This study was conducted to determine the relationship between care burden and spiritual well-being of mothers of children with cerebral palsy and the topics of support that mothers need. This study, which was conducted as a relationship seeker, was completed in approximately 7 months. Data were collected through interviews with 270 mothers of children with cerebral palsy. A questionnaire, Spiritual Well-Being Scale and Burden Interview Scale was used to collect data. It was found that mothers needed a lot of support, such as requesting an increase in physical therapy hours and the need for financial support. There was a moderate negative relationship between SWBS and BIS (r = − 0.39, p = 0.01). According to the results of this study, we can say that spiritual well-being is related to the care burden of mothers, so nurses caring for these children should understand the burden of the mothers of these children and evaluate spiritual well-being