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Journal of Genetic Counseling

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12.07.2016 | Original Research

The Role of Knowledge on Genetic Counseling and Testing in Black Cancer Survivors at Increased Risk of Carrying a BRCA1/2 Mutation

verfasst von: Alejandra Hurtado-de-Mendoza, Monica C. Jackson, Lyndsay Anderson, Vanessa B. Sheppard

Erschienen in: Journal of Genetic Counseling | Ausgabe 1/2017

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Abstract

Genetic counseling and testing (GCT) for hereditary breast and ovarian cancers (HBOC) can inform treatment decisions in survivors. Black women at risk of HBOC have lower GCT engagement. There is limited data about Black survivors’ experiences. The goals of this study were to: 1) examine the factors associated with HBOC knowledge and 2) assess the impact of knowledge on GCT engagement in a sample of Black survivors at risk of HBOC. Fifty Black at-risk breast/ovarian cancer survivors participated in a telephone-based survey. GCT use was measured across a continuum (awareness, referral, and use). The primary predictor variable was HBOC knowledge. Other clinical, socio-demographic, and psychosocial variables were included. Multiple linear and ordinal regression models (knowledge as the outcome and GCT as the outcome) assessed the predictors of knowledge and GCT engagement. Less than half (48 %) of survivors were referred to or used GCT services. Knowledge was moderate (M = 7.78, SD = 1.61). In the multivariable analysis, lower age (β = −.34, p = .01) and lower stage (β = −.318, p = .017) were associated with higher knowledge. Higher knowledge (β = .567, p = .006) and higher self-efficacy (β = .406, p = .001) were significantly associated with GCT engagement. Future interventions directed at increasing knowledge, self-efficacy, and improving the referral process are warranted.

Armstrong, K., Micco, E., Carney, A., Stopfer, J., & Putt, M. (2005). Racial differences in the use of BRCA1/2 testing among women with a family history of breast or ovarian cancer. JAMA: The Journal of the American Medical Association, 293(1538–3598; 14), 1729–1736.CrossRefPubMed

Baty, B. J., Kinney, A. Y., & Ellis, S. M. (2003). Developing culturally sensitive cancer genetics communication aids for african americans. American Journal of Medical Genetics, 118 A(0148–7299; 2), 146–155.CrossRef

Brewster, K., Wileyto, E. P., Kessler, L., Collier, A., Weathers, B., Stopfer, J. E., et al. (2007). Sociocultural predictors of breast cancer risk perceptions in african american breast cancer survivors. Cancer Epidemiology, Biomarkers & Prevention: A Publication of the American Association for Cancer Research, Cosponsored by the American Society of Preventive Oncology, 16(2), 244–248. doi:10.1158/1055-9965.EPI-06-0481.CrossRef

Butrick, M., Kelly, S., Peskin, B., Luta, G., Nusbaum, R., Hooker, G., et al. (2015). Disparities in uptake of BRCA1/2 genetic testing in a randomized trial of telephone counseling. Genetics in Medicine, 17, 467–475.CrossRefPubMed

Charles, S., Kessler, L., Stopfer, J. E., Domchek, S., & Halbert, C. H. (2006). Satisfaction with genetic counseling for BRCA1 and BRCA2 mutations among african american women. Patient Education and Counseling, 63(1–2), 196–204. Retrieved from http://proxy.library.georgetown.edu/login?url=http://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med5&AN=16533589

Daly, B., & Olopade, O. I. (2015). A perfect storm: how tumor biology, genomics, and health care delivery patterns collide to create a racial survival disparity in breast cancer and proposed interventions for change. CA: a Cancer Journal for Clinicians, 65(3), 221–238. doi:10.3322/caac.21271.

DeSantis, C., Ma, J., Bryan, L., & Jemal, A. (2014). Breast cancer statistics, 2013. CA: a Cancer Journal for Clinicians, 64(1), 52–62. doi:10.3322/caac.21203.

Donovan, K. A., & Tucker, D. C. (2000). Knowledge about genetic risk for breast cancer and perceptions of genetic testing in a sociodemographically diverse sample. Journal of Behavioral Medicine, 23(0160–7715; 1), 15–36.CrossRefPubMed

Easton, D. F. (1999). How many more breast cancer predisposition genes are there? Breast Cancer Research: BCR, 1(1), 14–17.CrossRefPubMedPubMedCentral

Easton, D. F., & Ford, D. (1995). The genetics of breast and ovarian cancer. British Journal of Cancer, 72(4), 805–812.CrossRefPubMedPubMedCentral

Erblich, J., Brown, K., Kim, Y., Valdimarsdottir, H. B., Livingston, B. E., & Bovbjerg, D. H. (2005). Development and validation of a breast cancer genetic counseling knowledge questionnaire. Patient Education and Counseling, 56(2), 182–191. doi:S0738399104000837

Faul, F., Erdfelder, E., Buchner, A., & Lang, A. G. (2009). Statistical power analyses using G*power 3.1: tests for correlation and regression analyses. Behavior Research Methods, 41(4), 1149–1160. doi:10.3758/BRM.41.4.1149.CrossRefPubMed

Forman, A. D., & Hall, M. J. (2009). Influence of race/ethnicity on genetic counseling and testing for hereditary breast and ovarian cancer. The Breast Journal, 15 Suppl 1(1524–4741; 1075–122), S56–S62.CrossRefPubMed

Glenn, B. A., Chawla, N., & Bastani, R. (2012). Barriers to genetic testing for breast cancer risk among ethnic minority women: an exploratory study. Ethnicity & Disease, 22(3), 267–273.

Graeser, M. K., Engel, C., Rhiem, K., Gadzicki, D., Bick, U., Kast, K., et al. (2009). Contralateral breast cancer risk in BRCA1 and BRCA2 mutation carriers. Journal of Clinical Oncology: Official Journal of the American Society of Clinical Oncology, 27(35), 5887–5892. doi:10.1200/JCO.2008.19.9430.CrossRef

Halbert, C., Gomez-Caminero, A., Benkendorf, J., Kerner, J., Isaacs, C., Barter, J., et al. (1997). Ethnic differences in knowledge and attitudes about BRCA1 testing in women at increased risk. Patient Education and Counseling, 32(0738–3991; 1–2), 51–62.

Halbert, C. H., Schwartz, M. D., Wenzel, L., Narod, S., Peshkin, B. N., Cella, D., et al. (2004). Predictors of cognitive appraisals following genetic testing for BRCA1 and BRCA2 mutations. Journal of Behavioral Medicine, 27(0160–7715; 0160–7715; 4), 373–392.CrossRefPubMed

Halbert, C. H., Kessler, L., Troxel, A. B., Stopfer, J. E., & Domchek, S. (2010). Effect of genetic counseling and testing for BRCA1 and BRCA2 mutations in african american women: a randomized trial. Public Health Genomics, 13, 440–448.CrossRefPubMedPubMedCentral

Halbert, C., Kessler, L., Collier, A., Weathers, B., Stopfer, J., Domcheck, S., et al. (2012). Low rates of african american participation in genetic counseling and testing for BRCA1/2 mutations: racial disparities or just a difference? Journal of Genetic Counseling, 21(5), 676–683.CrossRefPubMedPubMedCentral

Hall, M., & Olopade, O. I. (2005). Confronting genetic testing disparities: Knowledge is power. JAMA: The Journal of the American Medical Association, 293(1538–3598; 14), 1783–1785.CrossRefPubMed

Hamilton, R., Williams, J. K., Bowers, B. J., & Calzone, K. (2009). Life trajectories, genetic testing, and risk reduction decisions in 18-39 year old women at risk for hereditary breast and ovarian cancer. Journal of Genetic Counseling, 18(2), 147–159. doi:10.1007/s10897-008-9200-1.CrossRefPubMed

IBM, C. (2015). IBM SPSS statistics for windows, version 23.0. armonk, NY: IBM corp.

Jagsi, R., Griffith, K. A., Kurian, A. W., Morrow, M., Hamilton, A. S., Graff, J. J., et al. (2015). Concerns about cancer risk and experiences with genetic testing in a diverse population of patients with breast cancer. Journal of Clinical Oncology: Official Journal of the American Society of Clinical Oncology, 33(14), 1584–1591. doi:10.1200/JCO.2014.58.5885.CrossRef

Julian-Reynier, C., Mancini, J., Mouret-Fourme, E., Gauthier-Villars, M., Bonadona, V., Berthet, P., et al. (2011). Cancer risk management strategies and perceptions of unaffected women 5 years after predictive genetic testing for BRCA1/2 mutations. European Journal of Human Genetics: EJHG, 19(5), 500–506. doi:10.1038/ejhg.2010.241.CrossRefPubMedPubMedCentral

Kaphingst, K. A., Stafford, J. D., McGowan, L. D., Seo, J., Lachance, C. R., & Goodman, M. S. (2015). Effects of racial and ethnic group and health literacy on responses to genomic risk information in a medically underserved population. Health Psychology: Official Journal of the Division of Health Psychology, American Psychological Association, 34(2), 101–110. doi:10.1037/hea0000177.CrossRef

Kinney, A. Y., Simonsen, S. E., Baty, B. J., Mandal, D., Neuhausen, S. L., Seggar, K., et al. (2006). Acceptance of genetic testing for hereditary breast ovarian cancer among study enrollees from an african american kindred. American Journal of Medical Genetics. Part A, 140(1552–4825; 1552–4825; 8), 813–826.CrossRefPubMedPubMedCentral

LaVeist, T. A., Isaac, L. A., & Williams, K. P. (2009). Mistrust of health care organizations is associated with underutilization of health services. Health Services Research, 44(1475–6773; 0017–9124; 6), 2093–2105.CrossRefPubMedPubMedCentral

Lea, D. H., Kaphingst, K. A., Bowen, D., Lipkus, I., & Hadley, D. W. (2011). Communicating genetic and genomic information: health literacy and numeracy considerations. Public Health Genomics, 14(4–5), 279–289. doi:10.1159/000294191.CrossRefPubMed

Levy, D. E., Byfield, S. D., Comstock, C. B., Garber, J. E., Syngal, S., Crown, W. H., et al. (2011). Underutilization of BRCA1/2 testing to guide breast cancer treatment: Black and hispanic women particularly at risk. Genetics in Medicine: Official Journal of the American College of Medical Genetics, 13(4), 349–355. doi:10.1097/GIM.0b013e3182091ba4.CrossRef

Lipkus, I. M., Iden, D., Terrenoire, J., & Feaganes, J. R. (1999). Relationships among breast cancer concern, risk perceptions, and interest in genetic testing for breast cancer susceptibility among african-american women with and without a family history of breast cancer. Cancer Epidemiology, Biomarkers & Prevention: A Publication of the American Association for Cancer Research, Cosponsored by the American Society of Preventive Oncology, 8(6), 533–539.

Malone, K. E., Begg, C. B., Haile, R. W., Borg, A., Concannon, P., Tellhed, L., et al. (2010). Population-based study of the risk of second primary contralateral breast cancer associated with carrying a mutation in BRCA1 or BRCA2. Journal of Clinical Oncology: Official Journal of the American Society of Clinical Oncology, 28(14), 2404–2410. doi:10.1200/JCO.2009.24.2495.CrossRef

Mays, D., Sharff, M. E., DeMarco, T. A., Williams, B., Beck, B., Sheppard, V. B., et al. (2012). Outcomes of a systems-level intervention offering breast cancer risk assessments to low-income underserved women. Familial Cancer, 11(3), 493–502. doi:10.1007/s10689-012-9541-7.CrossRefPubMedPubMedCentral

Metcalfe, K., Lynch, H. T., Ghadirian, P., Tung, N., Olivotto, I., Warner, E., et al. (2004). Contralateral breast cancer in BRCA1 and BRCA2 mutation carriers. Journal of Clinical Oncology: Official Journal of the American Society of Clinical Oncology, 22(12), 2328–2335. doi:10.1200/JCO.2004.04.033.CrossRef

Metcalfe, K., Gershman, S., Ghadirian, P., Lynch, H. T., Snyder, C., Tung, N., et al. (2014). Contralateral mastectomy and survival after breast cancer in carriers of BRCA1 and BRCA2 mutations: retrospective analysis. BMJ (Clinical Research Ed.), 348, g226. doi:10.1136/bmj.g226.

Nanda, R., Schumm, L. P., Cummings, S., Fackenthal, J. D., Sveen, L., Ademuyiwa, F., et al. (2005). Genetic testing in an ethnically diverse cohort of high-risk women, a comparative analysis of BRCA1 and BRCA2 mutations in american families of european and african ancestry. JAMA: The Journal of the American Medical Association, 294(15), 1925–1933.CrossRefPubMed

National Comprehensive Cancer Network. (2015). NCCN clinical practice guidelines in oncology: Genetic/familial high-risk assessment: Breast and ovarian. version 1.2015. accessed june 10, 2015. Retrieved from http://www.nccn.org/professionals/physician_gls/f_guidelines.asp#detection.

Pal, T., Bonner, D., Kim, J., Monteiro, A. N., Kessler, L., Royer, R.,.. . Vadaparampil, S. T. (2013). Early onset breast cancer in a registry-based sample of african-american women: BRCA mutation prevalence, and other personal and system-level clinical characteristics. The Breast Journal, 19(2), 189–192. Retrieved from http://proxy.library.georgetown.edu/login?url=Smithttp://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=medl&AN=23320992

Rebbeck, T. R., Friebel, T., Lynch, H. T., Neuhausen, S. L., van, t V.L, Garber, J. E.,.. . Weber, B. L. (2004). Bilateral prophylactic mastectomy reduces breast cancer risk in BRCA1 and BRCA2 mutation carriers: The PROSE study group. Journal of Clinical Oncology: Official Journal of the American Society of Clinical Oncology, 22(0732–183; 0732–183; 6), 1055–1062.

Schwartz, M. D., Lerman, C., Brogan, B., Peshkin, B. N., Isaacs, C., DeMarco, T., . . . Finch, C. (2005). Utilization of BRCA1/BRCA2 mutation testing in newly diagnosed breast cancer patients. Cancer Epidemiology, Biomarkers & Prevention: A Publication of the American Association for Cancer Research, Cosponsored by the American Society of Preventive Oncology, 14(4), 1003–1007. doi:14/4/1003

Schwartz, M. D., Isaacs, C., Graves, K. D., Poggi, E., Peshkin, B. N., Gell, C., et al. (2012). Long-term outcomes of BRCA1/BRCA2 testing: Risk reduction and surveillance. Cancer, 118(2), 510–517. doi:10.1002/cncr.26294.CrossRefPubMed

Sheppard, V. B., Mays, D., LaVeist, T., & Tercyak, K. P. (2013). Medical mistrust influences black women’s level of engagement in BRCA 1/2 genetic counseling and testing. Journal of the National Medical Association, 105(1), 17–22.CrossRefPubMedPubMedCentral

Sheppard, V. B., Graves, K. D., Christopher, J., Hurtado-de-Mendoza, A., Talley, C., & Williams, K. P. (2014). African american women’s limited knowledge and experiences with genetic counseling for hereditary breast cancer. Journal of Genetic Counseling, 23(3), 311–322. doi:10.1007/s10897-013-9663-6.CrossRefPubMed

Sherman, K. A., Miller, S. M., Shaw, L., Cavanagh, K., & Gorin, S. S. (2013). Psychosocial approaches to participation in BRCA1/2 genetic risk assessment among african american women: a systematic review. Journal of Community Genetics, 5(2), 89–98.CrossRefPubMedPubMedCentral

Siegel, R., Ma, J., Zou, Z., & Jemal, A. (2014). Cancer statistics, 2014. CA: a Cancer Journal for Clinicians, 64(1), 9–29. doi:10.3322/caac.21208.

Smith, K. L., & Isaacs, C. (2011). BRCA mutation testing in determining breast cancer therapy. Cancer Journal (Sudbury, Mass.), 17(6), 492–499. doi:10.1097/PPO.0b013e318238f579.CrossRef

Thompson, H. S., Valdimarsdottir, H. B., Duteau-Buck, C., Guevarra, J., Bovbjerg, D. H., Richmond-Avellaneda, C., et al. (2002). Psychosocial predictors of BRCA counseling and testing decisions among urban african-american women. Cancer Epidemiology, Biomarkers & Prevention: A Publication of the American Association for Cancer Research, Cosponsored by the American Society of Preventive Oncology, 11(12), 1579–1585.

Thompson, H. S., Sussner, K., Schwartz, M. D., Edwards, T., Forman, A., Jandorf, L., et al. (2012). Receipt of genetic counseling recommendations among black women at high risk for BRCA mutations. Genetic Testing and Molecular Biomarkers, 16(11), 1257–1262. doi:10.1089/gtmb.2012.0114.CrossRefPubMed

Weitzel, J. N., McCaffrey, S. M., Nedelcu, R., MacDonald, D. J., Blazer, K. R., & Cullinane, C. A. (2003). Effect of genetic cancer risk assessment on surgical decisions at breast cancer diagnosis. Archives of Surgery (Chicago, Ill.: 1960), 138(12), 1323–1328 discussion 1329. doi:10.1001/archsurg.138.12.1323.CrossRef

Wheeler, S. B., Reeder-Hayes, K. E., & Carey, L. A. (2013). Disparities in breast cancer treatment and outcomes: biological, social, and health system determinants and opportunities for research. The Oncologist, 18(9), 986–993. doi:10.1634/theoncologist.2013-0243.CrossRefPubMedPubMedCentral

Titel: The Role of Knowledge on Genetic Counseling and Testing in Black Cancer Survivors at Increased Risk of Carrying a BRCA1/2 Mutation
verfasst von: Alejandra Hurtado-de-Mendoza
Monica C. Jackson
Lyndsay Anderson
Vanessa B. Sheppard
Publikationsdatum: 12.07.2016
Verlag: Springer US
Erschienen in: Journal of Genetic Counseling / Ausgabe 1/2017
Print ISSN: 1059-7700
Elektronische ISSN: 1573-3599
DOI: https://doi.org/10.1007/s10897-016-9986-1

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The Role of Knowledge on Genetic Counseling and Testing in Black Cancer Survivors at Increased Risk of Carrying a BRCA1/2 Mutation

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