Background
Methods
Study population
Criteria for inclusion and exclusion
Inclusion criteria
-
The patient was diagnosed with STEMI according to the STEMI guidelines in China [17]
-
The onset of chest pain was greater than 12 h earlier
Exclusion criteria
-
Previous PCI or coronary artery bypass graft (CABG) or thrombolytic therapy
-
Myocardial reinfarction
-
Severe myocardial infarction complications before admission
-
Coronary angiography followed by no stent implantation
Treatment
Data extraction
Endpoint
Statistical analysis
variable | First round | second round | third round | fourth round | fifth round | sixth round | seventh round | eighth round | ninth round | tenth round |
---|---|---|---|---|---|---|---|---|---|---|
EF | 3.328 | 3.379 | 3.402 | 3.398 | 3.379 | 3.27 | 3.169 | 3.218 | 3.256 | 3.581 |
LDL | 2.876 | 2.871 | 2.871 | |||||||
HDL | 3.175 | 3.17 | 3.218 | 3.134 | 3.127 | 3.014 | 3.123 | 2.902 | ||
UA | 3.373 | 3.374 | 3.412 | 3.351 | 3.351 | 3.367 | 4.281 | 3.903 | 3.77 | 4.298 |
Scr | 3.09 | 3.095 | 3.088 | 3.067 | 3.056 | 2.964 | ||||
Sex | 2.846 | 2.849 | 2.851 | 2.846 | 2.804 | |||||
Hypertension | 2.8 | 2.796 | 2.807 | 2.775 | 2.763 | 2.614 | 2.76 | |||
Diabetes | 2.895 | 2.897 | ||||||||
Smoking | 2.859 | 2.854 | 2.856 | 2.863 | ||||||
Alcohol | 2.895 | |||||||||
Age | 3.144 | 3.142 | 3.155 | 3.141 | 3.141 | 2.997 | 3.154 | 2.933 | 3.074 |
Results
Baseline characteristics
PCI < 3 days | 3 days < PCI < 7 days | PCI > 7 days | MED | P | ALL PATIENTS | |
---|---|---|---|---|---|---|
N | 62 (14.87%) | 88 (21.10%) | 143 (34.29%) | 124 (29.74%) | ||
Age | 63 (51–72) | 68 (57–77) | 69 (58–78) | 79 (69–84) | < 0.0001 | 71 (58–79) |
Sex | 0.03 | |||||
Male | 46 (74.2%) | 59 (67.0%) | 107 (74.8%) | 73 (58.9%) | 68.30% | |
Female | 16 (25.8%) | 29 (33.0%) | 36 (25.2%) | 51 (41.1%) | 31.70% | |
Hypertension | 34 (54.8%) | 51 (58%) | 82 (57.3%) | 75 (60.5%) | 0.898 | 58.00% |
Hyperlipidaemia | 5 (8.1%) | 1 (1.1%) | 4 (2.8%) | 1 (0.8%) | 0.023 | 2.60% |
Smoking | 28 (45.2%) | 38 (43.2%) | 67 (46.9%) | 47 (38.2%) | 0.548 | 43.30% |
Alcohol | 17 (27.4%) | 21 (23.9%) | 30 (21.0%) | 28 (22.6%) | 0.786 | 23.00% |
Diabetes | 10 (16.1) | 21 (23.9%) | 37 (25.9%) | 19 (15.3%) | 0.122 | 20.90% |
LDL | 2.70 (2.09–3.58) | 3.01 (2.26–4.72) | 2.82 (2.07–3.81) | 2.81 (2.14–3.88) | 0.256 | 2.83 (2.11–3.94) |
HDL | 1.28 (1.00–1.70) | 1.55 (1.03–2.47) | 1.26 (0.91–2.28) | 1.34 (1.01–2.35) | 0.383 | 1.32 (0.99–2.33) |
TC | 4.79 (3.94–6.44) | 5.45 (3.84–9.20) | 5.15 (3.79–8.48) | 4.99 (4.09–7.49) | 0.288 | 4.99 (3.87–7.94) |
UA | 313 (249–413) | 297 (231–361) | 311 (239–401) | 392 (264–507) | < 0.0001 | 324 (245–418) |
Scr | 86 (73–96) | 80 (71–95) | 86 (72–101) | 98 (79–139) | < 0.0001 | 86 (74–107) |
HbA1c | 5.6 (5.2–7.1) | 5.6 (5.2–6.9) | 6.0 (5.5–7.3) | 5.9 (5.5–6.6) | 0.129 | 5.8 (5.4–6.9) |
Glu | 5.75 (4.84–7.08) | 5.61 (4.77–6.50) | 6.03 (5.10–7.28) | 6.06 (4.89–7.87) | 0.114 | 5.87 (4.94–7.44) |
CCS | ||||||
Admission | < 0.0001 | |||||
I | 3 (3.4%) | 11 (7.7%) | 3.40% | |||
II | 2 (3.2%) | 20 (22.7%) | 42 (39.4%) | 8 (6.5%) | 17.30% | |
III | 9 (14.5%) | 23 (26.1%) | 35 (24.5%) | 35 (28.2%) | 24.50% | |
IV | 51 (82.3%) | 42 (47.7%) | 55 (38.5%) | 81 (65.3%) | 54.90% | |
Discharge | < 0.0001 | |||||
I | 20 (32.3%) | 28 (31.8%) | 53 (37.1%) | 10 (8.1%) | 26.60% | |
II | 40 (64.5%) | 59 (67.0%) | 87 (60.8%) | 66 (53.2%) | 60.40% | |
III | 14 (11.3%) | 3.40% | ||||
IV | 2 (3.2%) | 1 (1.1%) | 3 (2.1%) | 34 (27.4%) | 9.60% | |
LV Function | ||||||
EF | 0.61 (0.52–0.67) | 0.64 (0.53–0.70) | 0.60 (0.51–0.66) | 0.57 (0.51–0.67) | 0.251 | 0.61 (0.52–0.67) |
FS | 0.32 ± 0.065 | 0.34 ± 0.084 | 0.312 ± 0.081 | 0.31 ± 0.090 | 0.215 | 0.32 ± 0.08 |
LVDd | 4.99 (4.68–5.30) | 4.99 (4.50–5.43) | 5.12 (4.55–5.55) | 5.05 (4.45–5.49) | 0.635 | 5.03 (4.54–5.48) |
LVDs | 3.50 (3.10–4.21) | 3.20 (2.78–3.82) | 3.52 (2.95–4.23) | 3.33 (2.86–4.06) | 0.091 | 3.36 (2.95–4.12) |
Angiographic | ||||||
LM | 6 (9.7%) | 4 (4.5%) | 11 (7.7%) | 0.459 | 7.20% | |
Single | 24 (38.7%) | 33 (37.5%) | 54 (378%) | 0.988 | 37.90% | |
More | 36 (58.1%) | 53 (60.2%) | 88 (61.5%) | 0.894 | 60.60% |
Primary endpoint
Event | PCI < 3 days (n = 62) | 3 days < PCI < 7 days (n = 88) | PCI > 7 days (n = 143) | MED (n = 124) | P |
---|---|---|---|---|---|
MACE | 7 (11.29) | 7 (7.95) | 6 (4.20) | 32 (25.81) | < 0.0001 |
Heart failure | 3 | 4 | 2 | 17 | < 0.0001 |
Cardiac death | 2 | 3 | 2 | 14 | 0.003 |
Recurrent MI | 0 | 0 | 1 | 1 | 0.328 |
Malignant arrhythmia | 2 | 0 | 0 | 5 | 0.009 |
Bleeding or thrombotic events | 1 | 0 | 1 | 4 | 0.192 |
CCS1 | 2 | 3 | 4 |
---|---|---|---|
1 | < 0.0001 | < 0.0001 | 0.018 |
2 | 0.072 | 0.001 | |
3 | < 0.0001 | ||
CCS2 | |||
1 | 0.901 | 0.468 | < 0.0001 |
2 | 0.491 | < 0.0001 | |
3 | < 0.0001 | ||
MACE | |||
1 | 0.491 | 0.056 | 0.022 |
2 | 0.23 | 0.001 | |
3 | < 0.0001 | ||
Heart failure | |||
1 | 0.933 | 0.143 | 0.066 |
2 | 0.145 | 0.028 | |
3 | < 0.0001 | ||
Cardiac death | |||
1 | 0.951 | 0.386 | 0.065 |
2 | 0.309 | 0.038 | |
3 | 0.001 |