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Journal of Cancer Research and Clinical Oncology
Erschienen in: Journal of Cancer Research and Clinical Oncology 7/2019

24.05.2019 | Review – Cancer Research

The role of dietary phytochemicals in the carcinogenesis via the modulation of miRNA expression

verfasst von: Marek Samec, Alena Liskova, Peter Kubatka, Sona Uramova, Pavol Zubor, Samson Mathews Samuel, Anthony Zulli, Martin Pec, Tibor Bielik, Kamil Biringer, Erik Kudela, Jozef Benacka, Mariusz Adamek, Luis Rodrigo, Rachele Ciccocioppo, Taeg Kyu Kwon, Denis Baranenko, Peter Kruzliak, Dietrich Büsselberg

Erschienen in: Journal of Cancer Research and Clinical Oncology | Ausgabe 7/2019

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Abstract

Purpose

Phytochemicals are naturally occurring plant-derived compounds and some of them have the potential to serve as anticancer drugs. Based on recent evidence, aberrantly regulated expression of microRNAs (miRNAs) is closely associated with malignancy. MicroRNAs are characterized as small non-coding RNAs functioning as posttranscriptional regulators of gene expression. Accordingly, miRNAs regulate various target genes, some of which are involved in the process of carcinogenesis.

Results

This comprehensive review emphasizes the anticancer potential of phytochemicals, either isolated or in combination, mediated by miRNAs. The ability to modulate the expression of miRNAs demonstrates their importance as regulators of tumorigenesis. Phytochemicals as anticancer agents targeting miRNAs are widely studied in preclinical in vitro and in vivo research. Unfortunately, their anticancer efficacy in targeting miRNAs is less investigated in clinical research.

Conclusions

Significant anticancer properties of phytochemicals as regulators of miRNA expression have been proven, but more studies investigating their clinical relevance are needed.
Literatur
Abba ML, Patil N, Leupold JH, Moniuszko M, Utikal J, Niklinski J, Allgayer H (2017) MicroRNAs as novel targets and tools in cancer therapy. Cancer Lett 387:84–94CrossRefPubMed
Abbasi BA, Iqbal J, Mahmood T, Khalil AT, Ali B, Kanwal S, Sayed Shah A, Ahmad R (2018) Role of dietary phytochemicals in modulation of miRNA expression: natural swords combating breast cancer. Asian Pac J Trop Med 11:501–509CrossRef
Abotaleb M, Samuel SM, Varghese E, Varghese S, Kubatka P, Liskova A, Büsselberg D (2018) Flavonoids in cancer and apoptosis. Cancers (Basel) 11:28CrossRef
Avci CB, Susluer SY, Caglar HO, Balci T, Aygunes D, Dodurga Y, Gunduz C (2014) Genistein-induced mir-23b expression inhibits the growth of breast cancer cells. Contemp Oncol (Pozn) 19:32–35
Bahena-Ocampo I, Espinosa M, Ceballos-Cancino G, Lizarraga F, Campos-Arroyo D, Schwarz A, Maldonado V, Melendez-Zajgla J, Garcia-Lopez P (2016) miR-10b expression in breast cancer stem cells supports self-renewal through negative PTEN regulation and sustained AKT activation. EMBO Rep 17:648–658CrossRefPubMedPubMedCentral
Bai JW, Wang X, Zhang YF, Yao GD, Liu H (2017) MicroRNA-320 inhibits cell proliferation and invasion in breast cancer cells by targeting SOX4. Oncol Lett 14:7145–7152CrossRefPubMedPubMedCentral
Bespalov VG, Alexandrov VA, Vysochina GI, Kostikova VA, Baranenko DA (2017) The inhibiting activity of meadowsweet extract on neurocarcinogenesis induced transplacentally in rats by ethylnitrosourea. J Neurooncol 131:459–467CrossRefPubMed
Bespalov VG, Alexandrov VA, Semenov AL, Vysochina GI, Kostikova VA, Baranenko DA (2018) The inhibitory effect of Filipendula ulmaria (L.) Maxim. on colorectal carcinogenesis induced in rats by methylnitrosourea. J Ethnopharmacol 227:1–7CrossRefPubMed
Catalanotto C, Cogoni C, Zardo G (2016) MicroRNA in control of gene expression: an overview of nuclear functions. Int J Mol Sci 17:1712CrossRefPubMedCentral
Chen Y, Gao DY, Huang L (2015) In vivo delivery of miRNAs for cancer therapy: challenges and strategies. Adv Drug Deliv Rev 81:128–141CrossRefPubMed
Cheng CW, Wang HW, Chang CW, Chu HW, Chen CY, Yu JC, Chao JI, Liu HF, Ding SL, Shen CY (2012) MicroRNA-30a inhibits cell migration and invasion by downregulating vimentin expression and is a potential prognostic marker in breast cancer. Breast Cancer Res Treat 134:1081–1093CrossRefPubMed
Chiou YS, Li S, Ho CT, Pan MH (2018) Prevention of breast cancer by natural phytochemicals: focusing on molecular targets and combinational strategy. Mol Nutr Food Res 62:e1800392CrossRefPubMed
Chiu HS, Martínez MR, Komissarova EV, Llobet-Navas D, Bansal M, Paull EO, Califano A (2018) The number of titrated microRNA species dictates ceRNA regulation. Nucleic Acids Res 46:4354–4369CrossRefPubMedPubMedCentral
Choi SK, Kim HS, Jin T, Hwang EH, Jung M, Moon WK (2016) Overexpression of the miR-141/200c cluster promotes the migratory and invasive ability of triple-negative breast cancer cells through the activation of the FAK and PI3 K/AKT signaling pathways by secreting VEGF-A. BMC Cancer 16:570CrossRefPubMedPubMedCentral
Coker-Gurkan A, Bulut D, Genc R, Arisan ED, Obakan-Yerlikaya P, Palavan-Unsal N (2018) Curcumin prevented human autocrine growth hormone (GH) signaling mediated NF-κB activation and miR-183-96-182 cluster stimulated epithelial mesenchymal transition in T47D breast cancer cells. Mol Biol Rep 46:355–369CrossRefPubMed
Cong N, Du P, Zhang A, Shen F, Su J, Pu P, Wang T, Zjang J, Kang C, Zhang Q (2013) Downregulated microRNA-200a promotes EMT and tumor growth through the wnt/β-catenin pathway by targeting the E-cadherin repressors ZEB1/ZEB2 in gastric adenocarcinoma. Oncol Rep 29:1579–1587CrossRefPubMed
Dacosta C, Bao Y (2017) The role of MicroRNAs in the chemopreventive activity of sulforaphane from cruciferous vegetables. Nutrients 9:902CrossRefPubMedCentral
Dahiya N, Sherman-Baust CA, Wang TL, Davidson B, Shih I, Zhang Y, Wood W, Becker KG, Morin PJ (2008) MicroRNA expression and identification of putative miRNA targets in ovarian cancer. PLoS One 3:e2436CrossRefPubMedPubMedCentral
de la Parra C, Castillo-Pichardo L, Cruz-Collazo A, Cubano L, Redis R, Calin GA, Dharmawardhane S (2016) Soy isoflavone genistein-mediated downregulation of miR-155 contributes to the anticancer effects of genistein. Nutr Cancer 68:154–164CrossRefPubMedPubMedCentral
Derosa G, Maffioli P, Sahebkar A (2016) Ellagic acid and its role in chronic diseases. Adv Exp Med Biol 928:473–479CrossRefPubMed
Diaz-Gerevini GT, Repossi G, Dain A, Tarres MC, Das UN, Eynard AR (2016) Beneficial action of resveratrol: how and why? Nutrition 32:174–178CrossRefPubMed
Dong J, Liu Y, Liao W, Liu R, Shi P, Wang L (2016) miRNA-223 is a potential diagnostic and prognostic marker for osteosarcoma. J Bone Oncol 5:74–79CrossRefPubMedPubMedCentral
Dou H, Shen R, Tao J, Huang L, Shi H, Chen H, Wang Y, Wang T (2017) Curcumin suppresses the colon cancer proliferation by inhibiting Wnt/β-catenin pathways via miR-130a. Front Pharmacol 8:877CrossRefPubMedPubMedCentral
Du C, Weng X, Hu W, Lv Z, Xiao H, Ding C, Gyabaah OA, Xie H, Zhou L, Wu J et al (2015) Hypoxia-inducible MiR-182 promotes angiogenesis by targeting RASA1 in hepatocellular carcinoma. J Exp Clin Cancer Res 34:67CrossRefPubMedPubMedCentral
Duan J, Zhang H, Qu Y, Deng T, Huang D, Liu R, Zhang L, Bai M, Zhou L, Ying G, Ba Y (2016) Onco-miR-130 promotes cell proliferation and migration by targeting TGFβR2 in gastric cancer. Oncotarget 7:44522–44533PubMedPubMedCentral
Fan Y, Ma X, Li H, Gao Y, Huang Q, Zhang Y, Bao X, Du Q, Luo G, Liu K et al (2018) miR-122 promotes metastasis of clear-cell renal cell carcinoma by downregulating Dicer. Int J Cancer 142:547–560CrossRefPubMed
Feitelson MA, Arzumanyan A, Kulathinal RJ, Blain SW, Holcombe RF, Mahajna J, Marino M, Martinez-Chantar ML, Nawroth R, Sanchez-Garcia I et al (2015) Sustained proliferation in cancer: mechanisms and novel therapeutic targets. Semin Cancer Biol 35(Suppl):S25–S54CrossRefPubMedPubMedCentral
Gandhi NS, Tekade RK, Chougule MB (2014) Nanocarrier mediated delivery of siRNA/miRNA in combination with chemotherapeutic agents for cancer therapy: current progress and advances. J Control Release 194:238–256CrossRefPubMed
Ghoncheh M, Pournamdar Z, Salehiniya H (2016) Incidence and mortality and epidemiology of breast cancer in the world. Asian Pac J Cancer Prev 17(S3):43–46CrossRefPubMed
Golubnitschaja O, Debald M, Yeghiazaryan K, Kuhn W, Pešta M, Costigliola V, Grech G (2016) Breast cancer epidemic in the early twenty-first century: evaluation of risk factors, cumulative questionnaires and recommendations for preventive measures. Tumour Biol 37:12941–12957CrossRefPubMed
Gong J, Cui Z, Li L, Ma Q, Wang Q, Gao Y, Sun H (2015) MicroRNA-25 promotes gastric cancer proliferation, invasion, and migration by directly targeting F-box and WD-40 Domain Protein 7, FBXW7. Tumour Biol 36:7831–7840CrossRefPubMed
González-Sarrías A, Núñez-Sánchez MÁ, Tomé-Carneiro J, Tomás-Barberán FA, García-Conesa MT, Espín JC (2016) Comprehensive characterization of the effects of ellagic acid and urolithins on colorectal cancer and key-associated molecular hallmarks: microRNA cell specific induction of CDKN1A (p21) as a common mechanism involved. Mol Nutr Food Res 60:701–716CrossRefPubMed
Gu JB, Bao XB, Ma Z (2018) Effects of miR-21 on proliferation and apoptosis in human gastric adenocarcinoma cells. Oncol Lett 15:618–622PubMed
Guan H, Li W, Li Y, Wang J, Li Y, Tang Y, Lu S (2017) MicroRNA-93 promotes proliferation and metastasis of gastric cancer via targeting TIMP2. PLoS One 12:e0189490CrossRefPubMedPubMedCentral
Guo R, Wang Y, Shi WY, Liu B, Hou SQ, Liu L (2012) MicroRNA miR-491-5p targeting both TP53 and Bcl-XL induces cell apoptosis in SW1990 pancreatic cancer cells through mitochondria mediated pathway. Molecules 17:14733–14747CrossRefPubMedPubMedCentral
Guo F, Cogdell D, Hu L, Yang D, Sood AK, Xue F, Zhang W (2014) MiR-101 suppresses the epithelial-to-mesenchymal transition by targeting ZEB1 and ZEB2 in ovarian carcinoma. Oncol Rep 31:2021–2028CrossRefPubMedPubMedCentral
Guo X, Cai Q, Bao P, Wu J, Wen W, Ye F, Zheng W, Zheng Y, Shu XO (2016) Long-term soy consumption and tumor tissue MicroRNA and gene expression in triple-negative breast cancer. Cancer 122:2544–2551CrossRefPubMed
Hamam R, Ali AM, Alsaleh KA, Kassem M, Alfayez M, Aldahmash A, Alajez NM (2016) microRNA expression profiling on individual breast cancer patients identifies novel panel of circulating microRNA for early detection. Sci Rep 6:25997CrossRefPubMedPubMedCentral
Hargraves KG, He L, Firestone GL (2015) Phytochemical regulation of the tumor suppressive microRNA, miR-34a, by p53-dependent and independent responses in human breast cancer cells. Mol Carcinog 55:486–498CrossRefPubMedPubMedCentral
Hatley ME, Patrick DM, Garcia MR, Richardson JA, Bassel-Duby R, van Rooij E, Olson EN (2010) Modulation of K-Ras-dependent lung tumorigenesis by MicroRNA-21. Cancer Cell 18:282–293CrossRefPubMedPubMedCentral
Herbert KM, Sarkar SK, Mills M, Delgado De la Herran HC, Neuman KC, Steitz JA (2016) A heterotrimer model of the complete microprocessor complex revealed by single-molecule subunit counting. RNA 22:175–183CrossRefPubMedPubMedCentral
Humphreys KJ, Conlon MA, Young GP, Topping DL, Hu Y, Winter JM, Le Leu RK (2014) Dietary manipulation of oncogenic microRNA expression in human rectal mucosa: a randomized trial. Cancer Prev Res (Phila) 7:786–795CrossRef
Jiang S, Zhang HW, Lu MH, He XH, Li Y, Gu H, Liu MF, Wang ED (2010) MicroRNA-155 functions as an OncomiR in breast cancer by targeting the suppressor of cytokine signaling 1 gene. Cancer Res 70:3119–3127CrossRefPubMed
Jiang F, Zhao W, Zhou L, Zhang L, Liu Z, Yu D (2014) miR-222 regulates the cell biological behavior of oral squamous cell carcinoma by targeting PUMA. Oncol Rep 31:1255–1262CrossRefPubMed
Kapinova A, Kubatka P, Golubnitschaja O, Kello M, Zubor P, Solar P, Pec M (2018) Dietary phytochemicals in breast cancer research: anticancer effects and potential utility for effective chemoprevention. Environ Health Prev Med 23:36CrossRefPubMedPubMedCentral
Katchy A, Williams C (2014) Profiling of estrogen-regulated microRNAs in breast cancer cells. J Vis Exp JoVE 84:e51285
Ke HL, Li WM, Lin HH, Hsu WC, Hsu YL, Chang LL, Huang CN, Li CC, Chang HP, Yeh HC et al (2017) Hypoxia-regulated MicroRNA-210 overexpression is associated with tumor development and progression in upper tract urothelial carcinoma. Int J Med Sci 14:578–584CrossRefPubMedPubMedCentral
Kim YJ, Chung SO, Kim JK, Park SU (2017) Recent studies on resveratrol and its biological and pharmacological activity. EXCLI J 16:602–608PubMedPubMedCentral
Klinge CM (2015) miRNAs regulated by estrogens, tamoxifen, and endocrine disruptors and their downstream gene targets. Mol Cell Endocrinol 418:273–297CrossRefPubMedPubMedCentral
Kong D, Heath E, Chen W, Cher M, Powell I, Heilbrun L, Li Y, Ali S, Sethi S, Hassan O et al (2012) Epigenetic silencing of miR-34a in human prostate cancer cells and tumor tissue specimens can be reversed by BR-DIM treatment. Am J Transl Res 4:14–23PubMedPubMedCentral
Kong W, He L, Richards EJ, Challa S, Xu CX, Permuth-Wey J, Lancaster JM, Coppola D, Sellers TA, Djeu JY et al (2014) Upregulation of miRNA-155 promotes tumour angiogenesis by targeting VHL and is associated with poor prognosis and triple-negative breast cancer. Oncogene 33:679–689CrossRefPubMed
Koo KH, Kwon H (2018) MicroRNA miR-4779 suppresses tumor growth by inducing apoptosis and cell cycle arrest through direct targeting of PAK2 and CCND3. Cell Death Dis 9:77CrossRefPubMedPubMedCentral
Korpal M, Lee ES, Hu G, Kang Y (2008) The miR-200 family inhibits epithelial-mesenchymal transition and cancer cell migration by direct targeting of E-cadherin transcriptional repressors ZEB1 and ZEB2. J Biol Chem 283:14910–14914CrossRefPubMedPubMedCentral
Kubatka P, Uramova S, Kello M, Kajo Karol, Kruzliak P, Mojzis J, Vybohova D, Adamkov M, Jasek K, Lasabova Z et al (2017) Antineoplastic effects of clove buds (Syzygium aromaticum L.) in the model of breast carcinoma. J Cell Mol Med 21:2837–2851CrossRefPubMedPubMedCentral
Kumarswamy R, Mudduluru G, Ceppi P, Muppala S, Kozlowski M, Niklinski J, Papotti M, Allgayer H (2012) MicroRNA-30a inhibits epithelial-to-mesenchymal transition by targeting Snai1 and is downregulated in non-small cell lung cancer. Int J Cancer 130:2044–2053CrossRefPubMed
Kurozumi S, Yamaguchi Y, Kurosumi M, Ohira M, Matsumoto H, Horiguchi J (2017) Recent trends in microRNA research into breast cancer with particular focus on the associations between microRNAs and intrinsic subtypes. J Hum Genet 62:15–24CrossRefPubMed
Ladomery MR, Maddocks DG, Wilson ID (2011) MicroRNAs: their discovery, biogenesis, function and potential use as biomarkers in non-invasive prenatal diagnostics. Int J Mol Epidemiol Genet 2:253–260PubMedPubMedCentral
Lan H, Chen W, He G, Yang S (2015) miR-140-5p inhibits ovarian cancer growth partially by repression of PDGFRA. Biomed Pharmacother 75:117–122CrossRefPubMed
le Sage C, Nagel R, Egan DA, Schrier M, Mesman E, Mangiola A, Anile C, Maira G, Mercatelli N, Ciafrè SA, Farace MG, Agami R (2007) Regulation of the p27(Kip1) tumor suppressor by miR-221 and miR-222 promotes cancer cell proliferation. EMBO J 26:3699–3708CrossRefPubMedPubMedCentral
Lee CM, Lee J, Nam MJ, Park SH (2018) Indole-3-carbinol induces apoptosis in human osteosarcoma MG-63 and U2OS cells. Biomed Res Int 2018:7970618PubMedPubMedCentral
Lewinska A, Adamczyk-Grochala J, Deregowska A, Wnuk M (2017) Sulforaphane-induced cell cycle arrest and senescence are accompanied by DNA hypomethylation and changes in microRNA profile in breast cancer cells. Theranostics 7:3461–3477CrossRefPubMedPubMedCentral
Li C, Hashimi SM, Good DA, Cao S, Duan W, Plummer PN, Mellick AS, Wei MQ (2012) Apoptosis and microRNA aberrations in cancer. Clin Exp Pharmacol Physiol 39:739–746CrossRefPubMed
Li Q, Eades G, Yao Y, Zhang Y, Zhou Q (2014a) Characterization of a stem-like subpopulation in basal-like ductal carcinoma in situ (DCIS) lesions. J Biol Chem 289:1303–1312CrossRefPubMed
Li L, Huang K, You Y, Fu X, Hu L, Song L, Meng Y (2014b) Hypoxia-induced miR-210 in epithelial ovarian cancer enhances cancer cell viability via promoting proliferation and inhibiting apoptosis. Int J Oncol 44:2111–2120CrossRefPubMed
Li L, Li B, Chen D, Liu L, Huang C, Lu Z, Lun L, Wan X (2015a) miR-139 and miR-200c regulate pancreatic cancer endothelial cell migration and angiogenesis. Oncol Rep 34:51–58CrossRefPubMed
Li D, Xia H, Li ZY, Hua L, Li L (2015b) Identification of novel breast cancer subtype-specific biomarkers by integrating genomics analysis of DNA copy number aberrations and miRNA-mRNA dual expression profiling. Biomed Res Int 2015:746970PubMedPubMedCentral
Li Y, Zhang D, Wang X, Yao X, Ye C, Zhang S, Wang H, Chang C, Xia H, Wang YC et al (2015c) Hypoxia-inducible miR-182 enhances HIF1α signaling via targeting PHD2 and FIH1 in prostate cancer. Sci Rep 5:12495CrossRefPubMedPubMedCentral
Li Y, Chen S, Shan Z, Bi L, Yu S, Li Y, Xu S (2017a) miR-182-5p improves the viability, mitosis, migration, and invasion ability of human gastric cancer cells by down-regulating RAB27A. Biosci Rep 37:BSR20170136CrossRefPubMedPubMedCentral
Li W, Yang W, Liu Y, Chen S, Chin S, Qi X, Zhao Y, Liu H, Wang J, Mei X, Huang P, Xu D (2017b) MicroRNA-378 enhances inhibitory effect of curcumin on glioblastoma. Oncotarget 8:73938–73946PubMedPubMedCentral
Li M, Yang Y, Kuang Y, Gan X, Zeng W, Liu Y, Guan H (2017c) miR-365 induces hepatocellular carcinoma cell apoptosis through targeting Bcl-2. Exp Ther Med 13:2279–2285CrossRefPubMedPubMedCentral
Li Y, Domina A, Lim G, Chang T, Zhang T (2018a) Evaluation of curcumin, a natural product in turmeric, on Burkitt lymphoma and acute myeloid leukemia cancer stem cell markers. Future Oncol 14:2353–2360CrossRefPubMed
Li X, Zhao Z, Li M, Liu M, Bahena A, Zhang Y, Zhang Y, Nambiar C, Liu G (2018b) Sulforaphane promotes apoptosis, and inhibits proliferation and self-renewal of nasopharyngeal cancer cells by targeting STAT signal through miRNA-124-3p. Biomed Pharmacother 103:473–481CrossRefPubMed
Lima RT, Busacca S, Almeida GM, Gaudino G, Fennell DA, Vasconcelos MH (2011) MicroRNA regulation of core apoptosis pathways in cancer. Eur J Cancer 47:163–174CrossRefPubMed
Liu L, Yu X, Guo X, Tian Z, Su M, Long Y, Huang C, Zhou F, Liu M, Wu X et al (2012) miR-143 is downregulated in cervical cancer and promotes apoptosis and inhibits tumor formation by targeting Bcl-2. Mol Med Rep 5:753–760CrossRefPubMed
Liu ZL, Wang H, Liu J, Wang ZX (2013) MicroRNA-21 (miR-21) expression promotes growth, metastasis, and chemo- or radioresistance in non-small cell lung cancer cells by targeting PTEN. Mol Cell Biochem 372:35–45CrossRefPubMed
Liu Z, Tu K, Liu Q (2014) Effects of microRNA-30a on migration, invasion and prognosis of hepatocellular carcinoma. FEBS Lett 588:3089–3097CrossRefPubMed
Liu J, Meng T, Yuan M, Wen L, Cheng B, Liu N, Huang X, Hong Y, Yuan H, Hu F (2016) MicroRNA-200c delivered by solid lipid nanoparticles enhances the effect of paclitaxel on breast cancer stem cell. Int J Nanomed 11:6713–6725CrossRef
Lopez-Camarillo C, Marchat LA, Arechaga-Ocampo E, Perez-Plasencia C, Del Moral-Hernandez O, Castaneda-Ortiz EJ, Rodriguez-Cuevas S (2012) MetastamiRs: non-coding MicroRNAs driving cancer invasion and metastasis. Int J Mol Sci 13:1347–1379CrossRefPubMedPubMedCentral
Lu Y, Qin T, Li J, Wang L, Zhang Q, Jiang Z, Mao J (2017) MicroRNA-140-5p inhibits invasion and angiogenesis through targeting VEGF-A in breast cancer. Cancer Gene Ther 24:386–392CrossRefPubMedPubMedCentral
Macfarlane LA, Murphy PR (2010) MicroRNA: biogenesis, function and role in cancer. Curr Genom 11:537–561CrossRef
Martin del Campo SE, Latchana N, Levine KM, Grignol VP, Fairchild ET, Jaime-Ramirez AC, Dao TV, Karpa VI, Carson M, Ganju A et al (2015) MiR-21 enhances melanoma invasiveness via inhibition of tissue inhibitor of metalloproteinases 3 expression: in vivo effects of MiR-21 inhibitor. PLoS One 10:e0115919CrossRefPubMedPubMedCentral
McGuire A, Brown JA, Kerin MJ (2015) Metastatic breast cancer: the potential of miRNA for diagnosis and treatment monitoring. Cancer Metastasis Rev 34:145–155CrossRefPubMedPubMedCentral
Mehrgou A, Akouchekian M (2017) Therapeutic impacts of microRNAs in breast cancer by their roles in regulating processes involved in this disease. J Res Med Sci 22:130CrossRefPubMedPubMedCentral
Morales S, Monzo M, Navarro A (2017) Epigenetic regulation mechanisms of microRNA expression. Biomol Concepts 8:203–212CrossRefPubMed
Munagala R, Aqil F, Vadhanam MV, Gupta RC (2013) MicroRNA ‘signature’ during estrogen-mediated mammary carcinogenesis and its reversal by ellagic acid intervention. Cancer Lett 339:175–184CrossRefPubMedPubMedCentral
O’Brien J, Hayder H, Zayed Y, Peng C (2018) Overview of microRNA biogenesis, mechanisms of actions, and circulation. Front Endocrinol (Lausanne) 9:402CrossRef
Otsuka K, Yamamoto Y, Ochiya T (2018) Regulatory role of resveratrol, a microRNA-controlling compound, in HNRNPA1 expression, which is associated with poor prognosis in breast cancer. Oncotarget 9:24718–24730CrossRefPubMedPubMedCentral
Pan Z, Zhang M, Ma T, Xue ZY, Li GF, Hao LY, Cao JL (2016) Hydroxymethylation of microRNA-365-3p regulates nociceptive behaviors via Kcnh2. J Neurosci 36:2769–2781CrossRefPubMedPubMedCentral
Pan JH, Abernathy B, Kim YJ, Lee JH, Kim JH, Shin EC, Kim JK (2017) Cruciferous vegetables and colorectal cancer prevention through microRNA regulation: a review. Crit Rev Food Sci Nutr 58:2026–2038CrossRefPubMed
Pang L, Li B, Zheng B, Niu L, Ge L (2017) miR-138 inhibits gastric cancer growth by suppressing SOX4. Oncol Rep 38:1295–1302CrossRefPubMed
Pasculli B, Barbano R, Parrella P (2018) Epigenetics of breast cancer: biology and clinical implication in the era of precision medicine. Semin Cancer Biol 51:22–35CrossRefPubMed
Patafio FM, Brooks SC, Wei X, Peng Y, Biagi J, Booth CM (2016) Research output and the public health burden of cancer: is there any relationship? Curr Oncol 23:75–80CrossRefPubMedPubMedCentral
Peschansky VJ, Wahlestedt C (2014) Non-coding RNAs as direct and indirect modulators of epigenetic regulation. Epigenetics 9:3–12CrossRefPubMed
Qadir MI, Faheem A (2017) miRNA: a diagnostic and therapeutic tool for pancreatic cancer. Crit Rev Eukaryot Gene Expr 27:197–204CrossRefPubMed
Qin W, Zhang K, Clarke K, Weiland T, Sauter ER (2014) Methylation and miRNA effects of resveratrol on mammary tumors vs. normal tissue. Nutr Cancer 66:270–277CrossRefPubMed
Qu J, Li M, An J, Zhao B, Zhong W, Gu Q, Cao L, Yang H, Hu C (2015) MicroRNA-33b inhibits lung adenocarcinoma cell growth, invasion, and epithelial-mesenchymal transition by suppressing Wnt/β-catenin/ZEB1 signaling. Int J Oncol 47:2141–2152CrossRefPubMed
Razumilava N, Bronk SF, Smoot RL, Fingas CD, Werneburg NW, Roberts LR, Mott JL (2012) miR-25 targets TNF-related apoptosis inducing ligand (TRAIL) death receptor-4 and promotes apoptosis resistance in cholangiocarcinoma. Hepatology 55:465–475CrossRefPubMed
Remenyi J, Bajan S, Fuller-Pace FV, Arthur JSC, Hutvagner G (2016) The loop structure and the RNA helicase p72/DDX17 influence the processing efficiency of the mice miR-132. Sci Rep 6:22848CrossRefPubMedPubMedCentral
Rhodes LV, Martin EC, Segar HC, Miller DF, Buechlein A, Rusch DB, Nephew KP, Burow ME, Collins-Burow BM (2015) Dual regulation by microRNA-200b-3p and microRNA-200b-5p in the inhibition of epithelial-to-mesenchymal transition in triple-negative breast cancer. Oncotarget 6:16638–16652CrossRefPubMedPubMedCentral
Rigalli JP, Tocchetti GN, Arana MR, Villanueva SS, Catania VA, Theile D, Ruiz ML, Weiss J (2016) The phytoestrogen genistein enhances multidrug resistance in breast cancer cell lines by translational regulation of ABC transporters. Cancer Lett 376:165–172CrossRefPubMed
Rokavec M, Li H, Jiang L, Hermeking H (2014) The p53/miR-34 axis in development and disease. J Mol Cell Biol 6:214–230CrossRefPubMed
Roscigno G, Puoti I, Giordano I, Donnarumma E, Russo V, Affinito A, Adamo A, Quintavalle C, Todaro M, Vivanco MD et al (2017) MiR-24 induces chemotherapy resistance and hypoxic advantage in breast cancer. Oncotarget 8:19507–19521CrossRefPubMedPubMedCentral
Ross SA, Davis CD (2014) The emerging role of microRNAs and nutrition in modulating health and disease. Annu Rev Nutr 34:305–336CrossRefPubMed
Rupaimoole R, Slack FJ (2017) MicroRNA therapeutics: towards a new era for the management of cancer and other diseases. Nat Rev Drug Discov 16:203–222CrossRefPubMed
Sayeed A, Bracci M, Lazzarini R, Tomasetti M, Amati M, Lucarini G, Di Primio R, Santarelli L (2017) Use of potential dietary phytochemicals to target miRNA: promising option for breast cancer prevention and treatment? J Funct Foods 28:177–193CrossRef
Setijono SR, Park M, Kim G, Kim Y, Cho KW, Song SJ (2018) miR-218 and miR-129 regulate breast cancer progression by targeting Lamins. Biochem Biophys Res Commun 496:826–833CrossRefPubMed
Shi W, Bruce J, Lee M, Yue S, Rowe M, Pintilie M, Kogo R, Bissey PA, Fyles A, Yip KW et al (2016) MiR-449a promotes breast cancer progression by targeting CRIP2. Oncotarget 7:18906–18918PubMedPubMedCentral
Slaby O, Sachlova M, Brezkova V, Hezova R, Kovarikova A, Bischofová S, Sevcikova S, Bienertova-Vasku J, Vasku A, Svoboda M et al (2013) Identification of microRNAs regulated by isothiocyanates and association of polymorphisms inside their target sites with risk of sporadic colorectal cancer. Nutr Cancer 65:247–254CrossRefPubMed
Song J, Shao Q, Li C, Liu H, Li J, Wang Y, Song W, Li L, Wang G, Shao Z et al (2017) Effects of microRNA-21 on apoptosis by regulating the expression of PTEN in diffuse large B-cell lymphoma. Medicine 96:e7952CrossRefPubMedPubMedCentral
Spagnuolo C, Russo GL, Orhan IE, Habtemariam S, Daglia M, Sureda A, Nabavi SF, Devi KP, Loizzo MR, Tundis R et al (2015) Genistein and cancer: current status, challenges, and future directions. Adv Nutr 6:408–419CrossRefPubMedPubMedCentral
Srivastava SK, Arora S, Averett C, Singh S, Singh AP (2015) Modulation of microRNAs by phytochemicals in cancer: underlying mechanisms and translational significance. Biomed Res Int 2015:848710PubMedPubMedCentral
Takahashi RU, Miyazaki H, Ochiya T (2015) The roles of MicroRNAs in breast cancer. Cancers (Basel) 7:598–616CrossRef
Tan W, Liu B, Qu S, Liang G, Luo W, Gong C (2017) MicroRNAs and cancer: key paradigms in molecular therapy. Oncol Lett 15:2735–2742PubMedPubMedCentral
Tao Z, Shi A, Lu C, Song T, Zhang Z, Zhao J (2015) Breast cancer: epidemiology and etiology. Cell Biochem Biophys 72:333–338CrossRefPubMed
Tarallo S, Pardini B, Mancuso G, Rosa F, Di Gaetano C, Rosina F, Vineis P, Naccarati A (2014) MicroRNA expression in relation to different dietary habits: a comparison in stool and plasma samples. Mutagenesis 29:385–391CrossRefPubMed
Treiber T, Treiber N, Meister G (2018) Regulation of microRNA biogenesis and its crosstalk with other cellular pathways. Nat Rev Mol Cell Biol 20:5–20CrossRef
Tsai HP, Huang SF, Li CF, Chien HT, Chen SC (2018) Differential microRNA expression in breast cancer with different onset age. PLoS One 13:e0191195CrossRefPubMedPubMedCentral
Uramova S, Kubatka P, Dankova Z, Kapinova A, Zolakova B, Samec M, Zubor P, Zulli A, Valentova V, Kwon TK et al (2018) Plant natural modulators in breast cancer prevention: status quo and future perspectives reinforced by predictive, preventive, and personalized medical approach. EPMA J 9:403–419CrossRefPubMedPubMedCentral
Ustianenko D, Chiu HS, Treiber T, Weyn-Vanhentenryck SM, Treiber N, Meister G, Zhang C (2018) LIN28 selectively modulates a subclass of Let-7 MicroRNAs. Mol Cell 71:271–283.e5CrossRefPubMedPubMedCentral
van Schooneveld E, Wildiers H, Vergote I, Vermeulen PB, Dirix LY, Van Laere SJ (2015) Dysregulation of microRNAs in breast cancer and their potential role as prognostic and predictive biomarkers in patient management. Breast Cancer Res 17:21CrossRefPubMedPubMedCentral
Varghese E, Samuel SM, Abotaleb M, Cheema S, Mamtani R, Büsselberg D (2018) The “Yin and Yang” of natural compounds in anticancer therapy of triple-negative breast cancers. Cancers (Basel) 10:346CrossRef
Venkatadri R, Muni T, Iyer AK, Yakisich JS, Azad N (2016) Role of apoptosis-related miRNAs in resveratrol-induced breast cancer cell death. Cell Death Dis 7:e2104CrossRefPubMedPubMedCentral
Wang W, Ren F, Wu Q, Jiang D, Li H, Shi H (2014a) MicroRNA-497 suppresses angiogenesis by targeting vascular endothelial growth factor A through the PI3 K/AKT and MAPK/ERK pathways in ovarian cancer. Oncol Rep 32:2127–2133CrossRefPubMed
Wang X, He H, Lu Y, Ren W, Teng KY, Chiang CL, Yang Z, Yu B, Hsu S, Jacob ST et al (2014b) Indole-3-carbinol inhibits tumorigenicity of hepatocellular carcinoma cells via suppression of microRNA-21 and upregulation of phosphatase and tensin homolog. Biochim Biophys Acta 1853:244–253CrossRefPubMedPubMedCentral
Wang CZ, Yuan P, Li Y (2015) MiR-126 regulated breast cancer cell invasion by targeting ADAM9. Int J Clin Exp Pathol 8:6547–6553PubMedPubMedCentral
Wang Y, Zeng J, Pan J, Geng X, Liu Y, Wu J, Song P, Wang Y, Jia J, Wang L (2016) MicroRNA-200c is involved in proliferation of gastric cancer by directly repressing p27Kip1. Biochem Biophys Rep 8:227–233PubMedPubMedCentral
Wang DX, Zou YJ, Zhuang XB, Chen SX, Lin Y, Li WL, Lin JJ, Lin ZQ (2017) Sulforaphane suppresses EMT and metastasis in human lung cancer through miR-616-5p-mediated GSK3β/β-catenin signaling pathways. Acta Pharmacol Sin 38:241–251CrossRefPubMed
Wang D, Tang L, Wu H, Wang K, Gu D (2018a) MiR-127-3p inhibits cell growth and invasiveness by targeting ITGA6 in human osteosarcoma. IUBMB Life 70:411–419CrossRefPubMed
Wang K, Tan SL, Lu Q, Xu R, Cao J, Wu SQ, Wang YH, Zhao XK, Zhong ZH (2018b) Curcumin suppresses microRNA-7641-mediated regulation of p16 expression in bladder cancer. Am J Chin Med 46:1357–1368CrossRefPubMed
Wang Y, Wang L, Chen C, Chu X (2018c) New insights into the regulatory role of microRNA in tumor angiogenesis and clinical implications. Mol Cancer 17:22CrossRefPubMedPubMedCentral
Webster RJ, Giles KM, Price KJ, Zhang PM, Mattick JS, Leedman PJ (2009) Regulation of epidermal growth factor receptor signaling in human cancer cells by microRNA-7. J Biol Chem 284:5731–5741CrossRefPubMed
Wei D, Yang L, Lv B, Chen L (2017) Genistein suppresses retinoblastoma cell viability and growth and induces apoptosis by upregulating miR-145 and inhibiting its target ABCE1. Mol Vis 23:385–394PubMedPubMedCentral
Weiss CN, Ito K (2017) A macro view of microRNAs: the discovery of MicroRNAs and their role in hematopoiesis and hematologic disease. Int Rev Cell Mol Biol 334:99–175CrossRefPubMedPubMedCentral
Wilk G, Braun R (2018) regQTLs: single nucleotide polymorphisms that modulate microRNA regulation of gene expression in tumors. PLoS Genet 14:e1007837CrossRefPubMedPubMedCentral
Winther M, Alsner J, Sørensen BS, Wittrup CF, Tramm T, Baeksgaard L, Hofland K, Holtved E, Nordsmark M (2016) Hypoxia-regulated MicroRNAs in gastroesophageal cancer. Anticancer Res 36:721–730PubMed
Wu Y, Song Y, Xiong Y, Wang X, Xu K, Han B, Bai Y, Li L, Zhang Y, Zhou L (2017) MicroRNA-21 (Mir-21) promotes cell growth and invasion by repressing tumor suppressor PTEN in colorectal cancer. Cell Physiol Biochem 43:945–958CrossRefPubMed
Xu H, Hu Y, Qiu W (2017) Potential mechanisms of microRNA-129-5p in inhibiting cell processes including viability, proliferation, migration and invasiveness of glioblastoma cells U87 through targeting FNDC3B. Biomed Pharmacother 87:405–411CrossRefPubMed
Xu X, Gao F, Wang J, Tao L, Ye J, Ding L, Ji W, Chen X (2018) MiR-122-5p inhibits cell migration and invasion in gastric cancer by down-regulating DUSP4. Cancer Biol Ther 19:427–435CrossRefPubMedPubMedCentral
Xue X, Liu Y, Wang Y, Meng M, Wang K, Zang X, Zhao S, Sun X, Cui L, Pan L et al (2016) MiR-21 and MiR-155 promote non-small cell lung cancer progression by downregulating SOCS1, SOCS6, and PTEN. Oncotarget 7:84508–84519PubMedPubMedCentral
Yamada S, Tsukamoto S, Huang Y, Makio A, Kumazoe M, Yamashita S, Tachibana H (2016) Epigallocatechin-3-O-gallate up-regulates microRNA-let-7b expression by activating 67-kDa laminin receptor signaling in melanoma cells. Sci Rep 6:19225CrossRefPubMedPubMedCentral
Yang Y, Zhang J, Xia T, Li G, Tian T, Wang M, Wang R, Zhao L, Yang Y, Lan K et al (2016) MicroRNA-210 promotes cancer angiogenesis by targeting fibroblast growth factor receptor-like 1 in hepatocellular carcinoma. Oncol Rep 36:2553–2562CrossRefPubMed
Yang X, Shi L, Yi C, Yang Y, Chang L, Song D (2017) MiR-210-3p inhibits the tumor growth and metastasis of bladder cancer via targeting fibroblast growth factor receptor-like 1. Am J Cancer Res 7:1738–1753PubMedPubMedCentral
Yang H, Zhang H, Ge S, Ning T, Bai M, Li J, Li S, Sun W, Deng T, Zhang L et al (2018) Exosome-derived miR-130a activates angiogenesis in gastric cancer by targeting C-MYB in vascular endothelial cells. Mol Ther 26:2466–2475CrossRefPubMedPubMedCentral
Zendehdel E, Abdollahi E, Momtazi-Borojeni AA, Korani M, Alavizadeh SH, Sahebkar A (2018) The molecular mechanisms of curcumin’s inhibitory effects on cancer stem cells. J Cell Biochem 120:4739–4747CrossRefPubMed
Zhan Y, Liang X, Li L, Wang B, Ding F, Li Y, Wang X, Zhan Q, Liu Z (2016) MicroRNA-548j functions as a metastasis promoter in human breast cancer by targeting Tensin1. Mol Oncol 10:838–849CrossRefPubMedPubMedCentral
Zhang Y, Callaway EC (2002) High cellular accumulation of sulphoraphane, a dietary anticarcinogen, is followed by rapid transporter-mediated export as a glutathione conjugate. Biochem J364(Pt 1):301–307CrossRef
Zhang YQ, Wang WY, Xue JX, Xu Y, Fan P, Caughey BA, Tan WW, Cao GQ, Jiang LL, Lu Y et al (2016) Expression profile on solid subtype of invasive lung adenocarcinoma reveals a panel of four miRNAs to be associated with poor prognosis in Chinese patients. J Cancer 7:1610–1620CrossRefPubMedPubMedCentral
Zhou H, Chen JX, Yang CS, Yang MQ, Deng Y, Wang H (2014) Gene regulation mediated by microRNAs in response to green tea polyphenol EGCG in mouse lung cancer. BMC Genom 15(Suppl 11):S3CrossRef
Zhu J, Ye Q, Chang L, Xiong W, He Q, Li W (2015) Upregulation of miR-195 enhances the radiosensitivity of breast cancer cells through the inhibition of BCL-2. Int J Clin Exp Med 8:9142–9148PubMedPubMedCentral
Zubor P, Kubatka P, Dankova Z, Gondova A, Kajo K, Hatok J, Samec M, Jagelkova M, Krivus S, Holubekova V et al (2018) miRNA in a multiomic context for diagnosis, treatment monitoring and personalized management of metastatic breast cancer. Future Oncol 14:1847–1867CrossRefPubMed
Metadaten
Titel
The role of dietary phytochemicals in the carcinogenesis via the modulation of miRNA expression
verfasst von
Marek Samec
Alena Liskova
Peter Kubatka
Sona Uramova
Pavol Zubor
Samson Mathews Samuel
Anthony Zulli
Martin Pec
Tibor Bielik
Kamil Biringer
Erik Kudela
Jozef Benacka
Mariusz Adamek
Luis Rodrigo
Rachele Ciccocioppo
Taeg Kyu Kwon
Denis Baranenko
Peter Kruzliak
Dietrich Büsselberg
Publikationsdatum
24.05.2019
Verlag
Springer Berlin Heidelberg
Erschienen in
Journal of Cancer Research and Clinical Oncology / Ausgabe 7/2019
Print ISSN: 0171-5216
Elektronische ISSN: 1432-1335
DOI
https://doi.org/10.1007/s00432-019-02940-0

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