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Erschienen in: European Archives of Oto-Rhino-Laryngology 5/2019

16.03.2019 | Head & Neck

The role of F18-fluorocholine positron emission tomography/magnetic resonance imaging in localizing parathyroid adenomas

verfasst von: Avi Khafif, Muhamed Masalha, Roee Landsberg, Liran Domachevsky, Hanna Bernstine, David Groshar, Ofer Azoulay, Yehudit Lockman

Erschienen in: European Archives of Oto-Rhino-Laryngology | Ausgabe 5/2019

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Abstract

Purpose

Preoperative localization of a parathyroid adenoma is usually obtained by the combination of ultrasound and scintigraphy with technetium-99m methoxyisobutylisonitrile. We evaluated the role of F18-fluorocholine in neck positron emission tomography/magnetic resonance imaging as a novel tool for localizing parathyroid adenomas.

Methods

Patients with primary hyperparathyroidism were recruited from February 2016 to August 2017 and F18-fluorocholine positron emission tomography/magnetic resonance imaging was performed to localize the parathyroid adenoma prior to surgery. We compared sensitivity and accuracy of this modality with ultrasound and technetium-99m methoxyisobutylisonitrile scintigraphy using the verified location of the diseased parathyroid as found in surgery.

Results

Nineteen patients were included in our study (15 women and 4 men, mean age 60.5 ± 9.8 years). Positron emission tomography/magnetic resonance imaging precisely localized the pathologic parathyroid gland in 16/19 cases (84.2%) and predicted the diseased side in 19/19 cases (100%). Ultrasound and technetium 99 m methoxyisobutylisonitrile sestamibi scintigraphy predicted the location of the parathyroid adenoma in 16/19 (84.2%) and 14/19 (74%), respectively. In 3/19 patients, positron emission tomography/magnetic resonance imaging localized the parathyroid adenoma where as other modalities failed. Positron emission tomography/magnetic resonance imaging was more accurate when compared to each modality separately (p < 0.001, p = 0.017), however, when comparing the three modalities all together no differences were found (p = 0.506).

Conclusions

Localizing parathyroid adenomas with F18-fluorocholine positron emission tomography/magnetic resonance imaging may be a promising secondary imaging modality.
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Metadaten
Titel
The role of F18-fluorocholine positron emission tomography/magnetic resonance imaging in localizing parathyroid adenomas
verfasst von
Avi Khafif
Muhamed Masalha
Roee Landsberg
Liran Domachevsky
Hanna Bernstine
David Groshar
Ofer Azoulay
Yehudit Lockman
Publikationsdatum
16.03.2019
Verlag
Springer Berlin Heidelberg
Erschienen in
European Archives of Oto-Rhino-Laryngology / Ausgabe 5/2019
Print ISSN: 0937-4477
Elektronische ISSN: 1434-4726
DOI
https://doi.org/10.1007/s00405-019-05301-2

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