95% CI, 0.68–0.81), with a specificity of 69.3% and a sensitivity of 61%.

Conclusion

NLR may be useful as a marker of CTO.
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