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22.07.2020 | Review

The role of interferon-γ in cardiovascular disease: an update

verfasst von: Ailin Elyasi, Iryna Voloshyna, Saba Ahmed, Lora J. Kasselman, Jennifer Behbodikhah, Joshua De Leon, Allison B. Reiss

Erschienen in: Inflammation Research | Ausgabe 10/2020

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Abstract

Purpose

Cardiovascular disease (CVD) is the leading cause of death, globally, and its prevalence is only expected to rise due to the increasing incidence of co-morbidities such as obesity and diabetes. Medical treatment of CVD is directed primarily at slowing or reversing the underlying atherosclerotic process by managing circulating lipids with an emphasis on control of low-density lipoprotein (LDL) cholesterol. However, over the past several decades, there has been increasing recognition that chronic inflammation and immune system activation are important contributors to atherosclerosis. This shift in focus has led to the elucidation of the complex interplay between cholesterol and cellular secretion of cytokines involved in CVD pathogenesis. Of the vast array of cytokine promoting atherosclerosis, interferon (IFN)-γ is highly implicated and, therefore, of great interest.

Methods

Literature review was performed to further understand the effect of IFN-γ on the development of atherosclerotic CVD.

Results

IFN-γ, the sole member of the type II IFN family, is produced by T cells and macrophages, and has been found to induce production of other cytokines and to have multiple effects on all stages of atherogenesis. IFN-γ activates a variety of signaling pathways, most commonly the Janus kinase (JAK)/signal transducer and activator of transcription (STAT) pathway, to induce oxidative stress, promote foam cell accumulation, stimulate smooth muscle cell proliferation and migration into the arterial intima, enhance platelet-derived growth factor expression, and destabilize plaque. These are just a few of the contributions of IFN-γ to the initiation and progression of atherosclerotic CVD.

Conclusion

Given the pivotal role of IFN-γ in the advancement of CVD, activation of its signaling pathways is being explored as a driver of atherosclerosis. Manipulation of this key cytokine may lead to novel therapeutic avenues for CVD prevention and treatment. A number of therapies are being explored with IFN-γ as the potential target.

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Titel: The role of interferon-γ in cardiovascular disease: an update
verfasst von: Ailin Elyasi
Iryna Voloshyna
Saba Ahmed
Lora J. Kasselman
Jennifer Behbodikhah
Joshua De Leon
Allison B. Reiss
Publikationsdatum: 22.07.2020
Verlag: Springer International Publishing
Erschienen in: Inflammation Research / Ausgabe 10/2020
Print ISSN: 1023-3830
Elektronische ISSN: 1420-908X
DOI: https://doi.org/10.1007/s00011-020-01382-6

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Weitere Artikel der Ausgabe 10/2020

Meeting report of the 49th annual meeting of the European Histamine Research Society (EHRS)

A role for mast cells and mast cell tryptase in driving neutrophil recruitment in LPS-induced lung inflammation via protease-activated receptor 2 in mice

The impact of the duration of HAART on cytokine profiles in pregnancy

Omega-3 polyunsaturated fatty acids: a promising approach for the management of oral lichen planus

Systematic review and meta-analysis of association of polymorphisms in inflammatory cytokine genes with coronary artery disease

Transcriptomic analysis of hidradenitis suppurativa skin suggests roles for multiple inflammatory pathways in disease pathogenesis

Leitlinien kompakt für die Innere Medizin

Neu im Fachgebiet Innere Medizin

Metformin rückt in den Hintergrund

Myokarditis nach Infekt – richtig schwierig wird es bei Profisportlern

Thrombophiliescreening – Wenn, dann richtig und nur bei therapeutischer Konsequenz

Bei Senioren mit Prostatakarzinom auf Anämie achten!

Update Innere Medizin