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Breast Cancer Research

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01.02.2001 | Review

The role of bisphosphonates in breast cancer: The present and future role of bisphosphonates in the management of patients with breast cancer

verfasst von: Janet E Brown, Robert E Coleman

Erschienen in: Breast Cancer Research | Ausgabe 1/2001

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Abstract

At least 25% of patients with breast cancer develop skeletal metastases, with bone the site of disease producing the greatest morbidity. It is apparent that the bisphosphonates present an important component of the treatment strategy. They are now the treatment of choice in tumour-induced hypercalcaemia, and they can reduce bone pain and skeletal complications such as pathological fractures. In addition, bisphosphonates are being increasingly evaluated in the prevention of bone metastases and to prevent and treat cancer therapy-induced osteoporosis. Ongoing research is aimed at trying to define the optimum route, dose, schedule and type of bisphosphonate.

Theriault RL, Lipton A, Hortobagyi GN, Leff R, Gluck S, Stewart JF, Costello S, Kennedy I, Simeone J, Seman JJ, Knight RD, Mellars K, Heffernan M, Reitsma DJ: Pamidronate reduces skeletal morbidity in women with advance breast cancer and lytic bone lesions: A randomised, placebo-controlled trial. J Clin Oncol. 1999, 17: 846-854.PubMed

Hortobagyi GN, Theriault RL, Porter L, Blayney D, Lipton A, Sinoff C, Wheeler H, Simeone JF, Seaman J, Knight RD: Efficacy of pamidronate in reducing skeletal complications in patients with breast cancer and lytic bone metastases. N Engl J Med. 1996, 335: 1785-1791. 10.1056/NEJM199612123352401.CrossRefPubMed

Coleman RE: Management of bone metastases. The Oncologist. 2000, 5: 463-470.CrossRefPubMed

Major P, Lortholary A, Hon J, Abdi E, Mills G, Menssen HD, Yunus F, Bell R, Body J, Quebe-Fehling E, Seaman J: Zoledronic acid is superior to pamidronate in the treatment of hypercalcemia of malignancy: A pooled analysis of two randomised, controlled clinical trials. J Clin Oncol. 2001, 19: 558-567.PubMed

Berenson JR, Rosen LS, Howell A, Porter L, Coleman RE, Morley W, Dreicer R, Kuross SA, Lipton A, Seaman JJ: Zoledronic acid reduces skeletal related events in patients with osteolytic metastases: a double-blind, randomised dose-response study. Cancer. 2001, 91: 1191-1200. 10.1002/1097-0142(20010401)91:7<1191::AID-CNCR1119>3.0.CO;2-0.CrossRefPubMed

Coleman R, Apffelstaedt J, Major P, Mackey J, Howell A, Theriault R, Gordon D, Ambros Y: Zometa is equivalent to pamidronate in the prevention of skeletal related events secondary to metastatic breast cancer treated with hormonal therapy [abstract]. Eur J Cancer. 2001, 37(6): S152-10.1016/S0959-8049(01)81045-5.CrossRef

Body JJ, Lichinitser MR, Diehl IE, Schlosser K, Pfarr E, Cavalli V, Dornoff V, Gorbuova VA, McCloskey E, Weiss J, Kanis JA: Double-blind placebo controlled trial of ibandronate in breast cancer metastatic to bone [abstract]. Proc ASCO. 1999, 18: 575a-

Coleman RE, Purohit OP, Black C, Vinholes JJ, Schlosser K, Huss H, Quinn KJ, Kanis J: Double-blind, randomised, placebo-controlled study of oral ibandronate in patients with metastatic bone disease. Ann Oncol. 1999, 10: 311-316. 10.1023/A:1008386501738.CrossRefPubMed

Body JJ, Bartl R, Burckhardt P, Delmas PD, Diel IJ, Fleish H, Kanis JA, Kyle RA, Mundy GR, Paterson AH, Rubens RD: Current use of bisphosphonates in oncology. International Bone and Cancer Study Group. J Clin Oncol. 1998, 16: 3890-3899.PubMed

10.

Jagdev SP, Purohit OP, Heatley S, Herling C, Coleman RE: Comparison of the effects of intravenous pamidronate and oral clodronate on symptoms and bone resorption in patients with metastatic bone disease. Ann Oncol. 2001

11.

Berenson JR, Lipton A, Rosen LS: Phase I clinical study of a new bisphosphonate, zoledronate (CGP-42446), in patients with osteolytic bone metastases [abstract]. Blood. 1998, 88(suppl 1): 586a-

12.

Vinholes JJ, Purohit OP, Abbey ME, Eastell R, Coleman RE: Relationships between biochemical and symptomatic response in a double-blind trial of pamidronate for metastatic bone disease. Ann Oncol. 1997, 8: 1243-1250. 10.1023/A:1008238422151.CrossRefPubMed

13.

Diel IJ, Marschner N, Kindler M, Lange O, Untch M, Hurtz HJ, Bre-itbach GP, Richter B: Continual oral versus intravenous interval therapy with bisphosphonates in patients with breast cancer and bone metastases [abstract]. Proc ASCO. 1999, 18: 128-

14.

Conte PF, Latreille J, Mauriac L, Calabresi F, Santos R, Campos D, Bonneterre J, Francini G, Ford JM: Delay in progression of bone metastases treated with intravenous pamidronate: Results from a multicentre randomised controlled trial. J Clin Oncol. 1996, 14: 2552-2559.PubMed

15.

Hultborn R, Ryden S, Gunderson S, Holmberg E, Wallgren U-B: Efficacy of pamidronate on skeletal complications from breast cancer metastases. A randomised prospective double blind placebo controlled trial. Acta Oncol. 1996, 35(suppl 5): 73-74.CrossRef

16.

Lipton A, Theriault RL, Hortobagyi GN, Simeone J, Knight RD, Mellars K, Reitsma DJ, Heffernan M, Seamann JJ: Pamidronate prevents skeletal complications and is effective palliative treatment in women with breast cancer and osteolytic bone metastases: long-term results of two randomised, placebo-controlled trials. Cancer. 2000, 88: 1082-1090. 10.1002/(SICI)1097-0142(20000301)88:5<1082::AID-CNCR20>3.3.CO;2-Q.CrossRefPubMed

17.

Lipton A, Demers L, Curley E, Chinchilli V, Gaydos L, Hortobagyi G, Theriault R, Clemens D, Costa L, Seaman J, Knight R: Markers of bone resorption in patients treated with pamidronate. Eur J Cancer. 1998, 34: 2021-2026. 10.1016/S0959-8049(98)00277-9.CrossRefPubMed

18.

Fontana A, Delmas PD: Osteoporosis in cancer patients. In Cancer and the Skeleton. Edited by Rubens RD, Mundy GR. London: Martin Dunitz Ltd;. 2000, 263-270.

19.

Powles TJ, Paterson AHG, Nevantaus A, Legault S, Pajunen M, Tidy VA, Rosenquist K, Smith IE, Ottestad L, Ashley S, Walsh G, McCloskey E, Kanis JA: Adjuvant clodronate reduces the incidence of bone metastases in patients with primary operable breast cancer [abstract]. Proc ASCO. 1998, 17: 468-

20.

Diel I, Solomayer EF, Costa SD, Gollan C, Goerner R, Wallwiener D, Kaufmann M, Bastert G: Reduction in new metastases in breast cancer with adjuvant clodronate treatment. N Engl J Med. 1998, 339: 357-363. 10.1056/NEJM199808063390601.CrossRefPubMed

21.

Saarto T, Blomqvist C, Virkkunen P, Eloma A: Adjuvant clodronate treatment does not reduce the frequency of skeletal metastases in node-positive breast cancer patients: 5-year results of a randomized controlled trial. J Clin Oncol. 2001, 19: 10-17.PubMed

22.

Kong YY, Yoshida H, Sarosi I, Tan HL, Timms E, Morony S, Oliveira-dos-Santos AJ, Van G, Itie A, Khoo W, Wakeham A, Dunstan CR, Lacey DI, Mak TW, Boyle WJ, Penninger JM: OPGL is a key regulator of osteoclastogenesis, lymphocyte development and lymph-node organogenesis. Nature. 1999, 397: 315-323. 10.1038/16852.CrossRefPubMed

23.

Honore P, Luger NM, Sabino AC, Schwei MJ, Rogers SD, Mach DB, O'Keefe PF, Ramnaraine ML, Clohisy DR, Mantyh PW: Osteoprotogerin blocks bone cancer-induced skeletal destruction. Skeletal pain and pain-related neurochemical re-organisation of the spinal cord. Nat Med. 2000, 6: 521-528. 10.1038/74999.CrossRefPubMed

24.

van Holten-Verzantvoort AT, Bijvoet OLM, Cleton FJ, Hermans J, Kroon HM, Harinck HI, Vermey P, Elte JW, Neijt JP, Beex LV: Reduced morbidity from skeletal metastases in breast cancer patients during long term bisphosphonate (APD) treatment. Lancet. 1987, ii: 983-985. 10.1016/S0140-6736(87)92555-4.CrossRef

25.

Paterson AHG, Powles TJ, Kanis JA, McCloskey E, Hanson J, Ashley S: Double-blind controlled trial of oral clodronate in patients with bone metastases from breast cancer. J Clin Oncol. 1993, 11: 59-65.PubMed

Titel: The role of bisphosphonates in breast cancer: The present and future role of bisphosphonates in the management of patients with breast cancer
verfasst von: Janet E Brown
Robert E Coleman
Publikationsdatum: 01.02.2001
Verlag: BioMed Central
Erschienen in: Breast Cancer Research / Ausgabe 1/2001
Elektronische ISSN: 1465-542X
DOI: https://doi.org/10.1186/bcr413

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