The online version of this article (doi:10.1186/1758-5996-6-49) contains supplementary material, which is available to authorized users.
There are no competing interests relevant to this article to report.
P-WW, T-YC and C-JH collected data from their patients. C-JH performed the data analysis and wrote the manuscript. All authors read and approved the final manuscript.
Obesity is associated with a high risk of insulin resistance (IR) and its metabolic complications. It is still debated that distributions of adipose tissue relate to an excess risk of IR and chronic inflammation in different race. This study was designed to examine the relation between insulin sensitivity, chronic inflammation and central fat distribution in non-diabetic volunteers in Taiwanese.
There were 328 volunteers without family history of diabetes mellitus and with normal oral glucose tolerance test enrolled. Total body fat and abdominal fat were measured. Abdominal fat was categorized into intraperitoneal (IP), retroperitoneal (RP) and subcutaneous (SC) fat. The IR index was estimated by homeostatic model assessment. Five inflammatory markers: adiponectin, leptin, tumor necrosing factor-α (TNF-α), resistin and high sensitive CRP (hs-CRP) were measured.
IR was related to IP fat (r = 0.23, p < 0.001), but not RP fat, SC fat or total body fat. After correcting for age and sex, IP fat was the only significant predictor of IR (r2 = 58%, p = 0.001). Leptin showed the strongest relationship with all fat compartments (IP fat: r = 0.44, p = 0.001; RP fat: r = 0.36, p = 0.005, SC fat: r = 0.54, p < 0.001; total body fat: r = 0.61, p < 0.001). The hs-CRP and adiponectin were closely related both to IP (r = 0.29, p = 0.004; r = -0.20, p = 0.046, respectively) and total body fat (r = 0.29, p = 0.004; r = -0.29, p = 0.005, respectively), but not RP, or SC fat. TNF-α and resistin were not correlated to any fat compartment. After correcting for age and sex, leptin variance was mostly explained by SC fat (41.3%), followed by IP fat (33.6%) and RP fat (25.3%). The hs-CRP and adiponectin variance were mostly explained by IP fat (40% and 49% respectively).
IP fat is better predictors of IR and subclinical chronic inflammation in Taiwanese adults. A disproportionate accumulation of abdominal fat is associated with increased risk of cardiovascular diseases.
Hung KC: Obesity and its related diseases in Taiwan. Obes Rev. 2005, 6: 271-274. 10.1111/j.1467-789X.2005.00175.x. CrossRef
Langenberg C, Sharp SJ, Schulze MB, Rolandsson O, Overvad K, Forouhi NG, Spranger J, Drogan D, Huerta JM, Arriola L, de Lauzon-Guillan B, Tormo MJ, Ardanaz E, Balkau B, Beulens JW, Boeing H, Bueno-de-Mesquita HB, Clavel-Chapelon F, Crowe FL, Franks PW, Gonzalez CA, Grioni S, Halkjaer J, Hallmans G, Kaaks R, Kerrison ND, Key TJ, Khaw KT, Mattiello A, InterAct Consortium: Long-term risk of incident type 2 diabetes and measures of overall and regional obesity: the EPIC-InterAct case-cohort study. PLoS Med. 2012, 9: e1001230-10.1371/journal.pmed.1001230. CrossRefPubMed
Bremer AA, Jialal I: Adipose tissue dysfunction in nascent metabolic syndrome. J Obese. 2013, 2013: 393192-
Pou KM, Massaro JM, Hoffmann U, Vasan RS, Maurovich-Horvat P, Larson MG, Keaney JF, Meigs JB, Lipinska I, Kathiresan S, Murabito JM, O’Donnell CJ, Benjamin EJ, Fox CS: Visceral and subcutaneous adipose tissue volumes are cross-sectionally related to markers of inflammation and oxidative stress: the Framingham Heart Study. Circulation. 2007, 116: 1234-1241. 10.1161/CIRCULATIONAHA.107.710509. CrossRefPubMed
Bu J, Feng Q, Ran J, Li Q, Mei G, Zhang Y: Visceral fat mass is always, but adipokines (adiponectin and resistin) are diversely associated with insulin resistance in Chinese type 2 diabetic and normoglycemic subjects. Diabetes Res Clin Pract. 2012, 96: 163-169. 10.1016/j.diabres.2011.12.014. CrossRefPubMed
Preis SR, Massaro JM, Robins SJ, Hoffmann U, Vasan RS, Irlbeck T, Meigs JB, Sutherland P, D’Agostino RB, O’Donnell CJ, Fox CS: Abdominal subcutaneous and visceral adipose tissue and insulin resistance in the Framingham heart study. Obesity. 2010, 18: 2191-21988. 10.1038/oby.2010.59. PubMedCentralCrossRefPubMed
Chowdhury B, Sjostrom L, Alpsten M, Kostanty J, Kvist H, Lofgren R: A multicompartment body composition technique based on computerized tomography. Int J Obes Relat Metab Disord. 1994, 18: 219-234. PubMed
Abate N, Burns D, Peshock RM, Garg A, Grundy S: Estimation of adipose tissue mass by magnetic resonance imaging: validation against dissection in human cadavers. J Lipid Res. 1994, 35: 1490-1496. PubMed
Smith J, Al-Amri M, Sniderman A, Cianflone K: Leptin and adiponectin in relation to body fat percentage, waist to hip ratio and the apoB/apoA1 ratio in Asian Indian and Caucasian men and women. Nutr Metab. 2006, 3: 18-10.1186/1743-7075-3-18. CrossRef
Pearson TA, Mensah GA, Alexander RW, Anderson JL, Cannon RO, Criqui M, Fadl YY, Fortmann SP, Hong Y, Myers GL, Rifai N, Smith SC, Taubert K, Tracy RP, Vinicor F, Centers for Disease Control and Prevention; American Heart Association: Markers of inflammation and cardiovascular disease: application to clinical and public health practice: A statement for healthcare professionals from the Centers for Disease Control and Prevention and the American Heart Association. Circulation. 2003, 107: 499-511. 10.1161/01.CIR.0000052939.59093.45. CrossRefPubMed
Hanley AJ, Bowden D, Wagenknecht LE, Balasubramanyam A, Langfeld C, Saad MF, Rotter JI, Guo X, Chen YD, Bryer-Ash M, Norris JM, Haffner SM: Associations of adiponectin with body fat distribution and insulin sensitivity in nondiabetic Hispanics and African-Americans. J Clin Endocrinol Metab. 2007, 92: 2665-2671. 10.1210/jc.2006-2614. CrossRefPubMed
Shah A, Hernandez A, Mathur D, Budoff MJ, Kanaya AM: Adipokines and body fat composition in South Asians: results of the Metabolic Syndrome and Atherosclerosis in South Asians Living in America (MASALA) study. Int J Obes. 2012, 36: 810-816. 10.1038/ijo.2011.167. CrossRef
Indulekha K, Surendar J, Anjana RM, Gokulakrishnan K, Balasubramanyam M, Aravindhan V, Mohan V: Circulating levels of high molecular weight (HMW) adiponectin and total adiponectin in relation to fat distribution, oxidative stress and inflammation in Asian Indians. Dis Markers. 2012, 33: 185-192. 10.1155/2012/672939. PubMedCentralCrossRefPubMed
Haluzik M, Haluzikova D: The role of resistin in obesity-induced insulin resistance. Curr Opin Investig Drugs. 2006, 7: 306-311. PubMed
Piche ME, Lemieux S, Weisnagel SJ, Corneau L, Nadeau A, Bergeron J: Relation of high-sensitivity C-reactive protein, interleukin-6, tumor necrosis factor-alpha, and fibrinogen to abdominal adipose tissue, blood pressure, and cholesterol and triglyceride levels in healthy postmenopausal women. Am J Cardiol. 2005, 96: 92-97. 10.1016/j.amjcard.2005.02.051. CrossRefPubMed
Beasley LE1, Koster A, Newman AB, Javaid MK, Ferrucci L, Kritchevsky SB, Kuller LH, Pahor M, Schaap LA, Visser M, Rubin SM, Goodpaster BH, Harris TB: Health ABC study: Inflammation and race and gender differences in computerized tomography-measured adipose depots. Obesity. 2009, 17: 1062-1069. 10.1038/oby.2008.627. PubMedCentralCrossRefPubMed
Pang SS, Le YY: Role of resistin in inflammation and inflammation-related diseases. Cell Mol Immunol. 2006, 3: 29-34. PubMed
Kabir M, Catalano KJ, Ananthnarayan S, Kim SP, Van Citters GW, Dea MK, Bergman RN: Molecular evidence supporting the portal theory: a causative link between visceral adiposity and hepatic insulin resistance. Am J Physiol Endocrinol Metab. 2005, 288: E454-E461. 10.1152/ajpendo.00203.2004. CrossRefPubMed
- The relationship between regional abdominal fat distribution and both insulin resistance and subclinical chronic inflammation in non-diabetic adults
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