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Erschienen in: Cancer and Metastasis Reviews 3/2017

15.08.2017

The role of human papillomavirus on the prognosis and treatment of oropharyngeal carcinoma

verfasst von: Nicholas Fung, Farhoud Faraji, Hyunseok Kang, Carole Fakhry

Erschienen in: Cancer and Metastasis Reviews | Ausgabe 3/2017

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Abstract

Human papillomavirus positive oropharyngeal cancer (HPV-positive OPC) is a distinct subtype of head and neck carcinoma (HNC) distinguished from HPV-negative HNC by its risk factor profile, clinical behavior, and molecular biology. Compared to HPV-negative HNC, HPV-positive OPC exhibits significantly better prognosis and an enhanced response to treatment. Recognition of the survival benefit of HPV-positive tumors has led to therapeutic de-intensification strategies aiming to mitigate treatment-related toxicities while maintaining high response rates. In this review, we summarize key aspects of oral HPV infection and the molecular mechanisms of HPV-related carcinogenesis. We review the clinical and molecular characteristics of HPV-positive OPC that contribute to its improved prognosis compared to HPV-negative HNC. We also discuss current and emerging treatment strategies, emphasizing potential mechanisms of treatment sensitivity and the role of therapeutic de-intensification in HPV-positive OPC. Lastly, we examine literature on the management and prognosis of recurrent/metastatic HPV-positive OPC with a focus on the role of salvage surgery in its management.
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Metadaten
Titel
The role of human papillomavirus on the prognosis and treatment of oropharyngeal carcinoma
verfasst von
Nicholas Fung
Farhoud Faraji
Hyunseok Kang
Carole Fakhry
Publikationsdatum
15.08.2017
Verlag
Springer US
Erschienen in
Cancer and Metastasis Reviews / Ausgabe 3/2017
Print ISSN: 0167-7659
Elektronische ISSN: 1573-7233
DOI
https://doi.org/10.1007/s10555-017-9686-9

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