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01.12.2012 | Review | Ausgabe 1/2012 Open Access

Cancer Cell International 1/2012

The role of A20 in the pathogenesis of lymphocytic malignancy

Zeitschrift:
Cancer Cell International > Ausgabe 1/2012
Autoren:
Fan Zhang, Lijiang Yang, Yangqiu Li
Wichtige Hinweise

Electronic supplementary material

The online version of this article (doi:10.​1186/​1475-2867-12-44) contains supplementary material, which is available to authorized users.

Competing interests

The authors declare that they have no competing interests.

Authors' contributions

The concept of this paper was devised by YQL. FZ, LJY and YQL contributed to the intellectual input of the paper. All authors read and approved the final manuscript.

Abstract

Autoimmune phenomena were identified in many different cases of hematological diseases and solid tumors, which may be due to alterations in the expression and function of the NF-κB signaling pathway. Recently, a number of studies have shown that the deletion or mutation of A20, a negative regulator of NF-κB, is frequently found in lymphomas, suggesting that it may be a linker between the altered immune response and leukemogenesis. The aim of this review is to summarize current findings of the A20 biological functions and its molecular mechanism as a tumor suppressor and immune regulator. The identification of A20 mutations and deletions in lymphocytic malignancy and the predictive significance of these aberrations are also reviewed.
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Authors’ original file for figure 1
12935_2012_364_MOESM1_ESM.tiff
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