Few studies have investigated the relationship between carotid-femoral pulse wave velocity (cfPWV) and serum alanine aminotransferase (ALT) normal-range levels across the world. The current analysis was designed to explore the relationship of serum ALT normal-range levels to cfPWV and metabolic syndrome (Mets) in non-drinkers and drinkers in a Chinese community-dwelling population.
There were 2202 participants with serum ALT levels within normal range enrolled for the current analysis.
Median (range) age of participants was 53 (18–96) years, 51.5% were males, and 31.2% were drinkers. Prevalence of Mets was 29.4%. Median (range) of cfPWV was 10.1 (2.4-32.7) m/s. Hazard ratios for prevalence of Mets, central obesity and high triglyceride significantly increased with elevated levels of serum ALT in both non-drinkers and drinkers (p < 0.05 for all). Hazard ratios for prevalence of cfPWV > 10 m/s, high blood pressure and high blood glucose significantly increased with elevated levels of serum ALT in non-drinkers (p < 0.05 for all), but not in drinkers (p ≥ 0.05 for all).
In a Chinese community-dwelling population, prevalence of Mets and its components (including central obesity and high TG) increased with an elevation in serum ALT levels within normal range in both non-drinkers and drinkers, while cfPWV and other components of Mets, such as high blood pressure and glucose, increased with an elevation in serum ALT levels in non-drinkers, but not in drinkers.
Bedogni G, Bellentani S. Fatty liver: how frequent is it and why? Ann Hepatol. 2004;3:63–5. PubMed
Chen C, Lu FC, Department of Disease Control Ministry of Health, PR China. The guidelines for prevention and control of overweight and obesity in Chinese adults. Biomed Environ Sci. 2004;17 Suppl:1–36. PubMed
Cheng HY, Wang HY, Chang WH, et al. Nonalcoholic fatty liver disease: prevalence, influence on age and sex, and relationship with metabolic syndrome and insulin resistance. Int J Gerontol. 2013;9:194–8. CrossRef
- The relationship of serum alanine aminotransferase normal-range levels to arterial stiffness and metabolic syndrome in non-drinkers and drinkers: a Chinese community-based analysis
- BioMed Central
Neu im Fachgebiet Innere Medizin
Meistgelesene Bücher aus der Inneren Medizin
Mail Icon II