The Role of Adipose Tissue and Adipokines in Sepsis: Inflammatory and Metabolic Considerations, and the Obesity Paradox
- 21.10.2019
- Metabolism (M Dalamaga, Section Editor)
Erschienen in:
- Verfasst von
- Irene Karampela
- Gerasimos Socrates Christodoulatos
- Maria Dalamaga
- Erschienen in
- Current Obesity Reports | Ausgabe 4/2019
Abstract
Purpose
Sepsis has become a global health problem with rising incidence and high mortality, creating a substantial social and economic burden. Early diagnosis and treatment can improve outcome, but reliable sepsis biomarkers are lacking. This review summarizes current evidence of the pathophysiological mechanisms linking adipose tissue to sepsis and presents experimental and clinical data on adipokines and sepsis along with important insights into the obesity paradox in sepsis survival.
Recent findings
Sepsis is characterized by significant alterations in circulating cytokines and adipokines, biologically active molecules produced by the adipose tissue, being implicated in metabolic and inflammatory processes. Although data are inconclusive regarding classic adipokines such as leptin and adiponectin, recent evidence have highlighted the striking elevation of resistin and visfatin in critical illness and sepsis as well as their association with sepsis severity and outcomes.
Summary
Given that inflammatory and metabolic pathways are involved in sepsis, studying adipokines presents an attractive, innovative, and promising research field that may provide more powerful diagnostic and prognostic biomarkers as well as novel therapeutic targets, empowering the therapeutic armamentarium for sepsis management in order to improve survival.
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- Titel
- The Role of Adipose Tissue and Adipokines in Sepsis: Inflammatory and Metabolic Considerations, and the Obesity Paradox
- Verfasst von
-
Irene Karampela
Gerasimos Socrates Christodoulatos
Maria Dalamaga
- Publikationsdatum
- 21.10.2019
- Verlag
- Springer US
- Erschienen in
-
Current Obesity Reports / Ausgabe 4/2019
Elektronische ISSN: 2162-4968 - DOI
- https://doi.org/10.1007/s13679-019-00360-2
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