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Erschienen in:
15.08.2024 | Colorectal Cancer
The Rise of Patients Declining Rectal Cancer Surgery in the Era of Total Neoadjuvant Therapy
verfasst von: Bailey K. Hilty Chu, MD, Anthony Loria, MD, MSCI, Totadri Dhimal, MD, Yue Li, PhD, Fernando Colugnati, PhD, Reza Yousefi Nooraie, PhD, MSc, Paula Cupertino, PhD, Christopher T. Aquina, MD, MPH, Erika E. Ramsdale, MD, MS, Fergal J. Fleming, MD, MPH, FRCSI, FACS
Erschienen in: Annals of Surgical Oncology | Ausgabe 12/2024
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Background
The treatment landscape for rectal cancer is rapidly evolving, particularly with the increasing use of neoadjuvant therapies. Still, up to 50% of patients with stage II–III disease require surgical resection post-neoadjuvant therapy to achieve the best oncologic outcomes. Many patients, however, hope to avoid surgery. This study aimed to assess trends and factors associated with declining recommended oncologic resection after systemic therapy nationally and in our institution.
Patients and Methods
This is a retrospective analysis using the National Cancer Database from 2009 to 2021 and an institutional cohort at an academic center between 2009 and 2022 including adults with stage I–III rectal adenocarcinoma who underwent neoadjuvant therapy and were suitable for surgery.
Results
Of 96,997 patients nationally, the rate of declining surgery increased from 2.3% in 2009 to 6.3% in 2021, a trend mirrored in our institutional cohort of 365 patients (0% in 2009/2010 to approximately 6–12% in 2021/2022). Locally, patients who declined surgery had higher rates of tobacco use, temporary loss to follow-up during therapy, and a more robust, albeit incomplete, tumor response to neoadjuvant therapy compared with controls who underwent surgery. Despite a stoma being the most cited reason for declining surgery, 30.4% of patients who declined oncologic resection died with a stoma.
Conclusions
Our findings underscore a notable trend of patients declining oncologic resections following neoadjuvant therapy for rectal cancer. By shedding light on the outcomes of patients who opt against surgery, we address a critical gap in the literature essential for informing patients about potential risks.
