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20.10.2015 | Original Article | Ausgabe 3/2016

Tumor Biology 3/2016

The role of MALAT1/miR-1/slug axis on radioresistance in nasopharyngeal carcinoma

Zeitschrift:
Tumor Biology > Ausgabe 3/2016
Autoren:
Chuan Jin, Bingchuan Yan, Qin Lu, Yanmin Lin, Lei Ma
Wichtige Hinweise

Electronic supplementary material

The online version of this article (doi:10.​1007/​s13277-015-4227-z) contains supplementary material, which is available to authorized users.
Chuan Jin, Bingchuan Yan, Qin Lu and Yanmin Lin contributed equally to this work.

Abstract

Recent studies demonstrated that long non-coding RNAs (lncRNAs) have a critical role in the regulation of cancer progression and metastasis. However, little is known whether lncRNA regulated nasopharyngeal carcinoma (NPC) cell radioresistance. In the present study, we found that MALAT1 was significantly upregulated in NPC cell lines and tissues. Knockdown of MALAT1 could sensitize NPC cells to radiation both in vitro and in vivo. Interestingly, we found that MALAT1 regulated radioresistance by modulating cancer stem cell (CSC) activity. Furthermore, we found that there was reciprocal repression between MALAT1 and miR-1, and slug was identified as a downstream target of miR-1. Taking these observations into consideration, we proposed that MALAT1 regulated CSC activity and radioresistance by modulating miR-1/slug axis, which indicated that MALAT1 could act as a therapeutic target for NPC patients.

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Zusatzmaterial
High resolution image (TIFF 2208kb)
13277_2015_4227_MOESM1_ESM.tif
High resolution image (TIFF 4240 kb)
13277_2015_4227_MOESM2_ESM.tif
High resolution image (TIFF 4560kb)
13277_2015_4227_MOESM3_ESM.tif
High resolution image (TIFF 656kb)
13277_2015_4227_MOESM4_ESM.tif
Supplementary Table 1 The complementary base pairing among microRNAs and MALAT1. (PDF 79 kb)
13277_2015_4227_MOESM5_ESM.pdf
Supplementary Table 2 The primers used in the study. (DOC 31kb)
13277_2015_4227_MOESM6_ESM.doc
Supplementary Table 3 (DOC 29kb)
13277_2015_4227_MOESM7_ESM.doc
Literatur
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